KEGG   PATHWAY: cata04010
Entry
cata04010                   Pathway                                
Name
MAPK signaling pathway - Cygnus atratus (black swan)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
cata04010  MAPK signaling pathway
cata04010

Other DBs
GO: 0000165
Organism
Cygnus atratus (black swan) [GN:cata]
Gene
118257069  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
118250054  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
118253668  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
118243275  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
118261499  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
118253869  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
118256395  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
118250464  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
118255291  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
118249509  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
118248051  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
118253745  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
118250073  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
118247429  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
118261358  CACNB3; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864]
118257760  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
118253972  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
118250687  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
118256471  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
118253922  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
118253940  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
118243752  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
118253863  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
118256461  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
118249105  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
118256969  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
118247564  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118256073  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118245074  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
118251164  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
118259432  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
118258647  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X2 [KO:K12326]
118244228  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
118254707  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
118248181  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
118255148  NF1; neurofibromin isoform X1 [KO:K08052]
118256325  RASA1; ras GTPase-activating protein 1 [KO:K04352]
118247270  RASA2; ras GTPase-activating protein 2 [KO:K08053]
118255454  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
118246831  RAP1B; ras-related protein Rap-1b [KO:K07836]
118254590  EGF; pro-epidermal growth factor [KO:K04357]
118256047  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
118249999  EREG; proepiregulin [KO:K09784]
118249955  AREG; amphiregulin [KO:K09782]
118254886  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
118251228  FGF2; fibroblast growth factor 2 [KO:K18497]
118247617  FGF6; fibroblast growth factor 6 isoform X1 [KO:K04358]
118260053  FGF22; fibroblast growth factor 22 [KO:K04358]
118248655  FGF8; fibroblast growth factor 8 [KO:K04358]
118256164  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
118256023  FGF17; fibroblast growth factor 17 [KO:K04358]
118250779  FGF3; fibroblast growth factor 3 isoform X1 [KO:K04358]
118250820  FGF4; fibroblast growth factor 4 [KO:K04358]
118250874  FGF5; fibroblast growth factor 5 [KO:K04358]
118245199  FGF20; fibroblast growth factor 20 [KO:K04358]
118245387  FGF16; fibroblast growth factor 16 [KO:K04358]
118251706  FGF7; fibroblast growth factor 7 isoform X2 [KO:K04358]
118257796  FGF10; fibroblast growth factor 10 isoform X1 [KO:K04358]
118245958  FGF9; fibroblast growth factor 9 [KO:K04358]
118250765  FGF19; fibroblast growth factor 19 [KO:K22603]
118247709  FGF23; fibroblast growth factor 23 [KO:K22428]
118255306  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
118249880  BDNF; brain-derived neurotrophic factor [KO:K04355]
118245014  NTF3; neurotrophin-3 [KO:K04356]
118244761  INS; insulin [KO:K04526]
118256041  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
118244520  IGF2; insulin-like growth factor II [KO:K13769]
118249111  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
118250471  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
118249045  PDGFC; platelet-derived growth factor C [KO:K05450]
118245944  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
118260397  CSF1; macrophage colony-stimulating factor 1 isoform X2 [KO:K05453]
118250548  KITLG; kit ligand isoform X1 [KO:K05461]
118255887  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
118244475  PGF; placenta growth factor isoform X1 [KO:K16859]
118253495  VEGFC; vascular endothelial growth factor C [KO:K05449]
118245718  VEGFD; vascular endothelial growth factor D [KO:K05449]
118249402  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
118247971  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
118246213  ANGPT2; angiopoietin-2 isoform X2 [KO:K05466]
118258354  ANGPT4; angiopoietin-4 [KO:K05467]
118260868  EFNA2; ephrin-A2 [KO:K05462]
118255957  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
118258586  EFNA3; ephrin-A3 [KO:K05462]
118258624  EFNA1; ephrin-A1 [KO:K05462]
118258626  EFNA4; ephrin-A4 [KO:K05462]
118256666  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
118260549  NRTN; neurturin isoform X2 [KO:K25414]
118243726  ARTN; LOW QUALITY PROTEIN: artemin [KO:K25415]
118250916  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
118261002  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
118260545  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
118256011  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
118248680  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
118248370  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
118254384  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
118251838  tumor necrosis factor receptor superfamily member 16-like isoform X2 [KO:K02583]
118259179  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
118258616  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
118257362  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
118258731  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
118251997  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
118248600  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
118260560  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
118260579  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X2 [KO:K05090] [EC:2.7.10.1]
118252124  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
118246030  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
118245452  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
118246029  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
118260573  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
118252123  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
118246692  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
118256250  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
118258836  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
118246107  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
118253962  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
118250305  SOS2; son of sevenless homolog 2 [KO:K03099]
118251111  SOS1; son of sevenless homolog 1 [KO:K03099]
118250718  HRAS; GTPase HRas [KO:K02833]
118245139  KRAS; GTPase KRas isoform X1 [KO:K07827]
118255298  NRAS; GTPase NRas [KO:K07828]
118249900  RRAS2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
118261251  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
118259202  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
118253692  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118252022  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
118258785  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
118244612  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
118252877  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
118259839  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
118243646  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
118255812  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X2 [KO:K04373] [EC:2.7.11.1]
118244201  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
118245516  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
118245696  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
118250509  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
118255355  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
118252717  MYC; LOW QUALITY PROTEIN: myc proto-oncogene protein [KO:K04377]
118261688  serum response factor-like [KO:K04378]
118244473  FOS; LOW QUALITY PROTEIN: protein c-Fos [KO:K04379]
118261227  microtubule-associated protein tau isoform X1 [KO:K04380]
118255794  STMN1; stathmin [KO:K04381]
118243262  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
118244227  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
118244782  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
118244261  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
118244481  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
118244496  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
118244543  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
118244781  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
118244827  PLA2G4B; cytosolic phospholipase A2 beta isoform X2 [KO:K16342] [EC:3.1.1.4]
118261248  interleukin-1 beta-like [KO:K04519]
118253345  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
118244426  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
118245101  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
118253534  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
118246954  IL1RAP; interleukin-1 receptor accessory protein isoform X2 [KO:K04723]
118260847  LOW QUALITY PROTEIN: TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
118249615  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
118243636  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
118243457  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
118254453  monocyte differentiation antigen CD14-like [KO:K04391]
118249373  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
118250700  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
118259247  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
118258809  CDC42; cell division control protein 42 homolog [KO:K04393]
118246384  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
118253463  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
118260735  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
118251776  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
118246720  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
118250786  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
118259579  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
118260854  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
118256951  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
118250627  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
118244069  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
118251104  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
118253539  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
118245254  NRK; nik-related protein kinase isoform X1 [KO:K04407] [EC:2.7.11.1]
118254800  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
118247234  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
118248992  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
118247932  STK3; serine/threonine-protein kinase 3 [KO:K04412]
118247484  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
118251484  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
118259964  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
118251789  mitogen-activated protein kinase kinase kinase 3-like isoform X1 [KO:K04421] [EC:2.7.11.25]
118258931  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
118244627  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
118254125  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
118247087  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
118258810  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
118255810  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
118243870  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
118254314  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
118243843  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X2 [KO:K04428] [EC:2.7.11.25]
118255088  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
118253009  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
118255568  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
118256504  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
118253982  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
118244338  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
118259639  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
118249119  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
118254099  CRK; adapter molecule crk isoform X1 [KO:K04438]
118252963  CRKL; crk-like protein [KO:K04438]
118260834  ARRB1; beta-arrestin-1 [KO:K04439]
118254865  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118248962  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118243928  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118254235  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
118254236  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
118255378  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118255379  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
118257588  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
118255301  MAPKAPK2; LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
118248286  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
118244811  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
118261102  CDC25B; LOW QUALITY PROTEIN: M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
118249618  NFATC1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
118246598  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
118243795  JUN; transcription factor Jun [KO:K04448]
118258511  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
118244719  MAX; protein max [KO:K04453]
118256346  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
118254133  HSPB1; heat shock protein beta-1 [KO:K04455]
118261257  AKT2; LOW QUALITY PROTEIN: RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118250209  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118256722  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118250396  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
118246734  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
118244774  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
118255288  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
118254382  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
118248278  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118248667  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118250202  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118244754  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118252135  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118250552  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
118254929  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
118259129  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
118252575  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
118252411  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
118253106  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
118259689  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
118261621  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
118260224  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
118258242  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
118247527  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
118256066  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118255046  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
118244650  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118244373  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
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Reference
PMID:23085193
  Authors
Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
cata04070  Phosphatidylinositol signaling system
cata04110  Cell cycle
cata04115  p53 signaling pathway
cata04210  Apoptosis
cata04310  Wnt signaling pathway
KO pathway
ko04010   
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