KEGG   PATHWAY: cmao04010
Entry
cmao04010                   Pathway                                
Name
MAPK signaling pathway - Colossoma macropomum (tambaqui)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
cmao04010  MAPK signaling pathway
cmao04010

Other DBs
GO: 0000165
Organism
Colossoma macropomum (tambaqui) [GN:cmao]
Gene
118802488  cacna1aa; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
118803808  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b [KO:K04344]
118819918  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
118827091  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a [KO:K04849]
118812645  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
118799526  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
118813381  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
118825888  cacna1eb; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
118814116  voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
118813159  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
118813635  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
118809456  cacna1g; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
118805692  cacna1ha; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
118807435  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
118821231  cacna1ia; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
118799299  cacna1sa; calcium channel, voltage-dependent, L type, alpha 1S subunit, a isoform X1 [KO:K04857]
118813753  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
118817770  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
118812078  cacna2d1a; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-1a [KO:K04858]
118799797  cacna2d2b; voltage-dependent calcium channel subunit alpha-2/delta-2b [KO:K04859]
118808552  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a [KO:K04859]
118799965  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
118813375  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
118806735  cacna2d4b; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
118812647  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
118821080  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
118826609  voltage-dependent L-type calcium channel subunit beta-1-like isoform X1 [KO:K04863]
118822305  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
118823080  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a isoform X1 [KO:K04864]
118807752  cacnb4b; voltage-dependent L-type calcium channel subunit beta-4b isoform X1 [KO:K04865]
118809457  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a [KO:K04865]
118807927  cacng1a; calcium channel, voltage-dependent, gamma subunit 1a [KO:K04866]
118821345  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
118807880  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
118821647  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
118802156  voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
118821056  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
118807928  voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
118821284  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
118807503  cacng5a; calcium channel, voltage-dependent, gamma subunit 5a isoform X1 [KO:K04870]
118820896  cacng5b; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
118806009  cacng6a; calcium channel, voltage-dependent, gamma subunit 6a [KO:K04871]
118825114  cacng6b; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
118806007  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a isoform X1 [KO:K04872]
118825076  cacng7b; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
118806008  cacng8a; calcium channel, voltage-dependent, gamma subunit 8a [KO:K04873]
118825058  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
118797821  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
118806091  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
118818861  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
118825617  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
118807929  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
118820893  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
118802149  prkcba; protein kinase C, beta a [KO:K19662] [EC:2.7.11.13]
118821144  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
118824989  prkcg; protein kinase C alpha type isoform X1 [KO:K19663] [EC:2.7.11.13]
118805729  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
118807728  si:dkey-44g17.6; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
118821274  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
118796989  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a isoform X1 [KO:K04347]
118824301  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
118801443  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
118819941  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118826616  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118826839  ppp3cca; LOW QUALITY PROTEIN: protein phosphatase 3, catalytic subunit, gamma isozyme, a [KO:K04348] [EC:3.1.3.16]
118797878  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
118810135  ppp3r1a; calcineurin subunit B type 1 isoform X1 [KO:K06268]
118801429  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
118824275  rasgrf2a; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
118827113  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
118818114  rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K04350]
118824094  LOW QUALITY PROTEIN: RAS guanyl-releasing protein 1-like [KO:K04350]
118816665  RAS guanyl-releasing protein 2-like [KO:K12361]
118820318  rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
118823184  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
118816528  si:dkey-253i9.4; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
118807008  rapgef2; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2 [KO:K08018]
118824835  nf1b; neurofibromin isoform X1 [KO:K08052]
118802011  nf1a; neurofibromin isoform X1 [KO:K08052]
118825294  rasa1b; LOW QUALITY PROTEIN: ras GTPase-activating protein 1 [KO:K04352]
118826842  rasa1a; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
118818021  rasa2; ras GTPase-activating protein 2 [KO:K08053]
118799483  rap1ab; ras-related protein rap1ab [KO:K04353]
118813406  rap1aa; RAP1A, member of RAS oncogene family a [KO:K04353]
118812483  rap1b; ras-related protein Rap-1b [KO:K07836]
118806475  egf; pro-epidermal growth factor [KO:K04357]
118808331  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
118811423  fgf1a; putative fibroblast growth factor 1 [KO:K18496]
118820141  fgf1b; fibroblast growth factor 1b [KO:K18496]
118821109  fgf2; fibroblast growth factor 2 [KO:K18497]
118810478  fgf8a; fibroblast growth factor 8 [KO:K04358]
118806702  fgf6a; fibroblast growth factor 6a [KO:K04358]
118810812  fgf9; fibroblast growth factor 4B [KO:K04358]
118816911  fgf20a; fibroblast growth factor 20a [KO:K04358]
118806916  fgf24; fibroblast growth factor 24 isoform X1 [KO:K04358]
118806955  fgf20b; fibroblast growth factor 20b [KO:K04358]
118811193  fgf6b; fibroblast growth factor 6b [KO:K04358]
118811450  fgf18a; fibroblast growth factor 18a isoform X1 [KO:K04358]
118812863  fgf17; fibroblast growth factor 17 [KO:K04358]
118807349  fgf16; fibroblast growth factor 16 [KO:K04358]
118819076  fgf3; fibroblast growth factor 3 [KO:K04358]
118825253  fgf18b; fibroblast growth factor 18b [KO:K04358]
118801957  fgf8b; LOW QUALITY PROTEIN: fibroblast growth factor 8b [KO:K04358]
118819465  fgf4; LOW QUALITY PROTEIN: fibroblast growth factor 4 [KO:K04358]
118819537  fgf22; fibroblast growth factor 22 [KO:K04358]
118820063  fgf10a; fibroblast growth factor 10a [KO:K04358]
118804008  fgf7; fibroblast growth factor 7 [KO:K04358]
118827000  fgf10b; fibroblast growth factor 10b [KO:K04358]
118827564  fgf5; fibroblast growth factor 5 [KO:K04358]
118819340  fgf19; fibroblast growth factor 19 [KO:K22603]
118812796  fibroblast growth factor 19-like [KO:K22429]
118820923  fgf21; fibroblast growth factor 21 [KO:K22429]
118811370  fgf23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428]
118806701  uncharacterized protein LOC118806701 [KO:K22428]
118823119  ngfa; neurotrophin-7 [KO:K02582]
118807564  ngfb; nerve growth factor [KO:K02582]
118817676  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
118811384  ntf3; neurotrophin-3 [KO:K04356]
118806420  insb; preproinsulin b [KO:K04526]
118800533  insulin [KO:K04526]
118801651  ins; insulin [KO:K04526]
118812612  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
118817533  igf2a; insulin-like growth factor 2a [KO:K13769]
118811538  igf2b; insulin-like growth factor 2b isoform X1 [KO:K13769]
118801273  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
118804610  platelet-derived growth factor subunit A [KO:K04359]
118804635  si:ch211-79m20.1; LIM domain-containing protein A isoform X1 [KO:K17386]
118798611  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
118807284  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
118799836  csf1a; macrophage colony-stimulating factor 1a [KO:K05453]
118806720  kitlga; kit ligand a [KO:K05461]
118812546  kitlgb; kit ligand b isoform X1 [KO:K05461]
118812293  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
118820167  vascular endothelial growth factor A isoform X1 [KO:K05448]
118796942  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
118824184  pgfb; vascular endothelial growth factor A [KO:K16859]
118815583  pgfa; placenta growth factor isoform X1 [KO:K16859]
118810813  vegfc; vascular endothelial growth factor C [KO:K05449]
118802702  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
118817902  hepatocyte growth factor [KO:K05460]
118812079  hgfa; hepatocyte growth factor a [KO:K05460]
118813603  angiopoietin-1-like [KO:K05465]
118805668  angpt1; angiopoietin-1 [KO:K05465]
118810152  angpt2a; angiopoietin-2a [KO:K05466]
118805529  angpt2b; angiopoietin-2b [KO:K05466]
118805960  efna3a; ephrin-A3 [KO:K05462]
118805961  efna1a; ephrin-A1a [KO:K05462]
118823342  si:dkey-246i14.3; ephrin-A4 [KO:K05462]
118823348  efna3b; ephrin-A3b [KO:K05462]
118823355  efna1b; ephrin-A1b [KO:K05462]
118819370  ephrin-A2-like [KO:K05462]
118813444  efna5b; ephrin-A5b isoform X1 [KO:K05462]
118820371  efna5a; ephrin-A5 isoform X1 [KO:K05462]
118804768  efna2a; ephrin-A2 [KO:K05462]
118825156  gdnfa; glial cell line-derived neurotrophic factor [KO:K05452]
118827050  glial cell line-derived neurotrophic factor [KO:K05452]
118819059  nrtn; neurturin [KO:K25414]
118797117  neurturin [KO:K25414]
118807596  artemin [KO:K25415]
118796907  artemin [KO:K25415]
118804575  persephin [KO:K25416]
118823220  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
118796721  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
118809704  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
118822368  erbb3b; receptor tyrosine-protein kinase erbB-3b isoform X1 [KO:K05084] [EC:2.7.10.1]
118808408  erbb3a; receptor tyrosine-protein kinase erbB-3a [KO:K05084] [EC:2.7.10.1]
118796652  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
118803545  si:ch73-383l1.1; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
118804330  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
118813294  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
118810105  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
118824710  fibroblast growth factor receptor 2-like isoform X1 [KO:K05093] [EC:2.7.10.1]
118810287  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
118819728  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
118814452  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
118821354  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
118809686  ngfrb; nerve growth factor receptor b [KO:K02583]
118798677  ntrk1; LOW QUALITY PROTEIN: high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
118813320  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a [KO:K04360] [EC:2.7.10.1]
118814584  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b [KO:K04360] [EC:2.7.10.1]
118818705  insrb; insulin receptor b isoform X1 [KO:K04527] [EC:2.7.10.1]
118826559  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
118818325  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
118819471  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
118815384  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
118811440  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
118811442  csf1ra; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
118820479  csf1rb; macrophage colony-stimulating factor 1 receptor 1 [KO:K05090] [EC:2.7.10.1]
118816588  kitb; KIT proto-oncogene, receptor tyrosine kinase b [KO:K05091] [EC:2.7.10.1]
118815386  kita; mast/stem cell growth factor receptor kita isoform X1 [KO:K05091] [EC:2.7.10.1]
118798656  receptor-type tyrosine-protein kinase FLT3-like [KO:K05092] [EC:2.7.10.1]
118798658  receptor-type tyrosine-protein kinase FLT3-like isoform X1 [KO:K05092] [EC:2.7.10.1]
118798654  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
118807172  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
118807325  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
118815391  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
118806734  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
118814883  tek; tyrosine-protein kinase receptor Tie-2 isoform X1 [KO:K05121] [EC:2.7.10.1]
118822159  epha2b; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
118808468  epha2a; ephrin type-A receptor 2a [KO:K05103] [EC:2.7.10.1]
118810504  ret; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
118808138  grb2a; LOW QUALITY PROTEIN: growth factor receptor-bound protein 2a [KO:K04364]
118820918  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
118811059  sos2; son of sevenless homolog 2 [KO:K03099]
118819349  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
118817540  hrasb; HRas proto-oncogene, GTPase b isoform X1 [KO:K02833]
118811525  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
118811569  kras; GTPase KRas isoform X1 [KO:K07827]
118821270  zgc:55558; GTPase HRas [KO:K07827]
118813822  nras; GTPase NRas [KO:K07828]
118800505  rras; ras-related protein R-Ras [KO:K07830]
118818761  rras2; ras-related protein R-Ras2 [KO:K07830]
118800919  mras; ras-related protein M-Ras [KO:K07831]
118808692  si:ch73-116o1.2; ras-related protein M-Ras isoform X1 [KO:K07831]
118827772  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
118812517  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118822149  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
118799451  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
118818240  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
118818647  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
118797185  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
118810269  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
118820974  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
118827508  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
118818721  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
118813913  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
118804718  mknk2a; MAP kinase-interacting serine/threonine-protein kinase 2a [KO:K04372] [EC:2.7.11.1]
118810156  rps6ka2; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
118798850  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
118823168  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
118807265  rps6kal; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
118814908  rps6ka3a; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
118807890  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
118813800  elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
118799703  elk4; ETS domain-containing protein Elk-4 [KO:K04376]
118799079  myca; transcriptional regulator Myc-A [KO:K04377]
118826448  mycb; transcriptional regulator Myc-B [KO:K04377]
118810653  srfb; serum response factor b isoform X1 [KO:K04378]
118818993  srfa; serum response factor a [KO:K04378]
118816011  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
118816012  si:ch211-153j24.3; proto-oncogene c-Fos isoform X1 [KO:K04379]
118823609  fosaa; proto-oncogene c-Fos [KO:K04379]
118809739  mapta; microtubule-associated protein tau isoform X1 [KO:K04380]
118819313  stmn1b; stathmin 1b [KO:K04381]
118802126  stmn1a; stathmin 1a [KO:K04381]
118806033  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
118806034  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
118806035  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
118806040  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
118806041  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
118806042  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
118806044  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
118823685  pla2g4f.1; LOW QUALITY PROTEIN: cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
118802833  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
118804709  pla2g4aa; LOW QUALITY PROTEIN: cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
118804945  cytosolic phospholipase A2 delta-like [KO:K16342] [EC:3.1.1.4]
118804946  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
118804947  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
118804949  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
118804951  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
118804952  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
118805116  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
118805117  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
118815281  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
118805034  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
118824594  interleukin-1 beta-like [KO:K04519]
118824620  il1b; interleukin-1 beta [KO:K04519]
118819844  tgfb1b; transforming growth factor beta-1 proprotein [KO:K13375]
118796969  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
118806906  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
118819641  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
118823493  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
118817653  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
118798130  interleukin-1 receptor type 1-like [KO:K04386]
118801536  zmp:0000000936; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
118801537  interleukin-1 receptor type 1 [KO:K04386]
118798495  interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
118816435  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
118807159  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
118801892  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
118819778  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
118816146  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
118823507  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
118823508  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390]
118821068  rac1b; ras-related C3 botulinum toxin substrate 1b [KO:K04392]
118809209  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
118821228  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
118820980  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
118809795  rac3b; ras-related C3 botulinum toxin substrate 3b isoform X1 [KO:K07861]
118805943  cell division control protein 42 homolog [KO:K04393]
118822088  cdc42l2; cell division cycle 42 like 2 [KO:K04393]
118799432  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
118820543  cdc42l; cell division cycle 42, like [KO:K04393]
118818639  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
118817001  LOW QUALITY PROTEIN: caspase-3-like [KO:K02187] [EC:3.4.22.56]
118806926  caspase-3-like [KO:K02187] [EC:3.4.22.56]
118806927  caspase-3-like [KO:K02187] [EC:3.4.22.56]
118814555  traf2b; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
118827146  traf2a; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
118805918  daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
118798879  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
118813884  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
118811803  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
118817529  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
118818878  gadd45ba; growth arrest and DNA-damage-inducible, beta a isoform X1 [KO:K04402]
118813019  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
118807727  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
118820040  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
118825864  gadd45bb; growth arrest and DNA-damage-inducible, beta b [KO:K04402]
118797223  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
118807882  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
118815291  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
118826698  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
118824176  map4k3b; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
118803795  map4k3a; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
118798351  LOW QUALITY PROTEIN: TRAF2 and NCK-interacting protein kinase-like [KO:K04407] [EC:2.7.11.1]
118801552  map4k4; TRAF2 and NCK-interacting protein kinase isoform X1 [KO:K04407] [EC:2.7.11.1]
118807237  si:zfos-2326c3.2; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
118817917  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
118818963  pak2b; serine/threonine-protein kinase PAK 2b isoform X1 [KO:K04410] [EC:2.7.11.1]
118825772  pak2a; serine/threonine-protein kinase PAK 2a [KO:K04410] [EC:2.7.11.1]
118808687  serine/threonine-protein kinase 4-like [KO:K04411]
118805484  stk3; serine/threonine-protein kinase 3 [KO:K04412]
118825666  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
118819927  map4k6; mitogen-activated protein kinase kinase kinase kinase 6 [KO:K04414] [EC:2.7.11.1]
118809321  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
118825293  map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
118816669  mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
118807844  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
118798602  map3k22; mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
118821192  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
118810015  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
118817968  map3k10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
118810573  map3k21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
118813354  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
118807602  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
118808074  protein kinase Npk [KO:K04424] [EC:2.7.11.25]
118805584  zak; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
118800999  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
118819190  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
118815329  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
118816782  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
118801660  taok1a; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
118802442  taok3b; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
118820186  taok1b; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
118821103  taok2a; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
118827490  taok3a; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
118809760  taok2b; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
118805346  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
118809534  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b [KO:K04430] [EC:2.7.12.2]
118802941  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
118809070  map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
118806602  mapk8ip1a; C-Jun-amino-terminal kinase-interacting protein 1a [KO:K04434]
118819420  mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
118817955  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
118821003  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
118821975  flna; filamin-A isoform X1 [KO:K04437]
118801389  crk; adapter molecule crk [KO:K04438]
118819899  crkl; crk-like protein [KO:K04438]
118814796  adapter molecule crk-like [KO:K04438]
118801235  arrb2b; arrestin, beta 2b [KO:K04439]
118825258  arrb2a; arrestin, beta 2a isoform X1 [KO:K04439]
118802438  arrb1; beta-arrestin-1 [KO:K04439]
118810413  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118820022  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118820354  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118809785  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118822615  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
118799753  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
118818088  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
118812248  mapk12b; mitogen-activated protein kinase 12b isoform X1 [KO:K04441] [EC:2.7.11.24]
118812249  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
118813192  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
118813814  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118826855  mapkapk5; LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
118799279  mapkapk2a; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
118813618  mapkapk2b; MAP kinase-activated protein kinase 2b isoform X1 [KO:K04443] [EC:2.7.11.1]
118799535  mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
118823360  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
118814398  rps6ka4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
118810298  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
118806194  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
118797143  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
118817450  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
118811620  nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
118814879  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
118815433  jun; transcription factor AP-1 [KO:K04448]
118797227  jund; transcription factor jun-D [KO:K04449]
118805699  atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
118826251  cellular tumor antigen p53-like [KO:K04451]
118814925  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
118808477  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
118823232  protein max-like isoform X1 [KO:K04453]
118815693  max; protein max isoform X1 [KO:K04453]
118824338  mef2ca; myocyte enhancer factor 2ca isoform X1 [KO:K04454]
118827543  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
118802425  hspb15; heat shock protein, alpha-crystallin-related, b15 [KO:K04455]
118814768  hspb1; heat shock protein beta-1 [KO:K04455]
118827189  LOW QUALITY PROTEIN: heat shock protein beta-1-like [KO:K04455]
118810240  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118815953  LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
118798278  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118823237  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118818017  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118811031  ppm1aa; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
118803116  ppm1na; protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) isoform X1 [KO:K04457] [EC:3.1.3.16]
118820417  ppm1nb; protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) [KO:K04457] [EC:3.1.3.16]
118815530  ppm1ab; protein phosphatase, Mg2+/Mn2+ dependent, 1Ab isoform X1 [KO:K04457] [EC:3.1.3.16]
118812228  ptprr; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
118817644  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
118807327  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
118822558  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118811547  dusp8a; dual specificity protein phosphatase 8a isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118800391  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118812269  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118813221  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118820305  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118804632  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118806722  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
118815857  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
118801277  dusp3b; dual specificity protein phosphatase 3b [KO:K17614] [EC:3.1.3.16 3.1.3.48]
118809463  dusp3a; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
118797034  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
118810231  ppm1ba; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
118809267  ppm1bb; protein phosphatase 1bb isoform X1 [KO:K04461] [EC:3.1.3.16]
118800213  hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283]
118824749  heat shock cognate 71 kDa protein-like [KO:K03283]
118824892  heat shock cognate 71 kDa protein [KO:K03283]
118813786  hspa1b; LOW QUALITY PROTEIN: heat shock 70 kDa protein 1B [KO:K03283]
118803729  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
118821360  heat shock 70 kDa protein-like [KO:K03283]
118821361  heat shock 70 kDa protein-like [KO:K03283]
118821362  heat shock 70 kDa protein-like [KO:K03283]
118821363  heat shock 70 kDa protein [KO:K03283]
118798921  mecom; MDS1 and EVI1 complex locus protein EVI1-A isoform X1 [KO:K04462] [EC:2.1.1.367]
118817496  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
118809727  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
118822639  nr4a1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
118799563  probable nuclear hormone receptor HR38 isoform X1 [KO:K04465]
118822540  uncharacterized protein LOC118822540 isoform X1 [KO:K04466] [EC:2.7.11.25]
118821145  map3k14a; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
118810516  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
118810719  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118813511  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
118822022  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118804040  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
118820972  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
118821638  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
118810057  LOW QUALITY PROTEIN: uncharacterized protein LOC118810057 [KO:K04469]
118816672  rela; transcription factor p65 [KO:K04735]
118799712  relb; putative transcription factor p65 homolog isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
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PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
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PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
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PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
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PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
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PMID:22296764
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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PMID:23664135
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Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
cmao04070  Phosphatidylinositol signaling system
cmao04110  Cell cycle
cmao04115  p53 signaling pathway
cmao04210  Apoptosis
cmao04310  Wnt signaling pathway
KO pathway
ko04010   
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