KEGG   PATHWAY: aml05010
Entry
aml05010                    Pathway                                
Name
Alzheimer disease - Ailuropoda melanoleuca (giant panda)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
aml05010  Alzheimer disease
aml05010

Organism
Ailuropoda melanoleuca (giant panda) [GN:aml]
Gene
100476350  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
100482770  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
100466827  APP; amyloid-beta precursor protein isoform X1 [KO:K04520]
100481584  NAE1; NEDD8-activating enzyme E1 regulatory subunit isoform X1 [KO:K04532]
100475168  APBB1; amyloid-beta A4 precursor protein-binding family B member 1 isoform X2 [KO:K04529]
100478741  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
100480864  glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
100475419  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
117800152  glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
117800205  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
100475881  BACE1; beta-secretase 1 [KO:K04521] [EC:3.4.23.46]
100477612  BACE2; beta-secretase 2 [KO:K07747] [EC:3.4.23.45]
100476123  RTN3; reticulon-3 isoform X2 [KO:K20723]
100480807  RTN4; reticulon-4 isoform X3 [KO:K20720]
100464419  PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]
100477956  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
100466510  PSEN2; presenilin-2 [KO:K04522] [EC:3.4.23.-]
100477937  NCSTN; nicastrin [KO:K06171]
100470513  APH1A; gamma-secretase subunit APH-1A [KO:K06172]
100479798  APH1B; gamma-secretase subunit APH-1B [KO:K06172]
100482236  IDE; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
100474251  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
100476507  MAPT; microtubule-associated protein tau [KO:K04380]
5179729  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
5179725  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
5179736  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
5179726  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
5179735  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
5179734  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
5179730  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
100466993  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
100465323  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
100469433  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X2 [KO:K03944]
100479846  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
117801911  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
100470822  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
100484973  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
100476950  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 isoform X2 [KO:K03948]
100475666  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
100469925  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
100472043  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
100474497  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
100481984  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
100469424  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
100477408  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
100477501  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
100468209  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
100471683  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
100480549  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
100478953  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
117802616  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
100469603  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
100472586  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
100476249  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
100481052  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
100469963  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
100467282  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
117801866  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7-like [KO:K03963]
100463673  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
100468035  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
100479731  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
100467366  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
100484187  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
100481212  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
100477724  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
100467769  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
100478105  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
100478653  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform X1 [KO:K03939]
100478931  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
100468168  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X2 [KO:K03941] [EC:7.1.1.2]
100470756  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
100467558  NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
100483034  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
100473290  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
100480530  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
117794997  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
100465810  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
5179733  CYTB; cytochrome b [KO:K00412]
100480854  cytochrome c1, heme protein, mitochondrial [KO:K00413]
100469760  LOW QUALITY PROTEIN: cytochrome c1, heme protein, mitochondrial-like [KO:K00413]
100478686  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
100483213  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
100469420  cytochrome b-c1 complex subunit 6, mitochondrial isoform X2 [KO:K00416]
100466991  cytochrome b-c1 complex subunit 7 [KO:K00417]
100483229  UQCRQ; cytochrome b-c1 complex subunit 8 [KO:K00418]
100484841  cytochrome b-c1 complex subunit 9 isoform X2 [KO:K00419]
100479434  cytochrome b-c1 complex subunit 10 [KO:K00420]
5179732  COX3; cytochrome c oxidase subunit III [KO:K02262]
5179727  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
5179728  COX2; cytochrome c oxidase subunit II [KO:K02261]
100463627  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
100470176  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
100471452  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
100464713  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
100479689  cytochrome c oxidase subunit 6A2, mitochondrial isoform X2 [KO:K02266]
100479884  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
100473625  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
100472635  cytochrome c oxidase subunit 6B2 [KO:K02267]
100464665  cytochrome c oxidase subunit 6B1 [KO:K02267]
109489277  cytochrome c oxidase subunit 6B1-like [KO:K02267]
100470634  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
100475268  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
100479346  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
100475526  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
100466075  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
100466302  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
100475627  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
100464901  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
117800373  ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
100473933  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
100475678  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X3 [KO:K02136]
100477917  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
105235972  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
5179731  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
100472298  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
100474391  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
100473960  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X2 [KO:K02128]
100475794  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
117798555  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
117799069  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
100466087  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
100478407  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
100466166  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
5179737  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
100483379  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
100482761  PPID; peptidyl-prolyl cis-trans isomerase D isoform X2 [KO:K05864] [EC:5.2.1.8]
100463625  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100465507  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100470763  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
100473508  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100464085  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
100469507  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
100476732  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
117799792  ADP/ATP translocase 2-like [KO:K05863]
100481603  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
100482804  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
100477661  APOE; apolipoprotein E [KO:K04524]
100476452  LRP1; prolow-density lipoprotein receptor-related protein 1 isoform X1 [KO:K04550]
100473767  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
100479926  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100468003  FADD; FAS-associated death domain protein isoform X1 [KO:K02373]
100472842  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100465439  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
100478600  CALML6; calmodulin-like protein 6 [KO:K02183]
100470909  CALM2; calmodulin-2 [KO:K02183]
100484519  calmodulin [KO:K02183]
100484770  calmodulin-like protein 3 [KO:K02183]
100481177  CALM1; calmodulin-1 [KO:K02183]
100472122  CALM3; calmodulin-3 [KO:K02183]
100478732  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
117799706  calmodulin-alpha-like [KO:K02183]
100477289  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
100467653  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X5 [KO:K04348] [EC:3.1.3.16]
100474970  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X5 [KO:K04348] [EC:3.1.3.16]
100474742  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100467683  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
100473937  BAD; bcl2-associated agonist of cell death [KO:K02158]
100472074  cytochrome c [KO:K08738]
105241648  cytochrome c-like [KO:K08738]
100464163  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
100483760  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
100469056  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
100481445  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
109488507  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
100480193  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
100466868  GRM5; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5 [KO:K04604]
100464853  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
100481755  PLCB1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
100480603  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
100465232  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100474779  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
100465687  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100469843  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
100466153  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100475562  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
100473622  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
100479715  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X3 [KO:K04850]
100467700  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
100468661  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
100472835  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
100469287  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
100475721  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
100470035  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100472388  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100481196  RYR3; ryanodine receptor 3 [KO:K04963]
100467161  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X8 [KO:K04958]
100477888  ITPR2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100471747  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100465699  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X6 [KO:K05853] [EC:7.2.2.10]
100470716  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
100465047  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
100481422  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
100471419  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
100479063  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
100474476  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
100479743  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
100474087  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100475304  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
100475975  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
100477951  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100482196  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100477600  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
100470706  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
100476284  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100466744  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
100466847  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
100480504  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
100464969  PSMA8; proteasome subunit alpha-type 8 [KO:K02731] [EC:3.4.25.1]
100472677  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
100481497  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
100482015  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
100468723  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
117798324  proteasome subunit alpha type-3-like [KO:K02727] [EC:3.4.25.1]
100477839  PSMB6; LOW QUALITY PROTEIN: proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
100465153  proteasome subunit beta type-6-like [KO:K02738] [EC:3.4.25.1]
117795988  proteasome subunit beta type-6-like [KO:K02738] [EC:3.4.25.1]
100470604  PSMB7; proteasome subunit beta type-7 isoform X3 [KO:K02739] [EC:3.4.25.1]
100471505  PSMB3; proteasome subunit beta type-3 isoform X2 [KO:K02735] [EC:3.4.25.1]
100483175  PSMB2; proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
100470383  proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
100482702  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
100463743  proteasome subunit beta type-1-like [KO:K02732] [EC:3.4.25.1]
100477062  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
100479952  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
117798292  26S proteasome regulatory subunit 7-like [KO:K03061]
100483435  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
100469015  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
100474244  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
100472740  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 10B [KO:K03064]
100476973  PSMC3; 26S proteasome regulatory subunit 6A isoform X2 [KO:K03065]
100471784  PSMC5; 26S proteasome regulatory subunit 8 [KO:K03066]
100470925  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
100465828  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X2 [KO:K03032]
100481540  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
100467795  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
100481520  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
100463710  PSMD11; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
100468057  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
100473896  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
100467708  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
105237685  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X2 [KO:K03029]
100484033  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
100468437  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
100480012  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
100465742  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
100465168  caspase-12-like isoform X1 [KO:K04741] [EC:3.4.22.-]
100468087  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
100468407  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
100476150  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
100473330  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
100466613  SLC39A2; zinc transporter ZIP2 isoform X1 [KO:K14709]
100483375  SLC39A3; zinc transporter ZIP3 isoform X1 [KO:K14709]
100484781  SLC39A1; zinc transporter ZIP1 [KO:K14709]
100477825  SLC39A4; zinc transporter ZIP4 [KO:K14710]
100471175  SLC39A5; zinc transporter ZIP5 [KO:K14711]
100471459  SLC39A6; zinc transporter ZIP6 isoform X2 [KO:K14712]
100475942  SLC39A7; zinc transporter SLC39A7 isoform X1 [KO:K14713]
100470583  SLC39A8; metal cation symporter ZIP8 [KO:K14714]
100470256  SLC39A9; zinc transporter ZIP9 [KO:K14715]
100469161  SLC39A10; zinc transporter ZIP10 [KO:K14716]
105239614  SLC39A11; zinc transporter ZIP11 isoform X1 [KO:K14717]
100479037  SLC39A12; zinc transporter ZIP12 [KO:K14718]
100476566  SLC39A13; zinc transporter ZIP13 isoform X4 [KO:K14719]
100472331  SLC39A14; metal cation symporter ZIP14 isoform X1 [KO:K14720]
100479673  SLC11A2; natural resistance-associated macrophage protein 2 isoform X4 [KO:K21398]
100483328  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
100479224  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
100471992  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
100481257  DKK1; dickkopf-related protein 1 precursor [KO:K02165]
100466975  DKK2; dickkopf-related protein 2 [KO:K02165]
100471186  DKK4; dickkopf-related protein 4 [KO:K02165]
100475007  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100480237  WNT2; protein Wnt-2 isoform X1 [KO:K00182]
100481665  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
100471555  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100473835  WNT3A; protein Wnt-3a [KO:K00312]
100468584  WNT4; protein Wnt-4 [KO:K00408]
100484068  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
100473854  WNT5B; protein Wnt-5b isoform X3 [KO:K00444]
100467896  WNT6; protein Wnt-6 [KO:K00445]
100475153  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
100474982  WNT7B; protein Wnt-7b [KO:K00572]
100466672  WNT8B; protein Wnt-8b isoform X1 [KO:K00714]
100481684  WNT8A; LOW QUALITY PROTEIN: protein Wnt-8a [KO:K00714]
100472460  WNT9B; protein Wnt-9b [KO:K01064]
100475103  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
100467643  protein Wnt-10a isoform X1 [KO:K01357]
100475265  WNT10B; protein Wnt-10b isoform X1 [KO:K01357]
117795031  WNT10A; LOW QUALITY PROTEIN: protein Wnt-10a [KO:K01357]
100468561  WNT11; protein Wnt-11 [KO:K01384]
100464171  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
100469196  FZD1; frizzled-1 [KO:K02432]
109489608  FZD7; frizzled-7 [KO:K02432]
100469249  FZD2; frizzled-2 [KO:K02235]
100468831  FZD3; frizzled-3 isoform X1 [KO:K02329]
100470379  FZD4; frizzled-4 [KO:K02354]
100478649  FZD5; frizzled-5 [KO:K02375]
100467779  FZD8; frizzled-8 [KO:K02375]
100464621  FZD6; frizzled-6 isoform X1 [KO:K02376]
100479765  FZD10; frizzled-10 [KO:K02842]
100469765  FZD9; LOW QUALITY PROTEIN: frizzled-9 [KO:K02842]
100473379  LRP5; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5 [KO:K03068]
100477840  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
100473087  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
100466067  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
100471972  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X2 [KO:K02353]
100480005  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
105236609  FRAT1; proto-oncogene FRAT1 [KO:K03069]
117802815  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
100471788  CSNK2A1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
100479210  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
100469386  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
100473018  AXIN1; axin-1 isoform X1 [KO:K02157]
100477069  AXIN2; axin-2 isoform X1 [KO:K04385]
100472257  APC; adenomatous polyposis coli protein isoform X5 [KO:K02085]
100465768  APC2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
100477834  CTNNB1; catenin beta-1 [KO:K02105]
100473522  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
100479975  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
100474200  KIF5B; kinesin-1 heavy chain [KO:K10396]
100484204  KIF5C; kinesin heavy chain [KO:K10396]
100484737  KLC4; kinesin light chain 4 [KO:K10407]
100481191  KLC3; kinesin light chain 3 [KO:K10407]
100464655  KLC1; kinesin light chain 1 isoform X3 [KO:K10407]
100483172  KLC2; kinesin light chain 2 [KO:K10407]
100480515  tubulin alpha-8 chain [KO:K07374]
100468269  TUBA4B; LOW QUALITY PROTEIN: putative tubulin-like protein alpha-4B [KO:K07374]
100470688  LOW QUALITY PROTEIN: tubulin alpha-3 chain [KO:K07374]
100463766  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
100464995  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
100475162  LOW QUALITY PROTEIN: tubulin alpha-1C chain [KO:K07374]
100466505  tubulin alpha-4A chain isoform X2 [KO:K07374]
100468734  TUBB1; LOW QUALITY PROTEIN: tubulin beta-1 chain [KO:K07375]
100463763  TUBB4B; tubulin beta-4B chain [KO:K07375]
100484048  TUBB6; tubulin beta-6 chain [KO:K07375]
100470125  tubulin beta-2 chain [KO:K07375]
100468119  tubulin beta-3 chain [KO:K07375]
100478851  tubulin beta chain-like [KO:K07375]
105240041  tubulin beta chain [KO:K07375]
100475096  TUBB4A; tubulin beta-4A chain [KO:K07375]
100476093  TUBB; tubulin beta chain [KO:K07375]
117800503  tubulin beta-4B chain-like isoform X1 [KO:K07375]
100477105  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
100473836  HRAS; GTPase HRas isoform X1 [KO:K02833]
100483919  KRAS; GTPase KRas isoform X1 [KO:K07827]
100464196  NRAS; GTPase NRas [KO:K07828]
100475955  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
100469346  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100482255  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100478039  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100465700  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100470141  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
100468223  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
109490984  LOW QUALITY PROTEIN: dual oxidase 1 [KO:K21421] [EC:1.-.-.-]
100472390  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
100480158  RELA; transcription factor p65 isoform X1 [KO:K04735]
100467906  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100470060  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
100481615  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100471563  TNF; tumor necrosis factor [KO:K03156]
100477151  IL6; interleukin-6 precursor [KO:K05405]
117803984  interleukin-6-like [KO:K05405]
100481122  IL1A; interleukin-1 alpha [KO:K04383]
100480874  IL1B; interleukin-1 beta [KO:K04519]
100467411  CSF1; macrophage colony-stimulating factor 1 isoform X2 [KO:K05453]
100478316  SNCA; alpha-synuclein [KO:K04528]
100469151  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
100464675  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100471679  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100470223  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100483432  INS; insulin isoform X2 [KO:K04526]
100473956  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100477645  IRS1; insulin receptor substrate 1 [KO:K16172]
100477685  IRS2; LOW QUALITY PROTEIN: insulin receptor substrate 2 [KO:K07187]
100467269  uncharacterized protein LOC100467269 [KO:K17445]
105240373  IRS4; LOW QUALITY PROTEIN: insulin receptor substrate 4 [KO:K17446]
100475291  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100483828  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100467916  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100463775  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100479294  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100479580  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100468763  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100480414  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100465793  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100471122  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100470276  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
100484867  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
100477068  ATG101; autophagy-related protein 101 [KO:K19730]
117798143  autophagy-related protein 101 [KO:K19730]
100472114  ATG13; autophagy-related protein 13 isoform X4 [KO:K08331]
100466043  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
100471614  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X7 [KO:K17985]
100473538  BECN1; beclin-1 isoform X2 [KO:K08334]
105237277  BECN2; beclin-2 [KO:K08334]
100484642  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
100468289  ATG14; beclin 1-associated autophagy-related key regulator isoform X1 [KO:K17889]
100468177  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
100465351  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
100472170  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
100483146  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
100475501  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
100483830  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X5 [KO:K17908]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Related
pathway
aml00190  Oxidative phosphorylation
aml03050  Proteasome
aml04020  Calcium signaling pathway
aml04140  Autophagy - animal
aml04141  Protein processing in endoplasmic reticulum
aml04210  Apoptosis
aml04310  Wnt signaling pathway
aml04910  Insulin signaling pathway
aml04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   
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