KEGG   PATHWAY: ecb05166
Entry
ecb05166                    Pathway                                
Name
Human T-cell leukemia virus 1 infection - Equus caballus (horse)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
ecb05166  Human T-cell leukemia virus 1 infection
ecb05166

Organism
Equus caballus (horse) [GN:ecb]
Gene
100034080  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
100060430  NRP1; neuropilin-1 isoform X2 [KO:K06724]
100068097  MYC; myc proto-oncogene protein [KO:K04377]
100059214  TRRAP; transformation/transcription domain-associated protein isoform X1 [KO:K08874]
100051541  KAT5; histone acetyltransferase KAT5 isoform X1 [KO:K11304] [EC:2.3.1.48]
100051150  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100065508  ITGAL; integrin alpha-L isoform X2 [KO:K05718]
100056128  ITGB2; integrin beta-2 [KO:K06464]
100056049  integrin beta-2 [KO:K06464]
100058207  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
100055481  HRAS; GTPase HRas isoform X1 [KO:K02833]
100064473  KRAS; GTPase KRas isoform X1 [KO:K07827]
100051785  LOW QUALITY PROTEIN: GTPase KRas-like [KO:K07827]
100059469  NRAS; GTPase NRas [KO:K07828]
100065996  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
100063190  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100057701  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100066173  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100052502  CD4; T-cell surface glycoprotein CD4 isoform X2 [KO:K06454]
100054133  TLN2; talin-2 isoform X1 [KO:K06271]
100055501  TLN1; talin-1 isoform X3 [KO:K06271]
100065287  RANBP3; ran-binding protein 3 isoform X1 [KO:K15304]
100062767  RAN; GTP-binding nuclear protein Ran [KO:K07936]
100051994  XPO1; exportin-1 isoform X1 [KO:K14290]
100064107  CALR; calreticulin [KO:K08057]
100062428  calreticulin [KO:K08057]
100067402  CANX; calnexin [KO:K08054]
100057357  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100067434  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
100072862  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100061874  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102148270  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100065378  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100052657  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X4 [KO:K17332]
100053856  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100054213  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
100069676  IL2RB; interleukin-2 receptor subunit beta isoform X2 [KO:K05069]
100055911  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
100054008  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100147451  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
100052904  STAT5A; signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
100052954  signal transducer and activator of transcription 5B isoform X3 [KO:K11224]
100034204  IL2; interleukin-2 precursor [KO:K05429]
100034212  MHCB3; MHC class I heavy chain precursor [KO:K06751]
100056062  MHC class I antigen 9.2 precursor [KO:K06751]
100034210  EQMHCB2; MHC class I heavy chain precursor [KO:K06751]
100054114  HLA class I histocompatibility antigen, alpha chain G isoform X1 [KO:K06751]
100051657  7-51 putative nonclassical MHC class I antigen precursor [KO:K06751]
100057920  HLA class I histocompatibility antigen, Cw-12 alpha chain isoform X2 [KO:K06751]
100050550  EQMCE1; MHC class I antigen 3.7 precursor [KO:K06751]
100056182  HLA class I histocompatibility antigen, B-40 alpha chain isoform X1 [KO:K06751]
100056391  MHCX1; MHC class I antigen 3.5 precursor [KO:K06751]
100034211  EQMHCC1; MHC class I heavy chain precursor [KO:K06751]
100049798  class I histocompatibility antigen, Gogo-OKO alpha chain isoform X12 [KO:K06751]
100050473  class I histocompatibility antigen, Gogo-B*0103 alpha chain isoform X1 [KO:K06751]
100050706  saoe class I histocompatibility antigen, A alpha chain isoform X1 [KO:K06751]
100053918  HLA class I histocompatibility antigen, B-46 alpha chain isoform X2 [KO:K06751]
100054397  saoe class I histocompatibility antigen, A alpha chain [KO:K06751]
100054448  HLA class I histocompatibility antigen, alpha chain G isoform X3 [KO:K06751]
100056309  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
100056099  HLA class I histocompatibility antigen, alpha chain G isoform X1 [KO:K06751]
100056231  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
100059994  HLA class I histocompatibility antigen, B-15 alpha chain isoform X1 [KO:K06751]
100060096  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
100034203  B2M; beta-2-microglobulin precursor [KO:K08055]
100063641  FDPS; farnesyl pyrophosphate synthase [KO:K00787] [EC:2.5.1.1 2.5.1.10]
100062974  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100050762  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100059103  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
100071908  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
100146128  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
100064276  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100050036  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100071110  TSPO; translocator protein [KO:K05770]
100066031  TSPO2; translocator protein 2 [KO:K05770]
100054657  VAC14; protein VAC14 homolog isoform X2 [KO:K15305]
100050559  RANBP1; ran-specific GTPase-activating protein isoform X1 [KO:K15306]
100058904  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
100072353  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A isoform X1 [KO:K02537]
100629735  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X1 [KO:K06637] [EC:2.7.11.1]
100050269  BUB3; mitotic checkpoint protein BUB3 isoform X2 [KO:K02180]
100051869  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
111767487  anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
111768045  anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
100059767  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
100054552  CDC27; cell division cycle protein 27 homolog isoform X6 [KO:K03350]
100067388  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
100058548  ANAPC5; anaphase-promoting complex subunit 5 [KO:K03352]
100069285  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
100058376  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
100072599  CDC23; cell division cycle protein 23 homolog [KO:K03355]
100062837  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
100055053  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
100053266  CDC26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
100053101  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
100066106  ANAPC15; anaphase-promoting complex subunit 15 isoform X2 [KO:K25228]
100072806  ANAPC16; anaphase-promoting complex subunit 16 isoform X2 [KO:K25229]
100053348  CDC20; cell division cycle protein 20 homolog [KO:K03363]
100059640  PTTG1; securin isoform X1 [KO:K06635]
100063779  ESPL1; separin [KO:K02365] [EC:3.4.22.49]
100054413  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
100034122  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
100146270  cyclin-dependent kinase 4 inhibitor B [KO:K06621]
100051005  CDK4; cyclin-dependent kinase 4 isoform X2 [KO:K02089] [EC:2.7.11.22]
102149114  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100066590  CCND3; G1/S-specific cyclin-D3 isoform X3 [KO:K10152]
100064022  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100147188  CCNA1; cyclin-A1 [KO:K06627]
100072219  CCNA2; cyclin-A2 [KO:K06627]
100055302  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
100053882  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
100051790  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
100057080  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
100069192  E2F1; transcription factor E2F1 [KO:K17454]
100057866  E2F2; transcription factor E2F2 isoform X2 [KO:K09389]
100052248  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
100061765  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
100062529  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
100064353  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
100059288  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
100062044  TP53; cellular tumor antigen p53 [KO:K04451]
100052122  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100050227  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
100146348  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100051623  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100058141  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100051753  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100064671  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100054961  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100061130  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100060094  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
100062388  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100033834  TNF; tumor necrosis factor [KO:K03156]
100059548  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100061688  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
100073094  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
100052608  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100057961  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100051798  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100067469  JUN; transcription factor AP-1 [KO:K04448]
100068985  MMP7; matrilysin [KO:K01397] [EC:3.4.24.23]
100009699  IL1R1; interleukin-1 receptor type 1 precursor [KO:K04386]
100033831  IL1R2; interleukin-1 receptor type 2 precursor [KO:K04387]
111772100  uncharacterized protein LOC111772100 [KO:K10784]
106783094  uncharacterized protein LOC106783094 [KO:K10785]
100062931  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
100629532  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
100062960  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
100064751  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
100070393  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100050167  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100058432  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100058000  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100067894  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X4 [KO:K02580]
100057483  RELA; transcription factor p65 [KO:K04735]
100061712  GPS2; G protein pathway suppressor 2 [KO:K15307]
100059650  LTBR; tumor necrosis factor receptor superfamily member 3 isoform X2 [KO:K03159]
100034049  CD40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160]
100070724  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
100050140  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
100070664  RELB; transcription factor RelB [KO:K09253]
100069984  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
111775192  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
100070292  IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068]
100034058  IL15; interleukin-15 [KO:K05433]
100070311  IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
100034196  IL6; interleukin-6 precursor [KO:K05405]
100033981  CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427]
100058321  LTA; lymphotoxin-alpha [KO:K05468]
100053597  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
100060870  XIAP; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
100033900  TGFB1; transforming growth factor beta-1 precursor [KO:K13375]
100050377  TGFB2; transforming growth factor beta-2 isoform X2 [KO:K13376]
111771316  transforming growth factor beta-2-like isoform X1 [KO:K13376]
100051765  TGFB3; transforming growth factor beta-3 [KO:K13377]
100034117  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
100033860  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
100033843  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
100033845  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
100033846  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
100065563  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100071337  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100055961  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100054305  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100070498  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
100051295  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
100058891  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100057796  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100066046  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
100052828  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100064302  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
100034044  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
100061035  HLA class II histocompatibility antigen, DM alpha chain-like precursor [KO:K06752]
100060770  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
100052249  DQA; MHC class II DQ-alpha precursor [KO:K06752]
100052310  DRB; MHC class II DR-beta chain precursor [KO:K06752]
100052364  DRB; MHC class II DR-beta chain precursor [KO:K06752]
100051944  DRA; MHC class II DR alpha chain precursor [KO:K06752]
100052184  DQB; MHC class II DQ-beta chain precursor [KO:K06752]
100061127  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
100060996  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
100052006  DRB; MHC class II DR-beta chain precursor [KO:K06752]
100052125  DQA; MHC class II DQ-alpha chain precursor [KO:K06752]
100060531  HLA class II histocompatibility antigen, DQ beta 2 chain isoform X1 [KO:K06752]
100052063  DQA; MHC class II DQ-alpha chain [KO:K06752]
100060320  DQB; MHC class II DQ-beta chain precursor [KO:K06752]
111767457  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
100060697  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
100055059  SRF; serum response factor [KO:K04378]
100050315  ELK4; ETS domain-containing protein Elk-4 isoform X2 [KO:K04376]
100051388  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
100051397  SPI1; transcription factor PU.1 isoform X2 [KO:K09438]
100064559  ETS1; protein C-ets-1 isoform X2 [KO:K02678]
100059969  ETS2; protein C-ets-2 [KO:K21932]
100067729  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
100049846  TBP; TATA-box-binding protein [KO:K03120]
100051632  FOS; proto-oncogene c-Fos [KO:K04379]
100072574  EGR1; early growth response protein 1 [KO:K09203]
100051930  FOSL1; fos-related antigen 1 [KO:K04502]
100062890  EGR2; E3 SUMO-protein ligase EGR2 isoform X2 [KO:K12496]
100066388  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
100062307  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100064828  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
100057002  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100067794  CREB3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100063153  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
100053304  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100070334  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100054803  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
100059348  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
100071052  CRTC1; CREB-regulated transcription coactivator 1 isoform X1 [KO:K15309]
100056571  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
100068775  CRTC3; CREB-regulated transcription coactivator 3 isoform X1 [KO:K16334]
100055626  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
100069613  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
100061976  KAT2B; histone acetyltransferase KAT2B isoform X3 [KO:K06062] [EC:2.3.1.48]
100053057  KAT2A; histone acetyltransferase KAT2A isoform X2 [KO:K06062] [EC:2.3.1.48]
100147220  TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
100050102  POLB; DNA polymerase beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
100146139  LCK; tyrosine-protein kinase Lck isoform X1 [KO:K05856] [EC:2.7.10.2]
100054674  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100051195  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
100630695  TERT; telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
100058880  MSX2; homeobox protein MSX-2 [KO:K09341]
100069768  MSX1; homeobox protein MSX-1 [KO:K09341]
100146619  homeobox protein MSX-3-like [KO:K09341]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
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Related
pathway
ecb03013  Nucleocytoplasmic transport
ecb04010  MAPK signaling pathway
ecb04064  NF-kappa B signaling pathway
ecb04110  Cell cycle
ecb04115  p53 signaling pathway
ecb04151  PI3K-Akt signaling pathway
ecb04210  Apoptosis
ecb04350  TGF-beta signaling pathway
ecb04612  Antigen processing and presentation
ecb04660  T cell receptor signaling pathway
ecb04668  TNF signaling pathway
KO pathway
ko05166   
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