KEGG   PATHWAY: mlx05010
Entry
mlx05010                    Pathway                                
Name
Alzheimer disease - Mirounga leonina (Southern elephant seal)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
mlx05010  Alzheimer disease
mlx05010

Disease
H00056  Alzheimer disease
Organism
Mirounga leonina (Southern elephant seal) [GN:mlx]
Gene
117997521  [KO:K11352]
117997912  [KO:K02267]
117997916  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
117997961  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
117998118  APOE; apolipoprotein E [KO:K04524]
117998137  KLC3; kinesin light chain 3 [KO:K10407]
117998176  CALM3; calmodulin-3 [KO:K02183]
117998200  [KO:K03938]
117998425  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
117998506  [KO:K02273]
117998525  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
117998533  [KO:K02272]
117998566  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
117998612  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
117998657  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
117998682  [KO:K08960] [EC:2.7.11.1]
117998841  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
117998878  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
117999059  [KO:K03938]
117999128  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
117999153  [KO:K00415]
117999192  [KO:K03945]
117999200  FZD9; frizzled-9 [KO:K02842]
117999311  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
117999416  [KO:K17445]
117999517  [KO:K02138]
117999554  [KO:K02266]
117999637  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
117999657  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
117999772  [KO:K03061]
117999803  [KO:K07374]
117999807  [KO:K07374]
117999826  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
117999966  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
117999990  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
118000121  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
118000291  APH1A; gamma-secretase subunit APH-1A [KO:K06172]
118000306  [KO:K03948]
118000336  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
118000345  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
118000495  NRAS; GTPase NRas [KO:K07828]
118000514  [KO:K02131]
118000829  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
118000847  [KO:K02128]
118000958  [KO:K03949]
118001023  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
118001049  [KO:K00236]
118001187  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
118001264  [KO:K02267]
118001326  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
118001468  [KO:K02270]
118001502  [KO:K02263]
118001601  [KO:K02137]
118001623  SLC39A7; zinc transporter SLC39A7 isoform X1 [KO:K14713]
118001772  [KO:K02732] [EC:3.4.25.1]
118001885  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
118002024  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118002128  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
118002179  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
118002288  CTNNB1; catenin beta-1 [KO:K02105]
118002313  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
118002372  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
118002381  SLC39A9; zinc transporter ZIP9 isoform X1 [KO:K14715]
118002393  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
118002427  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
118002566  CALM1; calmodulin-1 [KO:K02183]
118002576  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
118002671  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
118002675  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
118002818  [KO:K02730] [EC:3.4.25.1]
118002863  [KO:K02730] [EC:3.4.25.1]
118002938  [KO:K02266]
118003073  [KO:K02267]
118003092  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
118003100  [KO:K02264]
118003137  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
118003203  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
118003328  SLC39A2; zinc transporter ZIP2 [KO:K14709]
118003336  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
118003444  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 isoform X1 [KO:K06704] [EC:3.4.24.81]
118003487  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
118003636  APH1B; gamma-secretase subunit APH-1B [KO:K06172]
118003737  RYR3; ryanodine receptor 3 [KO:K04963]
118003738  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
118003939  FZD4; frizzled-4 [KO:K02354]
118004067  WNT11; protein Wnt-11 [KO:K01384]
118004098  [KO:K02137]
118004250  APBB1; amyloid-beta A4 precursor protein-binding family B member 1 [KO:K04529]
118004305  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
118004315  PSMA1; proteasome subunit alpha type-1 isoform X1 [KO:K02725] [EC:3.4.25.1]
118004320  [KO:K03948]
118004415  SLC39A6; zinc transporter ZIP6 [KO:K14712]
118004416  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
118004424  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
118004524  [KO:K05862]
118004526  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
118004647  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
118004882  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
118005005  [KO:K03945]
118005025  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
118005048  [KO:K00414]
118005105  TUBB4A; tubulin beta-4A chain [KO:K07375]
118005112  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
118005119  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
118005134  WNT7A; protein Wnt-7a [KO:K00572]
118005180  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
118005236  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
118005260  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
118005325  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
118005417  [KO:K02268]
118005431  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118005442  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
118005521  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
118005536  SLC39A3; zinc transporter ZIP3 [KO:K14709]
118005738  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
118005812  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
118005924  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
118005969  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
118006000  [KO:K00420]
118006042  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118006050  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
118006077  [KO:K03945]
118006183  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
118006277  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
118006556  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118006627  [KO:K03945]
118006658  [KO:K08957] [EC:2.7.11.1]
118006687  [KO:K03937]
118006688  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
118006792  [KO:K08957] [EC:2.7.11.1]
118006809  [KO:K03937]
118006887  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
118006897  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
118007053  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
118007057  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
118007302  [KO:K06059] [EC:3.4.24.86]
118007360  [KO:K06059] [EC:3.4.24.86]
118007769  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
118007814  [KO:K02270]
118007866  IL1A; interleukin-1 alpha isoform X1 [KO:K04383]
118007867  IL1B; interleukin-1 beta [KO:K04519]
118007879  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
118008037  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
118008123  RTN4; reticulon-4 isoform X1 [KO:K20720]
118008161  CALM2; calmodulin-2 [KO:K02183]
118008215  [KO:K02265]
118008426  KIF5A; kinesin heavy chain [KO:K10396]
118008496  WNT1; proto-oncogene Wnt-1 [KO:K03209]
118008635  [KO:K02270]
118008672  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
118008679  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
118008682  LRP1; prolow-density lipoprotein receptor-related protein 1 isoform X1 [KO:K04550]
118008699  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
118008715  SLC39A5; zinc transporter ZIP5 [KO:K14711]
118008780  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
118008824  ATG101; autophagy-related protein 101 [KO:K19730]
118008847  SLC11A2; natural resistance-associated macrophage protein 2 [KO:K21398]
118008882  [KO:K07374]
118008883  [KO:K07374]
118008885  TUBA1C; tubulin alpha-1C chain [KO:K07374]
118008893  WNT10B; protein Wnt-10b [KO:K01357]
118008941  [KO:K03947]
118008962  [KO:K00417]
118008972  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
118008977  [KO:K03967]
118009132  [KO:K00417]
118009146  [KO:K21421] [EC:1.-.-.-]
118009157  [KO:K03952]
118009264  [KO:K03957]
118009645  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
118009801  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
118009813  [KO:K02265]
118009891  [KO:K02272]
118009917  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
118009919  DKK4; dickkopf-related protein 4 [KO:K02165]
118009921  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118010066  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
118010074  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
118010248  [KO:K02271]
118010255  [KO:K02273]
118010299  [KO:K02138]
118010330  SNCA; alpha-synuclein [KO:K04528]
118010368  [KO:K04440] [EC:2.7.11.24]
118010572  [KO:K02725] [EC:3.4.25.1]
118010624  [KO:K02725] [EC:3.4.25.1]
118010742  IRS4; insulin receptor substrate 4 [KO:K17446]
118011073  [KO:K03948]
118011244  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
118011247  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
118011354  [KO:K02263]
118011365  CSNK2A1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
118011750  WNT10A; protein Wnt-10a [KO:K01357]
118011751  WNT6; protein Wnt-6 [KO:K00445]
118011878  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
118011954  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
118011983  IRS1; insulin receptor substrate 1 [KO:K16172]
118012024  [KO:K07374]
118012097  FZD5; frizzled-5 [KO:K02375]
118012110  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
118012141  FZD7; frizzled-7 [KO:K02432]
118012152  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
118012157  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
118012193  SLC39A10; zinc transporter ZIP10 [KO:K14716]
118012240  [KO:K02128]
118012283  [KO:K08738]
118012306  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
118012351  [KO:K02267]
118012355  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
118012403  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
118012420  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
118012462  KIF5C; kinesin heavy chain [KO:K10396]
118012486  [KO:K02183]
118012526  [KO:K15041]
118012585  [KO:K02132]
118012948  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
118012958  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
118012979  DKK1; dickkopf-related protein 1 [KO:K02165]
118012992  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
118013136  [KO:K02272]
118013166  [KO:K04741] [EC:3.4.22.-]
118013193  [KO:K03947]
118013236  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
118013269  BACE1; beta-secretase 1 isoform X1 [KO:K04521] [EC:3.4.23.46]
118013457  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
118013460  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
118013637  [KO:K02135]
118013652  [KO:K03948]
118013662  [KO:K02135]
118013715  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
118013723  [KO:K03948]
118013834  SLC39A1; zinc transporter ZIP1 [KO:K14709]
118013984  NCSTN; nicastrin [KO:K06171]
118014015  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
118014021  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
118014029  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
118014190  [KO:K07374]
118014221  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
118014290  [KO:K02136]
118014376  [KO:K02138]
118014377  [KO:K02272]
118014480  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118014553  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118014566  [KO:K02131]
118014577  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
118014586  BECN2; LOW QUALITY PROTEIN: beclin-2 [KO:K08334]
118014709  [KO:K03064]
118014721  [KO:K00417]
118014818  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
118014830  [KO:K03035]
118015043  [KO:K00417]
118015096  FZD6; frizzled-6 [KO:K02376]
118015199  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
118015299  [KO:K00413]
118015318  SLC39A4; zinc transporter ZIP4 [KO:K14710]
118015397  [KO:K02726] [EC:3.4.25.1]
118015405  [KO:K02271]
118015629  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
118015656  INS; insulin [KO:K04526]
118015811  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
118015814  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
118015834  SLC39A13; zinc transporter ZIP13 isoform X1 [KO:K14719]
118015836  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
118015844  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
118015970  RTN3; reticulon-3 isoform X1 [KO:K20723]
118015981  [KO:K02273]
118015997  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
118016000  BAD; bcl2-associated agonist of cell death [KO:K02158]
118016016  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
118016038  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
118016059  RELA; transcription factor p65 [KO:K04735]
118016083  KLC2; kinesin light chain 2 [KO:K10407]
118016140  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
118016147  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
118016153  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
118016168  FADD; FAS-associated death domain protein [KO:K02373]
118016228  HRAS; GTPase HRas isoform X1 [KO:K02833]
118016235  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
118016240  [KO:K02128]
118016252  [KO:K17908]
118016431  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
118016456  TUBB6; tubulin beta-6 chain [KO:K07375]
118016476  [KO:K03952]
118016596  [KO:K02183]
118016628  [KO:K00418]
118016634  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
118016727  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
118016863  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118016969  [KO:K02272]
118017147  [KO:K02138]
118017183  WNT8A; protein Wnt-8a [KO:K00714]
118017483  TUBB4B; tubulin beta-4B chain [KO:K07375]
118017503  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
118017527  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
118017566  [KO:K03948]
118017695  PSMB7; proteasome subunit beta type-7 isoform X1 [KO:K02739] [EC:3.4.25.1]
118017734  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
118017875  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
118018036  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
118018060  [KO:K02131]
118018172  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
118018221  [KO:K02737] [EC:3.4.25.1]
118018362  ULK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
118018432  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
118018451  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
118018518  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
118018546  [KO:K02266]
118018617  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
118018636  [KO:K00419]
118018686  FZD10; frizzled-10 [KO:K02842]
118018787  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
118018789  APP; amyloid-beta precursor protein isoform X1 [KO:K04520]
118018842  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
118018995  WNT2B; protein Wnt-2b [KO:K00182]
118019006  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
118019025  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
118019037  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
118019306  [KO:K02131]
118019464  [KO:K00416]
118019468  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
118019589  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
118019622  [KO:K21246]
118019630  [KO:K08738]
118019658  CALML6; calmodulin-like protein 6 [KO:K02183]
118019701  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
118019784  [KO:K02131]
118019912  WNT4; protein Wnt-4 [KO:K00408]
118019915  [KO:K03948]
118019953  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
118019979  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
118019980  [KO:K00134] [EC:1.2.1.12]
118020008  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
118020028  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118020106  [KO:K21246]
118020123  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
118020657  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
118020691  [KO:K02183]
118020735  FZD1; frizzled-1 [KO:K02432]
118020809  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
118020828  [KO:K02131]
118020856  IL6; interleukin-6 [KO:K05405]
118020883  [KO:K08738]
118020909  [KO:K02131]
118020955  [KO:K02725] [EC:3.4.25.1]
118021014  WNT2; protein Wnt-2 [KO:K00182]
118021036  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
118021108  [KO:K02128]
118021159  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118021161  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
118021306  [KO:K02725] [EC:3.4.25.1]
118021333  [KO:K03937]
118021382  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
118021393  [KO:K02725] [EC:3.4.25.1]
118021446  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
118021524  SLC39A12; zinc transporter ZIP12 [KO:K14718]
118021556  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118021601  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
118021620  CALML3; calmodulin-like protein 3 [KO:K02183]
118021622  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
118021650  AXIN1; axin-1 isoform X1 [KO:K02157]
118021712  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
118021822  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
118021844  [KO:K02131]
118021900  [KO:K03948]
118021903  [KO:K02183]
118021936  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
118022060  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
118022078  SLC39A14; metal cation symporter ZIP14 [KO:K14720]
118022080  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118022125  FZD3; frizzled-3 [KO:K02329]
118022198  PPID; peptidyl-prolyl cis-trans isomerase D isoform X1 [KO:K05864] [EC:5.2.1.8]
118022199  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
118022312  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
118022338  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
118022658  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118022663  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
118022700  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
118022759  [KO:K00411] [EC:7.1.1.8]
118022776  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118022874  PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]
118022877  [KO:K02267]
118022879  [KO:K02270]
118022951  [KO:K02725] [EC:3.4.25.1]
118022967  [KO:K04809]
118023143  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
118023337  [KO:K02128]
118023396  [KO:K07375]
118023493  [KO:K02263]
118023514  NOX1; LOW QUALITY PROTEIN: NADPH oxidase 1 [KO:K08008]
118023545  [KO:K02273]
118023608  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
118023703  NAE1; NEDD8-activating enzyme E1 regulatory subunit [KO:K04532]
118023729  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
118023736  IDE; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
118023788  [KO:K03967]
118024014  TUBB1; tubulin beta-1 chain [KO:K07375]
118024015  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
118024028  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
118024030  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
118024289  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
118024295  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
118024320  SLC39A11; zinc transporter ZIP11 isoform X1 [KO:K14717]
118024338  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
118024344  AXIN2; axin-2 isoform X1 [KO:K04385]
118024353  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
118024369  FRAT1; proto-oncogene FRAT1 [KO:K03069]
118024372  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
118024374  FRAT2; GSK-3-binding protein FRAT2 [KO:K03069]
118024383  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
118024545  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
118024594  [KO:K03945]
118024680  [KO:K02730] [EC:3.4.25.1]
118024792  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
118024828  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
118024839  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118024848  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
118024937  BECN1; beclin-1 isoform X1 [KO:K08334]
118024980  FZD2; frizzled-2 isoform X1 [KO:K02235]
118024994  WNT8B; protein Wnt-8b [KO:K00714]
118025000  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
118025026  [KO:K02268]
118025163  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
118025303  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
118025330  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
118025332  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
118025410  [KO:K00134] [EC:1.2.1.12]
118025455  [KO:K03957]
118025560  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
118025572  KRAS; GTPase KRas isoform X1 [KO:K07827]
118025623  [KO:K02725] [EC:3.4.25.1]
118025638  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
118025656  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
118025740  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
118025746  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
118025758  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
118025802  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
118025809  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
118025823  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
118025829  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
118025936  [KO:K02273]
118025972  [KO:K03948]
118026049  [KO:K02271]
118026127  BACE2; beta-secretase 2 [KO:K07747] [EC:3.4.23.45]
118026254  [KO:K03965]
118026266  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
118026286  [KO:K03947]
118026298  [KO:K02138]
118026484  [KO:K02128]
118026506  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118026509  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
118026621  [KO:K00134] [EC:1.2.1.12]
118026631  FZD8; frizzled-8 [KO:K02375]
118026668  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
118026782  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
118026858  WNT3A; protein Wnt-3a [KO:K00312]
118026884  WNT9A; protein Wnt-9a [KO:K01064]
118026972  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
118027044  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118027046  SLC39A8; metal cation symporter ZIP8 [KO:K14714]
118027047  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118027074  DKK2; dickkopf-related protein 2 [KO:K02165]
118027171  WNT9B; protein Wnt-9b [KO:K01064]
118027173  WNT3; proto-oncogene Wnt-3 [KO:K00312]
118027177  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
118027195  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
118027255  TNF; tumor necrosis factor [KO:K03156]
118027278  [KO:K03938]
118027334  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
118027362  TUBB; tubulin beta chain [KO:K07375]
118027399  [KO:K07375]
118027402  TUBB2B; tubulin beta-2B chain [KO:K07375]
4355864  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
4355865  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
4355866  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
4355867  COX2; cytochrome c oxidase subunit II [KO:K02261]
4355868  COX3; cytochrome c oxidase subunit III [KO:K02262]
4355869  CYTB; cytochrome b [KO:K00412]
4355870  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
4355871  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
4355872  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
4355873  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
4355874  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
4355875  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
4355876  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Biochim Biophys Acta Mol Basis Dis 1864:1148-1159 (2018)
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Mol Neurodegener 9:48 (2014)
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Front Cell Neurosci 13:227 (2019)
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Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma.
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Front Neurosci 10:459 (2016)
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Front Cell Neurosci 9:191 (2015)
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Alzheimers Dement 10:S26-32 (2014)
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Related
pathway
mlx00190  Oxidative phosphorylation
mlx03050  Proteasome
mlx04020  Calcium signaling pathway
mlx04140  Autophagy - animal
mlx04141  Protein processing in endoplasmic reticulum
mlx04210  Apoptosis
mlx04310  Wnt signaling pathway
mlx04910  Insulin signaling pathway
mlx04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   

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