KEGG    Network variation - Pathways of neurodegeneration
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ENTRYnt06466
NamePathways of neurodegeneration
CategoryDisease view; Neurodegenerative disease
Pathwayhsa05022 Pathways of neurodegeneration - multiple diseases
DiseaseH00056 Alzheimer disease
H00057 Parkinson disease
H00058 Amyotrophic lateral sclerosis
H00059 Huntington disease
H00063 Spinocerebellar ataxia
H00061 Prion disease
Display drug-target relation   disease type
Calcium signaling
N00953      GlutamateGRM1GNAQPLCBIP3ITPRCa2+PKCTRPC3Ca2+
N00960    SCA   SPTBN2*GRM1GNAQPLCBIP3ITPRCa2+
N00954    SCA   GlutamateGRM1*GNAQPLCBIP3ITPRCa2+
N00958    SCA   GlutamateGRM1GNAQPLCBIP3ITPR1*Ca2+
N00959    SCA   GlutamateGRM1GNAQPLCBIP3ITPR1*Ca2+
N00955    SCA   GlutamateGRM1GNAQPLCBIP3ITPRCa2+PRKCG*TRPC3
N00956    SCA   GlutamateGRM1GNAQPLCBIP3ITPRCa2+PRKCG*TRPC3
N00961    SCA             TRPC3*Ca2+
N01032    PD       PRKN*PLCG1IP3ITPRCa2+
N00984      GlutamateGRM5GNAQPLCBIP3ITPRCa2+MCUCa2+(mito)MPTPCYCS=APAF1CASP9(CASP3,CASP7)
N01002    AD APP*AbetaGRM5GNAQPLCBIP3ITPRCa2+MCUCa2+(mito)MPTPCYCS=APAF1CASP9CASP3
N01151    ALS           SIGMAR1*ITPRCa2+MCUCa2+(mito)MPTPCYCS
N01008    AD           PSEN1*ITPRCa2+MCUCa2+(mito)MPTPCYCS
N01007    AD           (PSEN1*,PSEN2*)RYR3Ca2+MCUCa2+(mito)MPTPCYCS=APAF1CASP9(CASP3,CASP7)
N01199    PrD           PRNP*(RYR,ITPR)Ca2+MCUCa2+(mito)MPTPCYCS=APAF1CASP9CASP3
N00985    HD   GlutamateGRM5GNAQPLCBIP3(ITPR+HTT*)Ca2+MCUCa2+(mito)MPTPCYCS=APAF1CASP9(CASP3,CASP7)
N00957    SCA   GlutamateGRM1GNAQPLCBIP3(ITPR1+(ATXN2*,ATX..Ca2+MCUCa2+(mito)MPTPCYCS
N01000      AChmAChRGNAQPLCBIP3ITPRCa2+MCUCa2+(mito)MPTPCYCS
N01001    AD APP*AbetamAChRGNAQPLCBIP3ITPRCa2+MCUCa2+(mito)MPTPCYCS
N00967              Ca2+(extracellular..VGCCCa2+MCUCa2+(mito)MPTPCYCS=APAF1CASP9(CASP3,CASP7)
N00986    HD         HTT*STX1AVGCC(N-type)Ca2+
N01004    AD         APP*AbetaVGCC(L-type)Ca2+MCUCa2+(mito)MPTPCYCS
N01201    PrD           PRNP*VGCC(N,L-type)Ca2+
N01006    AD               APP*AbetaPPIDMPTPCYCS
N01031    PD           Ca2+(extracellular..SNCA*Ca2+MCUCa2+(mito)MPTPCYCS=APAF1CASP9CASP3
N00968    SCA           Ca2+(extracellular..CACNA1A*Ca2+
N00969    SCA           Ca2+(extracellular..CACNA1A*Ca2+
N00970              GlutamateNMDARCa2+
N00987    HD         HTT*DLG4NMDARCa2+MCUCa2+(mito)MPTPCYCS=APAF1CASP9CASP3
N01200    PrD           PRNP*NMDARCa2+MCUCa2+(mito)MPTPCYCS=APAF1CASP9CASP3
N00971    SCA           PDYN*NMDARCa2+
N01003    AD         APP*AbetaNMDARCa2+MCUCa2+(mito)MPTPCYCS
 
Ubiquitin-proteasome system
N01019    UBCH7/8=PRKNalphaSp22
N01020    PD UBCH7/8PRKN*alphaSp22
N01021    UBCH7/8=PRKNPAELR
N01022    PD UBCH7/8PRKN*PAELR
N01023    UBCH7/8=PRKNCDCREL1
N01024    PD UBCH7/8PRKN*CDCREL1
N01025    UBCH7/8=PRKNSYPH1
N01026    PD UBCH7/8PRKN*SYPH1
N01029        (Protein+UB)26SPeptide
N01144    ALS SOD1*DERL1(Protein+UB)26SPeptide
N01145    ALS   VCP*(Protein+UB)26SPeptide
N01146    ALS   UBQLN2*(Protein+UB)26SPeptide
N01060    AD   APP*Abeta26S
N01030    PD     SNCA*26S
N01061    HD     HTT*26S
N01197    PrD     PRNP*26S
N01027    UB(chain)UCHL1UB(free)
N01028    PD UB(chain)UCHL1*UB(free)
 
Unfolded protein response (UPR) signaling
N01009        EIF2AK3EIF2S1ATF4DDIT3
N01010    AD   PSEN1*EIF2AK3EIF2S1ATF4DDIT3
N01035    PD SNCA*BIPEIF2AK3EIF2S1ATF4DDIT3
N01149    ALS SOD1*BIPEIF2AK3EIF2S1ATF4DDIT3
N01198    PrD PRNP*BIPEIF2AK3EIF2S1ATF4DDIT3
N01011        ERN1XBP1DDIT3
N01012    AD   PSEN1*ERN1XBP1
N01034    PD SNCA*BIPERN1XBP1
N01148    ALS SOD1*BIPERN1XBP1
N01013    ERN1TRAF2MAP3K5MAP2K7JNK
N01014    AD APP*AbetaMAP3K5MAP2K7JNK
N01015        ATF6(DDIT3,XBP1,HSPA5)
N01016    AD   PSEN1*ATF6(DDIT3,XBP1)
N01150    ALS   VAPB*ATF6
N01033    PD SNCA*BIPATF6DDIT3
N01147    ALS SOD1*BIPATF6DDIT3
 
Autophagy
N01142    RAB1A(C9orf72+WDR41+SMC..ULK1_complex
N01143    ALS RAB1A(C9orf72*+WDR41+SM..(ULK1+RB1CC1+ATG10..
N00155    mTORC1ULK1_complexPI3KC3-C1
N00962    SCA   ATXN3*(BECN1+PIK3C3+ATG1..
N00993    HD   HTT*(BECN1+PIK3C3+ATG1..
 
Mitophagy
N01052    PINK1PRKNMFN1/2
N01053    PD PINK1*PRKNMFN1/2
N01054    PD   PRKN*MFN1/2
N01137    PINK1PRKN(CISD1,CISD2,FAF2,..=(SQSTM1,OPTN,NDP52..=LC3
N01138    ALS PINK1PRKN(CISD1,CISD2,FAF2,..OPTN*
N01139    ALS PINK1PRKN(CISD1,CISD2,FAF2,..SQSTM1*LC3
N01140    TBK1(SQSTM1,OPTN,NDP52..=LC3-II
N01141    ALS TBK1*(SQSTM1,OPTN,NDP52..=LC3-II
 
Apoptosis
N00146      (FASLG,TNFSF10)(FAS,TNFRSF10B)FADD(CASP8,CASP10)BID(BAX,BAK1)CYCS=APAF1CASP9(CASP3,CASP7)
N01005    AD APP*AbetaFASFADDCASP8BID(BAX,BAK1)CYCS=APAF1CASP9CASP3
N00098            (PMAIP1,BBC3,BAD,B..(BCL2,BCL2L1)(BAX,BAK1)CYCS=APAF1CASP9(CASP3,CASP7)
N01135    ALS         SOD1*BCL2(BAX,BAK1)CYCS=APAF1CASP9CASP3
N01051    PD         DJ1*BCL2L1BAX
N01050    PD         PINK1*PRKNBAXCYCS=APAF1CASP9CASP3
N01049    PD           PRKN*BAXCYCS=APAF1CASP9CASP3
N01048    PD           PINK1*(HTRA2,TRAP1)CYCS=APAF1CASP9CASP3
N01047    PD             LRRK2*CYCS=APAF1CASP9CASP3
 
AGE-RAGE signaling
N00994      AGEAGERRASRAFMEKERKNFKB(TNF,IL6,NOS2)
N00996    AD APP*AbetaAGERRASRAFMEKERKNFKB(TNF,IL6,NOS2)
 
Oxidative phosphorylation
N00995                  NADHCxIQ
N00997    AD APP*AbetaCHRNA7Ca2+CAPNCDK5R1=CDK5MAPTCxIQ
N01136    ALS               TARDBP*CxIQ
N01042    PD               SNCA*CxIQ
N01043    PD               PINK1*CxIQ
N01044    PD               MPP+CxIQ
N01045    PD               RotenoneCxIQ
N00988    SuccinateCxIIQH2
N00989    HD HTT*CxIIQH2
N01402    AD,PD Mn2+CxIIQH2
N00990    QH2CxIIICytC
N00991    HD HTT*CxIIICytC
N01046    PD ManebCxIIICytC
N00998      CytCCxIVH2O
N00999    AD APP*AbetaCxIVH2O
 
Microtubule-based transport
N00976                  (DCTN+DNAH+DNAI+DN..=(TUBA+TUBB)
N00977    HD             (HTT*+HAP1)(DCTN+DNAH+DNAI+DN..=(TUBA+TUBB)
N01160    ALS             SOD1*(DCTN+DNAH+DNAI+DN..
N01158    ALS               DCTN1*(TUBA+TUBB)
N01159    ALS               (DCTN+DNAH+DNAI+DN..TUBA4A*
N00978                  (KIF5+KLC)=(TUBA+TUBB)
N01055    PD             SNCA*(KIF5+KLC)(TUBA+TUBB)
N00979    HD           HTT*JNK3(KIF5+KLC)=(TUBA+TUBB)
N01017    AD           PSEN1*GSK3B(KIF5+KLC)
N01202    PrD           PRNP*(GSK3B,CK2)(KIF5+KLC)
N01018    AD APP*AbetaCHRNA7Ca2+CAPNCDK5R1=CDK5MAPT(TUBA+TUBB)
N01403    AD           Zn2+GSK3BMAPT(TUBA+TUBB)
N01414    AD           Fe2+CDK5MAPT(TUBA+TUBB)

Disease nameDisease category
SCAH00063Spinocerebellar ataxia (SCA)Neurodegenerative disease
PDH00057Parkinson diseaseNeurodegenerative disease
ADH00056Alzheimer diseaseNeurodegenerative disease
ALSH00058Amyotrophic lateral sclerosis (ALS)Neurodegenerative disease
PrDH00061Prion diseaseNeurodegenerative disease
HDH00059Huntington diseaseNeurodegenerative disease
AD,PDH00056Alzheimer diseaseNeurodegenerative disease
H00057Parkinson diseaseNeurodegenerative disease