KEGG   PATHWAY: cjc05022
Entry
cjc05022                    Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Callithrix jacchus (white-tufted-ear marmoset)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
cjc05022  Pathways of neurodegeneration - multiple diseases
cjc05022

Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100407052  APP; amyloid-beta precursor protein isoform X1 [KO:K04520]
100403309  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
100406180  SNCA; alpha-synuclein isoform X2 [KO:K04528]
100405373  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
100395517  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
100391925  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
100386696  ATXN2L; ataxin-2-like protein isoform X1 [KO:K23625]
100410598  ATXN2; ataxin-2 isoform X21 [KO:K23625]
100403524  HTT; huntingtin [KO:K04533]
100402564  ATXN1; ataxin-1 [KO:K23616]
100408610  ATXN1L; ataxin-1-like [KO:K23616]
100393557  ATXN3; ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
100399781  ATXN3L; ataxin-3-like protein [KO:K11863] [EC:3.4.22.-]
100398566  PRNP; major prion protein [KO:K05634]
100401418  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
100408980  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
100404308  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
100400444  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X3 [KO:K23932]
100410312  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
100400074  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
100403006  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X2 [KO:K04634]
100390242  PRKN; E3 ubiquitin-protein ligase parkin isoform X3 [KO:K04556] [EC:2.3.2.31]
100400803  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
100386921  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100409716  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100410075  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
100397497  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
100391814  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100410136  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100404028  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
100387575  TRPC3; short transient receptor potential channel 3 isoform X3 [KO:K04966]
100396237  SIGMAR1; sigma non-opioid intracellular receptor 1 isoform X1 [KO:K20719]
100385763  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
118144170  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
100390843  inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
100405957  RYR1; LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
100406916  RYR2; ryanodine receptor 2 isoform X7 [KO:K04962]
100397905  RYR3; ryanodine receptor 3 isoform X6 [KO:K04963]
100401482  PDYN; proenkephalin-B [KO:K15840]
100398576  DLG4; disks large homolog 4 isoform X7 [KO:K11828]
100413857  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100411569  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X2 [KO:K05209]
100415252  GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
100388195  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X4 [KO:K05211]
100401859  GRIN2D; glutamate receptor ionotropic, NMDA 2D isoform X1 [KO:K05212]
100389125  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
100392029  GRIA2; glutamate receptor 2 isoform X2 [KO:K05198]
100399063  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
100398622  GRIA4; glutamate receptor 4 isoform X4 [KO:K05200]
100390442  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
100406735  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X36 [KO:K04850]
100397940  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X11 [KO:K04851]
100386041  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
100390112  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
100399018  STX1A; syntaxin-1A isoform X1 [KO:K04560]
100385253  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
100403358  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
100414635  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
100398261  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X3 [KO:K05853] [EC:7.2.2.10]
100401034  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
100399890  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
100392139  DERL1; derlin-1 isoform X1 [KO:K11519]
100403131  VCP; transitional endoplasmic reticulum ATPase isoform X1 [KO:K13525]
103795515  uncharacterized protein LOC103795515 [KO:K02927]
100411827  ubiquitin-like [KO:K02927]
100413175  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
103788241  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
103796361  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
108592020  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
118142913  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
100401133  ubiquitin-40S ribosomal protein S27a [KO:K02977]
100394663  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
100385218  ubiquitin-like [KO:K02977]
100401239  ubiquitin-40S ribosomal protein S27a [KO:K02977]
100411672  ubiquitin-40S ribosomal protein S27a [KO:K02977]
100385444  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
100386441  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
100405901  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
108588089  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
108588670  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
108588938  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
108591598  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
118144144  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
118145538  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
118146375  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
118149224  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
118150936  ubiquitin-40S ribosomal protein S27a [KO:K02977]
118153476  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
118153894  ubiquitin-40S ribosomal protein S27a [KO:K02977]
100413671  UBB; polyubiquitin-B [KO:K04551]
100895630  PSMA6; proteasome subunit alpha type-6 isoform X2 [KO:K02730] [EC:3.4.25.1]
108590111  proteasome subunit alpha type-6-like [KO:K02730] [EC:3.4.25.1]
100402373  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
100386493  PSMA4; proteasome subunit alpha type-4 isoform X1 [KO:K02728] [EC:3.4.25.1]
100406765  PSMA8; proteasome subunit alpha-type 8 [KO:K02731] [EC:3.4.25.1]
100391324  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
100403566  PSMA5; proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
100392716  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
100398028  PSMA3; proteasome subunit alpha type-3 isoform X1 [KO:K02727] [EC:3.4.25.1]
100388032  proteasome subunit alpha type-3-like [KO:K02727] [EC:3.4.25.1]
100390863  PSMB6; proteasome subunit beta type-6 isoform X1 [KO:K02738] [EC:3.4.25.1]
100386238  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
100402585  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
100385354  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
100394411  PSMB5; proteasome subunit beta type-5 isoform X1 [KO:K02737] [EC:3.4.25.1]
100404747  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
100388778  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
100400663  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
100389462  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
100387347  PSMC4; LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 6B [KO:K03063]
100395251  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
100402042  26S proteasome regulatory subunit 10B-like [KO:K03064]
100391982  PSMC3; 26S proteasome regulatory subunit 6A isoform X1 [KO:K03065]
100392176  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
100399255  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
100394142  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
100395546  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 1-like [KO:K03032]
100412477  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
100399336  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
100403059  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 isoform X1 [KO:K03035]
100387732  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 12-like [KO:K03035]
100386531  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
100414464  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
100406192  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
100415274  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
100896765  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X5 [KO:K03029]
100394741  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
100404346  26S proteasome non-ATPase regulatory subunit 14-like [KO:K03030]
100388798  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 isoform X1 [KO:K03031]
100389162  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
100400302  SEM1; 26S proteasome complex subunit SEM1 isoform X1 [KO:K10881]
100409098  UCHL1; ubiquitin carboxyl-terminal hydrolase isozyme L1 isoform X1 [KO:K05611] [EC:3.4.19.12]
100403328  LOW QUALITY PROTEIN: ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
100414104  ubiquitin-like modifier-activating enzyme 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
100385080  UBA1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
100399374  UBA7; ubiquitin-like modifier-activating enzyme 7 [KO:K10698] [EC:6.2.1.45]
100391640  UBE2L3; ubiquitin-conjugating enzyme E2 L3 isoform X6 [KO:K04552] [EC:2.3.2.23]
100406123  ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
100386383  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
100390985  UBE2L5; ubiquitin-conjugating enzyme E2 L5 [KO:K04552] [EC:2.3.2.23]
100389967  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
128932040  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
100385742  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1 [KO:K04553] [EC:2.3.2.23]
100408771  UBE2J2; ubiquitin-conjugating enzyme E2 J2 isoform X6 [KO:K04554] [EC:2.3.2.23]
100398685  UBE2J1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
100400627  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
100412942  UBE2G1; ubiquitin-conjugating enzyme E2 G1 isoform X2 [KO:K10575] [EC:2.3.2.23]
100410356  GPR37; prosaposin receptor GPR37 [KO:K04243]
100411592  SEPTIN5; septin-5 isoform X1 [KO:K04557]
100406168  SNCAIP; synphilin-1 isoform X2 [KO:K04558]
100389117  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
100406329  VAPB; vesicle-associated membrane protein-associated protein B/C isoform X2 [KO:K10707]
100412913  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
103794361  DNA damage-inducible transcript 3 protein [KO:K04452]
100385367  DDIT3; DNA damage-inducible transcript 3 protein isoform X3 [KO:K04452]
100406291  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
100414862  ERN1; LOW QUALITY PROTEIN: serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
100404226  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100406322  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X2 [KO:K04426] [EC:2.7.11.25]
100412930  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
100392721  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100387686  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100390109  MAPK10; mitogen-activated protein kinase 10 isoform X7 [KO:K04440] [EC:2.7.11.24]
100395802  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
100394186  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
100399114  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
100392193  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100393968  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
100412264  PINK1; serine/threonine-protein kinase PINK1, mitochondrial isoform X1 [KO:K05688] [EC:2.7.11.1]
22203913  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
22203901  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
22203907  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
22203909  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
22203908  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
22203910  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
22203911  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
100409776  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
100392484  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
100413893  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
108593294  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
100389053  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
108591917  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
118153983  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
128929002  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
100395996  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 isoform X2 [KO:K03946]
100399555  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X2 [KO:K03947]
103787884  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
108591536  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
108593786  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
108591145  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
108591148  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
108588244  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
100399333  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 isoform X2 [KO:K03948]
100401020  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
108591756  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
100407930  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
103793463  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
100405683  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
103792673  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
100391205  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
100412505  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
100386544  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
100387095  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
100392002  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
100894474  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
118142891  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
100407958  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
100397974  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
100398383  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
103790691  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
108593137  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
100403449  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
100393424  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
100415627  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
108588099  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
100385890  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
100401813  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
100396715  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
100397671  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6-like [KO:K03962]
100409671  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X2 [KO:K03962]
100387818  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6-like [KO:K03962]
100397856  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
100415640  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
100415306  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
100393567  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
100415214  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
100413081  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X2 [KO:K03934] [EC:7.1.1.2]
100415319  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
100393702  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X1 [KO:K03936] [EC:7.1.1.2]
100412322  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
108590755  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
100398013  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
100894557  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
128930923  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
100397239  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
100400083  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
108590685  uncharacterized protein LOC108590685 [KO:K03941] [EC:7.1.1.2]
100385056  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
100895060  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
100400483  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
100403702  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
100386976  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
100413949  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
103788262  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like [KO:K00237]
100395443  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
22203912  CYTB; cytochrome b [KO:K00412]
100404483  CYC1; cytochrome c1, heme protein, mitochondrial [KO:K00413]
100413740  cytochrome b-c1 complex subunit 1, mitochondrial isoform X2 [KO:K00414]
100389097  cytochrome b-c1 complex subunit 2, mitochondrial isoform X3 [KO:K00415]
100406481  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
100411008  cytochrome b-c1 complex subunit 7 [KO:K00417]
100405068  UQCRQ; cytochrome b-c1 complex subunit 8 [KO:K00418]
100413619  UQCR10; cytochrome b-c1 complex subunit 9 [KO:K00419]
100407794  cytochrome b-c1 complex subunit 9 [KO:K00419]
118143847  cytochrome b-c1 complex subunit 9-like [KO:K00419]
118151171  cytochrome b-c1 complex subunit 10 [KO:K00420]
22203906  COX3; cytochrome c oxidase subunit III [KO:K02262]
22203902  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
22203903  COX2; cytochrome c oxidase subunit II [KO:K02261]
100407179  COX4I2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
100389143  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
100404859  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
100401281  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
103795040  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
100412088  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
100393757  COX6A2; cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
100412478  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
103792000  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
108588435  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
100390127  cytochrome c oxidase subunit 6B1 isoform X1 [KO:K02267]
100390131  COX6B2; cytochrome c oxidase subunit 6B2 isoform X1 [KO:K02267]
103789478  cytochrome c oxidase subunit 6B1-like [KO:K02267]
100409675  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
100412233  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
100389034  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
118148503  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
100414729  COX7B2; cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
100390732  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
118153966  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
108590808  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
108591742  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
108587827  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
100415550  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
108593880  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
128932486  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
100385011  COX8C; cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
100408082  COX8A; cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
100395383  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
118148334  ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
100401662  ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
100394984  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
100388706  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
108588397  LOW QUALITY PROTEIN: ATP synthase subunit gamma, mitochondrial-like [KO:K02136]
100391539  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
100409961  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
22203905  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
100392086  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
100412417  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
100412960  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
100396895  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
100396282  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
100388191  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
100407737  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
103792298  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
118144241  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
100391094  ATP5PD; ATP synthase subunit d, mitochondrial isoform X2 [KO:K02138]
100390177  ATP synthase subunit d, mitochondrial-like [KO:K02138]
100407961  ATP synthase subunit d, mitochondrial-like [KO:K02138]
118145167  ATP synthase subunit d, mitochondrial-like [KO:K02138]
118150906  LOW QUALITY PROTEIN: ATP synthase subunit d, mitochondrial [KO:K02138]
128928020  ATP synthase subunit d, mitochondrial [KO:K02138]
128930775  ATP synthase subunit d, mitochondrial-like [KO:K02138]
128930791  ATP synthase subunit d, mitochondrial-like [KO:K02138]
128930903  ATP synthase subunit d, mitochondrial-like [KO:K02138]
103789634  ATP5PO; ATP synthase subunit O, mitochondrial isoform X1 [KO:K02137]
100894898  ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
100411036  ATP5PF; ATP synthase-coupling factor 6, mitochondrial isoform X2 [KO:K02131]
22203904  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
100408947  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100399873  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
100385187  TOMM40L; mitochondrial import receptor subunit TOM40B isoform X1 [KO:K11518]
100401233  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
100395618  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
100390180  CALM1; calmodulin-1 [KO:K02183]
100386819  CALM2; calmodulin-2 isoform X2 [KO:K02183]
100406081  CALM3; calmodulin-3 [KO:K02183]
100408289  CALML3; calmodulin-like protein 3 [KO:K02183]
100392199  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
100396690  CALML4; calmodulin-like protein 4 isoform X2 [KO:K02183]
108592443  CALML5; calmodulin-like protein 5 [KO:K02183]
118148021  calmodulin-1-like [KO:K02183]
100386369  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
100387059  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
100386452  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X5 [KO:K04348] [EC:3.1.3.16]
100392986  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100388148  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
100412880  BAD; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
100404850  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100397803  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
100410616  FADD; FAS-associated death domain protein [KO:K02373]
100395220  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100403496  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
100391322  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100387945  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
100412740  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 isoform X3 [KO:K08844] [EC:2.7.11.1]
100385512  HTRA2; serine protease HTRA2, mitochondrial isoform X2 [KO:K08669] [EC:3.4.21.108]
100404684  TRAP1; heat shock protein 75 kDa, mitochondrial [KO:K09488]
100399481  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100398162  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100411371  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100397220  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
100403424  ADP/ATP translocase 3 [KO:K05863]
100387000  SLC25A5; LOW QUALITY PROTEIN: ADP/ATP translocase 2 [KO:K05863]
100405844  LOW QUALITY PROTEIN: probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [KO:K05863]
100404537  ADP/ATP translocase 3-like [KO:K05863]
100405490  ADP/ATP translocase 2-like [KO:K05863]
100409380  ADP/ATP translocase 2-like [KO:K05863]
108588103  ADP/ATP translocase 2 [KO:K05863]
128930731  ADP/ATP translocase 3 [KO:K05863]
100386343  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
108593648  cytochrome c-like [KO:K08738]
108593819  cytochrome c-like [KO:K08738]
108593835  cytochrome c-like [KO:K08738]
108588095  cytochrome c-like [KO:K08738]
100406761  cytochrome c-like [KO:K08738]
100401718  cytochrome c [KO:K08738]
100413276  cytochrome c-like [KO:K08738]
108591937  cytochrome c-like [KO:K08738]
108592162  cytochrome c-like [KO:K08738]
108591932  cytochrome c, somatic-like [KO:K08738]
100403825  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
100409028  CASP9; caspase-9 isoform X3 [KO:K04399] [EC:3.4.22.62]
100387570  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
100404703  HIP1; huntingtin-interacting protein 1 isoform X1 [KO:K04559]
100406529  IFT57; intraflagellar transport protein 57 homolog [KO:K04638]
100402832  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
100400963  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
100409607  LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase D-like [KO:K05864] [EC:5.2.1.8]
108588492  Parkinson disease protein 7-like [KO:K05687] [EC:3.5.1.124]
100413204  PARK7; Parkinson disease protein 7 isoform X1 [KO:K05687] [EC:3.5.1.124]
100410814  Parkinson disease protein 7-like [KO:K05687] [EC:3.5.1.124]
100401978  BCL2L1; bcl-2-like protein 1 [KO:K04570]
100394906  MFN1; mitofusin-1 isoform X1 [KO:K21356] [EC:3.6.5.-]
100412019  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
100398129  OPTN; optineurin isoform X3 [KO:K19946]
100385650  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
100400974  MAP1LC3C; LOW QUALITY PROTEIN: microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
100399550  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A isoform X1 [KO:K10435]
100410303  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
100399701  TBK1; serine/threonine-protein kinase TBK1 isoform X6 [KO:K05410] [EC:2.7.11.10]
100395103  TANK; TRAF family member-associated NF-kappa-B activator isoform X4 [KO:K12650]
100398190  WDR41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
100394718  SMCR8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
100403966  C9orf72; guanine nucleotide exchange factor C9orf72 homolog isoform X1 [KO:K23609]
100413294  RAB8A; ras-related protein Rab-8A isoform X1 [KO:K07901]
100391697  RAB39B; ras-related protein Rab-39B [KO:K07925]
100395022  RAB1A; ras-related protein Rab-1A isoform X1 [KO:K07874]
100406608  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100403342  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
100386171  ULK2; serine/threonine-protein kinase ULK2 isoform X6 [KO:K08269] [EC:2.7.11.1]
100393189  ATG101; autophagy-related protein 101 [KO:K19730]
100385491  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
100407986  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
100385379  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
100405335  BECN2; beclin-2 [KO:K08334]
100413058  BECN1; beclin-1 isoform X2 [KO:K08334]
100413515  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
100409170  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
100404457  NRBF2; nuclear receptor-binding factor 2 [KO:K21246]
100409059  LOW QUALITY PROTEIN: nuclear receptor-binding factor 2-like [KO:K21246]
100414570  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
100407000  ATG2A; autophagy-related protein 2 homolog A isoform X5 [KO:K17906]
100408194  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
100408705  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
100395323  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
100399837  ZFYVE1; zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603]
100398001  ALS2; alsin isoform X1 [KO:K04575]
100389972  RAB5A; ras-related protein Rab-5A [KO:K07887]
100894569  ras-related protein Rab-5A-like [KO:K07887]
100404109  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100895294  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
100408012  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
100397975  FIG4; polyphosphoinositide phosphatase isoform X1 [KO:K22913] [EC:3.1.3.-]
100402743  SPG11; spatacsin isoform X1 [KO:K19026]
100397484  TNF; tumor necrosis factor [KO:K03156]
100397418  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
100394148  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
100401218  DAXX; death domain-associated protein 6 [KO:K02308]
100398593  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
100397389  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X3 [KO:K04433] [EC:2.7.12.2]
100396611  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100396967  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100404377  MAPK14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
100405093  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
100895717  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
100398997  CCS; copper chaperone for superoxide dismutase [KO:K04569]
100388368  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
100392863  GPX1; glutathione peroxidase 1 isoform X1 [KO:K00432] [EC:1.11.1.9]
100408129  GPX6; glutathione peroxidase 6 isoform X2 [KO:K00432] [EC:1.11.1.9]
100397964  GPX5; epididymal secretory glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
100406786  GPX8; probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
100395166  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
100409268  GPX7; glutathione peroxidase 7 isoform X1 [KO:K00432] [EC:1.11.1.9]
100388372  CAT; catalase [KO:K03781] [EC:1.11.1.6]
100393188  PRPH; peripherin isoform X1 [KO:K07607]
100409901  NEFL; neurofilament light polypeptide [KO:K04572]
100410259  NEFM; neurofilament medium polypeptide isoform X1 [KO:K04573]
100411710  NEFH; neurofilament heavy polypeptide [KO:K04574]
100386081  KIF5A; kinesin heavy chain [KO:K10396]
100389442  KIF5B; kinesin-1 heavy chain [KO:K10396]
100392318  KIF5C; kinesin heavy chain [KO:K10396]
100394278  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
100393453  KLC2; kinesin light chain 2 [KO:K10407]
100385792  KLC4; kinesin light chain 4 [KO:K10407]
100398459  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
100404055  tubulin alpha-3 chain [KO:K07374]
100403861  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
100410702  tubulin alpha-4A chain-like [KO:K07374]
100400294  TUBA4A; tubulin alpha-4A chain isoform X3 [KO:K07374]
100410466  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
100392817  tubulin alpha-1A chain [KO:K07374]
100409161  TUBA1C; tubulin alpha-1C chain isoform X1 [KO:K07374]
100392213  tubulin alpha-1B chain [KO:K07374]
100390144  LOW QUALITY PROTEIN: tubulin alpha-3 chain [KO:K07374]
118147191  tubulin alpha-3 chain [KO:K07374]
100395528  TUBB4B; tubulin beta-4B chain [KO:K07375]
100403851  tubulin beta-8 chain [KO:K07375]
100389230  tubulin beta-8 chain [KO:K07375]
100409299  TUBB6; tubulin beta-6 chain isoform X2 [KO:K07375]
100386618  LOW QUALITY PROTEIN: tubulin beta-3 chain-like [KO:K07375]
100386505  TUBB2B; tubulin beta-2B chain [KO:K07375]
100409603  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
100415692  TUBB4A; tubulin beta-4A chain [KO:K07375]
100394345  LOW QUALITY PROTEIN: tubulin beta-3 chain-like [KO:K07375]
100400472  LOW QUALITY PROTEIN: tubulin beta chain [KO:K07375]
103792349  TUBB; tubulin beta chain [KO:K07375]
118152807  TUBB2A; tubulin beta-2A chain [KO:K07375]
100387683  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100414021  CSNK2A1; LOW QUALITY PROTEIN: casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
100388528  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
100895978  LOW QUALITY PROTEIN: casein kinase II subunit beta [KO:K03115]
100401722  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
100409412  BDNF; brain-derived neurotrophic factor isoform X2 [KO:K04355]
100401682  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
100402979  DCTN2; dynactin subunit 2 isoform X2 [KO:K10424]
100395156  DCTN3; dynactin subunit 3 isoform X1 [KO:K10425]
100393959  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
100408680  DCTN5; dynactin subunit 5 isoform X3 [KO:K10427]
100391509  DCTN6; dynactin subunit 6 isoform X2 [KO:K10428]
100398160  ACTR1A; alpha-centractin [KO:K16575]
100406171  ACTR1B; beta-centractin isoform X1 [KO:K16575]
100397670  ACTR10; actin-related protein 10 isoform X1 [KO:K16576]
100404721  DNAH5; dynein axonemal heavy chain 5 isoform X1 [KO:K10408]
100405411  DNAH6; dynein axonemal heavy chain 6 isoform X1 [KO:K10408]
100391575  DNAH9; dynein axonemal heavy chain 9 isoform X1 [KO:K10408]
100399216  DNAH11; dynein axonemal heavy chain 11 [KO:K10408]
100396871  DNAH8; dynein axonemal heavy chain 8 isoform X1 [KO:K10408]
100387517  DNAH10; dynein axonemal heavy chain 10 isoform X1 [KO:K10408]
100406829  DNAH17; dynein axonemal heavy chain 17 isoform X1 [KO:K10408]
100393091  DNAH3; dynein axonemal heavy chain 3 [KO:K10408]
100389726  DNAH1; dynein axonemal heavy chain 1 isoform X1 [KO:K10408]
100391441  DNAH2; dynein axonemal heavy chain 2 isoform X1 [KO:K10408]
108592250  DNAH7; dynein axonemal heavy chain 7 isoform X1 [KO:K10408]
103796853  DNAH12; dynein axonemal heavy chain 12 isoform X3 [KO:K10408]
100395955  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
100393712  DNAI1; dynein axonemal intermediate chain 1 isoform X2 [KO:K10409]
100414513  DNAI2; dynein axonemal intermediate chain 2 isoform X1 [KO:K11143]
100405641  DNAL1; dynein axonemal light chain 1 isoform X1 [KO:K10411]
100411241  DNAL4; dynein axonemal light chain 4 isoform X2 [KO:K10412]
100397956  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X9 [KO:K04515] [EC:2.7.11.17]
100405903  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
100391424  calcium/calmodulin-dependent protein kinase type II subunit delta-like [KO:K04515] [EC:2.7.11.17]
100390938  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100410352  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X4 [KO:K04515] [EC:2.7.11.17]
100411931  CAPN1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
100405215  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
100386175  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
100411309  CDK5; cyclin-dependent kinase 5 [KO:K02090] [EC:2.7.11.22]
100386577  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
100401841  DKK2; dickkopf-related protein 2 [KO:K02165]
100387662  DKK1; dickkopf-related protein 1 precursor [KO:K02165]
100394179  DKK4; dickkopf-related protein 4 [KO:K02165]
100389319  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100395234  WNT2B; protein Wnt-2b [KO:K00182]
100411308  WNT2; protein Wnt-2 [KO:K00182]
100385309  WNT3A; protein Wnt-3a [KO:K00312]
100398579  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100387135  WNT4; protein Wnt-4 [KO:K00408]
100401066  WNT5A; protein Wnt-5a isoform X2 [KO:K00444]
100405273  WNT5B; protein Wnt-5b [KO:K00444]
100394855  WNT6; protein Wnt-6 [KO:K00445]
100414221  WNT7B; protein Wnt-7b isoform X2 [KO:K00572]
100387909  WNT7A; protein Wnt-7a [KO:K00572]
100414921  WNT8B; protein Wnt-8b [KO:K00714]
100402422  WNT8A; protein Wnt-8a [KO:K00714]
100397032  WNT9A; protein Wnt-9a isoform X2 [KO:K01064]
100393646  WNT9B; protein Wnt-9b [KO:K01064]
100395222  WNT10A; protein Wnt-10a [KO:K01357]
100388949  WNT10B; protein Wnt-10b [KO:K01357]
100398625  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
100387388  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
100401631  FZD7; frizzled-7 [KO:K02432]
100404550  FZD1; frizzled-1 [KO:K02432]
100409481  FZD2; frizzled-2 [KO:K02235]
100396334  FZD3; frizzled-3 isoform X1 [KO:K02329]
100403228  FZD4; frizzled-4 isoform X1 [KO:K02354]
100410939  FZD5; frizzled-5 [KO:K02375]
100398598  FZD8; frizzled-8 [KO:K02375]
100387077  FZD6; frizzled-6 [KO:K02376]
100403975  FZD9; frizzled-9 [KO:K02842]
100398976  FZD10; frizzled-10 [KO:K02842]
100406268  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
100389922  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
100407384  CSNK1E; casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
100390081  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
100398229  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
100388569  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X3 [KO:K02353]
118154524  LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-1-like [KO:K02353]
108594172  FRAT1; proto-oncogene FRAT1 [KO:K03069]
100407124  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
100392475  AXIN1; axin-1 isoform X1 [KO:K02157]
100400518  AXIN2; axin-2 isoform X1 [KO:K04385]
100397972  APC2; adenomatous polyposis coli protein 2 isoform X2 [KO:K02085]
100385653  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
100395047  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
100385646  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
100407431  CSNK1A1L; casein kinase I [KO:K08957] [EC:2.7.11.1]
100414002  AGER; LOW QUALITY PROTEIN: advanced glycosylation end product-specific receptor [KO:K19722]
100406017  HRAS; GTPase HRas [KO:K02833]
118144179  KRAS; GTPase KRas isoform X2 [KO:K07827]
100414782  NRAS; GTPase NRas isoform X2 [KO:K07828]
108591807  GTPase NRas-like [KO:K07828]
100387961  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
100403091  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100415300  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100387394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100393991  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100400700  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100404815  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100403058  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
100415466  CYBB; cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
100398393  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
100388493  RELA; transcription factor p65 isoform X1 [KO:K04735]
100415321  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100403192  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
100407639  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100393440  IL6; interleukin-6 precursor [KO:K05405]
100406401  IL1A; interleukin-1 alpha [KO:K04383]
100406769  IL1B; interleukin-1 beta isoform X1 [KO:K04519]
100386071  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
  Authors
Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
  Journal
Nat Neurosci 21:1300-1309 (2018)
DOI:10.1038/s41593-018-0237-7
Reference
PMID:28062563
  Authors
Dugger BN, Dickson DW
  Title
Pathology of Neurodegenerative Diseases.
  Journal
Cold Spring Harb Perspect Biol 9:a028035 (2017)
DOI:10.1101/cshperspect.a028035
Reference
PMID:20070435
  Authors
Jellinger KA
  Title
Basic mechanisms of neurodegeneration: a critical update.
  Journal
J Cell Mol Med 14:457-87 (2010)
DOI:10.1111/j.1582-4934.2010.01010.x
Reference
PMID:19707851
  Authors
Jellinger KA
  Title
Recent advances in our understanding of neurodegeneration.
  Journal
J Neural Transm (Vienna) 116:1111-62 (2009)
DOI:10.1007/s00702-009-0240-y
Reference
PMID:30743990
  Authors
Van Bulck M, Sierra-Magro A, Alarcon-Gil J, Perez-Castillo A, Morales-Garcia JA
  Title
Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease.
  Journal
Int J Mol Sci 20:E719 (2019)
DOI:10.3390/ijms20030719
Reference
PMID:15272267
  Authors
Ross CA, Poirier MA
  Title
Protein aggregation and neurodegenerative disease.
  Journal
Nat Med 10 Suppl:S10-7 (2004)
DOI:10.1038/nm1066
Reference
PMID:30250260
  Authors
Soto C, Pritzkow S
  Title
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.
  Journal
Nat Neurosci 21:1332-1340 (2018)
DOI:10.1038/s41593-018-0235-9
Reference
PMID:25132814
  Authors
Dantuma NP, Bott LC
  Title
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution.
  Journal
Front Mol Neurosci 7:70 (2014)
DOI:10.3389/fnmol.2014.00070
Reference
PMID:25413678
  Authors
Zheng C, Geetha T, Babu JR
  Title
Failure of ubiquitin proteasome system: risk for neurodegenerative diseases.
  Journal
Neurodegener Dis 14:161-75 (2014)
DOI:10.1159/000367694
Reference
PMID:32397599
  Authors
Park H, Kang JH, Lee S
  Title
Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates.
  Journal
Int J Mol Sci 21:E3369 (2020)
DOI:10.3390/ijms21093369
Reference
PMID:31783880
  Authors
Malik BR, Maddison DC, Smith GA, Peters OM
  Title
Autophagic and endo-lysosomal dysfunction in neurodegenerative disease.
  Journal
Mol Brain 12:100 (2019)
DOI:10.1186/s13041-019-0504-x
Reference
PMID:29734735
  Authors
Metaxakis A, Ploumi C, Tavernarakis N
  Title
Autophagy in Age-Associated Neurodegeneration.
  Journal
Cells 7:E37 (2018)
DOI:10.3390/cells7050037
Reference
PMID:25270767
  Authors
Vidal RL, Matus S, Bargsted L, Hetz C
  Title
Targeting autophagy in neurodegenerative diseases.
  Journal
Trends Pharmacol Sci 35:583-91 (2014)
DOI:10.1016/j.tips.2014.09.002
Reference
PMID:28279350
  Authors
Menzies FM, Fleming A, Caricasole A, Bento CF, Andrews SP, Ashkenazi A, Fullgrabe J, Jackson A, Jimenez Sanchez M, Karabiyik C, Licitra F, Lopez Ramirez A, Pavel M, Puri C, Renna M, Ricketts T, Schlotawa L, Vicinanza M, Won H, Zhu Y, Skidmore J, Rubinsztein DC
  Title
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.
  Journal
Neuron 93:1015-1034 (2017)
DOI:10.1016/j.neuron.2017.01.022
Reference
PMID:30030024
  Authors
Chu CT
  Title
Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases.
  Journal
Neurobiol Dis 122:23-34 (2019)
DOI:10.1016/j.nbd.2018.07.015
Reference
PMID:19043451
  Authors
Kim I, Xu W, Reed JC
  Title
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 7:1013-30 (2008)
DOI:10.1038/nrd2755
Reference
PMID:21722302
  Authors
Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A
  Title
Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
  Journal
J Cell Mol Med 15:2025-39 (2011)
DOI:10.1111/j.1582-4934.2011.01374.x
Reference
PMID:28643372
  Authors
Halliday M, Hughes D, Mallucci GR
  Title
Fine-tuning PERK signaling for neuroprotection.
  Journal
J Neurochem 142:812-826 (2017)
DOI:10.1111/jnc.14112
Reference
PMID:32204380
  Authors
Rozpedek-Kaminska W, Siwecka N, Wawrzynkiewicz A, Wojtczak R, Pytel D, Diehl JA, Majsterek I
  Title
The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases.
  Journal
Int J Mol Sci 21:E2108 (2020)
DOI:10.3390/ijms21062108
Reference
PMID:24619348
  Authors
Hetz C, Mollereau B
  Title
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.
  Journal
Nat Rev Neurosci 15:233-49 (2014)
DOI:10.1038/nrn3689
Reference
PMID:19230774
  Authors
Bezprozvanny I
  Title
Calcium signaling and neurodegenerative diseases.
  Journal
Trends Mol Med 15:89-100 (2009)
DOI:10.1016/j.molmed.2009.01.001
Reference
PMID:31795242
  Authors
Ureshino RP, Erustes AG, Bassani TB, Wachilewski P, Guarache GC, Nascimento AC, Costa AJ, Smaili SS, Pereira GJDS
  Title
The Interplay between Ca(2+) Signaling Pathways and Neurodegeneration.
  Journal
Int J Mol Sci 20:E6004 (2019)
DOI:10.3390/ijms20236004
Reference
PMID:27873462
  Authors
Golpich M, Amini E, Mohamed Z, Azman Ali R, Mohamed Ibrahim N, Ahmadiani A
  Title
Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment.
  Journal
CNS Neurosci Ther 23:5-22 (2017)
DOI:10.1111/cns.12655
Reference
PMID:19828789
  Authors
Morfini GA, Burns M, Binder LI, Kanaan NM, LaPointe N, Bosco DA, Brown RH Jr, Brown H, Tiwari A, Hayward L, Edgar J, Nave KA, Garberrn J, Atagi Y, Song Y, Pigino G, Brady ST
  Title
Axonal transport defects in neurodegenerative diseases.
  Journal
J Neurosci 29:12776-86 (2009)
DOI:10.1523/JNEUROSCI.3463-09.2009
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:23361386
  Authors
Millecamps S, Julien JP
  Title
Axonal transport deficits and neurodegenerative diseases.
  Journal
Nat Rev Neurosci 14:161-76 (2013)
DOI:10.1038/nrn3380
Reference
PMID:31558780
  Authors
Sleigh JN, Rossor AM, Fellows AD, Tosolini AP, Schiavo G
  Title
Axonal transport and neurological disease.
  Journal
Nat Rev Neurol 15:691-703 (2019)
DOI:10.1038/s41582-019-0257-2
Reference
PMID:20434225
  Authors
Perlson E, Maday S, Fu MM, Moughamian AJ, Holzbaur EL
  Title
Retrograde axonal transport: pathways to cell death?
  Journal
Trends Neurosci 33:335-44 (2010)
DOI:10.1016/j.tins.2010.03.006
Related
pathway
cjc00190  Oxidative phosphorylation
cjc03050  Proteasome
cjc04020  Calcium signaling pathway
cjc04120  Ubiquitin mediated proteolysis
cjc04137  Mitophagy - animal
cjc04140  Autophagy - animal
cjc04141  Protein processing in endoplasmic reticulum
cjc04142  Lysosome
cjc04210  Apoptosis
cjc04310  Wnt signaling pathway
cjc04724  Glutamatergic synapse
cjc04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   
LinkDB

DBGET integrated database retrieval system