KEGG   PATHWAY: oaa05022
Entry
oaa05022                    Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Ornithorhynchus anatinus (platypus)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
oaa05022  Pathways of neurodegeneration - multiple diseases
oaa05022

Organism
Ornithorhynchus anatinus (platypus) [GN:oaa]
Gene
100090292  amyloid-beta precursor protein isoform X1 [KO:K04520]
100088033  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
100078687  TAR DNA-binding protein 43 [KO:K23600]
100087740  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
114817987  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
100074750  ATXN2; ataxin-2 isoform X1 [KO:K23625]
100090123  ATXN2L; ataxin-2-like protein isoform X4 [KO:K23625]
103169301  HTT; LOW QUALITY PROTEIN: huntingtin [KO:K04533]
100076905  ATXN1L; ataxin-1-like [KO:K23616]
103170056  ATXN1; ataxin-1 [KO:K23616]
100083794  ATXN3; ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
100086593  major prion protein isoform X1 [KO:K05634]
100086064  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
114815970  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04129]
100084007  CHRM3; muscarinic acetylcholine receptor M3 isoform X2 [KO:K04131]
100091346  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
100075372  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
100080549  GRM5; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5 [KO:K04604]
100080691  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
114809162  PRKN; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
100078508  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100084272  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100081349  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100086536  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
100078757  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
100079107  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100074181  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100085442  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100082395  TRPC3; short transient receptor potential channel 3 [KO:K04966]
114810011  SIGMAR1; sigma non-opioid intracellular receptor 1 [KO:K20719]
100075749  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
103164954  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100088770  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100681936  RYR1; ryanodine receptor 1 [KO:K04961]
100084273  RYR2; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
100089020  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
103167988  PDYN; proenkephalin-B isoform X1 [KO:K15840]
100078807  DLG4; disks large homolog 4 isoform X1 [KO:K11828]
100082705  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100074436  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
100090612  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100681823  GRIN2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
100084653  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
100075295  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
100079654  GRIA2; LOW QUALITY PROTEIN: glutamate receptor 2 [KO:K05198]
100079680  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
100078422  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
100681261  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
100082618  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
100077296  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
100075939  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
100093447  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
103169086  STX1A; LOW QUALITY PROTEIN: syntaxin-1A [KO:K04560]
100087588  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
100092580  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
100073740  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
100086258  ATP2A3; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
100091250  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
100076299  PSEN2; presenilin-2 [KO:K04522] [EC:3.4.23.-]
100080383  DERL1; derlin-1 isoform X1 [KO:K11519]
100091585  transitional endoplasmic reticulum ATPase [KO:K13525]
100077847  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
100078088  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
100074541  UBC; polyubiquitin-C isoform X1 [KO:K08770]
100077981  polyubiquitin-C isoform X1 [KO:K08770]
100077605  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
100075308  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
100082413  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
100073396  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
100086434  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
100093532  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
100086673  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
114808032  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
100078811  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
100087357  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
100077529  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
100089973  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
100082504  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
100091687  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
100076569  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
100088021  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
100088836  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
100093302  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
100080509  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
114815139  PSMC5; 26S proteasome regulatory subunit 8 [KO:K03066]
100076043  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
100077344  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
100080824  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
100074601  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
100079412  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 isoform X1 [KO:K03035]
103166362  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
100092874  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
100078921  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
100092761  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
100077210  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
100073491  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
100074418  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
100093442  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
114815493  UCHL1; ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
100079248  UBA1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
100092397  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
114806081  UBE2L3; ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
100080625  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1 [KO:K04553] [EC:2.3.2.23]
100081225  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
100082953  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
100083857  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
100092686  UBE2G1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
100076785  GPR37; prosaposin receptor GPR37 [KO:K04243]
114806141  SEPTIN5; septin-5 isoform X1 [KO:K04557]
100076747  synphilin-1 isoform X1 [KO:K04558]
100681083  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
100080121  VAPB; vesicle-associated membrane protein-associated protein B/C [KO:K10707]
100091907  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
103167225  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
100077370  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
100079980  ERN1; LOW QUALITY PROTEIN: serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
100681935  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
100681066  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
100081079  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
100089737  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X3 [KO:K04431] [EC:2.7.12.2]
100073424  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100076033  MAPK8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
100082590  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100092507  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
100081193  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
100074113  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
100089902  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100074809  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
100089816  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
808708  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
808700  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
808710  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
808699  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
808698  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
808701  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
808706  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
100092852  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
100076572  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
100080859  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X2 [KO:K03944]
100078945  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
100088525  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
103169972  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
100089801  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
114814719  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
100076349  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
100086818  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
103171189  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
100081651  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
100085363  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial isoform X1 [KO:K03953]
100080496  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
100073665  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
100082311  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
100073802  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
100682250  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
103167180  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
100086429  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
100089265  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
100089450  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
100083885  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
100680990  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
114813135  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
100084515  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
100080588  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
100081152  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
114812795  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
100085312  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
114807989  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
100082649  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
100075551  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
100076967  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
100081627  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
100076603  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
114809999  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
100092030  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
114805804  NADH dehydrogenase [ubiquinone] 1 subunit C2-like [KO:K03968]
100083131  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
100074487  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
100089418  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
114815211  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
100074926  cytochrome b-c1 complex subunit Rieske, mitochondrial isoform X1 [KO:K00411] [EC:7.1.1.8]
808703  CYTB; cytochrome b [KO:K00412]
107546954  cytochrome c1, heme protein, mitochondrial [KO:K00413]
100074417  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
100077249  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
114818207  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
100073821  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
100080559  cytochrome b-c1 complex subunit 8 [KO:K00418]
100088975  cytochrome b-c1 complex subunit 9 [KO:K00419]
100082774  UQCR11; cytochrome b-c1 complex subunit 10 [KO:K00420]
808707  COX3; cytochrome c oxidase subunit III [KO:K02262]
808704  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
808709  COX2; cytochrome c oxidase subunit II [KO:K02261]
100076685  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [KO:K02263]
114806037  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
100081055  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
100091270  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
100079440  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
114809040  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
114809154  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
100089037  cytochrome c oxidase subunit 6B1 [KO:K02267]
100074669  cytochrome c oxidase subunit 6C [KO:K02268]
100076020  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
100091985  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
114811991  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
100073487  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
100077093  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
100085791  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
100075472  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
100087676  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
100680772  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
100090214  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
100074047  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
808705  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
100076804  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
100084526  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
100090032  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
114814979  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
100085769  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
100083165  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
114817674  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
808702  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
114807635  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100079428  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100085676  TOMM40L; mitochondrial import receptor subunit TOM40B [KO:K11518]
103165965  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
100077394  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
100075369  CALM1; calmodulin-1 [KO:K02183]
100083509  CALM2; calmodulin-2 [KO:K02183]
100085837  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
103165382  calmodulin-A-like [KO:K02183]
114812128  CALM3; calmodulin-3 [KO:K02183]
114816270  CALML3; calmodulin-like protein 3 [KO:K02183]
100087467  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100083890  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100073776  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100083665  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
114810030  BAD; bcl2-associated agonist of cell death [KO:K02158]
100081646  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103165091  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
100075638  FADD; FAS-associated death domain protein [KO:K02373]
100082949  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100087835  caspase-8-like [KO:K04398] [EC:3.4.22.61]
100088569  BID; BH3-interacting domain death agonist [KO:K04726]
114814649  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
114813317  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
100080785  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 [KO:K08844] [EC:2.7.11.1]
114811155  HTRA2; serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
100080150  TRAP1; heat shock protein 75 kDa, mitochondrial [KO:K09488]
100075011  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100076584  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
100080434  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
100087351  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
114812883  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
100073904  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
100077443  cytochrome c [KO:K08738]
100073402  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
100092345  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
100087105  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100089983  HIP1; huntingtin-interacting protein 1 isoform X1 [KO:K04559]
100089127  IFT57; intraflagellar transport protein 57 homolog [KO:K04638]
100081790  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
100079388  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
100073498  PARK7; Parkinson disease protein 7 [KO:K05687] [EC:3.5.1.124]
107546921  BCL2L1; bcl-2-like protein 1 [KO:K04570]
100073872  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
100089939  MFN2; mitofusin-2 isoform X1 [KO:K06030] [EC:3.6.5.-]
100085347  OPTN; optineurin isoform X1 [KO:K19946]
100074478  SQSTM1; sequestosome-1 isoform X2 [KO:K14381]
100082738  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
114816899  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
100076520  TBK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
100077165  TANK; TRAF family member-associated NF-kappa-B activator [KO:K12650]
100083483  WDR41; WD repeat-containing protein 41 [KO:K23610]
100078736  SMCR8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
100073471  C9orf72; guanine nucleotide exchange C9orf72 homolog isoform X1 [KO:K23609]
100092137  RAB8A; ras-related protein Rab-8A isoform X1 [KO:K07901]
100084248  RAB39B; ras-related protein Rab-39B [KO:K07925]
100082751  RAB1A; ras-related protein Rab-1A isoform X1 [KO:K07874]
100079751  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
100093196  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
100077170  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
114814763  ATG101; autophagy-related protein 101 [KO:K19730]
100087432  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
100079581  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
100093574  AMBRA1; LOW QUALITY PROTEIN: activating molecule in BECN1-regulated autophagy protein 1 [KO:K17985]
100083983  BECN1; beclin-1 isoform X1 [KO:K08334]
100080711  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
100681077  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
100079809  NRBF2; nuclear receptor-binding factor 2 [KO:K21246]
100076306  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
100081216  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
100681456  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
100078638  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
100082003  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
100081199  zinc finger FYVE domain-containing protein 1-like [KO:K17603]
100090119  ZFYVE1; zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603]
100088146  ALS2; alsin isoform X1 [KO:K04575]
100076995  RAB5A; ras-related protein Rab-5A [KO:K07887]
100076220  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100084750  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
100076962  FIG4; polyphosphoinositide phosphatase isoform X1 [KO:K22913] [EC:3.1.3.-]
100082624  SPG11; spatacsin isoform X1 [KO:K19026]
100085643  TNF; tumor necrosis factor [KO:K03156]
100085735  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
103166118  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
114807616  DAXX; death domain-associated protein 6 [KO:K02308]
100080734  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
100078394  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
100078507  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
100091330  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100092264  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100093026  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100093259  NOS1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
114809982  CCS; copper chaperone for superoxide dismutase [KO:K04569]
100090031  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
100073567  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
100078236  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
100091665  GPX8; probable glutathione peroxidase 8 isoform X2 [KO:K00432] [EC:1.11.1.9]
100087034  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
100076353  CAT; catalase [KO:K03781] [EC:1.11.1.6]
103169832  PRPH; LOW QUALITY PROTEIN: peripherin [KO:K07607]
100077288  NEFL; neurofilament light polypeptide [KO:K04572]
100077333  NEFM; neurofilament medium polypeptide [KO:K04573]
100087063  NEFH; neurofilament heavy polypeptide [KO:K04574]
100076805  KIF5B; kinesin-1 heavy chain [KO:K10396]
100088788  KIF5C; kinesin heavy chain [KO:K10396]
103166538  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
100075996  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
100077087  KLC4; kinesin light chain 4 [KO:K10407]
114810131  KLC2; kinesin light chain 2 [KO:K10407]
114812115  KLC3; kinesin light chain 3 [KO:K10407]
100079742  TUBA1B; tubulin alpha-1B chain [KO:K07374]
100075816  tubulin alpha-8 chain [KO:K07374]
100079918  TUBA1A; tubulin alpha-1A chain [KO:K07374]
114811984  TUBA4A; tubulin alpha-4A chain [KO:K07374]
100088515  tubulin alpha-3 chain [KO:K07374]
100085942  tubulin alpha-4A chain [KO:K07374]
100077627  tubulin alpha-8 chain isoform X2 [KO:K07374]
100079040  tubulin beta-2A chain isoform X1 [KO:K07375]
100080473  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
100086969  TUBB4A; tubulin beta-4A chain [KO:K07375]
100089091  TUBB6; tubulin beta-6 chain [KO:K07375]
100080031  TUBB3; tubulin beta-3 chain [KO:K07375]
100077354  TUBB4B; tubulin beta-4B chain [KO:K07375]
100079562  tubulin beta-2B chain [KO:K07375]
107546818  TUBB; tubulin beta chain [KO:K07375]
114805411  tubulin beta-2B chain [KO:K07375]
114805389  tubulin beta-2A chain isoform X2 [KO:K07375]
100092089  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100074583  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
100079695  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
114808033  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
100081142  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
103166161  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
114814741  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
114809980  DCTN3; dynactin subunit 3 [KO:K10425]
100078372  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
100073579  DCTN5; dynactin subunit 5 [KO:K10427]
100092836  DCTN6; dynactin subunit 6 [KO:K10428]
100080973  ACTR1A; alpha-centractin [KO:K16575]
100091258  ACTR1B; beta-centractin isoform X1 [KO:K16575]
100086662  ACTR10; actin-related protein 10 [KO:K16576]
100076865  DNAH3; dynein heavy chain 3, axonemal isoform X1 [KO:K10408]
100083380  dynein heavy chain 11, axonemal [KO:K10408]
100089977  DNAH5; dynein heavy chain 5, axonemal [KO:K10408]
100077245  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
100076142  DNAH8; dynein heavy chain 8, axonemal isoform X1 [KO:K10408]
100083396  DNAH17; LOW QUALITY PROTEIN: dynein heavy chain 17, axonemal [KO:K10408]
100076321  DNAH10; dynein heavy chain 10, axonemal isoform X1 [KO:K10408]
100081861  DNAH14; dynein heavy chain 14, axonemal isoform X1 [KO:K10408]
100083401  dynein heavy chain 5, axonemal-like isoform X1 [KO:K10408]
100089249  LOW QUALITY PROTEIN: dynein heavy chain 9, axonemal-like [KO:K10408]
100073640  DNAH1; dynein heavy chain 1, axonemal isoform X1 [KO:K10408]
100075568  DNAH7; dynein heavy chain 7, axonemal isoform X1 [KO:K10408]
103167043  DNAH2; LOW QUALITY PROTEIN: dynein heavy chain 2, axonemal [KO:K10408]
100080252  DNAH12; dynein heavy chain 12, axonemal isoform X1 [KO:K10408]
100079142  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
100084774  DNAI1; dynein intermediate chain 1, axonemal [KO:K10409]
100080106  DNAI2; dynein intermediate chain 2, axonemal [KO:K11143]
100091068  DNAL1; dynein light chain 1, axonemal isoform X1 [KO:K10411]
100090273  DNAL4; dynein light chain 4, axonemal isoform X1 [KO:K10412]
100089453  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
100079279  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100074083  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
100089905  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100680746  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
100092537  CAPN11; calpain-11 [KO:K01367] [EC:3.4.22.52]
100081577  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
100084018  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
100091902  CDK5; cyclin-dependent-like kinase 5 isoform X1 [KO:K02090] [EC:2.7.11.22]
100082745  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
114817891  caspase-7-like [KO:K04397] [EC:3.4.22.60]
100073484  DKK1; dickkopf-related protein 1 [KO:K02165]
100080514  DKK2; dickkopf-related protein 2 [KO:K02165]
100093417  DKK4; dickkopf-related protein 4 [KO:K02165]
114814562  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100077640  WNT2; protein Wnt-2 precursor [KO:K00182]
100087253  WNT2B; protein Wnt-2b [KO:K00182]
100090103  WNT3A; LOW QUALITY PROTEIN: protein Wnt-3a [KO:K00312]
100075238  WNT4; protein Wnt-4 [KO:K00408]
100085809  WNT5B; protein Wnt-5b [KO:K00444]
100088897  WNT5A; protein Wnt-5a [KO:K00444]
100089786  WNT6; protein Wnt-6 [KO:K00445]
100075994  WNT7A; protein Wnt-7a [KO:K00572]
100093588  WNT7B; protein Wnt-7b [KO:K00572]
100088910  protein Wnt-7a-like [KO:K00572]
100079874  WNT8B; protein Wnt-8b [KO:K00714]
100085370  WNT8A; protein Wnt-8a [KO:K00714]
100074117  WNT9A; protein Wnt-9a [KO:K01064]
100090678  WNT10A; protein Wnt-10a [KO:K01357]
107547159  WNT10B; protein Wnt-10b [KO:K01357]
100091700  WNT11; protein Wnt-11 [KO:K01384]
100077974  WNT16; protein Wnt-16 [KO:K01558]
100081860  FZD7; frizzled-7 [KO:K02432]
114813907  FZD1; frizzled-1 [KO:K02432]
100090775  FZD2; frizzled-2 [KO:K02235]
100086058  FZD3; frizzled-3 [KO:K02329]
100080994  FZD4; frizzled-4 [KO:K02354]
100089547  FZD5; LOW QUALITY PROTEIN: frizzled-5 [KO:K02375]
114816216  FZD8; frizzled-8 [KO:K02375]
100080710  FZD6; frizzled-6 [KO:K02376]
100091844  FZD10; frizzled-10 [KO:K02842]
100080214  FZD9; frizzled-9 [KO:K02842]
100077194  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
100090166  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
100091980  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
100089867  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
100681615  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
114810222  GSK-3-binding protein FRAT2-like [KO:K03096]
100093450  AXIN1; axin-1 [KO:K02157]
100077932  AXIN2; axin-2 [KO:K04385]
100082114  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
100682203  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
100080628  CTNNB1; catenin beta-1 [KO:K02105]
100076676  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
100090019  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
114809992  HRAS; GTPase HRas [KO:K02833]
100085430  KRAS; GTPase KRas isoform X1 [KO:K07827]
100074671  NRAS; GTPase NRas [KO:K07828]
100084423  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
100086380  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100089456  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100080362  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100087942  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100085480  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100086487  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100082988  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
100081482  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
100074633  RELA; transcription factor p65 isoform X1 [KO:K04735]
100083819  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100075386  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
100086096  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100083298  IL6; interleukin-6 [KO:K05405]
103165286  interleukin-1 beta [KO:K04519]
100073393  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
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Nat Neurosci 21:1300-1309 (2018)
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Dugger BN, Dickson DW
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Pathology of Neurodegenerative Diseases.
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Cold Spring Harb Perspect Biol 9:a028035 (2017)
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PMID:20070435
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  Title
Basic mechanisms of neurodegeneration: a critical update.
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J Cell Mol Med 14:457-87 (2010)
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Recent advances in our understanding of neurodegeneration.
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J Neural Transm (Vienna) 116:1111-62 (2009)
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Int J Mol Sci 20:E719 (2019)
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Protein aggregation and neurodegenerative disease.
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Nat Med 10 Suppl:S10-7 (2004)
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Soto C, Pritzkow S
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Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.
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Nat Neurosci 21:1332-1340 (2018)
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Reference
PMID:25132814
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Dantuma NP, Bott LC
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The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution.
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Front Mol Neurosci 7:70 (2014)
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PMID:25413678
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Zheng C, Geetha T, Babu JR
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Failure of ubiquitin proteasome system: risk for neurodegenerative diseases.
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Neurodegener Dis 14:161-75 (2014)
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Reference
PMID:32397599
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Park H, Kang JH, Lee S
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Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates.
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Int J Mol Sci 21:E3369 (2020)
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Reference
PMID:31783880
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Malik BR, Maddison DC, Smith GA, Peters OM
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Autophagic and endo-lysosomal dysfunction in neurodegenerative disease.
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Mol Brain 12:100 (2019)
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Reference
PMID:29734735
  Authors
Metaxakis A, Ploumi C, Tavernarakis N
  Title
Autophagy in Age-Associated Neurodegeneration.
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Cells 7:E37 (2018)
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Reference
PMID:25270767
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Vidal RL, Matus S, Bargsted L, Hetz C
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Targeting autophagy in neurodegenerative diseases.
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Trends Pharmacol Sci 35:583-91 (2014)
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Reference
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  Title
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.
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Neuron 93:1015-1034 (2017)
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Reference
PMID:30030024
  Authors
Chu CT
  Title
Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases.
  Journal
Neurobiol Dis 122:23-34 (2019)
DOI:10.1016/j.nbd.2018.07.015
Reference
PMID:19043451
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Kim I, Xu W, Reed JC
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Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities.
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Nat Rev Drug Discov 7:1013-30 (2008)
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Reference
PMID:21722302
  Authors
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J Neurochem 142:812-826 (2017)
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The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases.
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Nat Rev Neurosci 15:233-49 (2014)
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Trends Mol Med 15:89-100 (2009)
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The Interplay between Ca(2+) Signaling Pathways and Neurodegeneration.
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Nat Rev Neurosci 14:161-76 (2013)
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Related
pathway
oaa00190  Oxidative phosphorylation
oaa03050  Proteasome
oaa04020  Calcium signaling pathway
oaa04120  Ubiquitin mediated proteolysis
oaa04137  Mitophagy - animal
oaa04140  Autophagy - animal
oaa04141  Protein processing in endoplasmic reticulum
oaa04142  Lysosome
oaa04210  Apoptosis
oaa04310  Wnt signaling pathway
oaa04724  Glutamatergic synapse
oaa04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   
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