KEGG   PATHWAY: mlf04014
Entry
mlf04014                    Pathway                                
Name
Ras signaling pathway - Myotis lucifugus (little brown bat)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
mlf04014  Ras signaling pathway
mlf04014

Other DBs
GO: 0032318
Organism
Myotis lucifugus (little brown bat) [GN:mlf]
Gene
102424256  EGF; pro-epidermal growth factor [KO:K04357]
102434624  TGFA; protransforming growth factor alpha isoform X2 [KO:K08774]
102431344  FGF1; fibroblast growth factor 1 [KO:K18496]
111825710  FGF2; fibroblast growth factor 2 [KO:K18497]
102420818  FGF16; fibroblast growth factor 16 [KO:K04358]
102438838  FGF10; fibroblast growth factor 10 [KO:K04358]
102421786  FGF6; fibroblast growth factor 6 [KO:K04358]
102422136  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
102432454  FGF20; fibroblast growth factor 20 [KO:K04358]
102442835  FGF9; fibroblast growth factor 9 [KO:K04358]
102426314  FGF4; fibroblast growth factor 4 [KO:K04358]
102428863  FGF7; fibroblast growth factor 7 [KO:K04358]
102428528  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
102429928  FGF8; LOW QUALITY PROTEIN: fibroblast growth factor 8 [KO:K04358]
102426634  FGF3; fibroblast growth factor 3 [KO:K04358]
102440432  FGF18; fibroblast growth factor 18 [KO:K04358]
102426451  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102426004  FGF19; fibroblast growth factor 19 [KO:K22603]
102432520  FGF21; fibroblast growth factor 21 [KO:K22429]
102439118  fibroblast growth factor 21-like [KO:K22429]
102432233  FGF23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428]
102427030  NGF; beta-nerve growth factor [KO:K02582]
102440705  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
102418196  NTF3; neurotrophin-3 [KO:K04356]
102430737  INS; insulin [KO:K04526]
102424041  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
102422469  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
102426780  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102442814  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102418575  PDGFD; platelet-derived growth factor D [KO:K05450]
102429105  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
102416825  KITLG; kit ligand isoform X6 [KO:K05461]
102426433  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
102438597  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
102421300  PGF; placenta growth factor isoform X1 [KO:K16859]
102421161  VEGFD; vascular endothelial growth factor D [KO:K05449]
102438038  VEGFC; vascular endothelial growth factor C [KO:K05449]
102441297  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102434406  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
106695515  uncharacterized protein LOC106695515 [KO:K05466]
102439232  ANGPT4; angiopoietin-4 [KO:K05467]
102418395  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
102436484  EFNA3; LOW QUALITY PROTEIN: ephrin-A3 [KO:K05462]
102428621  EFNA1; ephrin-A1 [KO:K05462]
102436800  EFNA4; ephrin-A4 [KO:K05462]
102435571  ephrin-A2 [KO:K05462]
102435209  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102423450  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
102419131  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102420805  NGFR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102431497  NTRK1; LOW QUALITY PROTEIN: high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
102426842  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
102437355  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
102430595  IGF1R; LOW QUALITY PROTEIN: insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102417415  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
102441579  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102442629  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
102442787  KIT; mast/stem cell growth factor receptor Kit isoform X2 [KO:K05091] [EC:2.7.10.1]
102420687  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
102417951  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
102422327  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
102430005  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
102442473  KDR; vascular endothelial growth factor receptor 2 isoform X3 [KO:K05098] [EC:2.7.10.1]
102441042  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
102429943  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
102437052  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
102421027  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
102428634  GAB1; GRB2-associated-binding protein 1 isoform X3 [KO:K09593]
102433673  GAB2; LOW QUALITY PROTEIN: GRB2-associated-binding protein 2 [KO:K08091]
102430334  SHC1; SHC-transforming protein 1 isoform X2 [KO:K06279]
102435382  SHC3; LOW QUALITY PROTEIN: SHC-transforming protein 3 [KO:K17448]
102431548  SHC4; LOW QUALITY PROTEIN: SHC-transforming protein 4 [KO:K17449]
102420806  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
102442926  SOS1; son of sevenless homolog 1 [KO:K03099]
102437531  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
102421330  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
102420000  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859] [EC:3.1.4.11]
102440792  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
102427498  RASGRP2; LOW QUALITY PROTEIN: RAS guanyl-releasing protein 2 [KO:K12361]
102420246  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
102439442  RASGRP4; LOW QUALITY PROTEIN: RAS guanyl-releasing protein 4 [KO:K12363]
102418755  LOW QUALITY PROTEIN: tyrosine-protein kinase ZAP-70-like [KO:K07360] [EC:2.7.10.2]
102438171  LAT; LOW QUALITY PROTEIN: linker for activation of T-cells family member 1 [KO:K07362]
102422303  5-hydroxytryptamine receptor 7-like [KO:K04163]
102420431  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
102420482  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
102428334  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
102431535  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
102420203  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
102441805  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
102442437  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102428001  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
102422498  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
106697041  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
102432910  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
102432599  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
102428066  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102431853  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
102432692  guanine nucleotide-binding protein G(T) subunit gamma-T1-like [KO:K04548]
102420164  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
102437773  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102417960  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102420695  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
102436175  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
102433108  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
102430787  CALM2; calmodulin-2 isoform X1 [KO:K02183]
102417912  calmodulin-A-like isoform X1 [KO:K02183]
102419493  calmodulin-like protein 3 [KO:K02183]
102419808  calmodulin-like protein 5 [KO:K02183]
102426645  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
102434863  CALM1; calmodulin-1 [KO:K02183]
102440407  calmodulin-like [KO:K02183]
102443136  calmodulin-like [KO:K02183]
102431999  KRAS; GTPase KRas isoform X1 [KO:K07827]
102430744  NRAS; GTPase NRas [KO:K07828]
102430727  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
102423374  RRAS; ras-related protein R-Ras [KO:K07829]
102426387  RRAS2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
102421097  NF1; neurofibromin [KO:K08052]
102443135  RASA1; ras GTPase-activating protein 1 [KO:K04352]
102420713  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
102431629  RASA3; ras GTPase-activating protein 3 [KO:K12380]
102428580  ras GTPase-activating protein 4 [KO:K17630]
102433745  SYNGAP1; LOW QUALITY PROTEIN: ras/Rap GTPase-activating protein SynGAP [KO:K17631]
102431552  RASAL1; rasGAP-activating-like protein 1 [KO:K17632]
102424497  RASAL2; ras GTPase-activating protein nGAP isoform X3 [KO:K17633]
102424852  RASAL3; LOW QUALITY PROTEIN: RAS protein activator like-3 [KO:K17634]
102422877  RASSF1; ras association domain-containing protein 1 isoform X2 [KO:K09850]
102442160  RASSF5; ras association domain-containing protein 5 [KO:K08015]
102429707  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
102435667  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102418852  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102423786  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
102436424  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102438044  PAK3; serine/threonine-protein kinase PAK 3 isoform X4 [KO:K05733] [EC:2.7.11.1]
102420569  PAK4; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
102443084  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
102431483  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
102422264  RHOA; transforming protein RhoA [KO:K04513]
102430746  transforming protein RhoA-like isoform X1 [KO:K04513]
102422649  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102441064  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102433534  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102427890  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
102441522  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
102429230  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102426106  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102419324  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
102443221  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102439923  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102436137  IKBKG; NF-kappa-B essential modulator isoform X3 [KO:K07210]
102425603  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102417312  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X4 [KO:K07209] [EC:2.7.11.10]
102435748  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102424236  RELA; transcription factor p65 [KO:K04735]
102437980  BAD; bcl2-associated agonist of cell death [KO:K02158]
102443091  BCL2L1; bcl-2-like protein 1 [KO:K04570]
102442512  FOXO4; forkhead box protein O4 [KO:K12358]
102439228  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102425832  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X9 [KO:K25768]
102440417  RALGAPA2; ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768]
102417351  RALGAPB; ral GTPase-activating protein subunit beta [KO:K25769]
102418938  ral guanine nucleotide dissociation stimulator [KO:K08732]
102418453  RGL1; ral guanine nucleotide dissociation stimulator-like 1 isoform X2 [KO:K17635]
102439499  RGL2; ral guanine nucleotide dissociation stimulator-like 2 isoform X5 [KO:K17636]
102432493  RALA; ras-related protein Ral-A [KO:K07834]
102417752  RALB; ras-related protein Ral-B isoform X1 [KO:K07835]
102443088  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
102423031  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
102429559  EXOC2; exocyst complex component 2 isoform X1 [KO:K17637]
102424113  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
102432995  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
102430582  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102437455  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102418507  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102425126  RALBP1; LOW QUALITY PROTEIN: ralA-binding protein 1 [KO:K08773]
102439024  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102439095  AFDN; LOW QUALITY PROTEIN: afadin [KO:K05702]
102424386  SHOC2; leucine-rich repeat protein SHOC-2 isoform X1 [KO:K19613]
102434453  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102417411  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
102423748  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102417755  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102422236  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102426606  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
102431173  PLA2G5; calcium-dependent phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102427978  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102428297  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102417707  phospholipase A2, membrane associated-like isoform X2 [KO:K01047] [EC:3.1.1.4]
102427359  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102431800  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102429635  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102430532  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102427659  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
102427037  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
102427352  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
102419823  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X2 [KO:K01047] [EC:3.1.1.4]
102441692  PLA2G3; LOW QUALITY PROTEIN: group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102425307  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102422494  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
102424085  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
102419721  cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
102420552  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
102422798  PLA2G4F; LOW QUALITY PROTEIN: cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
102428839  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
102440971  HRAS-like suppressor 3 isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
102418973  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
111824419  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
102419292  LOW QUALITY PROTEIN: HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
111823011  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
102419846  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
102437429  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
102418187  ETS2; protein C-ets-2 isoform X2 [KO:K21932]
102438949  BRAP; BRCA1-associated protein isoform X4 [KO:K10632] [EC:2.3.2.27]
102422701  KSR1; kinase suppressor of Ras 1 [KO:K14958]
102438649  KSR2; LOW QUALITY PROTEIN: kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
102432406  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X2 [KO:K08019]
102418362  RAP1A; ras-related protein Rap-1A [KO:K04353]
102441232  RAP1B; ras-related protein Rap-1b [KO:K07836]
102427329  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
102438932  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
102428240  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102419083  protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
102434862  RIN1; ras and Rab interactor 1 isoform X1 [KO:K17638]
102433845  ABL1; LOW QUALITY PROTEIN: tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
102427521  ABL2; Abelson tyrosine-protein kinase 2 isoform X1 [KO:K08887] [EC:2.7.10.2]
102439178  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
102439986  RAB5B; ras-related protein Rab-5B [KO:K07888]
102427535  RAB5C; ras-related protein Rab-5C isoform X1 [KO:K07889]
102426371  ARF6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
mlf04010  MAPK signaling pathway
mlf04015  Rap1 signaling pathway
mlf04020  Calcium signaling pathway
mlf04144  Endocytosis
mlf04151  PI3K-Akt signaling pathway
mlf04660  T cell receptor signaling pathway
mlf04720  Long-term potentiation
mlf04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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