KEGG   PATHWAY: dro04151
Entry
dro04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Desmodus rotundus (common vampire bat)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
dro04151  PI3K-Akt signaling pathway
dro04151

Other DBs
GO: 0043491
Organism
Desmodus rotundus (common vampire bat) [GN:dro]
Gene
112296254  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
112303034  TGFA; protransforming growth factor alpha [KO:K08774]
112320476  AREG; amphiregulin [KO:K09782]
112318067  FGF1; fibroblast growth factor 1 [KO:K18496]
112312217  FGF2; fibroblast growth factor 2 [KO:K18497]
112302323  FGF6; fibroblast growth factor 6 [KO:K04358]
112305225  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
112319711  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
112311746  FGF7; fibroblast growth factor 7 [KO:K04358]
112323185  FGF9; fibroblast growth factor 9 [KO:K04358]
112315295  FGF10; LOW QUALITY PROTEIN: fibroblast growth factor 10 [KO:K04358]
112319696  FGF18; fibroblast growth factor 18 [KO:K04358]
112306790  FGF20; fibroblast growth factor 20 [KO:K04358]
112312291  FGF22; fibroblast growth factor 22 [KO:K04358]
112317958  FGF16; LOW QUALITY PROTEIN: fibroblast growth factor 16 [KO:K04358]
112317419  FGF4; fibroblast growth factor 4 [KO:K04358]
112317420  FGF3; fibroblast growth factor 3 [KO:K04358]
112300468  fibroblast growth factor 8-like [KO:K04358]
112317418  FGF19; fibroblast growth factor 19 [KO:K22603]
112310055  FGF21; fibroblast growth factor 21 [KO:K22429]
112306914  FGF23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428]
112313781  NGF; beta-nerve growth factor [KO:K02582]
112303343  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
112321936  NTF3; neurotrophin-3 [KO:K04356]
112310216  NTF4; neurotrophin-4 [KO:K12457]
112321846  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
112317267  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
112319719  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
112321825  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
112314347  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
112312671  PDGFC; platelet-derived growth factor C [KO:K05450]
112313968  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
112315389  KITLG; kit ligand isoform X1 [KO:K05461]
112310213  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
112302143  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
112317384  VEGFB; vascular endothelial growth factor B [KO:K16858]
112311551  PGF; placenta growth factor [KO:K16859]
112306665  VEGFC; vascular endothelial growth factor C [KO:K05449]
112313412  VEGFD; vascular endothelial growth factor D [KO:K05449]
112301961  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
112315503  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
112321314  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
112304242  ANGPT4; angiopoietin-4 [KO:K05467]
112316763  EFNA1; ephrin-A1 [KO:K05462]
112314348  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
112312180  EFNA2; ephrin-A2 [KO:K05462]
112307205  EFNA5; ephrin-A5 [KO:K05462]
112315548  EFNA3; ephrin-A3 [KO:K05462]
112321122  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
112312601  NRTN; neurturin [KO:K25414]
112314450  ARTN; artemin [KO:K25415]
112312214  PSPN; persephin [KO:K25416]
112306912  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
112316215  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
112319025  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
112307700  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
112306733  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
112300272  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
112320339  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
112316485  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
112315668  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
112304477  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
112296365  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
112306076  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
112316918  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
112319577  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
112319552  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
112316812  KIT; LOW QUALITY PROTEIN: mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
112323198  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
112323117  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
112300051  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
112296393  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
112316796  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
112300421  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
112302877  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
112299135  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
112305517  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
112298645  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
112297971  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
112310995  SOS2; son of sevenless homolog 2 [KO:K03099]
112317099  HRAS; GTPase HRas isoform X1 [KO:K02833]
112318275  KRAS; LOW QUALITY PROTEIN: GTPase KRas [KO:K07827]
112304041  LOW QUALITY PROTEIN: GTPase KRas-like [KO:K07827]
112313707  NRAS; GTPase NRas [KO:K07828]
112301126  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112311345  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112312483  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112304801  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
112301746  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112307950  IRS1; insulin receptor substrate 1 [KO:K16172]
112312607  TLR2; toll-like receptor 2 [KO:K10159]
112306266  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
112319549  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
112307282  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
112304832  CD19; B-lymphocyte antigen CD19 [KO:K06465]
112307095  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
112316514  somatotropin-like [KO:K05438]
112309295  PRL; prolactin [KO:K05439]
112310359  OSM; oncostatin-M [KO:K05418]
112312503  IL2; interleukin-2 [KO:K05429]
112301616  IL3; interleukin-3 [KO:K04736]
112306851  IL6; interleukin-6 [KO:K05405]
112318159  IL4; interleukin-4 [KO:K05430]
112320869  IL7; interleukin-7 isoform X1 [KO:K05431]
112297048  interferon alpha-4-like [KO:K05414]
112302798  interferon alpha-4-like [KO:K05414]
112302800  interferon alpha-4-like [KO:K05414]
112300024  IFNB1; interferon beta [KO:K05415]
112315050  EPO; erythropoietin [KO:K05437]
112316577  CSF3; granulocyte colony-stimulating factor [KO:K05423]
112321076  GHR; growth hormone receptor [KO:K05080]
112321146  PRLR; prolactin receptor [KO:K05081]
112321081  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
112321040  IL2RA; LOW QUALITY PROTEIN: interleukin-2 receptor subunit alpha [KO:K05068]
112321925  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
112300079  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
112313317  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
112315493  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
112304724  interleukin-4 receptor subunit alpha-like [KO:K05071]
112304842  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
112321141  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
112305552  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
112305536  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
112301517  EPOR; erythropoietin receptor [KO:K05079]
112299557  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
112309187  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
112299737  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
112305180  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
112319841  COL1A2; collagen alpha-2(I) chain [KO:K06236]
112316389  COL1A1; collagen alpha-1(I) chain [KO:K06236]
112318365  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
112321420  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
112321451  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
112296845  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
112296867  COL4A6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237]
112307731  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
112307910  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
112308001  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
112309881  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
112309556  collagen alpha-4(VI) chain-like [KO:K06238]
112309687  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
112306524  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
112306535  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
112299197  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
112319309  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
112303890  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
112322610  LAMA1; laminin subunit alpha-1 [KO:K05637]
112297058  LAMA2; laminin subunit alpha-2 [KO:K05637]
112322675  laminin subunit alpha-3-like [KO:K06240]
112303887  LAMA5; laminin subunit alpha-5 [KO:K06240]
112302957  LAMB1; laminin subunit beta-1 [KO:K05636]
112309635  LAMB2; laminin subunit beta-2 [KO:K06243]
112309774  LOW QUALITY PROTEIN: laminin subunit beta-2-like [KO:K06243]
112297463  LAMB3; laminin subunit beta-3 [KO:K06244]
112302299  LAMB4; laminin subunit beta-4 [KO:K06245]
112297926  LAMC1; laminin subunit gamma-1 [KO:K05635]
112296770  LAMC2; laminin subunit gamma-2 [KO:K06246]
112306548  LAMC3; laminin subunit gamma-3 [KO:K06247]
112316447  CHAD; chondroadherin [KO:K06248]
112301870  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
112311111  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
112307475  THBS4; thrombospondin-4 [KO:K04659]
112316816  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
112305111  COMP; cartilage oligomeric matrix protein [KO:K04659]
112297305  THBS2; thrombospondin-2 [KO:K04659]
112307828  FN1; fibronectin isoform X1 [KO:K05717]
112317813  SPP1; osteopontin [KO:K06250]
112308898  VTN; vitronectin [KO:K06251]
112296964  TNR; tenascin-R [KO:K06252]
112296971  TNN; tenascin-N [KO:K06252]
112306301  TNC; tenascin isoform X1 [KO:K06252]
112302461  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
112321736  VWF; von Willebrand factor [KO:K03900]
112317872  IBSP; bone sialoprotein 2 [KO:K06253]
112315280  ITGA1; integrin alpha-1 [KO:K06480]
112315265  ITGA2; integrin alpha-2 [KO:K06481]
112298771  ITGA2B; integrin alpha-IIb [KO:K06476]
112316285  ITGA3; integrin alpha-3 [KO:K06482]
112305817  ITGA4; integrin alpha-4 [KO:K06483]
112318448  ITGA5; integrin alpha-5 [KO:K06484]
112305805  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
112319154  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
112320534  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
112309728  ITGA9; integrin alpha-9 [KO:K06585]
112314615  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
112311545  ITGA11; integrin alpha-11 [KO:K06587]
112305765  ITGAV; integrin alpha-V [KO:K06487]
112317701  ITGB1; integrin beta-1 [KO:K05719]
112316322  ITGB3; integrin beta-3 [KO:K06493]
112298656  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
112320641  ITGB5; integrin beta-5 [KO:K06588]
112322244  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
112318624  ITGB7; integrin beta-7 [KO:K06590]
112306853  ITGB8; integrin beta-8 [KO:K06591]
112310002  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112299448  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
112307667  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112321016  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112305224  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112314466  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112307510  F2R; proteinase-activated receptor 1 [KO:K03914]
112317249  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
112299910  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
112304468  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
112305257  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
112309315  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
112317954  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
112321636  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
112313055  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
112299038  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1 [KO:K04536]
112314848  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
112321762  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
112307690  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
112311263  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
112311848  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
112317210  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
112306067  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
112309348  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
112312610  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
112312956  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
112319855  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
112301587  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
112309207  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
112298501  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
112319891  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
112316579  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
112303039  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
112308895  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
112308643  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
112298319  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
112312378  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
112321079  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
112314641  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
112305601  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
112306281  TSC1; hamartin [KO:K07206]
112298303  TSC2; tuberin isoform X1 [KO:K07207]
112308268  RHEB; GTP-binding protein Rheb [KO:K07208]
112298308  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
112299108  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
112298706  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
112306701  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
112320352  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
112310287  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-like [KO:K03259]
112317824  EIF4E; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E [KO:K03259]
112307725  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
112316527  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
112317229  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
112318239  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
112302900  RPS6; 40S ribosomal protein S6 [KO:K02991]
112316515  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
112301377  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
112309049  PKN2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
112306283  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
112297072  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
112304125  SGK2; LOW QUALITY PROTEIN: serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
112315584  serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
112311458  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112318919  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112320130  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112301206  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
112302462  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
112307354  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112316018  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
112318081  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
112306709  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
112303160  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
112314247  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
112305238  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
112319536  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
112300238  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
112316681  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
112309842  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
112313320  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
112296522  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
112311482  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
112311490  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
112297593  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
112317077  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
112302106  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
112311492  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
112302203  HSP90AB1; LOW QUALITY PROTEIN: heat shock protein HSP 90-beta [KO:K04079]
112321712  HSP90B1; endoplasmin [KO:K09487]
112301537  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
112316349  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
112300771  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
112322856  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
112311777  T-cell leukemia/lymphoma protein 1A-like [KO:K10167]
112308206  MTCP1; protein p13 MTCP-1 [KO:K16837]
112308288  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
112298867  BRCA1; breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
112320540  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
112310186  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
112318340  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
112303849  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
112301208  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
112322295  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
112298835  G6PC; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
112298768  G6PC3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
112315592  MYC; myc proto-oncogene protein [KO:K04377]
112317273  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
112302262  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
112318485  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
112319068  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
112319119  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
112319896  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
112312821  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
112302074  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
112296785  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
112315543  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
112296999  forkhead box protein O3 [KO:K09408]
112296681  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
112297049  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
112319403  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
112303830  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
112297709  YWHAQ; 14-3-3 protein theta [KO:K16197]
112315411  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
112308406  YWHAE; 14-3-3 protein epsilon [KO:K06630]
112314844  YWHAG; 14-3-3 protein gamma [KO:K16198]
112310514  YWHAH; 14-3-3 protein eta [KO:K16198]
112317275  BAD; bcl2-associated agonist of cell death [KO:K02158]
112304196  BCL2L1; bcl-2-like protein 1 [KO:K04570]
112322759  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
112299456  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
112307981  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
112305718  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
112321682  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
112304550  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
112303463  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
112299769  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
112312688  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
112316383  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
112306927  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
112302085  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
112313500  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
112306469  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
112318469  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
112296261  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
112300474  CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
112321547  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
112317202  RELA; transcription factor p65 [KO:K04735]
112317867  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
112297381  MYB; transcriptional activator Myb [KO:K09420]
112319061  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
112308825  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
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Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
dro00010  Glycolysis / Gluconeogenesis
dro04010  MAPK signaling pathway
dro04012  ErbB signaling pathway
dro04062  Chemokine signaling pathway
dro04064  NF-kappa B signaling pathway
dro04068  FoxO signaling pathway
dro04110  Cell cycle
dro04115  p53 signaling pathway
dro04150  mTOR signaling pathway
dro04210  Apoptosis
dro04370  VEGF signaling pathway
dro04510  Focal adhesion
dro04620  Toll-like receptor signaling pathway
dro04630  JAK-STAT signaling pathway
dro04662  B cell receptor signaling pathway
dro04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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