KEGG   PATHWAY: oaa05022
Entry
oaa05022                    Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Ornithorhynchus anatinus (platypus)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
oaa05022  Pathways of neurodegeneration - multiple diseases
oaa05022

Organism
Ornithorhynchus anatinus (platypus) [GN:oaa]
Gene
100073393  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
100073396  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
100073402  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
100073424  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100073471  C9orf72; guanine nucleotide exchange C9orf72 homolog isoform X1 [KO:K23609]
100073484  DKK1; dickkopf-related protein 1 [KO:K02165]
100073487  [KO:K02271]
100073491  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
100073498  PARK7; Parkinson disease protein 7 [KO:K05687] [EC:3.5.1.124]
100073567  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
100073579  DCTN5; dynactin subunit 5 [KO:K10427]
100073640  DNAH1; dynein heavy chain 1, axonemal isoform X1 [KO:K10408]
100073665  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
100073740  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
100073776  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100073802  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
100073821  [KO:K00417]
100073872  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
100073904  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
100074047  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
100074083  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
100074113  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
100074117  WNT9A; protein Wnt-9a [KO:K01064]
100074181  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100074417  [KO:K00414]
100074418  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
100074436  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
100074478  SQSTM1; sequestosome-1 isoform X2 [KO:K14381]
100074487  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
100074541  UBC; polyubiquitin-C isoform X1 [KO:K08770]
100074583  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
100074601  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
100074633  RELA; transcription factor p65 isoform X1 [KO:K04735]
100074669  [KO:K02268]
100074671  NRAS; GTPase NRas [KO:K07828]
100074750  ATXN2; ataxin-2 isoform X1 [KO:K23625]
100074809  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
100074926  [KO:K00411] [EC:7.1.1.8]
100075011  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100075238  WNT4; protein Wnt-4 [KO:K00408]
100075295  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
100075308  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
100075369  CALM1; calmodulin-1 [KO:K02183]
100075372  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
100075386  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
100075472  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
100075551  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
100075568  DNAH7; dynein heavy chain 7, axonemal isoform X1 [KO:K10408]
100075638  FADD; FAS-associated death domain protein [KO:K02373]
100075749  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
100075816  [KO:K07374]
100075939  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
100075994  WNT7A; protein Wnt-7a [KO:K00572]
100075996  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
100076020  [KO:K02270]
100076033  MAPK8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
100076043  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
100076142  DNAH8; dynein heavy chain 8, axonemal isoform X1 [KO:K10408]
100076220  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100076299  PSEN2; presenilin-2 [KO:K04522] [EC:3.4.23.-]
100076306  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
100076321  DNAH10; dynein heavy chain 10, axonemal isoform X1 [KO:K10408]
100076349  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
100076353  CAT; catalase [KO:K03781] [EC:1.11.1.6]
100076520  TBK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
100076569  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
100076572  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
100076584  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
100076603  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
100076676  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
100076685  [KO:K02263]
100076747  [KO:K04558]
100076785  GPR37; prosaposin receptor GPR37 [KO:K04243]
100076804  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
100076805  KIF5B; kinesin-1 heavy chain [KO:K10396] [EC:5.6.1.3]
100076865  DNAH3; dynein heavy chain 3, axonemal isoform X1 [KO:K10408]
100076905  ATXN1L; ataxin-1-like [KO:K23616]
100076962  FIG4; polyphosphoinositide phosphatase isoform X1 [KO:K22913] [EC:3.1.3.-]
100076967  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
100076995  RAB5A; ras-related protein Rab-5A [KO:K07887]
100077087  KLC4; kinesin light chain 4 [KO:K10407]
100077093  [KO:K02272]
100077165  TANK; TRAF family member-associated NF-kappa-B activator [KO:K12650]
100077170  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
100077194  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
100077210  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
100077245  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
100077249  [KO:K00415]
100077288  NEFL; neurofilament light polypeptide [KO:K04572]
100077296  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
100077333  NEFM; neurofilament medium polypeptide [KO:K04573]
100077344  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
100077354  TUBB4B; tubulin beta-4B chain [KO:K07375]
100077370  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
100077394  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
100077443  [KO:K08738]
100077529  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
100077605  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
100077627  [KO:K07374]
100077640  WNT2; protein Wnt-2 precursor [KO:K00182]
100077847  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
100077932  AXIN2; axin-2 [KO:K04385]
100077974  WNT16; protein Wnt-16 [KO:K01558]
100077981  [KO:K08770]
100078088  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
100078236  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
100078372  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
100078394  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
100078422  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
100078507  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
100078508  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100078638  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
100078687  [KO:K23600]
100078736  SMCR8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
100078757  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
100078807  DLG4; disks large homolog 4 isoform X1 [KO:K11828]
100078811  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
100078921  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
100078945  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
100079040  [KO:K07375]
100079107  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100079142  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
100079248  UBA1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
100079279  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100079388  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
100079412  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 isoform X1 [KO:K03035]
100079428  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100079440  [KO:K02266]
100079562  [KO:K07375]
100079581  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
100079654  GRIA2; LOW QUALITY PROTEIN: glutamate receptor 2 [KO:K05198]
100079680  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
100079695  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
100079742  TUBA1B; tubulin alpha-1B chain [KO:K07374]
100079751  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
100079809  NRBF2; nuclear receptor-binding factor 2 [KO:K21246]
100079874  WNT8B; protein Wnt-8b [KO:K00714]
100079918  TUBA1A; tubulin alpha-1A chain [KO:K07374]
100079980  ERN1; LOW QUALITY PROTEIN: serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
100080031  TUBB3; tubulin beta-3 chain [KO:K07375]
100080106  DNAI2; dynein intermediate chain 2, axonemal [KO:K11143]
100080121  VAPB; vesicle-associated membrane protein-associated protein B/C [KO:K10707]
100080150  TRAP1; heat shock protein 75 kDa, mitochondrial [KO:K09488]
100080214  FZD9; frizzled-9 [KO:K02842]
100080252  DNAH12; dynein heavy chain 12, axonemal isoform X1 [KO:K10408]
100080362  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100080383  DERL1; derlin-1 isoform X1 [KO:K11519]
100080434  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
100080473  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
100080496  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
100080509  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
100080514  DKK2; dickkopf-related protein 2 [KO:K02165]
100080549  GRM5; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5 [KO:K04604]
100080559  [KO:K00418]
100080588  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
100080625  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1 [KO:K04553] [EC:2.3.2.23]
100080628  CTNNB1; catenin beta-1 [KO:K02105]
100080691  [KO:K04634]
100080710  FZD6; frizzled-6 [KO:K02376]
100080711  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
100080734  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
100080785  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 [KO:K08844] [EC:2.7.11.1]
100080824  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
100080859  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X2 [KO:K03944]
100080973  ACTR1A; alpha-centractin [KO:K16575]
100080994  FZD4; frizzled-4 [KO:K02354]
100081055  [KO:K02264]
100081079  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
100081142  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
100081152  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
100081193  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
100081199  [KO:K17603]
100081216  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
100081225  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
100081349  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100081482  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
100081577  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
100081627  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
100081646  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100081651  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
100081790  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
100081860  FZD7; frizzled-7 [KO:K02432]
100081861  DNAH14; dynein heavy chain 14, axonemal isoform X1 [KO:K10408]
100082003  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
100082114  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
100082311  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
100082395  TRPC3; short transient receptor potential channel 3 [KO:K04966]
100082413  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
100082504  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
100082590  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100082618  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
100082624  SPG11; spatacsin isoform X1 [KO:K19026]
100082649  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
100082705  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100082738  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
100082745  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
100082751  RAB1A; ras-related protein Rab-1A isoform X1 [KO:K07874]
100082774  UQCR11; cytochrome b-c1 complex subunit 10 [KO:K00420]
100082949  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100082953  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
100082988  [KO:K21421] [EC:1.-.-.-]
100083131  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
100083165  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
100083298  IL6; interleukin-6 [KO:K05405]
100083380  [KO:K10408]
100083396  DNAH17; LOW QUALITY PROTEIN: dynein heavy chain 17, axonemal [KO:K10408]
100083401  [KO:K10408]
100083483  WDR41; WD repeat-containing protein 41 [KO:K23610]
100083509  CALM2; calmodulin-2 [KO:K02183]
100083665  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
100083794  ATXN3; ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
100083819  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100083857  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
100083885  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
100083890  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100083983  BECN1; beclin-1 isoform X1 [KO:K08334]
100084007  CHRM3; muscarinic acetylcholine receptor M3 isoform X2 [KO:K04131]
100084018  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
100084248  RAB39B; ras-related protein Rab-39B [KO:K07925]
100084272  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100084273  RYR2; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
100084423  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
100084515  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
100084526  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
100084653  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
100084750  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
100084774  DNAI1; dynein intermediate chain 1, axonemal [KO:K10409]
100085312  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
100085347  OPTN; optineurin isoform X1 [KO:K19946]
100085363  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial isoform X1 [KO:K03953]
100085370  WNT8A; protein Wnt-8a [KO:K00714]
100085430  KRAS; GTPase KRas isoform X1 [KO:K07827]
100085442  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100085480  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100085643  TNF; tumor necrosis factor [KO:K03156]
100085676  TOMM40L; mitochondrial import receptor subunit TOM40B [KO:K11518]
100085735  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
100085769  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
100085791  [KO:K02272]
100085809  WNT5B; protein Wnt-5b [KO:K00444]
100085837  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
100085942  [KO:K07374]
100086058  FZD3; frizzled-3 [KO:K02329]
100086064  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
100086096  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100086258  ATP2A3; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
100086380  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100086429  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
100086434  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
100086487  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100086536  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
100086593  [KO:K05634]
100086662  ACTR10; actin-related protein 10 [KO:K16576]
100086673  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
100086818  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
100086969  TUBB4A; tubulin beta-4A chain [KO:K07375]
100087034  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
100087063  NEFH; neurofilament heavy polypeptide [KO:K04574]
100087105  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100087253  WNT2B; protein Wnt-2b [KO:K00182]
100087351  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100087357  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
100087432  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
100087467  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100087588  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
100087676  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
100087740  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
100087835  [KO:K04398] [EC:3.4.22.61]
100087942  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100088021  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
100088033  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
100088146  ALS2; alsin isoform X1 [KO:K04575]
100088515  [KO:K07374]
100088525  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
100088569  BID; BH3-interacting domain death agonist [KO:K04726]
100088770  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100088788  KIF5C; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
100088836  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
100088897  WNT5A; protein Wnt-5a [KO:K00444]
100088910  [KO:K00572]
100088975  [KO:K00419]
100089020  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
100089037  [KO:K02267]
100089091  TUBB6; tubulin beta-6 chain [KO:K07375]
100089127  IFT57; intraflagellar transport protein 57 homolog [KO:K04638]
100089249  [KO:K10408]
100089265  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
100089418  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
100089450  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
100089453  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
100089456  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100089547  FZD5; LOW QUALITY PROTEIN: frizzled-5 [KO:K02375]
100089737  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X3 [KO:K04431] [EC:2.7.12.2]
100089786  WNT6; protein Wnt-6 [KO:K00445]
100089801  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
100089816  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
100089867  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
100089902  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100089905  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100089939  MFN2; mitofusin-2 isoform X1 [KO:K06030] [EC:3.6.5.-]
100089973  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
100089977  DNAH5; dynein heavy chain 5, axonemal [KO:K10408]
100089983  HIP1; huntingtin-interacting protein 1 isoform X1 [KO:K04559]
100090019  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
100090031  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
100090032  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
100090103  WNT3A; LOW QUALITY PROTEIN: protein Wnt-3a [KO:K00312]
100090119  ZFYVE1; zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603]
100090123  ATXN2L; ataxin-2-like protein isoform X4 [KO:K23625]
100090166  [KO:K08960] [EC:2.7.11.1]
100090214  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
100090273  DNAL4; dynein light chain 4, axonemal isoform X1 [KO:K10412]
100090292  [KO:K04520]
100090612  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100090678  WNT10A; protein Wnt-10a [KO:K01357]
100090775  FZD2; frizzled-2 [KO:K02235]
100091068  DNAL1; dynein light chain 1, axonemal isoform X1 [KO:K10411]
100091250  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
100091258  ACTR1B; beta-centractin isoform X1 [KO:K16575]
100091270  [KO:K02265]
100091330  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100091346  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
100091585  [KO:K13525]
100091665  GPX8; probable glutathione peroxidase 8 isoform X2 [KO:K00432] [EC:1.11.1.9]
100091687  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
100091700  WNT11; protein Wnt-11 [KO:K01384]
100091844  FZD10; frizzled-10 [KO:K02842]
100091902  CDK5; cyclin-dependent-like kinase 5 isoform X1 [KO:K02090] [EC:2.7.11.22]
100091907  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
100091980  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
100091985  [KO:K02270]
100092030  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
100092089  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100092137  RAB8A; ras-related protein Rab-8A isoform X1 [KO:K07901]
100092264  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100092345  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
100092397  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
100092507  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
100092537  CAPN11; calpain-11 [KO:K01367] [EC:3.4.22.52]
100092580  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
100092686  UBE2G1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
100092761  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
100092836  DCTN6; dynactin subunit 6 [KO:K10428]
100092852  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
100092874  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
100093026  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100093196  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
100093259  NOS1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
100093302  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
100093417  DKK4; dickkopf-related protein 4 [KO:K02165]
100093442  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
100093447  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100093450  AXIN1; axin-1 [KO:K02157]
100093532  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
100093574  AMBRA1; LOW QUALITY PROTEIN: activating molecule in BECN1-regulated autophagy protein 1 [KO:K17985]
100093588  WNT7B; protein Wnt-7b [KO:K00572]
100680746  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
100680772  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
100680990  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
100681066  [KO:K03173] [EC:2.3.2.27]
100681077  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
100681083  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
100681261  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
100681456  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
100681615  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
100681823  GRIN2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
100681935  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
100681936  RYR1; ryanodine receptor 1 [KO:K04961]
100682203  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
100682250  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
103164954  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
103165091  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
103165286  [KO:K04519]
103165382  [KO:K02183]
103165965  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
103166118  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
103166161  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
103166362  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
103166538  KIF5A; kinesin heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
103167043  DNAH2; LOW QUALITY PROTEIN: dynein heavy chain 2, axonemal [KO:K10408]
103167180  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
103167225  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
103167988  PDYN; proenkephalin-B isoform X1 [KO:K15840]
103169086  STX1A; LOW QUALITY PROTEIN: syntaxin-1A [KO:K04560]
103169301  HTT; LOW QUALITY PROTEIN: huntingtin [KO:K04533]
103169832  PRPH; LOW QUALITY PROTEIN: peripherin [KO:K07607]
103169972  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
103170056  ATXN1; ataxin-1 [KO:K23616]
103171189  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
107546818  TUBB; tubulin beta chain [KO:K07375]
107546921  BCL2L1; bcl-2-like protein 1 [KO:K04570]
107546954  [KO:K00413]
107547159  WNT10B; protein Wnt-10b [KO:K01357]
114805389  [KO:K07375]
114805411  [KO:K07375]
114805804  [KO:K03968]
114806037  [KO:K02263]
114806081  UBE2L3; ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
114806141  SEPTIN5; septin-5 isoform X1 [KO:K04557]
114807616  DAXX; death domain-associated protein 6 [KO:K02308]
114807635  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
114807989  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
114808032  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
114808033  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
114809040  [KO:K02266]
114809154  [KO:K02266]
114809162  PRKN; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
114809980  DCTN3; dynactin subunit 3 [KO:K10425]
114809982  CCS; copper chaperone for superoxide dismutase [KO:K04569]
114809992  HRAS; GTPase HRas [KO:K02833]
114809999  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
114810011  SIGMAR1; sigma non-opioid intracellular receptor 1 [KO:K20719]
114810030  BAD; bcl2-associated agonist of cell death [KO:K02158]
114810131  KLC2; kinesin light chain 2 [KO:K10407]
114810222  [KO:K03096]
114811155  HTRA2; serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
114811984  TUBA4A; tubulin alpha-4A chain [KO:K07374]
114811991  [KO:K02270]
114812115  KLC3; kinesin light chain 3 [KO:K10407]
114812128  CALM3; calmodulin-3 [KO:K02183]
114812795  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
114812883  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
114813135  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
114813317  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
114813907  FZD1; frizzled-1 [KO:K02432]
114814562  WNT1; proto-oncogene Wnt-1 [KO:K03209]
114814649  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
114814719  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
114814741  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
114814763  ATG101; autophagy-related protein 101 [KO:K19730]
114814979  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
114815139  PSMC5; 26S proteasome regulatory subunit 8 [KO:K03066]
114815211  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
114815493  UCHL1; ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
114815970  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04129]
114816216  FZD8; frizzled-8 [KO:K02375]
114816270  CALML3; calmodulin-like protein 3 [KO:K02183]
114816899  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
114817674  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
114817891  [KO:K04397] [EC:3.4.22.60]
114817987  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
114818207  [KO:K00416]
808698  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
808699  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
808700  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
808701  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
808702  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
808703  CYTB; cytochrome b [KO:K00412]
808704  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
808705  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
808706  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
808707  COX3; cytochrome c oxidase subunit III [KO:K02262]
808708  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
808709  COX2; cytochrome c oxidase subunit II [KO:K02261]
808710  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
  Authors
Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
  Journal
Nat Neurosci 21:1300-1309 (2018)
DOI:10.1038/s41593-018-0237-7
Reference
PMID:28062563
  Authors
Dugger BN, Dickson DW
  Title
Pathology of Neurodegenerative Diseases.
  Journal
Cold Spring Harb Perspect Biol 9:a028035 (2017)
DOI:10.1101/cshperspect.a028035
Reference
PMID:20070435
  Authors
Jellinger KA
  Title
Basic mechanisms of neurodegeneration: a critical update.
  Journal
J Cell Mol Med 14:457-87 (2010)
DOI:10.1111/j.1582-4934.2010.01010.x
Reference
PMID:19707851
  Authors
Jellinger KA
  Title
Recent advances in our understanding of neurodegeneration.
  Journal
J Neural Transm (Vienna) 116:1111-62 (2009)
DOI:10.1007/s00702-009-0240-y
Reference
PMID:30743990
  Authors
Van Bulck M, Sierra-Magro A, Alarcon-Gil J, Perez-Castillo A, Morales-Garcia JA
  Title
Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease.
  Journal
Int J Mol Sci 20:E719 (2019)
DOI:10.3390/ijms20030719
Reference
PMID:15272267
  Authors
Ross CA, Poirier MA
  Title
Protein aggregation and neurodegenerative disease.
  Journal
Nat Med 10 Suppl:S10-7 (2004)
DOI:10.1038/nm1066
Reference
PMID:30250260
  Authors
Soto C, Pritzkow S
  Title
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.
  Journal
Nat Neurosci 21:1332-1340 (2018)
DOI:10.1038/s41593-018-0235-9
Reference
PMID:25132814
  Authors
Dantuma NP, Bott LC
  Title
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution.
  Journal
Front Mol Neurosci 7:70 (2014)
DOI:10.3389/fnmol.2014.00070
Reference
PMID:25413678
  Authors
Zheng C, Geetha T, Babu JR
  Title
Failure of ubiquitin proteasome system: risk for neurodegenerative diseases.
  Journal
Neurodegener Dis 14:161-75 (2014)
DOI:10.1159/000367694
Reference
PMID:32397599
  Authors
Park H, Kang JH, Lee S
  Title
Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates.
  Journal
Int J Mol Sci 21:E3369 (2020)
DOI:10.3390/ijms21093369
Reference
PMID:31783880
  Authors
Malik BR, Maddison DC, Smith GA, Peters OM
  Title
Autophagic and endo-lysosomal dysfunction in neurodegenerative disease.
  Journal
Mol Brain 12:100 (2019)
DOI:10.1186/s13041-019-0504-x
Reference
PMID:29734735
  Authors
Metaxakis A, Ploumi C, Tavernarakis N
  Title
Autophagy in Age-Associated Neurodegeneration.
  Journal
Cells 7:E37 (2018)
DOI:10.3390/cells7050037
Reference
PMID:25270767
  Authors
Vidal RL, Matus S, Bargsted L, Hetz C
  Title
Targeting autophagy in neurodegenerative diseases.
  Journal
Trends Pharmacol Sci 35:583-91 (2014)
DOI:10.1016/j.tips.2014.09.002
Reference
PMID:28279350
  Authors
Menzies FM, Fleming A, Caricasole A, Bento CF, Andrews SP, Ashkenazi A, Fullgrabe J, Jackson A, Jimenez Sanchez M, Karabiyik C, Licitra F, Lopez Ramirez A, Pavel M, Puri C, Renna M, Ricketts T, Schlotawa L, Vicinanza M, Won H, Zhu Y, Skidmore J, Rubinsztein DC
  Title
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.
  Journal
Neuron 93:1015-1034 (2017)
DOI:10.1016/j.neuron.2017.01.022
Reference
PMID:30030024
  Authors
Chu CT
  Title
Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases.
  Journal
Neurobiol Dis 122:23-34 (2019)
DOI:10.1016/j.nbd.2018.07.015
Reference
PMID:19043451
  Authors
Kim I, Xu W, Reed JC
  Title
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 7:1013-30 (2008)
DOI:10.1038/nrd2755
Reference
PMID:21722302
  Authors
Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A
  Title
Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
  Journal
J Cell Mol Med 15:2025-39 (2011)
DOI:10.1111/j.1582-4934.2011.01374.x
Reference
PMID:28643372
  Authors
Halliday M, Hughes D, Mallucci GR
  Title
Fine-tuning PERK signaling for neuroprotection.
  Journal
J Neurochem 142:812-826 (2017)
DOI:10.1111/jnc.14112
Reference
PMID:32204380
  Authors
Rozpedek-Kaminska W, Siwecka N, Wawrzynkiewicz A, Wojtczak R, Pytel D, Diehl JA, Majsterek I
  Title
The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases.
  Journal
Int J Mol Sci 21:E2108 (2020)
DOI:10.3390/ijms21062108
Reference
PMID:24619348
  Authors
Hetz C, Mollereau B
  Title
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.
  Journal
Nat Rev Neurosci 15:233-49 (2014)
DOI:10.1038/nrn3689
Reference
PMID:19230774
  Authors
Bezprozvanny I
  Title
Calcium signaling and neurodegenerative diseases.
  Journal
Trends Mol Med 15:89-100 (2009)
DOI:10.1016/j.molmed.2009.01.001
Reference
PMID:31795242
  Authors
Ureshino RP, Erustes AG, Bassani TB, Wachilewski P, Guarache GC, Nascimento AC, Costa AJ, Smaili SS, Pereira GJDS
  Title
The Interplay between Ca(2+) Signaling Pathways and Neurodegeneration.
  Journal
Int J Mol Sci 20:E6004 (2019)
DOI:10.3390/ijms20236004
Reference
PMID:27873462
  Authors
Golpich M, Amini E, Mohamed Z, Azman Ali R, Mohamed Ibrahim N, Ahmadiani A
  Title
Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment.
  Journal
CNS Neurosci Ther 23:5-22 (2017)
DOI:10.1111/cns.12655
Reference
PMID:19828789
  Authors
Morfini GA, Burns M, Binder LI, Kanaan NM, LaPointe N, Bosco DA, Brown RH Jr, Brown H, Tiwari A, Hayward L, Edgar J, Nave KA, Garberrn J, Atagi Y, Song Y, Pigino G, Brady ST
  Title
Axonal transport defects in neurodegenerative diseases.
  Journal
J Neurosci 29:12776-86 (2009)
DOI:10.1523/JNEUROSCI.3463-09.2009
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:23361386
  Authors
Millecamps S, Julien JP
  Title
Axonal transport deficits and neurodegenerative diseases.
  Journal
Nat Rev Neurosci 14:161-76 (2013)
DOI:10.1038/nrn3380
Reference
PMID:31558780
  Authors
Sleigh JN, Rossor AM, Fellows AD, Tosolini AP, Schiavo G
  Title
Axonal transport and neurological disease.
  Journal
Nat Rev Neurol 15:691-703 (2019)
DOI:10.1038/s41582-019-0257-2
Reference
PMID:20434225
  Authors
Perlson E, Maday S, Fu MM, Moughamian AJ, Holzbaur EL
  Title
Retrograde axonal transport: pathways to cell death?
  Journal
Trends Neurosci 33:335-44 (2010)
DOI:10.1016/j.tins.2010.03.006
Related
pathway
oaa00190  Oxidative phosphorylation
oaa03050  Proteasome
oaa04020  Calcium signaling pathway
oaa04120  Ubiquitin mediated proteolysis
oaa04137  Mitophagy - animal
oaa04140  Autophagy - animal
oaa04141  Protein processing in endoplasmic reticulum
oaa04142  Lysosome
oaa04210  Apoptosis
oaa04310  Wnt signaling pathway
oaa04724  Glutamatergic synapse
oaa04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   

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