PATHWAY: omc04010 Help
Entry
Name
MAPK signaling pathway - Onychostoma macrolepis
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Onychostoma macrolepis [GN:
omc ]
Gene
131549851 cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b isoform X1 [KO:K04344 ]
131538013 cacna1aa; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344 ]
131540658 cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a isoform X1 [KO:K04849 ]
131529438 cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849 ]
131538945 cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850 ]
131549742 cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851 ]
131546233 cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851 ]
131525642 cacna1eb; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852 ]
131545740 probable voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852 ]
131546303 cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853 ]
131546383 cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853 ]
131550723 cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854 ]
131536840 cacna1ha; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855 ]
131542155 voltage-dependent T-type calcium channel subunit alpha-1I-like isoform X1 [KO:K04856 ]
131535921 cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856 ]
131531222 cacna1sa; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, L type, alpha 1S subunit, a [KO:K04857 ]
131545431 cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857 ]
131524152 voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858 ]
131538580 cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a [KO:K04858 ]
131530733 cacna2d2b; voltage-dependent calcium channel subunit alpha-2/delta-2b isoform X1 [KO:K04859 ]
131541863 cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859 ]
131549743 cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860 ]
131546144 cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860 ]
131534182 cacna2d4b; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861 ]
131538522 cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861 ]
131536337 cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862 ]
131544229 cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863 ]
131531922 cacnb3b; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864 ]
131532216 cacnb3a; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-3a [KO:K04864 ]
131547319 cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a [KO:K04865 ]
131542555 cacnb4b; voltage-dependent L-type calcium channel subunit beta-4b isoform X1 [KO:K04865 ]
131542966 cacng1a; calcium channel, voltage-dependent, gamma subunit 1a [KO:K04866 ]
131537820 cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866 ]
131543041 cacng2b; calcium channel, voltage-dependent, gamma subunit 2b [KO:K04867 ]
131538104 cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867 ]
131543370 cacng3a; voltage-dependent calcium channel gamma-3 subunit [KO:K04868 ]
131538056 cacng3b; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868 ]
131542965 cacng4a; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-4 subunit [KO:K04869 ]
131536998 cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869 ]
131542553 cacng5a; calcium channel, voltage-dependent, gamma subunit 5a [KO:K04870 ]
131535945 cacng5b; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870 ]
131525937 cacng6a; calcium channel, voltage-dependent, gamma subunit 6a [KO:K04871 ]
131525167 cacng7a; calcium channel, voltage-dependent, gamma subunit 7a [KO:K04872 ]
131521207 cacng7b; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872 ]
131525834 cacng8a; calcium channel, voltage-dependent, gamma subunit 8a [KO:K04873 ]
131521585 cacng8b; voltage-dependent calcium channel gamma-4 subunit isoform X1 [KO:K04873 ]
131536154 prkacaa; LOW QUALITY PROTEIN: protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a [KO:K04345 ] [EC:2.7.11.11 ]
131537052 gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346 ]
131542622 gng12b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
131550767 gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a [KO:K04347 ]
131528958 ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
131553469 ppp3cb; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348 ] [EC:3.1.3.16 ]
131524536 rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349 ]
131540942 rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326 ]
131548776 rasgrf2a; LOW QUALITY PROTEIN: ras-specific guanine nucleotide-releasing factor 2 [KO:K12326 ]
131538485 rapgef2a; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018 ]
131552986 rapgef2b; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018 ]
131553762 fgf1a; putative fibroblast growth factor 1 isoform X1 [KO:K18496 ]
131553575 fgf20b; LOW QUALITY PROTEIN: fibroblast growth factor 20b [KO:K04358 ]
131540358 fgf5; LOW QUALITY PROTEIN: fibroblast growth factor 5 [KO:K04358 ]
131538005 pdgfab; platelet-derived growth factor alpha polypeptide b isoform X1 [KO:K04359 ]
131530560 pdgfaa; platelet-derived growth factor alpha polypeptide a isoform X1 [KO:K04359 ]
131531329 pdgfba; platelet-derived growth factor beta polypeptide a [KO:K17386 ]
131549842 csf1a; macrophage colony-stimulating factor 1a isoform X1 [KO:K05453 ]
131538292 vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448 ]
131522141 vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448 ]
131549034 vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449 ]
131549071 vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449 ]
131548758 gdnfa; LOW QUALITY PROTEIN: glial cell line-derived neurotrophic factor [KO:K05452 ]
131536243 ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
131521472 nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
131549289 mknk1; LOW QUALITY PROTEIN: MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372 ] [EC:2.7.11.1 ]
131542936 atf4a; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374 ]
131526674 fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379 ]
131525460 tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156 ]
131528700 tgfb1b; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375 ]
131523556 tgfb3; LOW QUALITY PROTEIN: transforming growth factor beta-3 proprotein [KO:K13377 ]
131521555 tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
131527369 faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
131549282 cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
131544350 tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
131533057 myd88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
131542074 gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402 ]
131524512 gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402 ]
131524878 gadd45bb; growth arrest and DNA-damage-inducible, beta b [KO:K04402 ]
131549350 gadd45ba; growth arrest and DNA-damage-inducible, beta a [KO:K04402 ]
131528161 gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402 ]
131545764 gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402 ]
131541848 tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
131526712 tab2; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
131543764 ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405 ]
131553041 si:zfos-2326c3.2; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407 ] [EC:2.7.11.1 ]
131550610 map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430 ] [EC:2.7.12.2 ]
131537043 map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430 ] [EC:2.7.12.2 ]
131534954 mapk8ip1a; C-Jun-amino-terminal kinase-interacting protein 1a [KO:K04434 ]
131544133 mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434 ]
131524731 mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435 ]
131537454 mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436 ]
131526084 nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
131534292 nfatc3b; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333 ]
131544966 nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
131540839 june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448 ]
131546731 atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450 ]
131554100 hspa8b; LOW QUALITY PROTEIN: heat shock protein family A (Hsp70) member 8b [KO:K03283 ]
131544102 map2k5; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463 ] [EC:2.7.12.2 ]
131532651 nr4a1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465 ]
131553086 nfkb1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580 ]
131551829 nuclear factor NF-kappa-B p100 subunit-like isoform X1 [KO:K04469 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference
Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
Title
MAP kinases.
Journal
Reference
Authors
Tanoue T, Nishida E.
Title
Docking interactions in the mitogen-activated protein kinase cascades.
Journal
Reference
Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
Title
MAPK pathways in radiation responses.
Journal
Reference
Authors
Huang EJ, Reichardt LF.
Title
Trk receptors: roles in neuronal signal transduction.
Journal
Reference
Authors
Harper SJ, LoGrasso P.
Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
Journal
Reference
Authors
Takeda K, Ichijo H
Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
Journal
Reference
Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
Title
Transcriptional regulation by the MAP kinase signaling cascades.
Journal
Reference
Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
Journal
Reference
Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
Journal
Reference
Authors
Lemmon MA, Schlessinger J
Title
Cell signaling by receptor tyrosine kinases.
Journal
Reference
Authors
Skaper SD
Title
The neurotrophin family of neurotrophic factors: an overview.
Journal
Reference
Authors
Chu WM
Title
Tumor necrosis factor.
Journal
Reference
Authors
Newton K, Dixit VM
Title
Signaling in innate immunity and inflammation.
Journal
Reference
Authors
Gaestel M, Kotlyarov A, Kracht M
Title
Targeting innate immunity protein kinase signalling in inflammation.
Journal
Reference
Authors
Ajibade AA, Wang HY, Wang RF
Title
Cell type-specific function of TAK1 in innate immune signaling.
Journal
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Related pathway
omc04070 Phosphatidylinositol signaling system
KO pathway
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