[ Network menu | Network entry | Help ]

ENTRY	nt06466
Name	Pathways of neurodegeneration
Category	Disease view; Neurodegenerative disease
Pathway	hsa05022 Pathways of neurodegeneration - multiple diseases
Disease	H00056 Alzheimer disease H00057 Parkinson disease H00058 Amyotrophic lateral sclerosis H00059 Huntington disease H00063 Spinocerebellar ataxia H00061 Prion disease
Display	drug-target relation   disease type

Calcium signaling N00953        Glutamate → GRM1 → GNAQ → PLCB → IP3 → ITPR → Ca2+ → PKC ⊣ TRPC3 → Ca2+ N00960    SCA     SPTBN2* ⊣ GRM1 → GNAQ → PLCB → IP3 → ITPR → Ca2+ N00954    SCA     Glutamate → GRM1* → GNAQ → PLCB → IP3 → ITPR → Ca2+ N00958    SCA     Glutamate → GRM1 → GNAQ → PLCB → IP3 → ITPR1* → Ca2+ N00959    SCA     Glutamate → GRM1 → GNAQ → PLCB → IP3 → ITPR1* ⌿ Ca2+ N00955    SCA     Glutamate → GRM1 → GNAQ → PLCB → IP3 → ITPR → Ca2+ → PRKCG* ⌿ TRPC3 N00956    SCA     Glutamate → GRM1 → GNAQ → PLCB → IP3 → ITPR → Ca2+ → PRKCG* ⊣ TRPC3 N00961    SCA                         TRPC3* → Ca2+ N01032    PD             PRKN* → PLCG1 → IP3 → ITPR → Ca2+ N00984        Glutamate → GRM5 → GNAQ → PLCB → IP3 → ITPR → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N01002    AD APP* → Abeta → GRM5 → GNAQ → PLCB → IP3 → ITPR → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → CASP3 N01151    ALS                     SIGMAR1* → ITPR → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS N01008    AD                     PSEN1* → ITPR → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS N01007    AD                     (PSEN1*,PSEN2*) → RYR3 → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N01199    PrD                     PRNP* → (RYR,ITPR) → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → CASP3 N00985    HD     Glutamate → GRM5 → GNAQ → PLCB → IP3 → (ITPR+HTT*) → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N00957    SCA     Glutamate → GRM1 → GNAQ → PLCB → IP3 → (ITPR1+(ATXN2*,ATX.. → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS N01000        ACh → mAChR → GNAQ → PLCB → IP3 → ITPR → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS N01001    AD APP* → Abeta → mAChR → GNAQ → PLCB → IP3 → ITPR → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS N00967                        Ca2+(extracellular.. − VGCC → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N00986    HD                 HTT* ⊣ STX1A ⊣ VGCC(N-type) → Ca2+ N01004    AD                 APP* → Abeta → VGCC(L-type) → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS N01201    PrD                     PRNP* ⊣ VGCC(N,L-type) → Ca2+ N01006    AD                             APP* → Abeta → PPID → MPTP → CYCS N01031    PD                     Ca2+(extracellular.. − SNCA* → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → CASP3 N00968    SCA                     Ca2+(extracellular.. − CACNA1A* → Ca2+ N00969    SCA                     Ca2+(extracellular.. ⌿ CACNA1A* ⌿ Ca2+ N00970                        Glutamate → NMDAR → Ca2+ N00987    HD                 HTT* ⌿ DLG4 → NMDAR → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → CASP3 N01200    PrD                     PRNP* → NMDAR → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → CASP3 N00971    SCA                     PDYN* → NMDAR → Ca2+ N01003    AD                 APP* → Abeta → NMDAR → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS   Ubiquitin-proteasome system N01019    UBCH7/8 = PRKN ⊣ alphaSp22 N01020    PD UBCH7/8 ⌿ PRKN* ⌿ alphaSp22 N01021    UBCH7/8 = PRKN ⊣ PAELR N01022    PD UBCH7/8 ⌿ PRKN* ⌿ PAELR N01023    UBCH7/8 = PRKN ⊣ CDCREL1 N01024    PD UBCH7/8 ⌿ PRKN* ⌿ CDCREL1 N01025    UBCH7/8 = PRKN ⊣ SYPH1 N01026    PD UBCH7/8 ⌿ PRKN* ⌿ SYPH1 N01029            (Protein+UB) − 26S → Peptide N01144    ALS SOD1* ⊣ DERL1 → (Protein+UB) − 26S → Peptide N01145    ALS     VCP* ⊣ (Protein+UB) − 26S → Peptide N01146    ALS     UBQLN2* ⊣ (Protein+UB) − 26S → Peptide N01060    AD     APP* → Abeta ⊣ 26S N01030    PD         SNCA* ⊣ 26S N01061    HD         HTT* ⊣ 26S N01197    PrD         PRNP* ⊣ 26S N01027    UB(chain) − UCHL1 → UB(free) N01028    PD UB(chain) ⌿ UCHL1* ⌿ UB(free)   Unfolded protein response (UPR) signaling N01009            EIF2AK3 → EIF2S1 → ATF4 ⇒ DDIT3 N01010    AD     PSEN1* ⊣ EIF2AK3 → EIF2S1 → ATF4 ⇒ DDIT3 N01035    PD SNCA* ⊣ BIP ⊣ EIF2AK3 → EIF2S1 → ATF4 ⇒ DDIT3 N01149    ALS SOD1* ⊣ BIP ⊣ EIF2AK3 → EIF2S1 → ATF4 ⇒ DDIT3 N01198    PrD PRNP* ⊣ BIP ⊣ EIF2AK3 → EIF2S1 → ATF4 ⇒ DDIT3 N01011            ERN1 → XBP1 ⇒ DDIT3 N01012    AD     PSEN1* ⊣ ERN1 → XBP1 N01034    PD SNCA* ⊣ BIP ⊣ ERN1 → XBP1 N01148    ALS SOD1* ⊣ BIP ⊣ ERN1 → XBP1 N01013    ERN1 → TRAF2 → MAP3K5 → MAP2K7 → JNK N01014    AD APP* → Abeta → MAP3K5 → MAP2K7 → JNK N01015            ATF6 ⇒ (DDIT3,XBP1,HSPA5) N01016    AD     PSEN1* ⊣ ATF6 ⇒ (DDIT3,XBP1) N01150    ALS     VAPB* ⊣ ATF6 N01033    PD SNCA* ⊣ BIP ⊣ ATF6 ⇒ DDIT3 N01147    ALS SOD1* ⊣ BIP ⊣ ATF6 ⇒ DDIT3   Autophagy N01142    RAB1A → (C9orf72+WDR41+SMC.. → ULK1_complex N01143    ALS RAB1A ⌿ (C9orf72*+WDR41+SM.. ⌿ (ULK1+RB1CC1+ATG10.. N00155    mTORC1 → ULK1_complex → PI3KC3-C1 N00962    SCA     ATXN3* ⌿ (BECN1+PIK3C3+ATG1.. N00993    HD     HTT* ⊣ (BECN1+PIK3C3+ATG1..   Mitophagy N01052    PINK1 → PRKN ⊣ MFN1/2 N01053    PD PINK1* ⌿ PRKN ⌿ MFN1/2 N01054    PD     PRKN* ⌿ MFN1/2 N01137    PINK1 → PRKN → (CISD1,CISD2,FAF2,.. = (SQSTM1,OPTN,NDP52.. = LC3 N01138    ALS PINK1 → PRKN → (CISD1,CISD2,FAF2,.. ⌿ OPTN* N01139    ALS PINK1 → PRKN → (CISD1,CISD2,FAF2,.. ⌿ SQSTM1* ⌿ LC3 N01140    TBK1 → (SQSTM1,OPTN,NDP52.. = LC3-II N01141    ALS TBK1* ⌿ (SQSTM1,OPTN,NDP52.. = LC3-II   Apoptosis N00146        (FASLG,TNFSF10) → (FAS,TNFRSF10B) → FADD → (CASP8,CASP10) → BID → (BAX,BAK1) → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N01005    AD APP* → Abeta → FAS → FADD → CASP8 → BID → (BAX,BAK1) → CYCS = APAF1 → CASP9 → CASP3 N00098                    (PMAIP1,BBC3,BAD,B.. ⊣ (BCL2,BCL2L1) ⊣ (BAX,BAK1) → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N01135    ALS                 SOD1* ⊣ BCL2 ⊣ (BAX,BAK1) → CYCS = APAF1 → CASP9 → CASP3 N01051    PD                 DJ1* ⌿ BCL2L1 ⌿ BAX N01050    PD                 PINK1* ⌿ PRKN ⌿ BAX → CYCS = APAF1 → CASP9 → CASP3 N01049    PD                     PRKN* ⌿ BAX → CYCS = APAF1 → CASP9 → CASP3 N01048    PD                     PINK1* ⌿ (HTRA2,TRAP1) ⌿ CYCS = APAF1 → CASP9 → CASP3 N01047    PD                         LRRK2* → CYCS = APAF1 → CASP9 → CASP3   AGE-RAGE signaling N00994        AGE → AGER → RAS → RAF → MEK → ERK → NFKB ⇒ (TNF,IL6,NOS2) N00996    AD APP* → Abeta → AGER → RAS → RAF → MEK → ERK → NFKB ⇒ (TNF,IL6,NOS2)   Oxidative phosphorylation N00995                                NADH − CxI → Q N00997    AD APP* → Abeta → CHRNA7 → Ca2+ → CAPN → CDK5R1 = CDK5 → MAPT ⊣ CxI → Q N01136    ALS                             TARDBP* ⊣ CxI → Q N01042    PD                             SNCA* ⊣ CxI → Q N01043    PD                             PINK1* ⊣ CxI → Q N01044    PD                             MPP+ ⊣ CxI → Q N01045    PD                             Rotenone ⊣ CxI → Q N00988    Succinate − CxII → QH2 N00989    HD HTT* ⊣ CxII → QH2 N01402    AD,PD Mn2+ ⊣ CxII → QH2 N00990    QH2 − CxIII → CytC N00991    HD HTT* ⊣ CxIII → CytC N01046    PD Maneb ⊣ CxIII → CytC N00998        CytC − CxIV → H2O N00999    AD APP* → Abeta ⊣ CxIV → H2O   Microtubule-based transport N00976                                (DCTN+DNAH+DNAI+DN.. = (TUBA+TUBB) N00977    HD                         (HTT*+HAP1) ⊣ (DCTN+DNAH+DNAI+DN.. = (TUBA+TUBB) N01160    ALS                         SOD1* ⊣ (DCTN+DNAH+DNAI+DN.. N01158    ALS                             DCTN1* ⌿ (TUBA+TUBB) N01159    ALS                             (DCTN+DNAH+DNAI+DN.. ⌿ TUBA4A* N00978                                (KIF5+KLC) = (TUBA+TUBB) N01055    PD                         SNCA* ⊣ (KIF5+KLC) ⌿ (TUBA+TUBB) N00979    HD                     HTT* → JNK3 ⊣ (KIF5+KLC) = (TUBA+TUBB) N01017    AD                     PSEN1* → GSK3B ⊣ (KIF5+KLC) N01202    PrD                     PRNP* → (GSK3B,CK2) ⊣ (KIF5+KLC) N01018    AD APP* → Abeta → CHRNA7 → Ca2+ → CAPN → CDK5R1 = CDK5 → MAPT ⊣ (TUBA+TUBB) N01403    AD                     Zn2+ → GSK3B → MAPT ⊣ (TUBA+TUBB) N01414    AD                     Fe2+ → CDK5 → MAPT ⊣ (TUBA+TUBB)

		Disease name	Disease category
SCA	H00063	Spinocerebellar ataxia (SCA)	Neurodegenerative disease
PD	H00057	Parkinson disease	Neurodegenerative disease
AD	H00056	Alzheimer disease	Neurodegenerative disease
ALS	H00058	Amyotrophic lateral sclerosis (ALS)	Neurodegenerative disease
PrD	H00061	Prion disease	Neurodegenerative disease
HD	H00059	Huntington disease	Neurodegenerative disease
AD,PD	H00056	Alzheimer disease	Neurodegenerative disease
	H00057	Parkinson disease	Neurodegenerative disease