KEGG   PATHWAY: pcoq04151
Entry
pcoq04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Propithecus coquereli (Coquerel's sifaka)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
pcoq04151  PI3K-Akt signaling pathway
pcoq04151

Other DBs
GO: 0043491
Organism
Propithecus coquereli (Coquerel's sifaka) [GN:pcoq]
Gene
105818935  EGF; pro-epidermal growth factor [KO:K04357]
105812073  TGFA; protransforming growth factor alpha [KO:K08774]
105822822  EREG; proepiregulin [KO:K09784]
105822819  AREG; amphiregulin [KO:K09782]
105811549  FGF1; fibroblast growth factor 1 [KO:K18496]
105815256  FGF2; fibroblast growth factor 2 [KO:K18497]
105824289  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
105825247  FGF20; fibroblast growth factor 20 [KO:K04358]
105825272  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105826180  FGF16; fibroblast growth factor 16 [KO:K04358]
105826735  FGF10; fibroblast growth factor 10 [KO:K04358]
105826776  FGF3; fibroblast growth factor 3 [KO:K04358]
105827331  FGF4; fibroblast growth factor 4 [KO:K04358]
105822621  fibroblast growth factor 6 [KO:K04358]
105808133  FGF9; fibroblast growth factor 9 [KO:K04358]
105814474  FGF7; fibroblast growth factor 7 [KO:K04358]
105814653  FGF18; fibroblast growth factor 18 [KO:K04358]
105805030  fibroblast growth factor 6-like [KO:K04358]
105811295  FGF22; fibroblast growth factor 22 [KO:K04358]
105827330  FGF19; fibroblast growth factor 19 [KO:K22603]
105809321  FGF21; fibroblast growth factor 21 [KO:K22429]
105822617  FGF23; fibroblast growth factor 23 [KO:K22428]
105810582  NGF; beta-nerve growth factor [KO:K02582]
105814556  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
105805058  NTF3; neurotrophin-3 [KO:K04356]
105809394  NTF4; neurotrophin-4 [KO:K12457]
105816531  INS; insulin [KO:K04526]
105815122  IGF1; insulin-like growth factor I [KO:K05459]
105816530  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
105806045  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
105805188  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
105822163  platelet-derived growth factor D [KO:K05450]
105822164  platelet-derived growth factor D-like [KO:K05450]
105817331  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
105825541  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
105815960  KITLG; kit ligand isoform X1 [KO:K05461]
105809290  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
105807498  VEGFA; vascular endothelial growth factor A [KO:K05448]
105827300  VEGFB; vascular endothelial growth factor B [KO:K16858]
105819783  PGF; placenta growth factor isoform X1 [KO:K16859]
105816267  VEGFC; vascular endothelial growth factor C [KO:K05449]
105805749  FIGF; vascular endothelial growth factor D [KO:K05449]
105811016  HGF; hepatocyte growth factor [KO:K05460]
105811166  ANGPT1; angiopoietin-1 [KO:K05465]
105811628  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
105827576  ANGPT4; angiopoietin-4 [KO:K05467]
105821936  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
105821937  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
105821975  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
105812813  EFNA5; ephrin-A5 [KO:K05462]
105811312  EFNA2; ephrin-A2 [KO:K05462]
105814712  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
105811902  NRTN; neurturin [KO:K25414]
105814060  ARTN; artemin isoform X1 [KO:K25415]
105811952  PSPN; persephin [KO:K25416]
105813943  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105824348  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105815912  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
105823921  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
105815854  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105808669  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
105826215  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105823513  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
105825293  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
105821881  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
105806839  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
105811840  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
105809892  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105807665  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105821582  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
105821583  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
105807681  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
105814785  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
105808489  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105823644  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
105807691  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
105817148  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
105812103  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
105824991  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
105818035  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
105824793  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105825853  SOS2; son of sevenless homolog 2 [KO:K03099]
105818006  SOS1; son of sevenless homolog 1 [KO:K03099]
105816561  HRAS; GTPase HRas isoform X1 [KO:K02833]
105807545  KRAS; GTPase KRas [KO:K07827]
105810591  NRAS; GTPase NRas [KO:K07828]
105819002  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105810783  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105811965  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105823104  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105810199  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105808835  IRS1; insulin receptor substrate 1 [KO:K16172]
105811134  TLR2; toll-like receptor 2 [KO:K10159]
105826455  TLR4; toll-like receptor 4 [KO:K10160]
105805988  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105825941  Ig heavy chain Mem5-like [KO:K06856]
105822769  uncharacterized protein LOC105822769 [KO:K06856]
105817784  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
105805962  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
105818489  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
105822566  somatotropin [KO:K05438]
105805714  PRL; prolactin [KO:K05439]
105821285  OSM; oncostatin-M [KO:K05418]
105815260  IL2; interleukin-2 [KO:K05429]
105822445  IL6; interleukin-6 [KO:K05405]
105816021  IL4; interleukin-4 isoform X1 [KO:K05430]
105825332  IL7; interleukin-7 isoform X1 [KO:K05431]
105827001  interferon alpha-5-like [KO:K05414]
105827006  IFNB1; interferon beta [KO:K05415]
105805971  EPO; erythropoietin isoform X1 [KO:K05437]
105824115  CSF3; granulocyte colony-stimulating factor [KO:K05423]
105826710  GHR; growth hormone receptor [KO:K05080]
105807202  PRLR; prolactin receptor isoform X1 [KO:K05081]
105814506  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
105826916  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
105805206  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
105809985  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
105820355  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
105821988  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
105810941  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
105814655  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
105820771  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
105820833  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
105807826  EPOR; erythropoietin receptor [KO:K05079]
105808649  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
105806352  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
105818130  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
105824021  COL1A1; collagen alpha-1(I) chain [KO:K06236]
105813090  COL1A2; collagen alpha-2(I) chain [KO:K06236]
105805556  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
105808741  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
105808765  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
105810615  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
105810725  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
105805127  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
105805131  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
105825462  collagen alpha-4(VI) chain-like [KO:K06238]
105825470  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
105825476  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
105813968  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
105817079  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
105817084  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
105818530  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
105812126  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
105812281  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
105823559  LAMA2; laminin subunit alpha-2 [KO:K05637]
105816588  LAMA1; laminin subunit alpha-1 [KO:K05637]
105818542  LAMA5; laminin subunit alpha-5 [KO:K06240]
105825024  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
105811010  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
105815196  LAMB1; laminin subunit beta-1 [KO:K05636]
105827311  LAMB2; laminin subunit beta-2 [KO:K06243]
105805467  LAMB3; laminin subunit beta-3 [KO:K06244]
105815168  LAMB4; laminin subunit beta-4 [KO:K06245]
105806763  LAMC1; laminin subunit gamma-1 [KO:K05635]
105806762  LAMC2; laminin subunit gamma-2 [KO:K06246]
105806551  LAMC3; laminin subunit gamma-3 [KO:K06247]
105824947  CHAD; chondroadherin [KO:K06248]
105815161  RELN; reelin [KO:K06249] [EC:3.4.21.-]
105814426  THBS1; thrombospondin-1 [KO:K16857]
105826536  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
105826784  THBS2; thrombospondin-2 [KO:K04659]
105821989  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
105818166  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
105816133  FN1; fibronectin [KO:K05717]
105812717  SPP1; osteopontin [KO:K06250]
105813545  VTN; vitronectin [KO:K06251]
105821100  TNN; tenascin-N [KO:K06252]
105827209  TNR; tenascin-R [KO:K06252]
105817841  TNXB; tenascin-X [KO:K06252]
105807739  TNC; tenascin isoform X1 [KO:K06252]
105805087  VWF; von Willebrand factor [KO:K03900]
105812683  IBSP; bone sialoprotein 2 [KO:K06253]
105819125  ITGA1; integrin alpha-1 [KO:K06480]
105819095  ITGA2; integrin alpha-2 [KO:K06481]
105822120  ITGA2B; integrin alpha-IIb [KO:K06476]
105824609  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
105815884  ITGA4; integrin alpha-4 [KO:K06483]
105816954  ITGA5; integrin alpha-5 [KO:K06484]
105815600  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
105817164  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
105823658  ITGA8; integrin alpha-8 [KO:K06584]
105827543  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
105809606  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
105826800  ITGA11; integrin alpha-11 [KO:K06587]
105825770  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
105808525  ITGB1; integrin beta-1 [KO:K05719]
105822640  integrin beta-3-like [KO:K06493]
105824713  ITGB4; integrin beta-4 [KO:K06525]
105808035  ITGB5; integrin beta-5 [KO:K06588]
105819557  ITGB6; integrin beta-6 [KO:K06589]
105817935  LOW QUALITY PROTEIN: integrin beta-7-like [KO:K06590]
105822435  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
105813423  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105824997  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105826540  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105806240  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105826612  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105818191  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105814042  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105826501  F2R; proteinase-activated receptor 1 [KO:K03914]
105827324  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
105809011  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
105807752  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
105818116  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
105823830  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
105826176  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
105805090  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
105813420  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
105820912  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
105806018  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
105805044  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
105806301  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
105821386  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105825893  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
105827172  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
105823098  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
105819816  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
105812945  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
105815179  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
105819419  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
105819482  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
105813132  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
105811307  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
105806302  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
105814830  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
105825484  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
105806636  TSC1; hamartin [KO:K07206]
105813061  TSC2; tuberin isoform X1 [KO:K07207]
105824616  RHEB; GTP-binding protein Rheb [KO:K07208]
105813066  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
105824883  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105826235  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
105815840  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
105822359  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
105822497  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
105807639  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
105827360  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
105813657  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
105816611  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
105827009  40S ribosomal protein S6 [KO:K02991]
105805907  40S ribosomal protein S6-like [KO:K02991]
105820421  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105807805  PKN1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
105823880  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
105806596  PKN3; serine/threonine-protein kinase N3 [KO:K23692] [EC:2.7.11.13]
105827188  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
105815943  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
105825431  serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
105820591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105812606  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105810397  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105805347  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
105815153  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
105822702  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105821748  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
105813802  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
105816012  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
105822194  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
105809563  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
105825276  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
105821415  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
105821578  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
105827094  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
105825709  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
105821244  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
105823611  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
105819900  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
105827459  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
105812602  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
105807462  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
105805455  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
105812585  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
105807468  HSP90AB1; heat shock protein HSP 90-beta isoform X1 [KO:K04079]
105808869  heat shock protein HSP 90-beta-like [KO:K04079]
105815124  HSP90B1; endoplasmin [KO:K09487]
105812820  hsp90 co-chaperone Cdc37 [KO:K09554]
105807832  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
105821908  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
105823306  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
105811153  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
105814955  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
105824213  MTCP1; protein p13 MTCP-1 [KO:K16837]
105824632  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
105806400  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
105807559  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
105809313  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
105820091  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
105812744  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
105820265  G6PC; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
105822129  G6PC3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
105815560  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
105811323  MYC; myc proto-oncogene protein [KO:K04377]
105827423  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
105812249  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
105819524  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
105817322  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
105816738  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
105820132  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
105822622  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
105807480  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
105812544  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
105809789  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
105815931  FOXO3; forkhead box protein O3 [KO:K09408]
105817052  RBL2; retinoblastoma-like protein 2 [KO:K16332]
105821114  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
105808300  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
105821252  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
105806742  YWHAQ; 14-3-3 protein theta [KO:K16197]
105809776  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
105817351  YWHAE; 14-3-3 protein epsilon [KO:K06630]
105823286  YWHAH; 14-3-3 protein eta [KO:K16198]
105807025  YWHAG; 14-3-3 protein gamma [KO:K16198]
105827296  BAD; bcl2-associated agonist of cell death [KO:K02158]
105814728  bcl-2-like protein 1 isoform X1 [KO:K04570]
105804942  BCL2L1; bcl-2-like protein 1 [KO:K04570]
105811149  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
105825008  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
105823945  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
105815570  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
105805232  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105820021  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
105821904  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
105811984  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
105809025  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
105811104  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
105807372  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
105817861  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
105821931  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
105822480  induced myeloid leukemia cell differentiation protein Mcl-1-like [KO:K02539]
105826705  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
105817898  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
105824538  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
105824261  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105819687  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105827383  RELA; transcription factor p65 isoform X1 [KO:K04735]
105819191  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105827164  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
105812777  E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
105819395  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
pcoq00010  Glycolysis / Gluconeogenesis
pcoq04010  MAPK signaling pathway
pcoq04012  ErbB signaling pathway
pcoq04062  Chemokine signaling pathway
pcoq04064  NF-kappa B signaling pathway
pcoq04068  FoxO signaling pathway
pcoq04110  Cell cycle
pcoq04115  p53 signaling pathway
pcoq04150  mTOR signaling pathway
pcoq04210  Apoptosis
pcoq04370  VEGF signaling pathway
pcoq04510  Focal adhesion
pcoq04620  Toll-like receptor signaling pathway
pcoq04630  JAK-STAT signaling pathway
pcoq04662  B cell receptor signaling pathway
pcoq04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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