KEGG   PATHWAY: ssc05010
Entry
ssc05010                    Pathway                                
Name
Alzheimer disease - Sus scrofa (pig)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
ssc05010  Alzheimer disease
ssc05010

Organism
Sus scrofa (pig) [GN:ssc]
Gene
397345  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 precursor [KO:K06704] [EC:3.4.24.81]
397343  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 precursor [KO:K06059] [EC:3.4.24.86]
397663  APP; amyloid beta A4 protein precursor [KO:K04520]
100623778  NAE1; NEDD8-activating enzyme E1 regulatory subunit [KO:K04532]
100519163  APBB1; amyloid beta A4 precursor protein-binding family B member 1 isoform X7 [KO:K04529]
396823  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
100511707  BACE1; beta-secretase 1 precursor [KO:K04521] [EC:3.4.23.46]
100517374  BACE2; beta-secretase 2 isoform X5 [KO:K07747] [EC:3.4.23.45]
100512087  RTN3; LOW QUALITY PROTEIN: reticulon-3 [KO:K20723]
100170118  RTN4; reticulon-4 [KO:K20720]
100518735  PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]
780411  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
780410  PSEN2; presenilin-2 [KO:K04522] [EC:3.4.23.-]
100156098  NCSTN; nicastrin isoform X1 [KO:K06171]
100154978  APH1A; gamma-secretase subunit APH-1A [KO:K06172]
100624829  APH1B; gamma-secretase subunit APH-1B isoform X1 [KO:K06172]
100155309  IDE; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
100511536  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
100738351  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
808501  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
808502  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
808508  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
808510  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
808509  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
808511  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
808512  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
100522783  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
100037991  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
100620809  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
100515069  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
100520950  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
100520312  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X2 [KO:K03947]
100156288  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
100579141  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
100525371  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
100157442  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
100517634  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
100154443  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
100524622  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
100521478  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
100312976  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
100514033  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
100518016  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
100622110  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
100739619  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
100513895  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
100525083  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 isoform X2 [KO:K03959]
100624335  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
100523751  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
733605  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
100737726  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
448979  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
100154130  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
100623873  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
100522775  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial isoform X2 [KO:K11351]
100516402  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
100156075  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
100510948  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
100516161  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
100514655  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
100520115  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
100624738  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X3 [KO:K03940] [EC:7.1.1.2]
100521945  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
100037985  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
100513030  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
780433  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
414412  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor [KO:K00235] [EC:1.3.5.1]
100524676  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
100048954  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
100522678  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
808513  CYTB; cytochrome b [KO:K00412]
100525869  cytochrome c1, heme protein, mitochondrial [KO:K00413]
100156879  cytochrome b-c1 complex subunit 1, mitochondrial isoform X4 [KO:K00414]
100524613  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
100524873  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
100157621  UQCRB; ubiquinol-cytochrome c reductase binding protein [KO:K00417]
100524308  cytochrome b-c1 complex subunit 8 [KO:K00418]
100155687  UQCR10; cytochrome b-c1 complex subunit 9 [KO:K00419]
100524239  cytochrome b-c1 complex subunit 10 [KO:K00420]
808507  COX3; cytochrome c oxidase subunit III [KO:K02262]
808503  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
808504  COX2; cytochrome c oxidase subunit II [KO:K02261]
100624067  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
110257420  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
100156967  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
492822  COX5B; cytochrome c oxidase subunit 5B, mitochondrial precursor [KO:K02265]
100152232  COX6A1; cytochrome c oxidase subunit VIa polypeptide 1 [KO:K02266]
100626250  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
100038022  COX6B; cytochrome c oxidase subunit 6B1 [KO:K02267]
110261055  cytochrome c oxidase subunit 6B2 [KO:K02267]
100037989  COX6C; cytochrome c oxidase subunit 6C [KO:K02268]
102157773  cytochrome c oxidase subunit 6C-like [KO:K02268]
399685  COX7A1; cytochrome c oxidase subunit 7A1, mitochondrial precursor [KO:K02270]
100038000  COX7A2; cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
100516606  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X4 [KO:K02270]
100516480  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
100517408  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
100037990  COX7C; cytochrome c oxidase subunit 7C, mitochondrial precursor [KO:K02272]
100038031  COX8H; COX8H protein [KO:K02273]
100522725  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
100157935  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
100157880  ATP5A1; ATP synthase subunit alpha, mitochondrial [KO:K02132]
100157156  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
102160861  ATP5C1; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
100523423  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
100134963  ATP5E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
808506  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
100154817  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
574054  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
100513629  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
100037988  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
100519871  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
100512624  ATP5H; ATP synthase subunit d, mitochondrial [KO:K02138]
733678  ATP5O; ATP synthase subunit O, mitochondrial precursor [KO:K02137]
100622245  ATP5J; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
808505  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
100524293  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 isoform X2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
100515957  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
397010  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
397659  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
397651  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
403155  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
100158185  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
100517196  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100518564  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
100152612  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
397537  LPL; lipoprotein lipase precursor [KO:K01059] [EC:3.1.1.34]
397576  APOE; apolipoprotein E precursor [KO:K04524]
100514839  LRP1; LOW QUALITY PROTEIN: prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
396826  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
397020  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
595129  FADD; FAS-associated death domain protein [KO:K02373]
595105  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
594852  BID; BH3-interacting domain death agonist [KO:K04726]
100154056  CALM1; calmodulin [KO:K02183]
396838  CALM3; calmodulin [KO:K02183]
100522926  CALM2; calmodulin [KO:K02183]
100738118  CALML5; calmodulin-like protein 5 [KO:K02183]
100623661  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
100519528  CALML4; calmodulin-like 4 [KO:K02183]
397241  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
100158082  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
396603  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X3 [KO:K04348] [EC:3.1.3.16]
100625117  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100627903  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
100521065  BAD; LOW QUALITY PROTEIN: bcl2-associated agonist of cell death [KO:K02158]
100170131  CYCS; cytochrome c [KO:K08738]
100522842  cytochrome c [KO:K08738]
100519295  cytochrome c-like [KO:K08738]
100621347  cytochrome c-like [KO:K08738]
100513283  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
100518913  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
397244  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
397099  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
100144478  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
100155818  CHRM5; LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M5 [KO:K04133]
102161751  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
654405  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
100152679  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100157641  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100516581  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100525148  PLCB3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
397440  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100736832  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
100626022  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100515684  GRIN2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
100521797  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
100518733  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
100511102  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X14 [KO:K04851]
100514745  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
100622149  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100415931  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
100153794  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
100153927  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
445013  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
396888  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
397454  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
100517279  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
100155015  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
100516962  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
396820  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
396875  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
100158076  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
100217386  XBP1; X-box-binding protein 1 isoform XBP1(U) [KO:K09027]
100240743  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
100510978  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
100513348  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
100513840  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100622769  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
100520418  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X5 [KO:K04431] [EC:2.7.12.2]
396610  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100521736  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
396609  MAPK9; mitogen-activated protein kinase 9 isoform X4 [KO:K04440] [EC:2.7.11.24]
100155472  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
100144302  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100156790  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
100620420  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
397058  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
100513739  PSMA8; proteasome subunit alpha type-7-like isoform X1 [KO:K02731] [EC:3.4.25.1]
100626738  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
497063  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
100516779  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
100154408  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
497065  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
100037992  PSMB7; proteasome subunit beta type-7 precursor [KO:K02739] [EC:3.4.25.1]
497064  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
100622444  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
100155139  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
100621969  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
100153923  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
100514865  PSMC2; 26S protease regulatory subunit 7 [KO:K03061]
100155274  PSMC1; 26S protease regulatory subunit 4 [KO:K03062]
110260986  PSMC4; 26S protease regulatory subunit 6B [KO:K03063]
100154148  PSMC6; 26S protease regulatory subunit 10B [KO:K03064]
100512454  PSMC3; 26S protease regulatory subunit 6A isoform X1 [KO:K03065]
397043  PSMC5; 26S protease regulatory subunit 8 [KO:K03066]
100627568  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
100153828  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
100512253  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
100525255  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
100524394  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
100523278  PSMD11; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
100519870  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
100626274  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
100517815  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
733583  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
100156327  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
100515483  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
102157770  proteasomal ubiquitin receptor ADRM1 [KO:K06691]
110257483  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
100155621  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
100520934  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
397027  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
397393  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
100113467  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
100153098  SLC39A1; zinc transporter ZIP1 [KO:K14709]
100515818  SLC39A3; zinc transporter ZIP3 [KO:K14709]
100625755  SLC39A2; zinc transporter ZIP2 [KO:K14709]
100156896  SLC39A4; zinc transporter ZIP4 isoform X1 [KO:K14710]
100155542  SLC39A5; zinc transporter ZIP5 [KO:K14711]
100621425  SLC39A6; zinc transporter ZIP6 [KO:K14712]
100155600  SLC39A7; zinc transporter SLC39A7 precursor [KO:K14713]
100524695  SLC39A8; zinc transporter ZIP8 [KO:K14714]
100158119  SLC39A9; zinc transporter ZIP9 isoform X1 [KO:K14715]
110257100  SLC39A10; zinc transporter ZIP10 isoform X1 [KO:K14716]
100518214  SLC39A11; zinc transporter ZIP11 isoform X1 [KO:K14717]
100523814  SLC39A12; zinc transporter ZIP12 isoform X2 [KO:K14718]
100512266  SLC39A13; zinc transporter ZIP13 [KO:K14719]
100152468  SLC39A14; zinc transporter ZIP14 isoform X2 [KO:K14720]
733595  SLC11A2; natural resistance-associated macrophage protein 2 [KO:K21398]
733700  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
100126852  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
100156777  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
100157640  DKK1; dickkopf-related protein 1 precursor [KO:K02165]
100519672  DKK2; dickkopf-related protein 2 [KO:K02165]
106508176  DKK4; dickkopf-related protein 4 [KO:K02165]
100525462  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100516839  WNT2; protein Wnt-2 [KO:K00182]
100520560  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
100514950  WNT3A; protein Wnt-3a isoform X1 [KO:K00312]
100519512  WNT3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
100327037  WNT4; protein Wnt-4 [KO:K00408]
100516268  WNT5B; LOW QUALITY PROTEIN: protein Wnt-5b [KO:K00444]
100627056  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
100622044  WNT6; protein Wnt-6 [KO:K00445]
100153445  WNT7A; protein Wnt-7a [KO:K00572]
100626947  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
100513655  WNT8B; protein Wnt-8b isoform X1 [KO:K00714]
100739710  WNT8A; protein Wnt-8a [KO:K00714]
100512949  WNT9A; protein Wnt-9a [KO:K01064]
100738655  WNT9B; protein Wnt-9b [KO:K01064]
100126276  WNT10B; protein Wnt-10b precursor [KO:K01357]
100623646  WNT10A; LOW QUALITY PROTEIN: protein Wnt-10a [KO:K01357]
100521912  WNT11; protein Wnt-11 [KO:K01384]
100511484  WNT16; protein Wnt-16 [KO:K01558]
100513691  FZD7; frizzled-7 [KO:K02432]
110262227  FZD1; frizzled-1 [KO:K02432]
100337669  FZD2; frizzled-2 precursor [KO:K02235]
100153078  FZD3; frizzled-3 isoform X1 [KO:K02329]
100520319  FZD4; LOW QUALITY PROTEIN: frizzled-4 [KO:K02354]
100519058  FZD5; frizzled-5 [KO:K02375]
110255708  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
100157360  FZD6; frizzled-6 precursor [KO:K02376]
100511782  FZD10; frizzled-10 [KO:K02842]
100625784  FZD9; frizzled-9 [KO:K02842]
100515777  LRP6; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 6 [KO:K03068]
100524299  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
100523244  casein kinase I isoform X2 [KO:K08960] [EC:2.7.11.1]
100525170  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X2 [KO:K02353]
100621038  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
100625452  DVL2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
110256598  FRAT1; proto-oncogene FRAT1 [KO:K03069]
110256599  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
100517435  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
100737256  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
397211  CSNK2B; casein kinase II subunit beta [KO:K03115]
100523725  AXIN1; axin-1 isoform X1 [KO:K02157]
100739604  AXIN2; axin-2 isoform X1 [KO:K04385]
100517932  APC; adenomatous polyposis coli protein [KO:K02085]
100579172  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
397657  CTNNB1; catenin beta-1 [KO:K02105]
100514516  CSNK1A1; casein kinase I isoform X4 [KO:K08957] [EC:2.7.11.1]
595132  KIF5B; kinesin-1 heavy chain [KO:K10396]
100622102  KIF5C; kinesin heavy chain [KO:K10396]
100519957  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
100157157  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
100521540  KLC2; kinesin light chain 2 isoform X2 [KO:K10407]
100523621  KLC1; kinesin light chain 1 isoform X7 [KO:K10407]
102158866  KLC3; kinesin light chain 3 [KO:K10407]
733594  TUBA1B; tubulin alpha-1B chain [KO:K07374]
100151951  TUBA4A; tubulin alpha-4A chain [KO:K07374]
100155138  tubulin alpha-3 chain isoform X2 [KO:K07374]
100158003  LOW QUALITY PROTEIN: tubulin alpha-1D chain [KO:K07374]
100127131  tubulin alpha-1C chain isoform X2 [KO:K07374]
100518253  TUBA8; tubulin alpha-8 chain [KO:K07374]
100510930  tubulin alpha-3 chain isoform X2 [KO:K07374]
100135051  TUBA1A; tubulin alpha-1A chain [KO:K07374]
100623355  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
733686  TUBB; tubulin beta chain [KO:K07375]
100134983  TUBB1; tubulin beta-1 chain [KO:K07375]
100153507  TUBB2B; tubulin beta-2B chain [KO:K07375]
100516352  TUBB4B; tubulin beta-4B chain [KO:K07375]
100736584  TUBB4A; tubulin beta-4A chain [KO:K07375]
100624785  tubulin beta-2A chain [KO:K07375]
100623583  TUBB6; LOW QUALITY PROTEIN: tubulin beta-6 chain [KO:K07375]
396591  AGER; advanced glycosylation end product-specific receptor precursor [KO:K19722]
110259208  HRAS; GTPase HRas isoform X1 [KO:K02833]
100518251  KRAS; GTPase KRas isoform X2 [KO:K07827]
100739349  NRAS; GTPase NRas precursor [KO:K07828]
397601  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
100514612  BRAF; serine/threonine-protein kinase B-raf isoform X6 [KO:K04365] [EC:2.7.11.1]
100737448  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100233191  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100525505  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100739822  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
397108  GP91-PHOX; cytochrome b-245 heavy chain precursor [KO:K21421] [EC:1.-.-.-]
100523323  NOX4; NADPH oxidase 4 isoform X2 [KO:K21423] [EC:1.6.3.-]
100135665  RELA; transcription factor p65 [KO:K04735]
751869  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
396859  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
397590  PTGS2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]
397086  TNF; tumor necrosis factor [KO:K03156]
399500  IL6; interleukin-6 precursor [KO:K05405]
397094  IL1A; interleukin-1 alpha precursor [KO:K04383]
396565  IL1B2; interleukin 1, beta [KO:K04519]
397122  IL1B; interleukin-1 beta precursor [KO:K04519]
100513084  CSF1; macrophage colony-stimulating factor 1 precursor [KO:K05453]
641350  SNCA; alpha-synuclein [KO:K04528]
397588  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
100135662  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
100101471  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100127355  IKBKG; NF-kappa-B essential modulator [KO:K07210]
397415  INS; insulin precursor [KO:K04526]
396755  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100512686  IRS1; insulin receptor substrate 1 [KO:K16172]
110255858  IRS2; LOW QUALITY PROTEIN: insulin receptor substrate 2 [KO:K07187]
100515824  insulin receptor substrate 1-like isoform X1 [KO:K17445]
100622674  IRS4; insulin receptor substrate 4 [KO:K17446]
100511937  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100739510  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100623707  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100518131  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100621789  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100622559  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100126861  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100513811  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100127478  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100127359  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100151990  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
100525780  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
110260663  ATG101; autophagy-related protein 101 [KO:K19730]
100516128  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
100622699  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
100519700  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X3 [KO:K17985]
733576  BECN1; beclin-1 [KO:K08334]
100512673  BECN2; beclin-2 [KO:K08334]
100516293  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
100155666  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
100157738  NRBF2; nuclear receptor-binding factor 2 isoform X3 [KO:K21246]
503700  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
100462716  ATG2B; autophagy-related protein 2 homolog B [KO:K17906]
100462717  ATG2A; autophagy-related protein 2 homolog A [KO:K17906]
100462758  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
100462759  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Related
pathway
ssc00190  Oxidative phosphorylation
ssc03050  Proteasome
ssc04020  Calcium signaling pathway
ssc04140  Autophagy - animal
ssc04141  Protein processing in endoplasmic reticulum
ssc04210  Apoptosis
ssc04310  Wnt signaling pathway
ssc04910  Insulin signaling pathway
ssc04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   
LinkDB

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