KEGG   PATHWAY: efus04014
Entry
efus04014                   Pathway                                
Name
Ras signaling pathway - Eptesicus fuscus (big brown bat)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
efus04014  Ras signaling pathway
efus04014

Other DBs
GO: 0032318
Organism
Eptesicus fuscus (big brown bat) [GN:efus]
Gene
114234667  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
103291446  TGFA; protransforming growth factor alpha [KO:K08774]
103285537  FGF1; fibroblast growth factor 1 [KO:K18496]
129149245  FGF2; fibroblast growth factor 2 [KO:K18497]
103287415  FGF7; fibroblast growth factor 7 [KO:K04358]
103287907  FGF5; fibroblast growth factor 5 [KO:K04358]
103288035  FGF6; fibroblast growth factor 6 [KO:K04358]
103290305  FGF20; fibroblast growth factor 20 [KO:K04358]
103291051  FGF3; fibroblast growth factor 3 [KO:K04358]
103291052  FGF4; fibroblast growth factor 4 [KO:K04358]
103294320  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
103295224  FGF10; fibroblast growth factor 10 isoform X1 [KO:K04358]
103303646  FGF16; fibroblast growth factor 16 [KO:K04358]
103304154  FGF9; fibroblast growth factor 9 isoform X1 [KO:K04358]
103295085  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
103288651  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
103291622  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
103291053  FGF19; fibroblast growth factor 19 [KO:K22603]
103297653  FGF21; fibroblast growth factor 21 [KO:K22429]
103288115  FGF23; fibroblast growth factor 23 [KO:K22428]
103291218  NGF; beta-nerve growth factor [KO:K02582]
103292699  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
103288995  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
103297641  NTF4; neurotrophin-4 [KO:K12457]
103303257  INS; insulin [KO:K04526]
103288953  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
103303256  IGF2; insulin-like growth factor II [KO:K13769]
103299170  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
103288853  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
103288794  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
103293793  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
103291338  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
103288064  KITLG; kit ligand isoform X2 [KO:K05461]
103297769  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
103296626  VEGFA; vascular endothelial growth factor A [KO:K05448]
103302042  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
103283571  PGF; placenta growth factor isoform X1 [KO:K16859]
103298181  VEGFD; vascular endothelial growth factor D [KO:K05449]
103295457  VEGFC; vascular endothelial growth factor C [KO:K05449]
103293251  HGF; hepatocyte growth factor [KO:K05460]
103287682  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
103300850  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
103285814  ANGPT4; angiopoietin-4 [KO:K05467]
103288735  EFNA5; ephrin-A5 isoform X2 [KO:K05462]
103294302  EFNA2; ephrin-A2 [KO:K05462]
103298904  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
103298905  EFNA3; ephrin-A3 isoform X4 [KO:K05462]
103298906  EFNA4; LOW QUALITY PROTEIN: ephrin-A4 [KO:K05462]
103294241  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103290249  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
103302464  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
103294577  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
103287256  FGFR4; fibroblast growth factor receptor 4 isoform X3 [KO:K05095] [EC:2.7.10.1]
103297077  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
103298850  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
103286498  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
103295001  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
103301950  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103284970  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103295746  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103295744  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
103284972  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
103296752  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
114229025  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
103301270  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
103301676  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
103284973  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
103295948  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
103297376  TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
103292019  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
103298291  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103288090  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
103293630  GAB2; GRB2-associated-binding protein 2 [KO:K08091]
103298913  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
103294446  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
103297925  SHC3; SHC-transforming protein 3 [KO:K17448]
103287410  SHC4; SHC-transforming protein 4 [KO:K17449]
103287068  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
103283761  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
103305666  SOS1; son of sevenless homolog 1 [KO:K03099]
103303954  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
103284403  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
103287296  RASGRP1; RAS guanyl-releasing protein 1 isoform X3 [KO:K04350]
103302054  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
103283126  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
103284349  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
103299676  tyrosine-protein kinase ZAP-70 [KO:K07360] [EC:2.7.10.2]
103300825  LAT; linker for activation of T-cells family member 1 [KO:K07362]
103300060  HTR7; 5-hydroxytryptamine receptor 7 isoform X2 [KO:K04163]
103295279  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X3 [KO:K04536]
103285992  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
103289027  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
103286752  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
103287561  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
103283745  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
103303734  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1 [KO:K04540]
103293513  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
103284162  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
103286474  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
103299657  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
103297851  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
103292609  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
129150929  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
103294263  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
114227350  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
103286557  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
103292756  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
103301022  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
103284108  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
103300750  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
114234933  guanine nucleotide-binding protein G(T) subunit gamma-T1-like [KO:K04548]
103297082  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
103300989  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
103284158  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103303839  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
103305235  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
103295972  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
103286119  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
129149821  glutamate receptor ionotropic, NMDA 2B [KO:K05210]
103292236  CALM1; calmodulin-1 isoform X2 [KO:K02183]
103298572  CALML5; calmodulin-like protein 5 [KO:K02183]
103304916  calmodulin-1-like [KO:K02183]
103305414  CALM2; calmodulin-2 [KO:K02183]
103297693  CALM3; calmodulin-3 isoform X1 [KO:K02183]
103298573  calmodulin-like protein 3 [KO:K02183]
103293186  calmodulin-1-like [KO:K02183]
129148572  calmodulin-1-like [KO:K02183]
103283955  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
129150189  CALML6; calmodulin-like protein 6 [KO:K02183]
103302548  HRAS; GTPase HRas isoform X1 [KO:K02833]
103285154  KRAS; GTPase KRas isoform X1 [KO:K07827]
103291212  NRAS; GTPase NRas [KO:K07828]
103296185  MRAS; ras-related protein M-Ras [KO:K07831]
103297766  RRAS; ras-related protein R-Ras [KO:K07829]
103303300  ras-related protein R-Ras2-like [KO:K07830]
103294676  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
103291696  NF1; neurofibromin isoform X1 [KO:K08052]
103305361  RASA1; ras GTPase-activating protein 1 isoform X2 [KO:K04352]
103296018  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
103288206  RASA3; ras GTPase-activating protein 3 [KO:K12380]
103286017  RASA4B; ras GTPase-activating protein 4B [KO:K17630]
103303017  SYNGAP1; LOW QUALITY PROTEIN: ras/Rap GTPase-activating protein SynGAP [KO:K17631]
103287242  RASAL1; rasGAP-activating-like protein 1 [KO:K17632]
103289987  RASAL2; ras GTPase-activating protein nGAP isoform X1 [KO:K17633]
103300940  RASAL3; RAS protein activator like-3 isoform X1 [KO:K17634]
103298589  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
103297480  RASSF5; ras association domain-containing protein 5 isoform X2 [KO:K08015]
103304083  STK4; serine/threonine-protein kinase 4 [KO:K04411]
103289940  TIAM1; rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
103299146  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
103288892  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
103298339  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
103293618  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
103303550  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
103301610  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
103284333  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
103285671  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
103287306  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
103298865  RHOA; transforming protein RhoA [KO:K04513]
103295254  transforming protein RhoA-like [KO:K04513]
103286747  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103296140  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103295411  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103299551  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103305161  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103294784  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103284312  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
103301793  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103293483  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103302255  IKBKG; NF-kappa-B essential modulator [KO:K07210]
103288473  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
103288179  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103299786  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103291087  RELA; transcription factor p65 isoform X1 [KO:K04735]
103302047  BAD; bcl2-associated agonist of cell death [KO:K02158]
103285583  BCL2L1; bcl-2-like protein 1 [KO:K04570]
103304359  FOXO4; forkhead box protein O4 [KO:K12358]
103289966  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103285709  RALGAPA2; ral GTPase-activating protein subunit alpha-2 [KO:K25768]
103301996  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X1 [KO:K25768]
103301403  RALGAPB; ral GTPase-activating protein subunit beta [KO:K25769]
103305000  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
103290022  RGL1; ral guanine nucleotide dissociation stimulator-like 1 isoform X3 [KO:K17635]
103303023  RGL2; ral guanine nucleotide dissociation stimulator-like 2 isoform X1 [KO:K17636]
103293905  RALA; ras-related protein Ral-A [KO:K07834]
103287731  RALB; ras-related protein Ral-B [KO:K07835]
103299852  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
103286804  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
103304189  EXOC2; exocyst complex component 2 [KO:K17637]
103292497  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
103305378  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
103301660  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
103292821  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103287875  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103304527  RALBP1; ralA-binding protein 1 isoform X1 [KO:K08773]
103291971  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
103289160  LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
103286714  cell division control protein 42 homolog [KO:K04393]
103299839  AFDN; afadin isoform X1 [KO:K05702]
103288561  SHOC2; leucine-rich repeat protein SHOC-2 isoform X1 [KO:K19613]
103295757  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103283794  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
103294231  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103287001  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103296283  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103290714  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
103286836  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
103289476  PLA2G12B; group XIIB secretory phospholipase A2-like protein [KO:K01047] [EC:3.1.1.4]
103292094  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
103292096  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
103291985  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
103291988  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
103293882  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
103286287  group 10 secretory phospholipase A2-like isoform X1 [KO:K01047] [EC:3.1.1.4]
103292093  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
103291987  PLA2G5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
103287254  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
103287344  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
103287518  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
103287517  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
103290127  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
103288871  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X2 [KO:K16343] [EC:3.1.1.4]
103302027  phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
103302085  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
103305316  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
103296406  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
103286926  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
103289813  ETS2; protein C-ets-2 [KO:K21932]
103287057  BRAP; BRCA1-associated protein isoform X2 [KO:K10632] [EC:2.3.2.27]
103291818  KSR1; kinase suppressor of Ras 1 isoform X3 [KO:K14958]
103287085  KSR2; kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
103294502  RAPGEF5; rap guanine nucleotide exchange factor 5 [KO:K08019]
103291183  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
103292519  RAP1B; ras-related protein Rap-1b [KO:K07836]
103288414  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
103293119  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
103296210  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103303678  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103291078  RIN1; ras and Rab interactor 1 [KO:K17638]
103296016  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
103289991  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
103296869  RAB5A; ras-related protein Rab-5A [KO:K07887]
103292407  RAB5B; ras-related protein Rab-5B [KO:K07888]
103293097  RAB5C; ras-related protein Rab-5C [KO:K07889]
103283767  ARF6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
efus04010  MAPK signaling pathway
efus04015  Rap1 signaling pathway
efus04020  Calcium signaling pathway
efus04144  Endocytosis
efus04151  PI3K-Akt signaling pathway
efus04660  T cell receptor signaling pathway
efus04720  Long-term potentiation
efus04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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