KEGG   PATHWAY: pcad04014
Entry
pcad04014                   Pathway                                
Name
Ras signaling pathway - Physeter catodon (sperm whale)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
pcad04014  Ras signaling pathway
pcad04014

Other DBs
GO: 0032318
Organism
Physeter catodon (sperm whale) [GN:pcad]
Gene
102977431  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102973542  TGFA; protransforming growth factor alpha isoform X4 [KO:K08774]
102979009  FGF1; fibroblast growth factor 1 isoform X2 [KO:K18496]
102989017  FGF2; fibroblast growth factor 2 [KO:K18497]
112067418  FGF4; fibroblast growth factor 4 [KO:K04358]
102974068  FGF3; fibroblast growth factor 3 [KO:K04358]
102994154  FGF7; fibroblast growth factor 7 [KO:K04358]
102992556  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102976992  FGF10; fibroblast growth factor 10 [KO:K04358]
102990012  FGF9; fibroblast growth factor 9 [KO:K04358]
102993417  FGF18; fibroblast growth factor 18 [KO:K04358]
102974802  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
102982984  FGF5; fibroblast growth factor 5 [KO:K04358]
102985937  FGF16; fibroblast growth factor 16 [KO:K04358]
102981134  FGF6; fibroblast growth factor 6 [KO:K04358]
102992726  FGF20; fibroblast growth factor 20 [KO:K04358]
102974372  FGF19; fibroblast growth factor 19 [KO:K22603]
102973747  FGF21; fibroblast growth factor 21 isoform X2 [KO:K22429]
102991966  FGF23; fibroblast growth factor 23 [KO:K22428]
102988669  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
102977934  BDNF; brain-derived neurotrophic factor isoform X6 [KO:K04355]
102991161  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
102978016  potassium voltage-gated channel subfamily A member 7 isoform X2 [KO:K12457]
112062628  INS; insulin [KO:K04526]
102990550  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
102973168  IGF2; insulin-like growth factor II [KO:K13769]
102989848  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
102982885  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102985889  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102995661  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102974293  CSF1; macrophage colony-stimulating factor 1 isoform X5 [KO:K05453]
102973751  KITLG; kit ligand isoform X1 [KO:K05461]
102983555  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X3 [KO:K05454]
102981739  VEGFA; vascular endothelial growth factor A isoform X7 [KO:K05448]
102978151  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
102979244  PGF; placenta growth factor isoform X1 [KO:K16859]
102980523  VEGFD; vascular endothelial growth factor D [KO:K05449]
102989984  VEGFC; vascular endothelial growth factor C isoform X2 [KO:K05449]
102992196  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
102995371  ANGPT1; angiopoietin-1 [KO:K05465]
102977369  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
102974176  ANGPT4; angiopoietin-4 [KO:K05467]
102994898  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
102996270  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
102989372  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
102974882  EFNA2; ephrin-A2 [KO:K05462]
102989089  EFNA1; ephrin-A1 isoform X2 [KO:K05462]
102975467  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
102989551  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
102982044  FGFR2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
102982240  FGFR3; fibroblast growth factor receptor 3 isoform X4 [KO:K05094] [EC:2.7.10.1]
114483863  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102984762  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102990275  NTRK1; high affinity nerve growth factor receptor isoform X2 [KO:K03176] [EC:2.7.10.1]
102987032  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
102977826  IGF1R; insulin-like growth factor 1 receptor isoform X3 [KO:K05087] [EC:2.7.10.1]
102994349  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102995915  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
102996862  macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102985479  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
102989448  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
102986927  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
102988868  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
102986785  KDR; vascular endothelial growth factor receptor 2 isoform X5 [KO:K05098] [EC:2.7.10.1]
102987522  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
102994335  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
102996744  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
114483947  growth factor receptor-bound protein 2 [KO:K04364]
102991751  GAB1; GRB2-associated-binding protein 1 isoform X3 [KO:K09593]
102984031  GAB2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
102991486  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
102974315  SHC2; SHC-transforming protein 2 [KO:K17447]
102977456  SHC3; SHC-transforming protein 3 [KO:K17448]
102988652  SHC4; SHC-transforming protein 4 isoform X2 [KO:K17449]
102979922  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
102987506  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
102991639  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102981677  LOW QUALITY PROTEIN: son of sevenless homolog 2-like [KO:K03099]
102978925  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
102992700  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
102983230  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
102981768  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
102990537  RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
102983100  RASGRP3; ras guanyl-releasing protein 3 isoform X2 [KO:K12362]
102996298  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
102996375  tyrosine-protein kinase ZAP-70 isoform X1 [KO:K07360] [EC:2.7.10.2]
102977886  LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
102995847  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
102986172  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
102975750  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
102982318  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
102990164  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
102995518  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
102981323  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2 [KO:K07826]
102975548  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
102976421  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
112063837  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
112062012  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
112064782  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
112067655  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
112067178  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
102985729  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
102994418  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
112063854  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102976485  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
112066479  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
112066563  GNGT2; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
102981091  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102995361  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
114487158  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
102974530  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
102979832  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
102987558  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
102992015  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
102976671  CALM1; calmodulin-1 [KO:K02183]
102988232  calmodulin-alpha [KO:K02183]
102996886  calmodulin-1-like [KO:K02183]
102993731  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
102988309  CALM3; calmodulin-3 [KO:K02183]
102977506  uncharacterized protein LOC102977506 [KO:K02183]
129392645  neo-calmodulin-like [KO:K02183]
102994715  HRAS; GTPase HRas isoform X2 [KO:K02833]
102977125  KRAS; GTPase KRas isoform X1 [KO:K07827]
102992439  LOW QUALITY PROTEIN: GTPase NRas-like [KO:K07828]
102982641  NRAS; LOW QUALITY PROTEIN: GTPase NRas [KO:K07828]
102974392  MRAS; ras-related protein M-Ras [KO:K07831]
102986000  RRAS; ras-related protein R-Ras [KO:K07829]
102980435  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
102984429  NF1; neurofibromin isoform X3 [KO:K08052]
102991867  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
102987293  RASA2; ras GTPase-activating protein 2 isoform X4 [KO:K08053]
102979451  RASA3; ras GTPase-activating protein 3 isoform X1 [KO:K12380]
102982481  ras GTPase-activating protein 4 isoform X1 [KO:K17630]
102989823  SYNGAP1; ras/Rap GTPase-activating protein SynGAP isoform X1 [KO:K17631]
102973712  RASAL1; rasGAP-activating-like protein 1 isoform X1 [KO:K17632]
102975123  RASAL2; ras GTPase-activating protein nGAP isoform X3 [KO:K17633]
102976271  RASAL3; RAS protein activator like-3 [KO:K17634]
102994734  RASSF1; ras association domain-containing protein 1 isoform X2 [KO:K09850]
102995774  RASSF5; ras association domain-containing protein 5 [KO:K08015]
102979937  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
102980632  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X2 [KO:K05731]
102979195  rho-related BTB domain-containing protein 2 [KO:K04392]
102990276  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
102990552  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
102992553  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
102992923  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102978005  LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
102985262  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
102978462  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
102974221  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
102996458  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
102985349  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
102983639  RHOA; transforming protein RhoA [KO:K04513]
102986098  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102978952  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102977108  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102975555  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102991779  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102991192  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
102981524  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102976971  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
102990087  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114485485  NF-kappa-B essential modulator-like isoform X1 [KO:K07210]
102980964  IKBKG; NF-kappa-B essential modulator [KO:K07210]
102977668  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2 [KO:K04467] [EC:2.7.11.10]
102976706  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102981135  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102974198  RELA; transcription factor p65 isoform X1 [KO:K04735]
102974655  BAD; bcl2-associated agonist of cell death [KO:K02158]
102980439  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
102980189  FOXO4; forkhead box protein O4 [KO:K12358]
102979864  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102985922  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X2 [KO:K25768]
102986585  RALGAPA2; ral GTPase-activating protein subunit alpha-2 isoform X4 [KO:K25768]
102996602  RALGAPB; ral GTPase-activating protein subunit beta isoform X3 [KO:K25769]
102992808  RALGDS; ral guanine nucleotide dissociation stimulator isoform X8 [KO:K08732]
102973859  RGL1; ral guanine nucleotide dissociation stimulator-like 1 [KO:K17635]
102995275  LOW QUALITY PROTEIN: ral guanine nucleotide dissociation stimulator-like 2 [KO:K17636]
112064357  RGL2; ral guanine nucleotide dissociation stimulator-like 2 isoform X1 [KO:K17636]
102987577  RALA; ras-related protein Ral-A [KO:K07834]
102979041  RALB; ras-related protein Ral-B [KO:K07835]
102978946  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
102986218  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
102982546  EXOC2; exocyst complex component 2 isoform X1 [KO:K17637]
102994775  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
102975426  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
102996353  MAPK8; mitogen-activated protein kinase 8 isoform X3 [KO:K04440] [EC:2.7.11.24]
102977417  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102984741  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102994813  RALBP1; ralA-binding protein 1 [KO:K08773]
102975958  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102990362  AFDN; afadin isoform X6 [KO:K05702]
102991979  SHOC2; leucine-rich repeat protein SHOC-2 isoform X1 [KO:K19613]
102987866  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
102992191  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102994150  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102984305  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102989074  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102974952  ADPRH; ADP-ribosylarginine hydrolase isoform X4 [KO:K13618] [EC:3.1.1.111]
102981090  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102974314  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102989306  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102989577  PLA2G2F; LOW QUALITY PROTEIN: group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102973811  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102988713  PLA2G5; phospholipase A2 group V isoform X2 [KO:K01047] [EC:3.1.1.4]
102989842  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102989284  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102994568  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
102977405  group IIE secretory phospholipase A2 isoform X2 [KO:K01047] [EC:3.1.1.4]
102985111  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
102984239  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X2 [KO:K16342] [EC:3.1.1.4]
102983188  PLA2G4D; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
102983681  PLA2G4F; LOW QUALITY PROTEIN: cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
102988839  phospholipase A and acyltransferase 3 isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
102976778  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
102976139  ETS1; protein C-ets-1 [KO:K02678]
102982538  ETS2; protein C-ets-2 isoform X1 [KO:K21932]
102991621  BRAP; BRCA1-associated protein isoform X1 [KO:K10632] [EC:2.3.2.27]
102989994  KSR1; kinase suppressor of Ras 1 [KO:K14958]
102979685  KSR2; kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
102980427  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X2 [KO:K08019]
102985661  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
102980344  RAP1B; ras-related protein Rap-1b [KO:K07836]
102989853  LOW QUALITY PROTEIN: ras-related protein Rap-1b-like [KO:K07836]
102989081  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2 [KO:K05860] [EC:3.1.4.11]
102974888  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102974383  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102983841  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102985149  RIN1; ras and Rab interactor 1 isoform X1 [KO:K17638]
102988541  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
102992173  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
102984481  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
102973277  RAB5B; ras-related protein Rab-5B [KO:K07888]
102984866  RAB5C; ras-related protein Rab-5C [KO:K07889]
112067148  ADP-ribosylation factor 6 isoform X2 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
pcad04010  MAPK signaling pathway
pcad04015  Rap1 signaling pathway
pcad04020  Calcium signaling pathway
pcad04144  Endocytosis
pcad04151  PI3K-Akt signaling pathway
pcad04660  T cell receptor signaling pathway
pcad04720  Long-term potentiation
pcad04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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