Neurotrophin signaling pathway - Homo sapiens (human)
Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and nagative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory.
Organismal Systems; Nervous system
Pathway map Ortholog table
D09010 Tarenflurbil (USAN/INN)
D09377 Semagacestat (USAN/INN)
D10399 Rebastinib Tosylate (USAN)
D11137 Larotrectinib (USAN/INN)
D11138 Larotrectinib sulfate (JAN/USAN)
D11454 Repotrectinib (JAN/USAN)
D11484 Pegcantratinib (USAN/INN)
D12181 Edasalonexent (USAN/INN)
D12363 Taletrectinib (USAN/INN)
D12364 Taletrectinib adipate (USAN)
D12580 Sudotaxel zendusortide (USAN/INN)
D12581 Zendusortide (USAN/INN)
D12646 Paltimatrectinib (USAN/INN)
Homo sapiens (human) [GN:
627 BDNF; brain derived neurotrophic factor [KO: K04355]
2885 GRB2; growth factor receptor bound protein 2 [KO: K04364]
6654 SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO: K03099]
6655 SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO: K03099]
3265 HRAS; HRas proto-oncogene, GTPase [KO: K02833]
3845 KRAS; KRAS proto-oncogene, GTPase [KO: K07827]
4893 NRAS; NRAS proto-oncogene, GTPase [KO: K07828]
468 ATF4; activating transcription factor 4 [KO: K04374]
596 BCL2; BCL2 apoptosis regulator [KO: K02161]
57498 KIDINS220; kinase D interacting substrate 220 [KO: K12460]
10818 FRS2; fibroblast growth factor receptor substrate 2 [KO: K12461]
1398 CRK; CRK proto-oncogene, adaptor protein [KO: K04438]
1399 CRKL; CRK like proto-oncogene, adaptor protein [KO: K04438]
2889 RAPGEF1; Rap guanine nucleotide exchange factor 1 [KO: K06277]
5906 RAP1A; RAP1A, member of RAS oncogene family [KO: K04353]
5908 RAP1B; RAP1B, member of RAS oncogene family [KO: K07836]
2549 GAB1; GRB2 associated binding protein 1 [KO: K09593]
5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO: K02649]
5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO: K02649]
8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO: K02649]
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO: K00922] [EC: 184.108.40.206]
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO: K00922] [EC: 220.127.116.11]
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO: K00922] [EC: 18.104.22.168]
4790 NFKB1; nuclear factor kappa B subunit 1 [KO: K02580]
5970 RELA; RELA proto-oncogene, NF-kB subunit [KO: K04735]
572 BAD; BCL2 associated agonist of cell death [KO: K02158]
3667 IRS1; insulin receptor substrate 1 [KO: K16172]
815 CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO: K04515] [EC: 22.214.171.124]
817 CAMK2D; calcium/calmodulin dependent protein kinase II delta [KO: K04515] [EC: 126.96.36.199]
816 CAMK2B; calcium/calmodulin dependent protein kinase II beta [KO: K04515] [EC: 188.8.131.52]
818 CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO: K04515] [EC: 184.108.40.206]
25 ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase [KO: K06619] [EC: 220.127.116.11]
4804 NGFR; nerve growth factor receptor [KO: K02583]
397 ARHGDIB; Rho GDP dissociation inhibitor beta [KO: K12462]
396 ARHGDIA; Rho GDP dissociation inhibitor alpha [KO: K12462]
398 ARHGDIG; Rho GDP dissociation inhibitor gamma [KO: K12462]
387 RHOA; ras homolog family member A [KO: K04513]
998 CDC42; cell division cycle 42 [KO: K04393]
3725 JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO: K04448]
581 BAX; BCL2 associated X, apoptosis regulator [KO: K02159]
7531 YWHAE; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon [KO: K06630]
5663 PSEN1; presenilin 1 [KO: K04505] [EC:3.4.23.-]
5664 PSEN2; presenilin 2 [KO: K04522] [EC:3.4.23.-]
C01245 D-myo-Inositol 1,4,5-trisphosphate
Huang EJ, Reichardt LF.
Trk receptors: roles in neuronal signal transduction.
Patapoutian A, Reichardt LF
Trk receptors: mediators of neurotrophin action.
Arevalo JC, Wu SH
Neurotrophin signaling: many exciting surprises!
Teng KK, Hempstead BL
Neurotrophins and their receptors: signaling trios in complex biological systems.
Miller FD, Kaplan DR
Neurotrophin signalling pathways regulating neuronal apoptosis.
Kaplan DR, Miller FD
Neurotrophin signal transduction in the nervous system.
Neurotrophin-regulated signalling pathways.
Zampieri N, Chao MV
Mechanisms of neurotrophin receptor signalling.
Rose CR, Blum R, Kafitz KW, Kovalchuk Y, Konnerth A
From modulator to mediator: rapid effects of BDNF on ion channels.
Yano H, Chao MV
Neurotrophin receptor structure and interactions.
Mukai J, Hachiya T, Shoji-Hoshino S, Kimura MT, Nadano D, Suvanto P, Hanaoka T, Li Y, Irie S, Greene LA, Sato TA
NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR.
Salehi AH, Roux PP, Kubu CJ, Zeindler C, Bhakar A, Tannis LL, Verdi JM, Barker PA
NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis.
hsa04810 Regulation of actin cytoskeleton
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