KEGG   PATHWAY: tup04015
Entry
tup04015                    Pathway                                
Name
Rap1 signaling pathway - Tupaia chinensis (Chinese tree shrew)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
tup04015  Rap1 signaling pathway
tup04015

Other DBs
GO: 0007264
Organism
Tupaia chinensis (Chinese tree shrew) [GN:tup]
Gene
102475072  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
102472381  RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
102468234  MRAS; muscle RAS oncogene homolog [KO:K07831]
102497002  RAPGEF5; Rap guanine nucleotide exchange factor 5 [KO:K08019]
102483635  DOCK4; dedicator of cytokinesis 4 [KO:K17697]
102469683  GRIN1; glutamate ionotropic receptor NMDA type subunit 1 [KO:K05208]
102487925  GRIN2A; glutamate ionotropic receptor NMDA type subunit 2A [KO:K05209]
102487806  GRIN2B; glutamate ionotropic receptor NMDA type subunit 2B [KO:K05210]
102493041  CALM3; calmodulin 3 [KO:K02183]
102484707  neo-calmodulin-like [KO:K02183]
102479773  CALML5; calmodulin like 5 [KO:K02183]
102475973  CALML3; calmodulin-like protein 3 [KO:K02183]
102485493  calmodulin-like [KO:K02183]
102472462  CALM1; calmodulin 1 [KO:K02183]
102493190  CALM2; calmodulin 2 [KO:K02183]
102468681  CALML6; calmodulin like 6 [KO:K02183]
102495258  CALMODULIN; calmodulin-alpha [KO:K02183]
102483795  CALML4; calmodulin like 4 [KO:K02183]
102485895  F2R; coagulation factor II thrombin receptor [KO:K03914]
102490146  F2RL3; F2R like thrombin/trypsin receptor 3 [KO:K04236]
102491707  P2RY1; purinergic receptor P2Y1 [KO:K04270]
102475967  FPR1; formyl peptide receptor 1 [KO:K04172]
102503029  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
102502351  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
102495978  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
102500888  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
102491630  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
102489555  ADORA2A; adenosine A2a receptor [KO:K04266]
102488122  ADORA2B; adenosine A2b receptor [KO:K04267]
102489563  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas [KO:K04632]
102501321  neuroendocrine secretory protein 55 [KO:K04632]
102468873  ADCY1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
102492353  ADCY2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
102477532  ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
102490273  ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
102490639  ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
102468478  ADCY6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
102496578  ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
102472317  ADCY8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
102477344  ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
102502265  RAPGEF3; Rap guanine nucleotide exchange factor 3 [KO:K08014]
102485451  RAPGEF4; Rap guanine nucleotide exchange factor 4 [KO:K04351]
102468263  GNAQ; G protein subunit alpha q [KO:K04634]
102477438  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
102476196  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
102472532  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
102492903  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
102498774  RASGRP3; RAS guanyl releasing protein 3 [KO:K12362]
102468592  RASGRP2; RAS guanyl releasing protein 2 [KO:K12361]
102490423  EGF; epidermal growth factor [KO:K04357]
102472932  FGF1; fibroblast growth factor 1 [KO:K18496]
102498637  FGF2; fibroblast growth factor 2 [KO:K18497]
102489294  FGF9; fibroblast growth factor 9 [KO:K04358]
102500824  FGF16; fibroblast growth factor 16 [KO:K04358]
102496950  FGF18; fibroblast growth factor 18 [KO:K04358]
102470973  FGF20; fibroblast growth factor 20 [KO:K04358]
102477924  FGF17; fibroblast growth factor 17 [KO:K04358]
102492980  FGF5; fibroblast growth factor 5 [KO:K04358]
102478652  FGF6; fibroblast growth factor 6 [KO:K04358]
102470048  FGF3; fibroblast growth factor 3 [KO:K04358]
102470471  FGF4; fibroblast growth factor 4 [KO:K04358]
102496545  FGF8; fibroblast growth factor 8 [KO:K04358]
102500031  FGF10; fibroblast growth factor 10 [KO:K04358]
102494532  FGF22; fibroblast growth factor 22 [KO:K04358]
102476072  FGF7; fibroblast growth factor 7 [KO:K04358]
102470889  FGF19; fibroblast growth factor 19 [KO:K22603]
102480823  fibroblast growth factor 19-like [KO:K22603]
102474175  FGF21; fibroblast growth factor 21 [KO:K22429]
102479073  FGF23; fibroblast growth factor 23 [KO:K22428]
102501945  NGF; nerve growth factor [KO:K02582]
102481191  INS; insulin [KO:K04526]
102490248  IGF1; insulin like growth factor 1 [KO:K05459]
102499235  PDGFA; platelet derived growth factor subunit A [KO:K04359]
102482500  PDGFB; platelet derived growth factor subunit B [KO:K17386]
102485007  PDGFD; platelet derived growth factor D [KO:K05450]
102487522  PDGFC; platelet derived growth factor C [KO:K05450]
102492960  CSF1; colony stimulating factor 1 [KO:K05453]
102501429  KITLG; KIT ligand [KO:K05461]
102499303  VEGFA; vascular endothelial growth factor A [KO:K05448]
102494761  VEGFB; vascular endothelial growth factor B [KO:K16858]
102480300  PGF; placental growth factor [KO:K16859]
102498502  VEGFC; vascular endothelial growth factor C [KO:K05449]
102486007  VEGFD; vascular endothelial growth factor D [KO:K05449]
102483689  HGF; hepatocyte growth factor [KO:K05460]
102471695  ANGPT1; angiopoietin 1 [KO:K05465]
102472273  angiopoietin-2 [KO:K05466]
102500020  ANGPT2; angiopoietin 2 [KO:K05466]
102482199  ANGPT4; angiopoietin 4 [KO:K05467]
102502764  EFNA5; ephrin A5 [KO:K05462]
102477308  EFNA1; ephrin A1 [KO:K05462]
102477745  EFNA4; ephrin A4 [KO:K05462]
102468360  EFNA2; ephrin A2 [KO:K05462]
102485304  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102484087  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
102484403  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
102500041  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
102475159  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102498614  NGFR; nerve growth factor receptor [KO:K02583]
102469167  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102473496  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102488187  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102492413  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102491581  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102489301  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
102480253  FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
102482918  FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
102489981  KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
102485847  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
102498017  TEK; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
102487364  EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
102482865  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
102486599  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
102490444  RAPGEF1; Rap guanine nucleotide exchange factor 1 [KO:K06277]
102488824  BCAR1; BCAR1, Cas family scaffolding protein [KO:K05726]
102499381  CDH1; cadherin 1 [KO:K05689]
102472740  CTNNB1; catenin beta 1 [KO:K02105]
102472485  MAGI1; membrane associated guanylate kinase, WW and PDZ domain containing 1 [KO:K05631]
102490087  MAGI2; membrane associated guanylate kinase, WW and PDZ domain containing 2 [KO:K05629]
102486157  MAGI3; membrane associated guanylate kinase, WW and PDZ domain containing 3 [KO:K06112]
102476593  RAPGEF2; Rap guanine nucleotide exchange factor 2 [KO:K08018]
102502097  RAPGEF6; Rap guanine nucleotide exchange factor 6 [KO:K08020]
102468690  uncharacterized LOC102468690 [KO:K10784]
102498024  T-cell receptor alpha chain V region CTL-F3 [KO:K10784]
102478258  T-cell receptor alpha chain V region PHDS58 [KO:K10784]
102481630  uncharacterized LOC102481630 [KO:K10785]
102483735  uncharacterized LOC102483735 [KO:K10785]
102485402  uncharacterized LOC102485402 [KO:K10785]
102486266  uncharacterized LOC102486266 [KO:K10785]
102501507  LAT; linker for activation of T-cells [KO:K07362]
102486641  FYB; FYN binding protein [KO:K17698]
102500142  LCP2; lymphocyte cytosolic protein 2 [KO:K07361]
102477151  SKAP1; src kinase associated phosphoprotein 1 [KO:K17699]
102469651  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
102495954  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102469271  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102497204  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
102494291  PRKD2; protein kinase D2 [KO:K06070] [EC:2.7.11.13]
102472549  PRKD3; protein kinase D3 [KO:K06070] [EC:2.7.11.13]
102492283  PRKD1; protein kinase D1 [KO:K06070] [EC:2.7.11.13]
102497400  DRD2; dopamine receptor D2 [KO:K04145]
102476019  CNR1; cannabinoid receptor 1 [KO:K04277]
102476737  GNAI3; G protein subunit alpha i3 [KO:K04630]
102479323  GNAI1; G protein subunit alpha i1 [KO:K04630]
102475420  GNAI2; G protein subunit alpha i2 [KO:K04630]
102483059  GNAO1; G protein subunit alpha o1 [KO:K04534]
102491110  RAP1GAP; RAP1 GTPase activating protein [KO:K17700]
102473566  SIPA1L1; signal induced proliferation associated 1 like 1 [KO:K17701]
102478420  SIPA1; signal-induced proliferation-associated 1 [KO:K08013]
102481222  SIPA1L2; signal induced proliferation associated 1 like 2 [KO:K17702]
102488203  SIPA1L3; signal induced proliferation associated 1 like 3 [KO:K17703]
102501427  ID1; inhibitor of DNA binding 1, HLH protein [KO:K04680]
102497602  THBS1; thrombospondin 1 [KO:K16857]
102479691  RALGDS; ral guanine nucleotide dissociation stimulator [KO:K08732]
102481337  RALA; RAS like proto-oncogene A [KO:K07834]
102486756  RALB; RAS like proto-oncogene B [KO:K07835]
102479102  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102495436  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
102494727  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
102502410  APBB1IP; amyloid beta precursor protein binding family B member 1 interacting protein [KO:K17704]
102487606  TLN2; talin 2 [KO:K06271]
102469799  TLN1; talin 1 [KO:K06271]
102493954  ITGA2B; integrin subunit alpha 2b [KO:K06476]
102486101  ITGB3; integrin subunit beta 3 [KO:K06493]
102473053  PFN3; profilin 3 [KO:K05759]
102477876  PFN2; profilin 2 [KO:K05759]
102503239  PFN1; profilin 1 [KO:K05759]
102495919  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
102498679  ENAH; enabled homolog (Drosophila) [KO:K05746]
102483727  EVL; Enah/Vasp-like [KO:K23487]
102479926  ACTB; actin beta [KO:K05692]
102498431  ACTG1; actin gamma 1 [KO:K05692]
102470245  ARAP3; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [KO:K12490]
102487039  RHOA; ras homolog family member A [KO:K04513]
102491807  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
102496391  FARP2; FERM, ARH/RhoGEF and pleckstrin domain protein 2 [KO:K06082]
102488344  CDC42; cell division cycle 42 [KO:K04393]
102488378  VAV3; vav guanine nucleotide exchange factor 3 [KO:K05730]
102467864  VAV2; vav guanine nucleotide exchange factor 2 [KO:K05730]
102485614  VAV1; vav guanine nucleotide exchange factor 1 [KO:K05730]
102500733  TIAM1; T-cell lymphoma invasion and metastasis 1 [KO:K05731]
102493456  PARD3; par-3 family cell polarity regulator [KO:K04237]
102482877  PARD6B; par-6 family cell polarity regulator beta [KO:K06093]
102483224  PARD6A; par-6 family cell polarity regulator alpha [KO:K06093]
102478144  PARD6G; par-6 family cell polarity regulator gamma [KO:K06093]
102503329  PRKCZ; protein kinase C zeta [KO:K18952] [EC:2.7.11.13]
102474505  PRKCI; protein kinase C iota [KO:K06069] [EC:2.7.11.13]
102477954  AFDN; afadin, adherens junction formation factor [KO:K05702]
102494023  CTNND1; catenin delta 1 [KO:K05690]
102493277  KRIT1; KRIT1, ankyrin repeat containing [KO:K17705]
102475018  RGS14; regulator of G-protein signaling 14 [KO:K17706]
102481620  RASSF5; Ras association domain family member 5 [KO:K08015]
102469543  ITGAL; integrin subunit alpha L [KO:K05718]
102483623  ITGAM; integrin subunit alpha M [KO:K06461]
102497567  integrin beta-2-like [KO:K06464]
102501274  ITGB2; integrin beta-2 [KO:K06464]
102489284  ITGB1; integrin subunit beta 1 [KO:K05719]
102477389  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
102497488  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102476496  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102483700  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102496453  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102483057  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102499419  MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
102482054  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102487603  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102501733  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102495693  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
102481241  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102500530  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102502163  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102483329  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
106736453  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
102469401  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102484444  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102484500  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102472172  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102492771  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
102474297  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102499439  PLCE1; phospholipase C epsilon 1 [KO:K05860] [EC:3.1.4.11]
102493230  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102500069  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102496534  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102491386  RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
tup04010  MAPK signaling pathway
tup04014  Ras signaling pathway
tup04020  Calcium signaling pathway
tup04151  PI3K-Akt signaling pathway
tup04510  Focal adhesion
tup04520  Adherens junction
tup04660  T cell receptor signaling pathway
tup04810  Regulation of actin cytoskeleton
KO pathway
ko04015   
LinkDB

DBGET integrated database retrieval system