KEGG   PATHWAY: npo05022
Entry
npo05022                    Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Nyctereutes procyonoides (raccoon dog)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
npo05022  Pathways of neurodegeneration - multiple diseases
npo05022

Organism
Nyctereutes procyonoides (raccoon dog) [GN:npo]
Gene
129502077  APP; amyloid-beta precursor protein isoform X1 [KO:K04520]
129507366  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
129501829  SNCA; alpha-synuclein [KO:K04528]
129513481  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
129499971  RNA-binding protein FUS-like [KO:K13098]
129519945  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
129502030  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
129508177  ATXN2; ataxin-2 isoform X1 [KO:K23625]
129519511  ATXN2L; LOW QUALITY PROTEIN: ataxin-2-like protein [KO:K23625]
129510518  HTT; huntingtin [KO:K04533]
129497532  ATXN1L; ataxin-1-like [KO:K23616]
129507462  ATXN1; ataxin-1 [KO:K23616]
129514988  ATXN3; ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
129495768  PRNP; major prion protein [KO:K05634]
129499185  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
129499244  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
129504266  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
129503104  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
129500488  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
129506787  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
129500644  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
129501049  PRKN; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
129496894  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
129504276  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
129497646  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
129500550  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
129493567  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
129494612  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
129519978  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
129500385  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
129504368  TRPC3; short transient receptor potential channel 3 isoform X1 [KO:K04966]
129494509  SIGMAR1; sigma non-opioid intracellular receptor 1 isoform X1 [KO:K20719]
129521608  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
129505465  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
129512495  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
129499919  RYR1; ryanodine receptor 1 [KO:K04961]
129499256  RYR2; ryanodine receptor 2 [KO:K04962]
129504130  RYR3; ryanodine receptor 3 [KO:K04963]
129495656  PDYN; proenkephalin-B [KO:K15840]
129496980  DLG4; disks large homolog 4 isoform X1 [KO:K11828]
129505656  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
129520006  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
129517144  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
129511343  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
129500619  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
129509702  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
129516741  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
129518361  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
129497696  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
129515558  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
129503382  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
129521343  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
129517804  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
129505985  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
129520204  STX1A; syntaxin-1A isoform X1 [KO:K04560]
129510377  neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
129508024  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
129520194  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
129513950  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
129496031  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
129509080  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
129502523  DERL1; derlin-1 [KO:K11519]
129494854  VCP; transitional endoplasmic reticulum ATPase [KO:K13525]
129508717  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
129521762  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
129508005  ubiquitin-40S ribosomal protein S27a [KO:K02977]
129518532  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
129511787  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
129520671  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
129497617  UBB; polyubiquitin-B [KO:K08770]
129499526  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
129514759  proteasome subunit alpha type-6-like [KO:K02730] [EC:3.4.25.1]
129494378  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
129519758  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
129509073  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
129498409  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
129516087  proteasome subunit alpha type-7-like [KO:K02731] [EC:3.4.25.1]
129519958  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
129508657  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
129494563  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
129494788  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
129496326  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
129496698  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
129504199  proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
129505151  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
129498861  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
129499236  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
129515388  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
129515397  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
129516469  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
129518477  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
129501655  proteasome subunit alpha type-3-like [KO:K02727] [EC:3.4.25.1]
129496265  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
129519536  proteasome subunit alpha type-3-like [KO:K02727] [EC:3.4.25.1]
129515093  proteasome subunit alpha type-3-like [KO:K02727] [EC:3.4.25.1]
129497339  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
129515341  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
129507717  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
129520861  PSMB2; proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
129499566  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
129512966  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
129501288  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
129494062  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
129496104  PSMC1; 26S proteasome regulatory subunit 4 isoform X1 [KO:K03062]
129501026  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
129496164  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
129503039  PSMC3; 26S proteasome regulatory subunit 6A isoform X1 [KO:K03065]
129511360  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
129498487  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
129493603  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
129505415  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
129508077  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
129515416  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
129512868  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 12-like [KO:K03035]
129515240  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
129522308  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
129497533  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
129494302  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
129501518  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
129498701  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
129499914  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
129498625  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
129504638  26S proteasome complex subunit SEM1-like [KO:K10881]
129498270  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
129510393  UCHL1; ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
129517789  UBA1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
129522373  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
129507957  UBE2L3; ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
129509257  ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
129502499  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
129494405  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1 [KO:K04553] [EC:2.3.2.23]
129497425  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
129512894  UBE2J1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
129501993  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
129496795  UBE2G1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
129498097  GPR37; prosaposin receptor GPR37 [KO:K04243]
129508093  SEPTIN5; septin-5 isoform X1 [KO:K04557]
129494907  SNCAIP; synphilin-1 isoform X1 [KO:K04558]
129505834  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
129493552  VAPB; vesicle-associated membrane protein-associated protein B/C isoform X1 [KO:K10707]
129515280  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
129511473  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
129508383  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
129506702  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
129515072  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
129509222  MAP3K5; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
129521885  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
129494670  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
129501796  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
129522825  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
129497876  caspase-12 [KO:K04741] [EC:3.4.22.-]
129501025  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
129511084  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
129496206  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
129511576  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
129498894  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
129513725  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
8690253  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
8690241  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
8690247  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
8690249  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
8690248  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
8690250  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
8690251  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
129503083  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
129508699  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
129502163  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
129496000  LOW QUALITY PROTEIN: uncharacterized protein LOC129496000 [KO:K03944]
129509004  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
129518265  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
129510084  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
129514260  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
129500932  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
129516053  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
129521197  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
129494510  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
129494624  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
129503020  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
129506342  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
129511392  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
129511553  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
129513361  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
129521225  LOW QUALITY PROTEIN: cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
129508091  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
129498109  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
129499056  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
129509859  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
129513410  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
129511720  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
129522012  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
129516722  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
129503435  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial isoform X1 [KO:K03953]
129521758  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial-like [KO:K03953]
129493906  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
129519296  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
129504115  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11-like [KO:K03956]
129521377  NDUFA11; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
129516999  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
129521333  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
129516190  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
129518682  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial-like [KO:K03958]
129522803  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
129503594  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
129498921  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
129494756  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
129522449  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
129493660  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
129502473  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
129507967  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10-like [KO:K03966]
129519719  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
129517809  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
129522770  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
129515347  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
129502501  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
129509375  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
129519941  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial-like [KO:K03937]
129520872  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
129498876  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
129521661  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
129501962  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
129503595  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial-like [KO:K03967]
129504424  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
129506735  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
129498603  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
129513882  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
129515276  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
129497237  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
129499648  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
8690252  CYTB; cytochrome b [KO:K00412]
129502532  cytochrome c1, heme protein, mitochondrial [KO:K00413]
129522437  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
129504493  cytochrome b-c1 complex subunit 2, mitochondrial-like [KO:K00415]
129500429  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit 2, mitochondrial-like [KO:K00415]
129519488  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
129520545  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
129495773  cytochrome b-c1 complex subunit 7 [KO:K00417]
129495294  cytochrome b-c1 complex subunit 8 [KO:K00418]
129508006  cytochrome b-c1 complex subunit 9 [KO:K00419]
129518582  cytochrome b-c1 complex subunit 10-like [KO:K00420]
129521701  cytochrome b-c1 complex subunit 10 [KO:K00420]
8690246  COX3; cytochrome c oxidase subunit III [KO:K02262]
8690242  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
8690243  COX2; cytochrome c oxidase subunit II [KO:K02261]
129495759  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
129497908  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
129506420  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
129503401  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
129511767  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
129506563  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
129507766  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
129515528  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
129517494  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
129517582  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
129519968  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
129500820  cytochrome c oxidase subunit 6B1 [KO:K02267]
129502847  cytochrome c oxidase subunit 6B1 [KO:K02267]
129496649  cytochrome c oxidase subunit 6B1-like [KO:K02267]
129496689  cytochrome c oxidase subunit 6B1-like [KO:K02267]
129500731  cytochrome c oxidase subunit 6B2 isoform X1 [KO:K02267]
129507555  cytochrome c oxidase subunit 6B1-like [KO:K02267]
129510891  cytochrome c oxidase subunit 6B1-like [KO:K02267]
129513370  cytochrome c oxidase subunit 6B1-like [KO:K02267]
129495809  cytochrome c oxidase subunit 6C [KO:K02268]
129495992  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
129500365  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
129516441  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
129510725  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
129518196  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
129513127  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
129503871  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
129517518  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
129517615  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
129510926  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
129518990  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
129504239  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
129504628  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
129512105  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
129521089  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
129513948  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
129502199  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
129507470  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
129510565  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
129517597  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
129509109  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
129504175  LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
129511451  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
129513489  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
129521532  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
129496069  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
8690245  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
129519449  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
129508686  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
129498171  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
129498343  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
129498425  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
129505346  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
129515951  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
129522930  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
129517425  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
129510792  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
129494111  ATP synthase subunit d, mitochondrial-like [KO:K02138]
129508600  ATP synthase subunit d, mitochondrial-like [KO:K02138]
129508642  ATP synthase subunit d, mitochondrial-like [KO:K02138]
129502961  ATP synthase subunit d, mitochondrial-like [KO:K02138]
129506018  ATP5PD; ATP synthase subunit d, mitochondrial isoform X1 [KO:K02138]
129499831  ATP synthase subunit d, mitochondrial-like [KO:K02138]
129506907  ATP synthase subunit d, mitochondrial-like [KO:K02138]
129506970  ATP synthase subunit d, mitochondrial-like [KO:K02138]
129507172  ATP synthase subunit d, mitochondrial-like [KO:K02138]
129516361  ATP synthase subunit d, mitochondrial-like [KO:K02138]
129516631  ATP synthase subunit d, mitochondrial-like [KO:K02138]
129516764  ATP synthase subunit d, mitochondrial-like [KO:K02138]
129517920  ATP synthase subunit d, mitochondrial-like [KO:K02138]
129518121  ATP synthase subunit d, mitochondrial-like [KO:K02138]
129512446  ATP synthase subunit d, mitochondrial-like [KO:K02138]
129502231  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
129509756  ATP synthase subunit O, mitochondrial-like [KO:K02137]
129501951  ATP synthase subunit O, mitochondrial-like [KO:K02137]
129502045  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
129503669  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
129516593  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
8690244  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
129495480  apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
129514527  apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
129495115  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
129500852  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
129515400  TOMM40L; mitochondrial import receptor subunit TOM40B [KO:K11518]
129509961  MCU; LOW QUALITY PROTEIN: calcium uniporter protein, mitochondrial [KO:K20858]
129495972  CALM1; calmodulin-1 [KO:K02183]
129497741  CALML6; calmodulin-like protein 6 [KO:K02183]
129506414  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
129500769  CALM3; calmodulin-3 [KO:K02183]
129511712  CALM2; calmodulin-2 isoform X1 [KO:K02183]
129513685  calmodulin-like protein 3 [KO:K02183]
129513765  CALML5; calmodulin-like protein 5 [KO:K02183]
129523448  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129509604  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129521210  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
129495049  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
129511439  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
129503119  BAD; bcl2-associated agonist of cell death [KO:K02158]
129506047  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
129508172  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
129503100  FADD; FAS-associated death domain protein [KO:K02373]
129523021  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
129503380  BID; BH3-interacting domain death agonist [KO:K04726]
129501028  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
129513046  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
129505565  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 [KO:K08844] [EC:2.7.11.1]
129501268  HTRA2; serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
129519297  TRAP1; heat shock protein 75 kDa, mitochondrial [KO:K09488]
129509516  VDAC2; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2 [KO:K15040]
129516170  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
129503580  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
129504390  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
129517475  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
129518875  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
129509841  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
129502969  cytochrome c [KO:K08738]
129506647  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
129515281  cytochrome c-like [KO:K08738]
129518214  cytochrome c-like [KO:K08738]
129516890  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
129513406  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
129503548  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
129519702  HIP1; huntingtin-interacting protein 1 isoform X1 [KO:K04559]
129503930  IFT57; intraflagellar transport protein 57 homolog [KO:K04638]
129518320  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
129516976  PPID; peptidyl-prolyl cis-trans isomerase D isoform X1 [KO:K05864] [EC:5.2.1.8]
129497193  PARK7; Parkinson disease protein 7 [KO:K05687] [EC:3.5.1.124]
129496481  BCL2L1; bcl-2-like protein 1 [KO:K04570]
129498347  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
129513732  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
129513763  OPTN; optineurin [KO:K19946]
129494502  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
129509010  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
129495106  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
129497511  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
129511757  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
129498574  TANK; TRAF family member-associated NF-kappa-B activator [KO:K12650]
129521055  WDR41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
129497260  SMCR8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
129495165  C9orf72; guanine nucleotide exchange factor C9orf72 homolog isoform X1 [KO:K23609]
129521621  RAB8A; ras-related protein Rab-8A [KO:K07901]
129517524  RAB39B; ras-related protein Rab-39B [KO:K07925]
129511355  RAB1A; ras-related protein Rab-1A [KO:K07874]
129513263  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
129507807  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
129497023  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
129517423  ATG101; autophagy-related protein 101 [KO:K19730]
129501354  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
129505276  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
129500433  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
129509009  BECN2; beclin-2 [KO:K08334]
129506607  BECN1; beclin-1 isoform X1 [KO:K08334]
129506936  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
129495994  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
129499216  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
129508763  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
129501816  ATG2A; autophagy-related protein 2 homolog A [KO:K17906]
129496179  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
129516094  LOW QUALITY PROTEIN: WD repeat domain phosphoinositide-interacting protein 2-like [KO:K17908]
129519616  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
129514227  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
129496269  ZFYVE1; zinc finger FYVE domain-containing protein 1 [KO:K17603]
129522822  ALS2; LOW QUALITY PROTEIN: alsin [KO:K04575]
129507132  RAB5A; ras-related protein Rab-5A [KO:K07887]
129519689  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
129502478  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
129512703  FIG4; polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
129504250  SPG11; spatacsin isoform X1 [KO:K19026]
129512779  TNF; tumor necrosis factor [KO:K03156]
129503428  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
129513994  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
129512302  DAXX; death domain-associated protein 6 [KO:K02308]
129497110  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
129508745  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
129511619  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
129511620  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
129512956  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
129512957  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
129508386  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
129500310  CCS; copper chaperone for superoxide dismutase [KO:K04569]
129508190  probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
129508203  GPX5; epididymal secretory glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
129508204  GPX6; glutathione peroxidase 6 [KO:K00432] [EC:1.11.1.9]
129496116  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
129509536  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
129520931  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
129521353  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
129514251  GPX8; probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
129494202  CAT; catalase [KO:K03781] [EC:1.11.1.6]
129517340  PRPH; peripherin isoform X1 [KO:K07607]
129493667  NEFL; neurofilament light polypeptide [KO:K04572]
129523247  NEFM; neurofilament medium polypeptide isoform X1 [KO:K04573]
129508034  NEFH; neurofilament heavy polypeptide [KO:K04574]
129495533  kinesin heavy chain isoform X1 [KO:K10396]
129515585  KIF5B; kinesin-1 heavy chain [KO:K10396]
129511795  KIF5A; LOW QUALITY PROTEIN: kinesin heavy chain [KO:K10396]
129514572  kinesin heavy chain isoform X1 [KO:K10396]
129501185  KLC2; kinesin light chain 2 [KO:K10407]
129496051  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
129500514  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
129512815  KLC4; kinesin light chain 4 [KO:K10407]
129508060  tubulin alpha-3 chain [KO:K07374]
129503404  TUBA8; tubulin alpha-8 chain [KO:K07374]
129505966  tubulin alpha-8 chain [KO:K07374]
129506205  tubulin alpha-1A chain-like [KO:K07374]
129507883  tubulin alpha-3 chain isoform X1 [KO:K07374]
129522834  TUBA4A; tubulin alpha-4A chain [KO:K07374]
129522967  tubulin alpha-1B chain-like [KO:K07374]
129517335  tubulin alpha-1B chain [KO:K07374]
129517394  tubulin alpha-1A chain [KO:K07374]
129517395  tubulin alpha-1C chain [KO:K07374]
129514115  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
129508836  TUBB8B; LOW QUALITY PROTEIN: tubulin beta 8B [KO:K07375]
129509114  TUBB6; tubulin beta-6 chain [KO:K07375]
129495197  TUBB1; tubulin beta-1 chain [KO:K07375]
129497915  TUBB3; tubulin beta-3 chain [KO:K07375]
129507825  TUBB2A; tubulin beta-2A chain [KO:K07375]
129507900  tubulin beta-2B chain [KO:K07375]
129512560  TUBB; tubulin beta chain [KO:K07375]
129521506  TUBB4A; tubulin beta-4A chain [KO:K07375]
129514811  TUBB4B; tubulin beta-4B chain isoform X1 [KO:K07375]
129503652  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
129494272  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
129509341  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
129513503  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
129512954  CSNK2B; casein kinase II subunit beta [KO:K03115]
129504949  BDNF; brain-derived neurotrophic factor [KO:K04355]
129501334  DCTN1; LOW QUALITY PROTEIN: dynactin subunit 1 [KO:K04648]
129511766  LOW QUALITY PROTEIN: dynactin subunit 2-like [KO:K10424]
129511805  DCTN2; dynactin subunit 2 [KO:K10424]
129495297  DCTN3; dynactin subunit 3 [KO:K10425]
129509443  DCTN4; dynactin subunit 4 [KO:K10426]
129519972  DCTN5; dynactin subunit 5 [KO:K10427]
129516017  DCTN6; dynactin subunit 6 [KO:K10428]
129512918  dynactin subunit 6-like [KO:K10428]
129523290  ACTR1A; alpha-centractin [KO:K16575]
129512045  ACTR1B; beta-centractin isoform X1 [KO:K16575]
129496001  ACTR10; actin-related protein 10 [KO:K16576]
129517653  HAP1; huntingtin-associated protein 1 isoform X1 [KO:K04647]
129501366  DNAH6; dynein axonemal heavy chain 6 [KO:K10408]
129509026  DNAH14; LOW QUALITY PROTEIN: dynein axonemal heavy chain 14 [KO:K10408]
129502879  DNAH11; dynein axonemal heavy chain 11 [KO:K10408]
129497097  DNAH2; dynein axonemal heavy chain 2 [KO:K10408]
129497853  DNAH9; dynein axonemal heavy chain 9 [KO:K10408]
129498902  DNAH5; dynein axonemal heavy chain 5 [KO:K10408]
129507676  DNAH10; dynein axonemal heavy chain 10 isoform X1 [KO:K10408]
129515219  DNAH17; dynein axonemal heavy chain 17 [KO:K10408]
129522675  DNAH7; LOW QUALITY PROTEIN: dynein axonemal heavy chain 7 [KO:K10408]
129519495  DNAH3; LOW QUALITY PROTEIN: dynein axonemal heavy chain 3 [KO:K10408]
129512720  DNAH8; dynein axonemal heavy chain 8 [KO:K10408]
129521813  DNAH1; dynein axonemal heavy chain 1 [KO:K10408]
129522026  DNAH12; dynein axonemal heavy chain 12 [KO:K10408]
129520731  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
129494571  DNAI1; dynein axonemal intermediate chain 1 [KO:K10409]
129511829  DNAI2; dynein axonemal intermediate chain 2 [KO:K11143]
129496027  DNAL1; dynein axonemal light chain 1 [KO:K10411]
129512076  DNAL4; dynein axonemal light chain 4 [KO:K10412]
129515997  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
129509461  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
129509507  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
129521159  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
129503235  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
129509084  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
129497386  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
129515944  CDK5; cyclin-dependent kinase 5 [KO:K02090] [EC:2.7.11.22]
129493702  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
129508026  DKK1; dickkopf-related protein 1 [KO:K02165]
129515626  DKK4; dickkopf-related protein 4 [KO:K02165]
129521193  DKK2; dickkopf-related protein 2 [KO:K02165]
129517408  WNT1; proto-oncogene Wnt-1 [KO:K03209]
129501220  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
129502893  WNT2; protein Wnt-2 [KO:K00182]
129506798  WNT3; LOW QUALITY PROTEIN: proto-oncogene Wnt-3 [KO:K00312]
129515047  WNT3A; protein Wnt-3a [KO:K00312]
129513678  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
129503341  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
129521805  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
129523023  WNT6; protein Wnt-6 [KO:K00445]
129511925  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
129521980  WNT7A; protein Wnt-7a [KO:K00572]
129494611  WNT8A; protein Wnt-8a [KO:K00714]
129493561  WNT8B; protein Wnt-8b [KO:K00714]
129500703  WNT9B; protein Wnt-9b [KO:K01064]
129514999  WNT9A; protein Wnt-9a [KO:K01064]
129522994  WNT10A; protein Wnt-10a [KO:K01357]
129517200  WNT10B; protein Wnt-10b [KO:K01357]
129506696  WNT11; protein Wnt-11 [KO:K01384]
129502963  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
129498263  FZD1; frizzled-1 [KO:K02432]
129522877  FZD7; frizzled-7 isoform X1 [KO:K02432]
129510346  FZD2; frizzled-2 [KO:K02235]
129493707  FZD3; frizzled-3 [KO:K02329]
129506743  FZD4; frizzled-4 [KO:K02354]
129499073  FZD8; frizzled-8 [KO:K02375]
129522741  FZD5; LOW QUALITY PROTEIN: frizzled-5 [KO:K02375]
129495713  FZD6; frizzled-6 isoform X1 [KO:K02376]
129508175  FZD10; frizzled-10 [KO:K02842]
129519529  FZD9; frizzled-9 [KO:K02842]
129500698  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
129517122  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
129511452  CSNK1E; casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
129496981  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
129497764  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
129498669  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
129523328  proto-oncogene FRAT1-like [KO:K03069]
129523327  LOW QUALITY PROTEIN: GSK-3-binding protein FRAT2-like [KO:K03096]
129519365  AXIN1; axin-1 isoform X1 [KO:K02157]
129507164  AXIN2; axin-2 isoform X1 [KO:K04385]
129519526  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
129521503  APC2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
129506984  CTNNB1; catenin beta-1 [KO:K02105]
129509530  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
129512915  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
129494224  HRAS; GTPase HRas isoform X1 [KO:K02833]
129505561  KRAS; GTPase KRas isoform X1 [KO:K07827]
129501466  NRAS; GTPase NRas [KO:K07828]
129518309  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
129515848  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
129522592  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
129506345  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
129522322  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
129502349  mitogen-activated protein kinase 3-like [KO:K04371] [EC:2.7.11.24]
129507918  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129519082  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129518564  NOX1; NADPH oxidase 1 [KO:K08008]
129517451  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
129506780  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
129503049  RELA; transcription factor p65 isoform X1 [KO:K04735]
129521190  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
129515870  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
129505764  PTGS2; prostaglandin G/H synthase 2 isoform X1 [KO:K11987] [EC:1.14.99.1]
129502880  IL6; interleukin-6 [KO:K05405]
129510729  IL1A; interleukin-1 alpha [KO:K04383]
129510730  IL1B; interleukin-1 beta [KO:K04519]
129519645  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
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Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
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Nat Neurosci 21:1300-1309 (2018)
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Reference
PMID:28062563
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Dugger BN, Dickson DW
  Title
Pathology of Neurodegenerative Diseases.
  Journal
Cold Spring Harb Perspect Biol 9:a028035 (2017)
DOI:10.1101/cshperspect.a028035
Reference
PMID:20070435
  Authors
Jellinger KA
  Title
Basic mechanisms of neurodegeneration: a critical update.
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J Cell Mol Med 14:457-87 (2010)
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Reference
PMID:19707851
  Authors
Jellinger KA
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Recent advances in our understanding of neurodegeneration.
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J Neural Transm (Vienna) 116:1111-62 (2009)
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Reference
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Int J Mol Sci 20:E719 (2019)
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PMID:15272267
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Protein aggregation and neurodegenerative disease.
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Nat Med 10 Suppl:S10-7 (2004)
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  Title
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.
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Nat Neurosci 21:1332-1340 (2018)
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  Authors
Dantuma NP, Bott LC
  Title
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution.
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Front Mol Neurosci 7:70 (2014)
DOI:10.3389/fnmol.2014.00070
Reference
PMID:25413678
  Authors
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  Title
Failure of ubiquitin proteasome system: risk for neurodegenerative diseases.
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Neurodegener Dis 14:161-75 (2014)
DOI:10.1159/000367694
Reference
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  Authors
Park H, Kang JH, Lee S
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Int J Mol Sci 21:E3369 (2020)
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Reference
PMID:31783880
  Authors
Malik BR, Maddison DC, Smith GA, Peters OM
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Autophagic and endo-lysosomal dysfunction in neurodegenerative disease.
  Journal
Mol Brain 12:100 (2019)
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Reference
PMID:29734735
  Authors
Metaxakis A, Ploumi C, Tavernarakis N
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Autophagy in Age-Associated Neurodegeneration.
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Cells 7:E37 (2018)
DOI:10.3390/cells7050037
Reference
PMID:25270767
  Authors
Vidal RL, Matus S, Bargsted L, Hetz C
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Targeting autophagy in neurodegenerative diseases.
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Trends Pharmacol Sci 35:583-91 (2014)
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Reference
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  Title
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.
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Neuron 93:1015-1034 (2017)
DOI:10.1016/j.neuron.2017.01.022
Reference
PMID:30030024
  Authors
Chu CT
  Title
Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases.
  Journal
Neurobiol Dis 122:23-34 (2019)
DOI:10.1016/j.nbd.2018.07.015
Reference
PMID:19043451
  Authors
Kim I, Xu W, Reed JC
  Title
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities.
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Nat Rev Drug Discov 7:1013-30 (2008)
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Reference
PMID:21722302
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Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
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J Cell Mol Med 15:2025-39 (2011)
DOI:10.1111/j.1582-4934.2011.01374.x
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Fine-tuning PERK signaling for neuroprotection.
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J Neurochem 142:812-826 (2017)
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Reference
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Axonal transport deficits and neurodegenerative diseases.
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Axonal transport and neurological disease.
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Retrograde axonal transport: pathways to cell death?
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Related
pathway
npo00190  Oxidative phosphorylation
npo03050  Proteasome
npo04020  Calcium signaling pathway
npo04120  Ubiquitin mediated proteolysis
npo04137  Mitophagy - animal
npo04140  Autophagy - animal
npo04141  Protein processing in endoplasmic reticulum
npo04142  Lysosome
npo04210  Apoptosis
npo04310  Wnt signaling pathway
npo04724  Glutamatergic synapse
npo04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   
LinkDB

DBGET integrated database retrieval system