KEGG   PATHWAY: cclu04621
Entry
cclu04621                   Pathway                                
Name
NOD-like receptor signaling pathway - Coregonus clupeaformis (lake whitefish)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
cclu04621  NOD-like receptor signaling pathway
cclu04621

Organism
Coregonus clupeaformis (lake whitefish) [GN:cclu]
Gene
121586018  nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
121543018  LOW QUALITY PROTEIN: nucleotide-binding oligomerization domain-containing protein 1-like [KO:K08727]
121580702  receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
121534977  receptor-interacting serine/threonine-protein kinase 2-like [KO:K08846] [EC:2.7.11.1]
121537221  NF-kappa-B essential modulator isoform X1 [KO:K07210]
121555481  NF-kappa-B essential modulator [KO:K07210]
121547254  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
121542592  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
121568297  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
121573284  inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
121539482  NF-kappa-B inhibitor alpha-like [KO:K04734]
121544745  NF-kappa-B inhibitor alpha-like [KO:K04734]
121552951  NF-kappa-B inhibitor alpha [KO:K04734]
121567159  NF-kappa-B inhibitor alpha [KO:K04734]
121532452  nuclear factor NF-kappa-B p105 subunit [KO:K02580]
121543405  nuclear factor NF-kappa-B p105 subunit [KO:K02580]
121554756  transcription factor p65 [KO:K04735]
121571123  transcription factor p65 [KO:K04735]
121585177  interleukin-1 beta [KO:K04519]
121587276  interleukin-1 beta-like [KO:K04519]
121573028  il6; interleukin-6 [KO:K05405]
121585646  interleukin-6 [KO:K05405]
121585680  tumor necrosis factor-like [KO:K03156]
121585681  tumor necrosis factor-like [KO:K03156]
121573010  tumor necrosis factor-like [KO:K03156]
121566279  tnfb; tumor necrosis factor b (TNF superfamily, member 2) [KO:K03156]
121561428  interleukin-8 [KO:K10030]
121550670  interleukin-8 [KO:K10030]
121568225  permeability factor 2 [KO:K10030]
121570517  interleukin-8-like [KO:K10030]
121535793  nod2; nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165]
121539145  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
121549021  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
121552876  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
121545052  mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
121555890  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
121548996  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
121552425  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like isoform X1 [KO:K04404]
121533747  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
121576540  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
121530742  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121584339  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123491220  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
121550334  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121582737  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121547071  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121539343  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121573400  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121541973  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
121568416  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121553311  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121544682  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
121531434  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
121548693  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
121548705  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
121574773  mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
121543539  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
121543540  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
121576985  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
121537818  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
121578329  mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
121537833  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
121538239  mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
121545911  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
121545919  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
121545988  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
121581081  transcription factor AP-1 [KO:K04448]
121539880  transcription factor AP-1-like [KO:K04448]
121533346  transcription factor AP-1-like [KO:K04448]
121535574  transcription factor AP-1-like [KO:K04448]
121573366  transcription factor AP-1-like [KO:K04448]
121583151  transcription factor AP-1-like [KO:K04448]
121561969  autophagy-related protein 16-1 isoform X1 [KO:K17890]
121567280  autophagy-related protein 16-1 isoform X1 [KO:K17890]
121570045  atg5; autophagy protein 5 [KO:K08339]
121556483  ubiquitin-like protein ATG12 [KO:K08336]
121542941  ubiquitin-like protein ATG12 [KO:K08336]
121583064  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
121580271  gabarapa; GABA(A) receptor-associated protein a [KO:K08341]
121576710  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
121554343  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
121571140  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
121586229  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
121583607  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
121543001  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
121531768  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
121572391  microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
121533487  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
121576743  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
121545914  microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
123492058  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
123483067  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
121581155  protein SGT1 homolog isoform X1 [KO:K12795]
121535662  protein SGT1 homolog isoform X1 [KO:K12795]
121581527  ranBP-type and C3HC4-type zinc finger-containing protein 1-like [KO:K20894]
121534445  ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K20894]
121575111  rbck1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
121569222  ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
121534552  si:dkey-181m9.8; uncharacterized protein si:dkey-181m9.8 [KO:K11974] [EC:2.3.2.31]
121535239  E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
121549863  E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
121569228  E3 ubiquitin-protein ligase RNF31 [KO:K11974] [EC:2.3.2.31]
121580938  E3 ubiquitin-protein ligase RNF31-like isoform X1 [KO:K11974] [EC:2.3.2.31]
121539527  E3 ubiquitin-protein ligase XIAP-like isoform X1 [KO:K04725] [EC:2.3.2.27]
121536486  E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
121572103  thyroid receptor-interacting protein 6 isoform X2 [KO:K12792]
121554275  trip6; thyroid receptor-interacting protein 6 isoform X1 [KO:K12792]
121582614  erbin isoform X3 [KO:K12796]
121541584  erbin isoform X1 [KO:K12796]
121559716  inhibitor of apoptosis protein-like isoform X1 [KO:K16060]
121558449  inhibitor of apoptosis protein-like isoform X1 [KO:K16060]
121582534  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
121585058  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
121582622  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
121541579  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
121541654  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
121572365  traf5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
123490781  TNF receptor-associated factor 5-like [KO:K09849]
121546400  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
121584063  card9; caspase recruitment domain-containing protein 9 isoform X2 [KO:K12794]
121551332  caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
121547633  tnfaip3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
121578069  tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
121539497  TNF receptor-associated factor 3-like [KO:K03174]
121544723  TNF receptor-associated factor 3-like isoform X1 [KO:K03174]
121563465  tbk1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
121574828  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
121578296  inhibitor of nuclear factor kappa-B kinase subunit epsilon-like [KO:K07211] [EC:2.7.11.10]
121551997  uncharacterized protein LOC121551997 [KO:K12650]
121536826  TRAF family member-associated NF-kappa-B activator [KO:K12650]
121572029  irf3; interferon regulatory factor 3 [KO:K05411]
121532193  interferon regulatory factor 3-like [KO:K09447]
121577211  interferon regulatory factor 7 [KO:K09447]
121561855  interferon a3-like [KO:K05414]
121550868  interferon a3 isoform X1 [KO:K05414]
121569702  interferon alpha-1-like [KO:K05414]
121570246  interferon beta-like [KO:K05414]
121570247  interferon beta-like [KO:K05414]
121570573  interferon alpha-1-like [KO:K05414]
121570574  interferon alpha-1-like [KO:K05414]
121570575  interferon alpha-1-like [KO:K05414]
121570579  interferon alpha-1-like [KO:K05414]
121564805  interferon a3-like isoform X1 [KO:K05414]
121569703  interferon alpha-1-like [KO:K05414]
121570568  interferon alpha-1-like [KO:K05414]
121570576  LOW QUALITY PROTEIN: interferon alpha-4-like [KO:K05414]
123482511  interferon beta-like [KO:K05414]
121550643  interferon beta-like [KO:K05414]
121550238  interferon a3-like [KO:K05414]
121550649  interferon alpha-B-like [KO:K05414]
121564507  interferon a3-like [KO:K05414]
121564802  interferon a3-like [KO:K05414]
121570564  interferon a3-like [KO:K05414]
121570566  interferon a3-like [KO:K05414]
121570567  interferon a3-like isoform X1 [KO:K05414]
121567360  NLR family member X1 isoform X1 [KO:K12653]
121582390  anthrax toxin receptor 1 [KO:K20909]
121584834  anthrax toxin receptor 1-like [KO:K20909]
121582850  antxr2b; ANTXR cell adhesion molecule 2b [KO:K20909]
121530884  anthrax toxin receptor 1-like isoform X1 [KO:K20909]
121547063  anthrax toxin receptor 1-like [KO:K20909]
121573473  anthrax toxin receptor 2-like [KO:K20909]
121574203  anthrax toxin receptor 1 [KO:K20909]
121545287  anthrax toxin receptor 2-like isoform X2 [KO:K20909]
121553414  anthrax toxin receptor 1 [KO:K20909]
121538726  anthrax toxin receptor 1-like [KO:K20909]
121587211  anthrax toxin receptor 2 [KO:K20909]
123484596  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
121563772  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
121567657  caspase a [KO:K01370] [EC:3.4.22.36]
121567662  caspase a-like isoform X1 [KO:K01370] [EC:3.4.22.36]
121581520  apoptosis regulator Bcl-2 [KO:K02161]
121549890  apoptosis regulator Bcl-2 [KO:K02161]
121535292  apoptosis regulator Bcl-2-like [KO:K02161]
121569203  apoptosis regulator Bcl-2-like [KO:K02161]
121538321  bcl-2-like protein 1 [KO:K04570]
121575865  bcl-2-like protein 1 [KO:K04570]
121578251  bcl-2-like protein 1 [KO:K04570]
121546024  bcl-2-like protein 1 [KO:K04570]
121539626  cathepsin B [KO:K01363] [EC:3.4.22.1]
121544613  cathepsin B [KO:K01363] [EC:3.4.22.1]
121566268  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
121573668  pannexin-1 [KO:K03443]
121565661  pannexin-1 isoform X1 [KO:K03443]
121568365  pannexin-1-like [KO:K03443]
121551193  p2rx7; P2X purinoceptor 7 isoform X1 [KO:K05220]
121555141  trpm2; transient receptor potential cation channel subfamily M member 2 [KO:K04977] [EC:3.6.1.13]
121579911  trpm7; LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1]
121541251  casr; extracellular calcium-sensing receptor [KO:K04612]
121585332  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
121585466  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
121585467  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
121559779  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
121585333  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
121548707  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
121544381  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like [KO:K05858] [EC:3.1.4.11]
121552187  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X2 [KO:K05858] [EC:3.1.4.11]
121552683  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
121571248  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like [KO:K05858] [EC:3.1.4.11]
121554349  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
121559874  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
121544287  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
121548687  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
121575032  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
121577563  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
121578264  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
121575199  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
121532247  inositol 1,4,5-trisphosphate receptor type 2-like [KO:K04959]
121577003  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
121538342  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
121546039  inositol 1,4,5-trisphosphate receptor type 3 isoform X2 [KO:K04960]
121574006  voltage-dependent anion-selective channel protein 1-like [KO:K05862]
121579233  voltage-dependent anion-selective channel protein 1 [KO:K05862]
121554977  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
121547746  voltage-dependent anion-selective channel protein 2 [KO:K15040]
121574257  voltage-dependent anion-selective channel protein 2 [KO:K15040]
121576221  voltage-dependent anion-selective channel protein 2 [KO:K15040]
121553204  voltage-dependent anion-selective channel protein 2 [KO:K15040]
121582231  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
121584978  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
121548046  voltage-dependent anion-selective channel protein 2-like [KO:K15041]
121573880  voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15041]
121573279  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
121547770  calcium uniporter protein, mitochondrial-like [KO:K20858]
121577730  mcu; calcium uniporter protein, mitochondrial [KO:K20858]
121574089  dhx33; ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
121533763  mitofusin-1 isoform X1 [KO:K21356] [EC:3.6.5.-]
121534548  mitofusin-1 [KO:K21356] [EC:3.6.5.-]
121576524  mitofusin-1 [KO:K21356] [EC:3.6.5.-]
121538236  mfn2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
121581011  receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
121535318  receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
121554607  ripk3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
121531630  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
121577056  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
121546242  LOW QUALITY PROTEIN: dynamin-1-like protein [KO:K17065] [EC:3.6.5.5]
121530877  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
121546224  nampt1; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
121531558  nicotinamide phosphoribosyltransferase-like [KO:K03462] [EC:2.4.2.12]
121574946  nampt2; nicotinamide phosphoribosyltransferase 2 isoform X1 [KO:K03462] [EC:2.4.2.12]
121543662  nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
121547810  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
121548252  cytochrome b-245 light chain-like [KO:K08009]
121558000  cytochrome b-245 light chain-like [KO:K08009]
121572433  thioredoxin-interacting protein [KO:K20910]
121570678  thioredoxin-interacting protein-like [KO:K20910]
123491528  thioredoxin-interacting protein-like [KO:K20910]
121585975  thioredoxin-interacting protein-like [KO:K20910]
121571778  thioredoxin, mitochondrial-like [KO:K03671]
121579348  thioredoxin [KO:K03671]
121572197  thioredoxin [KO:K03671]
121551021  thioredoxin, mitochondrial [KO:K03671]
121569445  thioredoxin, mitochondrial-like isoform X1 [KO:K03671]
123485948  thioredoxin-like [KO:K03671]
123482960  thioredoxin-like [KO:K03671]
121540415  serine/threonine-protein kinase Nek7 [KO:K20876] [EC:2.7.11.34]
121534081  nek7; serine/threonine-protein kinase Nek7 isoform X1 [KO:K20876] [EC:2.7.11.34]
121579468  lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
121541811  brcc3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
121548635  heat shock protein HSP 90-alpha 1 isoform X1 [KO:K04079]
121549082  heat shock protein HSP 90-beta [KO:K04079]
121552760  heat shock protein HSP 90-alpha isoform X2 [KO:K04079]
121552952  heat shock protein HSP 90-beta [KO:K04079]
121580141  proline-serine-threonine phosphatase-interacting protein 1 isoform X1 [KO:K12804]
121531913  proline-serine-threonine phosphatase-interacting protein 1 isoform X1 [KO:K12804]
121576609  proline-serine-threonine phosphatase-interacting protein 1 isoform X1 [KO:K12804]
121581147  caspase-8 [KO:K04398] [EC:3.4.22.61]
121536756  casp10; caspase-8 [KO:K04398] [EC:3.4.22.61]
121554909  LOW QUALITY PROTEIN: caspase-8 [KO:K04398] [EC:3.4.22.61]
121535655  caspase-8 [KO:K04398] [EC:3.4.22.61]
121557680  FAS-associated death domain protein-like [KO:K02373]
121573323  FAS-associated death domain protein-like [KO:K02373]
121574964  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
121575240  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
121577601  protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
121578203  protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
121583000  tp53bp1; TP53-binding protein 1 isoform X1 [KO:K20915]
121538399  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
121575450  transforming protein RhoA-like [KO:K04513]
121578110  transforming protein RhoA-like [KO:K04513]
121537342  rho-related GTP-binding protein RhoA-A-like [KO:K04513]
121545495  rho-related GTP-binding protein RhoA-B [KO:K04513]
121545542  rho-related GTP-binding protein RhoA-C [KO:K04513]
121578369  rho-related GTP-binding protein RhoA-D [KO:K04513]
121538165  rho-related GTP-binding protein RhoA-B [KO:K04513]
121545275  rho-related GTP-binding protein RhoA-A-like [KO:K04513]
121532558  serine/threonine-protein kinase N1-like isoform X1 [KO:K06071] [EC:2.7.11.13]
123481419  serine/threonine-protein kinase N1-like isoform X1 [KO:K06071] [EC:2.7.11.13]
121551016  serine/threonine-protein kinase N1-like isoform X1 [KO:K06071] [EC:2.7.11.13]
121580726  serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
121534150  serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
121535019  serine/threonine-protein kinase N2-like [KO:K23691] [EC:2.7.11.13]
121563153  ywhae1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 isoform X1 [KO:K06630]
121567461  14-3-3 protein epsilon isoform X1 [KO:K06630]
121537605  14-3-3 protein epsilon-like [KO:K06630]
123492149  14-3-3 protein epsilon isoform X1 [KO:K06630]
121555008  guanylate-binding protein 1-like [KO:K20899]
121571743  guanylate-binding protein 1-like [KO:K20899]
121571744  guanylate-binding protein 1-like [KO:K20899]
123489182  LOW QUALITY PROTEIN: guanylate-binding protein 1-like [KO:K20899]
123481192  guanylate-binding protein 1-like [KO:K20899]
121571740  guanylate-binding protein 1-like isoform X1 [KO:K20899]
123482899  guanylate-binding protein 1-like [KO:K20899]
121572537  guanylate-binding protein 1-like [KO:K20899]
121555040  guanylate-binding protein 1 [KO:K20899]
121580669  LOW QUALITY PROTEIN: tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
121540448  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
121534951  tyrosine-protein kinase JAK1-like [KO:K11217] [EC:2.7.10.2]
121533812  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
121550849  non-receptor tyrosine-protein kinase TYK2-like [KO:K11219] [EC:2.7.10.2]
121569071  non-receptor tyrosine-protein kinase TYK2-like [KO:K11219] [EC:2.7.10.2]
121551541  stat1b; signal transducer and activator of transcription 1b isoform X1 [KO:K11220]
121536664  signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
121568070  signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
123485102  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
121562503  signal transducer and activator of transcription 1-alpha/beta-like [KO:K11220]
121562466  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
123481194  signal transducer and activator of transcription 1-alpha/beta-like [KO:K11220]
121562465  signal transducer and activator of transcription 1-alpha/beta-like [KO:K11220]
121575263  stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
121569227  interferon regulatory factor 9 isoform X1 [KO:K04693]
121570728  interferon regulatory factor 9 isoform X1 [KO:K04693]
121549864  interferon regulatory factor 8-like isoform X1 [KO:K04693]
121540557  ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
121569950  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
121531748  interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
121558729  sting1; stimulator of interferon genes protein isoform X1 [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
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Vandenabeele P, Bertrand MJ
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The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
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Nat Rev Immunol 12:833-44 (2012)
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Reference
PMID:16493424
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Strober W, Murray PJ, Kitani A, Watanabe T
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Signalling pathways and molecular interactions of NOD1 and NOD2.
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Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
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Estornes Y, Bertrand MJ
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IAPs, regulators of innate immunity and inflammation.
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Semin Cell Dev Biol 39:106-14 (2015)
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Reference
PMID:24707857
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Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
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J Med Chem 57:6897-918 (2014)
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Reference
PMID:25526305
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NOD1 and NOD2: signaling, host defense, and inflammatory disease.
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Immunity 41:898-908 (2014)
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Reference
PMID:19767725
  Authors
Murray PJ
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Beyond peptidoglycan for Nod2.
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Nat Immunol 10:1053-4 (2009)
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Reference
PMID:20643110
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Lecat A, Piette J, Legrand-Poels S
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The protein Nod2: an innate receptor more complex than previously assumed.
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Biochem Pharmacol 80:2021-31 (2010)
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Reference
PMID:26655628
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Man SM, Kanneganti TD
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Converging roles of caspases in inflammasome activation, cell death and innate immunity.
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Nat Rev Immunol 16:7-21 (2016)
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Reference
PMID:27291964
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Broz P, Dixit VM
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Inflammasomes: mechanism of assembly, regulation and signalling.
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Nat Rev Immunol 16:407-20 (2016)
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PMID:25879280
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Man SM, Kanneganti TD
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Regulation of inflammasome activation.
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Immunol Rev 265:6-21 (2015)
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Reference
PMID:26549800
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Jo EK, Kim JK, Shin DM, Sasakawa C
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Molecular mechanisms regulating NLRP3 inflammasome activation.
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Cell Mol Immunol 13:148-59 (2016)
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Reference
PMID:23846113
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Broz P, Monack DM
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Newly described pattern recognition receptors team up against intracellular pathogens.
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Nat Rev Immunol 13:551-65 (2013)
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Reference
PMID:22430786
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Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
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Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
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Nat Rev Immunol 14:601-18 (2014)
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Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
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Recognition of bacteria by inflammasomes.
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Annu Rev Immunol 31:73-106 (2013)
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Reference
PMID:25330206
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Abais JM, Xia M, Zhang Y, Boini KM, Li PL
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Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
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Antioxid Redox Signal 22:1111-29 (2015)
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Reference
PMID:25879288
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Storek KM, Monack DM
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Bacterial recognition pathways that lead to inflammasome activation.
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Immunol Rev 265:112-29 (2015)
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Reference
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Hu H, Sun SC
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Ubiquitin signaling in immune responses.
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Cell Res 26:457-83 (2016)
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Guo H, Callaway JB, Ting JP
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Inflammasomes: mechanism of action, role in disease, and therapeutics.
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Nat Med 21:677-87 (2015)
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Reference
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Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
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Cell Res 25:1183-4 (2015)
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Reference
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Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
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TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
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Cell 150:606-19 (2012)
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Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
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Reference
PMID:29148036
  Authors
Heilig R, Broz P
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Function and mechanism of the pyrin inflammasome.
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Eur J Immunol 48:230-238 (2018)
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Reference
PMID:25816776
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Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
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RNase L activates the NLRP3 inflammasome during viral infections.
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Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
cclu04010  MAPK signaling pathway
cclu04140  Autophagy - animal
cclu04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
LinkDB

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