KEGG   PATHWAY: cfr05022
Entry
cfr05022                    Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Camelus ferus (Wild Bactrian camel)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
cfr05022  Pathways of neurodegeneration - multiple diseases
cfr05022

Organism
Camelus ferus (Wild Bactrian camel) [GN:cfr]
Gene
102507265  APP; amyloid-beta precursor protein isoform X1 [KO:K04520]
102508974  MAPT; microtubule-associated protein tau isoform X12 [KO:K04380]
102505805  SNCA; alpha-synuclein [KO:K04528]
102510362  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
102513734  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
102505386  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
102504600  LOW QUALITY PROTEIN: superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
102510277  ATXN2; ataxin-2 isoform X1 [KO:K23625]
102511383  ATXN2L; ataxin-2-like protein isoform X1 [KO:K23625]
102521890  HTT; LOW QUALITY PROTEIN: huntingtin [KO:K04533]
102516284  ATXN1L; ataxin-1-like [KO:K23616]
106730479  ATXN1; ataxin-1 [KO:K23616]
102520123  ATXN3; ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
102518771  PRNP; LOW QUALITY PROTEIN: major prion protein [KO:K05634]
102523660  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
102520584  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
102521882  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
102523306  SPTBN2; LOW QUALITY PROTEIN: spectrin beta chain, non-erythrocytic 2 [KO:K23932]
102523079  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
102508547  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
102508809  PRKN; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
102509058  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X3 [KO:K05858] [EC:3.1.4.11]
102505338  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
102513996  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
102513431  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
102524452  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
102507832  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
102511859  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
102513516  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102513654  TRPC3; short transient receptor potential channel 3 isoform X1 [KO:K04966]
102523406  SIGMAR1; sigma non-opioid intracellular receptor 1 isoform X1 [KO:K20719]
102521814  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
102517295  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
102524078  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
102516436  RYR1; LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
102523222  RYR2; ryanodine receptor 2 [KO:K04962]
102522121  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
102506405  PDYN; proenkephalin-B [KO:K15840]
102504814  DLG4; disks large homolog 4 isoform X1 [KO:K11828]
102506181  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
102503788  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
102517500  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
102516268  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
102522985  GRIN2D; glutamate receptor ionotropic, NMDA 2D isoform X1 [KO:K05212]
102513727  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
102509459  GRIA2; LOW QUALITY PROTEIN: glutamate receptor 2 [KO:K05198]
102508750  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
102513507  GRIA4; glutamate receptor 4 isoform X2 [KO:K05200]
102521766  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
102524149  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
102504854  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
102504151  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
102507309  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
102513495  STX1A; syntaxin-1A isoform X1 [KO:K04560]
102524002  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
102513364  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
102507440  ATP2A1; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
102506121  ATP2A2; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
102507075  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
102516800  PSEN2; presenilin-2 isoform X3 [KO:K04522] [EC:3.4.23.-]
102522634  DERL1; derlin-1 isoform X1 [KO:K11519]
102508944  VCP; transitional endoplasmic reticulum ATPase [KO:K13525]
102508136  ubiquitin-60S ribosomal protein L40 isoform X4 [KO:K02927]
102520555  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
102516164  UBB; polyubiquitin-B [KO:K04551]
102516292  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
102505753  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
102517648  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
102504963  PSMA7; proteasome subunit alpha type-7 isoform X1 [KO:K02731] [EC:3.4.25.1]
102506822  PSMA8; proteasome subunit alpha-type 8 [KO:K02731] [EC:3.4.25.1]
102523817  PSMA5; proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
102521944  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
102513698  LOW QUALITY PROTEIN: proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
102509508  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
102521312  PSMB6; proteasome subunit beta type-6 isoform X1 [KO:K02738] [EC:3.4.25.1]
102518943  PSMB7; proteasome subunit beta type-7 isoform X1 [KO:K02739] [EC:3.4.25.1]
102504556  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
102512214  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
102517423  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
102523305  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
102519021  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
102513574  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
102519658  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
102504898  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
102508776  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
102506679  PSMC3; 26S proteasome regulatory subunit 6A isoform X1 [KO:K03065]
102517432  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
116656643  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
102520605  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
102516065  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
102523988  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform X2 [KO:K06693]
102521709  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
102513989  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
102510119  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
102513652  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
102509607  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X2 [KO:K03039]
102516967  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X2 [KO:K03029]
102517910  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
102515414  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
102517207  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 8-like [KO:K03031]
102504204  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
102517349  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
102514352  UCHL1; ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
102505479  UBA1; ubiquitin-like modifier-activating enzyme 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
102503695  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
116660994  UBE2L3; ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
102514746  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X2 [KO:K04553] [EC:2.3.2.23]
102521443  UBE2J2; ubiquitin-conjugating enzyme E2 J2 isoform X1 [KO:K04554] [EC:2.3.2.23]
102514955  UBE2J1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
102511243  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
102516887  UBE2G1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
102522414  GPR37; prosaposin receptor GPR37 [KO:K04243]
102504630  SEPTIN5; septin-5 isoform X3 [KO:K04557]
102511903  SNCAIP; synphilin-1 isoform X1 [KO:K04558]
102515954  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
102511320  VAPB; vesicle-associated membrane protein-associated protein B/C [KO:K10707]
102515280  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
102517621  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
102510269  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
102518977  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
102511649  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
102522243  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
102506459  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
102518561  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102509448  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102503577  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102509143  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
102523410  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
102518617  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
102508076  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102510470  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
102521586  PINK1; serine/threonine-protein kinase PINK1, mitochondrial isoform X1 [KO:K05688] [EC:2.7.11.1]
5326219  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
5326218  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
5326226  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
5326228  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
5326227  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
5326229  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
5326221  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
102519984  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
102522489  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
102521191  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
102510141  LOW QUALITY PROTEIN: nucleolin 2-like [KO:K03944]
116662114  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
102523341  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
102515191  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
102515165  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
102516214  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
102523689  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
102510956  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
102512695  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
102505652  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
102510326  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
102509936  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
102512974  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
102504715  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
102518907  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
102520409  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12-like [KO:K11352]
102503878  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
102511004  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
116664480  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
116666587  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
102523839  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
102508877  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
102506336  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
102521082  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
102504305  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
102519500  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
102507693  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
102518585  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
102522078  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
102505428  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
102524292  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
102508476  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
102524104  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
102522662  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
102510949  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
102522433  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
102520779  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X2 [KO:K03941] [EC:7.1.1.2]
102522956  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
102517243  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
102523856  SDHA; LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
102524547  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
102506175  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
102521513  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
102517471  cytochrome b-c1 complex subunit Rieske, mitochondrial isoform X1 [KO:K00411] [EC:7.1.1.8]
5326230  CYTB; cytochrome b [KO:K00412]
102523866  cytochrome c1, heme protein, mitochondrial [KO:K00413]
102514495  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
102515646  cytochrome b-c1 complex subunit 2, mitochondrial isoform X1 [KO:K00415]
102504726  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
102511190  cytochrome b-c1 complex subunit 7 [KO:K00417]
102520672  cytochrome b-c1 complex subunit 8 [KO:K00418]
102514673  cytochrome b-c1 complex subunit 8-like [KO:K00418]
102522632  cytochrome b-c1 complex subunit 8 [KO:K00418]
102523993  cytochrome b-c1 complex subunit 9 [KO:K00419]
102505913  cytochrome b-c1 complex subunit 10 [KO:K00420]
5326220  COX3; cytochrome c oxidase subunit III [KO:K02262]
5326222  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
5326224  COX2; cytochrome c oxidase subunit II [KO:K02261]
102504739  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
102506135  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
102514933  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
102506544  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
102524231  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
102515110  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
102517088  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
102512681  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
102511501  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
102506051  cytochrome c oxidase subunit 6B1 [KO:K02267]
116666021  cytochrome c oxidase subunit 6B2 [KO:K02267]
102514870  cytochrome c oxidase subunit 6C [KO:K02268]
102507060  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
102509827  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
102511089  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
102509421  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
102506447  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
116662174  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
116666513  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
102514229  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
102513074  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
102505103  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
102517399  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
116657863  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
5326225  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
102515424  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
102512235  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
102512003  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
102508921  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
102518323  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
102515952  ATP5PO; LOW QUALITY PROTEIN: ATP synthase subunit O, mitochondrial [KO:K02137]
102507559  LOW QUALITY PROTEIN: ATP synthase subunit O, mitochondrial-like [KO:K02137]
102506489  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
5326223  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
102518434  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
102518825  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
116669325  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like [KO:K05862]
102507566  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
102504032  TOMM40L; mitochondrial import receptor subunit TOM40B [KO:K11518]
102507581  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
102512690  CALM1; calmodulin-1 [KO:K02183]
102516816  CALM3; calmodulin-3 [KO:K02183]
102509134  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
102517946  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
102512134  CALM2; calmodulin-2 [KO:K02183]
102518712  calmodulin [KO:K02183]
102513924  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102515660  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102505131  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
106729683  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
116669020  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102523295  BAD; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
102503604  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102518538  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
102519266  FADD; FAS-associated death domain protein [KO:K02373]
102508224  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
102522363  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
102512073  ferritin light chain isoform X1 [KO:K02159]
102513729  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
102505769  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 isoform X1 [KO:K08844] [EC:2.7.11.1]
102522927  HTRA2; serine protease HTRA2, mitochondrial isoform X2 [KO:K08669] [EC:3.4.21.108]
102508343  TRAP1; heat shock protein 75 kDa, mitochondrial [KO:K09488]
102520541  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
106730896  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2-like [KO:K15040]
102509027  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
102503644  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
102513318  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
102516285  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
102512378  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
102520419  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
102511134  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
102524306  cytochrome c [KO:K08738]
116663281  cytochrome c-like [KO:K08738]
116663681  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
102516966  APAF1; apoptotic protease-activating factor 1 isoform X3 [KO:K02084]
102519816  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
102520133  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
102511143  HIP1; huntingtin-interacting protein 1 isoform X1 [KO:K04559]
102509527  IFT57; intraflagellar transport protein 57 homolog [KO:K04638]
102504376  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
102511542  LOW QUALITY PROTEIN: 3-hydroxyacyl-CoA dehydrogenase type-2-like [KO:K08683] [EC:1.1.1.35 1.1.1.178]
102510841  PPID; peptidyl-prolyl cis-trans isomerase D isoform X1 [KO:K05864] [EC:5.2.1.8]
102503983  PARK7; protein/nucleic acid deglycase DJ-1 [KO:K05687] [EC:3.5.1.124]
102504996  BCL2L1; bcl-2-like protein 1 isoform X2 [KO:K04570]
102522742  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
102504460  MFN2; mitofusin-2 isoform X1 [KO:K06030] [EC:3.6.5.-]
102505918  OPTN; optineurin isoform X1 [KO:K19946]
102519914  SQSTM1; sequestosome-1 [KO:K14381]
102509665  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
102505462  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
102514948  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
102517502  TANK; TRAF family member-associated NF-kappa-B activator isoform X3 [KO:K12650]
102521985  WDR41; WD repeat-containing protein 41 [KO:K23610]
102506594  SMCR8; LOW QUALITY PROTEIN: guanine nucleotide exchange protein SMCR8 [KO:K23611]
102509537  C9orf72; guanine nucleotide exchange C9orf72 homolog [KO:K23609]
102517974  RAB8A; ras-related protein Rab-8A [KO:K07901]
102513155  RAB39B; ras-related protein Rab-39B [KO:K07925]
102509266  RAB1A; ras-related protein Rab-1A [KO:K07874]
102510836  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
102508563  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
102516695  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
102509718  ATG101; autophagy-related protein 101 isoform X2 [KO:K19730]
102513895  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
102518316  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
102512599  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
102515881  BECN1; beclin-1 isoform X3 [KO:K08334]
102517297  BECN2; beclin-2 [KO:K08334]
102508821  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
102522384  ATG14; beclin 1-associated autophagy-related key regulator isoform X1 [KO:K17889]
102515126  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
102503733  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
102524532  ATG2B; LOW QUALITY PROTEIN: autophagy-related protein 2 homolog B [KO:K17906]
102521302  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
102515887  WIPI2; LOW QUALITY PROTEIN: WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
102503459  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
102507784  ZFYVE1; zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603]
102506577  ALS2; alsin isoform X1 [KO:K04575]
102515139  RAB5A; ras-related protein Rab-5A [KO:K07887]
102516893  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102510627  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
102510940  FIG4; polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
102503712  spatacsin isoform X1 [KO:K19026]
102510424  TNF; tumor necrosis factor [KO:K03156]
102508884  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
102507931  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
102503654  DAXX; death domain-associated protein 6 [KO:K02308]
102523780  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
102519784  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102516847  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
102519781  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102511298  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
102511078  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102508946  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
102504999  CCS; copper chaperone for superoxide dismutase [KO:K04569]
102523217  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
102509450  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
102508398  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
102515413  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
102505123  GPX8; probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
102517670  GPX6; glutathione peroxidase 6 isoform X1 [KO:K00432] [EC:1.11.1.9]
102517908  epididymal secretory glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
102524165  CAT; catalase [KO:K03781] [EC:1.11.1.6]
102523724  PRPH; peripherin isoform X1 [KO:K07607]
102513324  NEFL; neurofilament light polypeptide [KO:K04572]
102513071  NEFM; neurofilament medium polypeptide isoform X1 [KO:K04573]
102505093  NEFH; neurofilament heavy polypeptide isoform X1 [KO:K04574]
102518661  KIF5A; kinesin heavy chain isoform X3 [KO:K10396]
102517013  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
102519328  KIF5C; kinesin heavy chain [KO:K10396]
102510359  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
102511669  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
102523618  KLC3; kinesin light chain 3 isoform X3 [KO:K10407]
102509206  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
102522963  tubulin alpha-1B chain [KO:K07374]
102523472  TUBA1A; tubulin alpha-1A chain [KO:K07374]
102515991  tubulin alpha-1C chain [KO:K07374]
102521054  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
102522237  TUBA4A; tubulin alpha-4A chain [KO:K07374]
102512533  LOW QUALITY PROTEIN: tubulin alpha-1D chain [KO:K07374]
102508381  tubulin alpha chain [KO:K07374]
102505604  LOW QUALITY PROTEIN: tubulin alpha-1A chain [KO:K07374]
102518229  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
102505031  tubulin alpha-3 chain [KO:K07374]
102511248  TUBB3; tubulin beta-3 chain [KO:K07375]
102514505  TUBB2A; LOW QUALITY PROTEIN: tubulin beta-2A chain [KO:K07375]
102514940  LOW QUALITY PROTEIN: tubulin beta-2B chain [KO:K07375]
102514277  TUBB1; tubulin beta-1 chain [KO:K07375]
102522960  TUBB4A; tubulin beta-4A chain [KO:K07375]
102511603  TUBB4B; LOW QUALITY PROTEIN: tubulin beta-4B chain [KO:K07375]
102523678  TUBB6; tubulin beta-6 chain [KO:K07375]
102506772  TUBB; tubulin beta chain isoform X2 [KO:K07375]
102504696  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
102507420  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
102513219  CSNK2A1; LOW QUALITY PROTEIN: casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
102513954  CSNK2B; casein kinase II subunit beta [KO:K03115]
102511705  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
102505844  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
102518272  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
102522650  DCTN3; dynactin subunit 3 [KO:K10425]
102510178  DCTN4; dynactin subunit 4 [KO:K10426]
102512500  DCTN5; dynactin subunit 5 [KO:K10427]
102519298  DCTN6; dynactin subunit 6 [KO:K10428]
102523981  ACTR1B; beta-centractin isoform X1 [KO:K16575]
102517533  ACTR1A; alpha-centractin [KO:K16575]
102509264  ACTR10; actin-related protein 10 isoform X1 [KO:K16576]
102518988  HAP1; huntingtin-associated protein 1 isoform X1 [KO:K04647]
102518700  DNAH7; dynein heavy chain 7, axonemal [KO:K10408]
102509803  DNAH5; LOW QUALITY PROTEIN: dynein heavy chain 5, axonemal [KO:K10408]
102507171  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
102513082  DNAH9; LOW QUALITY PROTEIN: dynein heavy chain 9, axonemal [KO:K10408]
102516457  DNAH12; dynein heavy chain 12, axonemal [KO:K10408]
102518470  DNAH8; LOW QUALITY PROTEIN: dynein heavy chain 8, axonemal [KO:K10408]
102520086  DNAH10; dynein heavy chain 10, axonemal [KO:K10408]
102513136  DNAH17; LOW QUALITY PROTEIN: dynein heavy chain 17, axonemal [KO:K10408]
102511164  DNAH14; dynein heavy chain 14, axonemal [KO:K10408]
102508411  DNAH2; dynein heavy chain 2, axonemal [KO:K10408]
102506868  DNAH3; LOW QUALITY PROTEIN: dynein heavy chain 3, axonemal [KO:K10408]
102514536  DNAH1; dynein heavy chain 1, axonemal isoform X1 [KO:K10408]
102518110  DNAH11; LOW QUALITY PROTEIN: dynein heavy chain 11, axonemal [KO:K10408]
102518938  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
102521975  DNAI1; LOW QUALITY PROTEIN: dynein intermediate chain 1, axonemal [KO:K10409]
102514425  DNAI2; dynein intermediate chain 2, axonemal isoform X1 [KO:K11143]
102504852  DNAL1; dynein light chain 1, axonemal [KO:K10411]
102509708  DNAL4; dynein light chain 4, axonemal isoform X1 [KO:K10412]
102522167  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
102512557  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
102521522  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
102506589  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
102517688  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
102512386  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
102514233  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
102522591  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
102509752  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
102509495  DKK1; dickkopf-related protein 1 [KO:K02165]
102509425  DKK2; dickkopf-related protein 2 [KO:K02165]
102508785  DKK4; dickkopf-related protein 4 [KO:K02165]
102521780  WNT1; proto-oncogene Wnt-1 [KO:K03209]
102505341  WNT2; protein Wnt-2 [KO:K00182]
102517871  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
102513236  WNT3A; protein Wnt-3a [KO:K00312]
102513805  WNT3; proto-oncogene Wnt-3 isoform X2 [KO:K00312]
102522577  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
102505627  WNT5A; LOW QUALITY PROTEIN: protein Wnt-5a [KO:K00444]
102515730  WNT5B; protein Wnt-5b [KO:K00444]
102511574  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
102506800  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
102519277  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
102514705  WNT8A; protein Wnt-8a [KO:K00714]
102507167  WNT8B; protein Wnt-8b [KO:K00714]
102513485  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
102514532  WNT9B; protein Wnt-9b [KO:K01064]
102514687  WNT10B; protein Wnt-10b [KO:K01357]
102511822  WNT10A; protein Wnt-10a [KO:K01357]
102508550  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
102505757  WNT16; protein Wnt-16 [KO:K01558]
102515569  FZD1; frizzled-1 [KO:K02432]
102513375  FZD2; frizzled-2 isoform X2 [KO:K02235]
102507159  FZD3; frizzled-3 [KO:K02329]
102517229  FZD4; frizzled-4 [KO:K02354]
102511876  FZD5; frizzled-5 [KO:K02375]
116661461  FZD8; frizzled-8 [KO:K02375]
102510205  FZD6; frizzled-6 [KO:K02376]
102522470  FZD9; frizzled-9 [KO:K02842]
102523163  FZD10; frizzled-10 [KO:K02842]
102519822  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
102519762  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
102514263  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
102516993  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
102504125  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
102508928  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
116667094  FRAT1; proto-oncogene FRAT1 [KO:K03069]
116667093  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
102508916  AXIN1; axin-1 isoform X1 [KO:K02157]
102508329  AXIN2; axin-2 isoform X2 [KO:K04385]
102522612  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
102521446  APC2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
102508568  CTNNB1; catenin beta-1 [KO:K02105]
102511594  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
106730358  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
116666301  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
102523226  AGER; LOW QUALITY PROTEIN: advanced glycosylation end product-specific receptor [KO:K19722]
102524334  HRAS; GTPase HRas isoform X1 [KO:K02833]
102516372  KRAS; GTPase KRas isoform X1 [KO:K07827]
102509562  NRAS; GTPase NRas [KO:K07828]
102506774  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
102524100  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
102517521  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102515937  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102511209  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
102517586  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102521659  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102514861  NOX1; NADPH oxidase 1 isoform X2 [KO:K08008]
102517434  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
102509221  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
102506204  RELA; transcription factor p65 isoform X1 [KO:K04735]
102505905  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102518523  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
102509586  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
102515320  IL6; interleukin-6 [KO:K05405]
102521743  IL1A; interleukin-1 alpha [KO:K04383]
102521979  IL1B; interleukin-1 beta [KO:K04519]
102518652  CSF1; macrophage colony-stimulating factor 1 isoform X2 [KO:K05453]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
  Authors
Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
  Journal
Nat Neurosci 21:1300-1309 (2018)
DOI:10.1038/s41593-018-0237-7
Reference
PMID:28062563
  Authors
Dugger BN, Dickson DW
  Title
Pathology of Neurodegenerative Diseases.
  Journal
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Related
pathway
cfr00190  Oxidative phosphorylation
cfr03050  Proteasome
cfr04020  Calcium signaling pathway
cfr04120  Ubiquitin mediated proteolysis
cfr04137  Mitophagy - animal
cfr04140  Autophagy - animal
cfr04141  Protein processing in endoplasmic reticulum
cfr04142  Lysosome
cfr04210  Apoptosis
cfr04310  Wnt signaling pathway
cfr04724  Glutamatergic synapse
cfr04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   
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