KEGG   PATHWAY: mmur05163
Entry
mmur05163                   Pathway                                
Name
Human cytomegalovirus infection - Microcebus murinus (gray mouse lemur)
Description
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
Class
Human Diseases; Infectious disease: viral
Pathway map
mmur05163  Human cytomegalovirus infection
mmur05163

Organism
Microcebus murinus (gray mouse lemur) [GN:mmur]
Gene
105867837  PDGFRA; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105862660  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105855821  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105886063  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105881219  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105855026  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105877483  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105861093  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105876768  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105863738  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105859868  TSC1; hamartin isoform X1 [KO:K07206]
105859584  TSC2; tuberin isoform X1 [KO:K07207]
105883192  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
105886039  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
105870389  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
105867475  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
105874527  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
105867131  LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
105873508  CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105878144  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105867816  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
105874819  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105878531  RELA; transcription factor p65 isoform X1 [KO:K04735]
105877217  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105878936  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105867678  SOS2; son of sevenless homolog 2 [KO:K03099]
105884529  SOS1; son of sevenless homolog 1 [KO:K03099]
105874032  HRAS; GTPase HRas [KO:K02833]
105857286  KRAS; GTPase KRas isoform X1 [KO:K07827]
105878710  NRAS; GTPase NRas [KO:K07828]
105882676  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105868083  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105873938  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105870697  mitogen-activated protein kinase 6-like [KO:K04371] [EC:2.7.11.24]
105877796  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105871124  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105862174  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
105870777  SP1; transcription factor Sp1 [KO:K04684]
105879310  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
105863671  ITGB3; integrin beta-3 [KO:K06493]
105866030  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
105868254  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105883746  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
105878067  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
105874961  RHOA; transforming protein RhoA [KO:K04513]
105881031  transforming protein RhoA-like isoform X1 [KO:K04513]
105884657  MB21D1; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
105858834  cyclic GMP-AMP synthase-like [KO:K17834] [EC:2.7.7.86]
105862625  TMEM173; stimulator of interferon genes protein isoform X1 [KO:K12654]
105880966  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
105865644  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
105874211  interferon alpha-10-like [KO:K05414]
105874212  interferon alpha-10-like [KO:K05414]
105874214  interferon alpha-4-like [KO:K05414]
105874217  interferon alpha-10-like [KO:K05414]
105874210  IFNB1; interferon beta [KO:K05415]
105858137  TNF; tumor necrosis factor isoform X1 [KO:K03156]
105869061  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105873484  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
105859037  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105880516  TRAF5; LOW QUALITY PROTEIN: TNF receptor-associated factor 5 [KO:K09849]
105882282  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
105859190  IL1B; interleukin-1 beta [KO:K04519]
105857833  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
105855502  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105859340  C-C motif chemokine 2-like [KO:K14624]
105882275  CCL5; C-C motif chemokine 5 [KO:K12499]
105860250  CXCL8; interleukin-8 [KO:K10030]
105875882  IL6; interleukin-6 [KO:K05405]
105877661  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
105868427  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1 [KO:K04537]
105869000  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X2 [KO:K07825]
105855818  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
105870695  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105867677  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
105878586  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
105856485  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
105861782  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
105873983  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
109729970  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
109731176  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
105885526  LOW QUALITY PROTEIN: uncharacterized LOC105372280 homolog [KO:K04347]
105872857  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
109729570  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
105867248  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
109729475  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
105868697  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
105873966  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
105861219  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
105878468  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
105872433  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
105880040  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
105869384  ITPR1; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
105857276  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
105861402  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
105867016  CALM2; calmodulin [KO:K02183]
105876291  CALM1; calmodulin [KO:K02183]
105869569  CALM3; calmodulin [KO:K02183]
105870055  calmodulin-like [KO:K02183]
105877681  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
105858210  calmodulin-alpha-like [KO:K02183]
105873434  CALML4; calmodulin-like protein 4 [KO:K02183]
105868798  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105863295  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105857150  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105863245  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
105873751  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105884723  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
105872262  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
105858914  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
105866622  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
105855505  PTGS2; prostaglandin G/H synthase 2 isoform X1 [KO:K11987] [EC:1.14.99.1]
105874990  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
105864008  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
105879338  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
105866545  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
105870668  ADCY1; LOW QUALITY PROTEIN: adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105859934  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105884349  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
105866617  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
105879870  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105867497  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
105884745  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105882731  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
105859653  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
105867963  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105861780  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
105881608  C-C motif chemokine 3-like [KO:K05408]
105881899  C-C motif chemokine 3-like [KO:K05408]
105882215  C-C motif chemokine 3-like [KO:K05408]
105881712  C-C motif chemokine 4 isoform X1 [KO:K12964]
105863892  CX3CL1; fractalkine [KO:K05508]
105868406  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
105861706  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
105867983  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
105873101  ARHGEF11; rho guanine nucleotide exchange factor 11 isoform X1 [KO:K12331]
105875996  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
105876518  AKAP13; A-kinase anchor protein 13 isoform X1 [KO:K16529]
105860971  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
105880217  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
105874413  CTNNB1; catenin beta-1 [KO:K02105]
105867915  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
105867692  PTGER2; prostaglandin E2 receptor EP2 subtype isoform X1 [KO:K04259]
105884236  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
105878396  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
105874518  guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X1 [KO:K04632]
105874520  neuroendocrine secretory protein 55-like [KO:K04632]
105879917  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105867511  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
105882748  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
105873204  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
105872820  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
105859419  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
105875869  VEGFA; vascular endothelial growth factor A [KO:K05448]
105861678  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
105861389  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105861390  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105885016  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
105885017  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
105864304  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
105865052  ATF2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
105858535  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105873936  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
105874305  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
105885209  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
105885942  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
105859108  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
105855129  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
105858143  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
105863684  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
105857645  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
105861618  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105879718  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105874723  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105877126  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
105855154  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105875451  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
105877776  CRKL; crk-like protein [KO:K04438]
105857910  CRK; adapter molecule crk isoform X1 [KO:K04438]
105866870  PXN; paxillin isoform X7 [KO:K05760]
105876063  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
109729198  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
105857650  C-X-C chemokine receptor type 2-like [KO:K05050]
105857653  C-X-C chemokine receptor type 2-like [KO:K05050]
105857711  C-X-C chemokine receptor type 2-like [KO:K05050]
105857712  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
105874444  CCR1; C-C chemokine receptor type 1 [KO:K04176]
105874442  CCR3; C-C chemokine receptor type 3 [KO:K04178]
105886022  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
105886025  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
105886000  TAPBP; tapasin isoform X1 [KO:K08058]
105872529  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
105877546  calreticulin-like isoform X1 [KO:K08057]
105885495  CALR; calreticulin [KO:K08057]
105855949  HLA class I histocompatibility antigen, B-81 alpha chain-like [KO:K06751]
105855951  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-37 alpha chain-like [KO:K06751]
105870762  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
105870764  HLA class I histocompatibility antigen, B-37 alpha chain-like isoform X1 [KO:K06751]
105870765  HLA class I histocompatibility antigen, B-48 alpha chain-like [KO:K06751]
105870766  HLA class I histocompatibility antigen, B-44 alpha chain-like [KO:K06751]
105870767  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
105858107  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-OKO alpha chain [KO:K06751]
105872549  B2M; beta-2-microglobulin [KO:K08055]
105874194  cyclin-dependent kinase inhibitor 2A [KO:K06621]
105884627  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
105877486  TP53; cellular tumor antigen p53 [KO:K04451]
105861439  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
105877995  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
105879410  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
105855966  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
105866012  E2F1; transcription factor E2F1 [KO:K17454]
105863547  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
105865199  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
105871667  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105871657  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
105867530  FADD; FAS-associated death domain protein [KO:K02373]
105856959  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
105861876  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
105865602  BAX; apoptosis regulator BAX isoform X2 [KO:K02159]
105861442  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
105883029  cytochrome c, testis-specific [KO:K08738]
105875906  cytochrome c, somatic [KO:K08738]
105876468  cytochrome c, somatic [KO:K08738]
105870442  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
105882502  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
105880624  LOW QUALITY PROTEIN: caspase-3-like [KO:K02187] [EC:3.4.22.56]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00584  Prostaglandin E2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:19107226
  Authors
Michaelis M, Doerr HW, Cinatl J
  Title
The story of human cytomegalovirus and cancer: increasing evidence and open questions.
  Journal
Neoplasia 11:1-9 (2009)
DOI:10.1593/neo.81178
Reference
PMID:24839861
  Authors
Roy S, Arav-Boger R
  Title
New cell-signaling pathways for controlling cytomegalovirus replication.
  Journal
Am J Transplant 14:1249-58 (2014)
DOI:10.1111/ajt.12725
Reference
PMID:14720582
  Authors
Cinatl J, Scholz M, Kotchetkov R, Vogel JU, Doerr HW
  Title
Molecular mechanisms of the modulatory effects of HCMV infection in tumor cell biology.
  Journal
Trends Mol Med 10:19-23 (2004)
DOI:10.1016/j.molmed.2003.11.002
Reference
PMID:15380778
  Authors
Evers DL, Wang X, Huang ES
  Title
Cellular stress and signal transduction responses to human cytomegalovirus infection.
  Journal
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Related
pathway
mmur00590  Arachidonic acid metabolism
mmur03050  Proteasome
mmur04010  MAPK signaling pathway
mmur04064  NF-kappa B signaling pathway
mmur04110  Cell cycle
mmur04150  mTOR signaling pathway
mmur04151  PI3K-Akt signaling pathway
mmur04210  Apoptosis
mmur04612  Antigen processing and presentation
mmur04623  Cytosolic DNA-sensing pathway
mmur04630  JAK-STAT signaling pathway
mmur04668  TNF signaling pathway
mmur04810  Regulation of actin cytoskeleton
KO pathway
ko05163   
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