KEGG   PATHWAY: hhv05170
Entry
hhv05170                    Pathway                                
Name
Human immunodeficiency virus 1 infection - Hyaena hyaena (striped hyena)
Description
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency syndrome), is a lentivirus belonging to the Retroviridae family. The primary cell surface receptor for HIV-1, the CD4 protein, and the co-receptor for HIV-1, either CCR5 or CXCR4, are found on macrophages and T lymphocytes. At the earliest step, sequential binding of virus envelope (Env) glycoprotein gp120 to CD4 and the co-receptor CCR5 or CXCR4 facilitates HIV-1 entry and has the potential to trigger critical signaling that may favor viral replication. At advanced stages of the disease, HIV-1 infection results in dramatic induction of T-cell (CD4+ T and CD8+ T cell) apoptosis both in infected and uninfected bystander T cells, a hallmark of HIV-1 pathogenesis. On the contrary, macrophages are resistant to the cytopathic effect of HIV-1 and produce virus for longer periods of time.
Class
Human Diseases; Infectious disease: viral
Pathway map
hhv05170  Human immunodeficiency virus 1 infection
hhv05170

Organism
Hyaena hyaena (striped hyena) [GN:hhv]
Gene
120220463  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
120243193  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
120234082  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
120237069  S-phase kinase-associated protein 1-like [KO:K03094]
120238518  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
120249038  LOW QUALITY PROTEIN: S-phase kinase-associated protein 1-like [KO:K03094]
120246394  CUL1; cullin-1 [KO:K03347]
120234320  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
120234672  E3 ubiquitin-protein ligase RBX1-like [KO:K03868] [EC:2.3.2.32]
120236827  E3 ubiquitin-protein ligase RBX1-like [KO:K03868] [EC:2.3.2.32]
120230386  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
120229184  C-C chemokine receptor type 5-like [KO:K04180]
120229291  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
120244506  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
120245414  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
120232146  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
120233608  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
120220979  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
120246696  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
120219997  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
120239233  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
120247089  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
120232325  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
120220289  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
120230646  PXN; paxillin isoform X1 [KO:K05760]
120238810  CRKL; crk-like protein [KO:K04438]
120245519  CRK; adapter molecule crk isoform X1 [KO:K04438]
120235277  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120244696  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120247774  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120233604  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
120233932  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
120241926  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
120222817  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
120240185  RELA; transcription factor p65 [KO:K04735]
120231952  FOS; proto-oncogene c-Fos [KO:K04379]
120236252  JUN; transcription factor AP-1 [KO:K04448]
120240137  BAD; bcl2-associated agonist of cell death [KO:K02158]
120223392  HRAS; GTPase HRas isoform X1 [KO:K02833]
120223531  KRAS; GTPase KRas [KO:K07827]
120243068  NRAS; GTPase NRas [KO:K07828]
120231327  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
120221655  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
120242086  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
120238830  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
120242212  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
120238451  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
120242104  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
120228585  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
120228197  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
120237135  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
120237482  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
120238181  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
120232098  CALM1; calmodulin-1 [KO:K02183]
120237182  calmodulin-like [KO:K02183]
120237195  calmodulin-like protein 3 [KO:K02183]
120241014  CALM2; calmodulin-2 [KO:K02183]
120221982  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
120241987  CALM3; calmodulin-3 isoform X1 [KO:K02183]
120242524  CALML6; calmodulin-like protein 6 [KO:K02183]
120225617  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
120233735  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120239494  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120220964  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
120236651  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
120240942  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
120230427  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
120223543  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
120247040  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
120234190  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
120233260  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
120239766  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
120242569  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
120223690  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1 [KO:K04537]
120220432  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
120246690  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
120235024  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
120247989  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
120249175  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
120241831  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
120241642  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
120244574  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
120242329  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
120237008  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
120234397  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
120220331  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
120245305  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
120241598  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
120234413  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
120229112  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
120227958  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
120241186  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
120228188  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
120229608  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
120244384  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
120241977  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
120242769  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
120226240  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
120232303  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
120247359  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
120227439  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
120240213  CFL1; cofilin-1 [KO:K05765]
120248603  CFL2; cofilin-2 isoform X1 [KO:K05765]
120221913  TNF; tumor necrosis factor [KO:K03156]
120224910  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
120235381  BCL2L1; bcl-2-like protein 1 [KO:K04570]
120233209  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
120240966  TLR4; toll-like receptor 4 [KO:K10160]
120235110  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
120246010  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
120221716  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
120232555  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
120233644  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
120237570  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
120231881  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
120243217  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
120233999  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
120226622  IKBKG; NF-kappa-B essential modulator [KO:K07210]
120248609  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
120239878  interferon alpha-like [KO:K05414]
120223241  interferon alpha-like [KO:K05414]
120223242  interferon alpha-like [KO:K05414]
120239877  IFNB1; interferon beta [KO:K05415]
120233796  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
120233829  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
120234701  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
120235253  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
120244180  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
120232781  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
120245677  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
120242942  CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
120245611  STING1; stimulator of interferon genes protein [KO:K12654]
120233179  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
120244065  IRF3; interferon regulatory factor 3 [KO:K05411]
120234545  DNA dC->dU-editing enzyme APOBEC-3D-like isoform X1 [KO:K18750] [EC:3.5.4.-]
120227638  APOBEC3A; DNA dC->dU-editing enzyme APOBEC-3A [KO:K18750] [EC:3.5.4.-]
120228612  SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [KO:K22544] [EC:3.1.5.-]
120225598  tripartite motif-containing protein 5-like [KO:K10648] [EC:2.3.2.27]
120239203  BST2; bone marrow stromal antigen 2 [KO:K06731]
120221151  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
120241444  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
120223347  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
120230541  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
120226445  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
120228759  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
120230246  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
120244848  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
120224200  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
120223778  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
120233869  FADD; FAS-associated death domain protein [KO:K02373]
120220675  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
120243781  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
120243716  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
120238211  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
120245032  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
120224242  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
120232774  cytochrome c-like [KO:K08738]
120233433  cytochrome c-like [KO:K08738]
120221184  cytochrome c [KO:K08738]
120221556  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
120230330  cytochrome c [KO:K08738]
120231297  cytochrome c-like [KO:K08738]
120236951  cytochrome c-like [KO:K08738]
120247050  cytochrome c-like [KO:K08738]
120229837  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
120246375  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
120229941  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
120229957  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
120229959  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
120238260  CD247; T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453]
120238159  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
120238160  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
120238209  tapasin [KO:K08058]
120232197  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
120243718  LOW QUALITY PROTEIN: calreticulin-like [KO:K08057]
120245285  CALR; calreticulin [KO:K08057]
120226363  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
120221878  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
120221918  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
120222660  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
120227454  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
120223586  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
120247021  AP1G2; AP-1 complex subunit gamma-like 2 isoform X1 [KO:K12391]
120239191  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
120244488  AP1M2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
120232929  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
120239266  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
120234833  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
120243816  B2M; beta-2-microglobulin [KO:K08055]
120241503  ELOB; elongin-B [KO:K03873]
120237581  elongin-C-like [KO:K03872]
120235868  ELOC; elongin-C [KO:K03872]
120224569  CUL5; LOW QUALITY PROTEIN: cullin-5 [KO:K10612]
120242665  RNF7; RING-box protein 2 isoform X1 [KO:K10611]
120239397  DCAF1; DDB1- and CUL4-associated factor 1 isoform X1 [KO:K11789] [EC:2.7.11.1]
120246155  DDB1; DNA damage-binding protein 1 [KO:K10610]
120228328  CUL4A; cullin-4A [KO:K10609]
120223382  CUL4B; cullin-4B isoform X1 [KO:K10609]
120229863  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
120221751  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
120243919  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
120220748  CDC25C; M-phase inducer phosphatase 3 isoform X1 [KO:K05867] [EC:3.1.3.48]
120232995  WEE2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
120240035  WEE1; wee1-like protein kinase isoform X1 [KO:K06632] [EC:2.7.11.1]
120247955  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
120230878  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
120223135  CCNB3; G2/mitotic-specific cyclin-B3 [KO:K21771]
120244139  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
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Evans VA, Khoury G, Saleh S, Cameron PU, Lewin SR
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HIV persistence: chemokines and their signalling pathways.
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Cytokine Growth Factor Rev 23:151-7 (2012)
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Reference
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Plasma membrane signaling in HIV-1 infection.
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Biochim Biophys Acta 1838:1132-42 (2014)
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PMID:20041213
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PLoS Pathog 5:e1000520 (2009)
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PMID:22085380
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Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).
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J Med Chem 55:977-94 (2012)
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Reference
PMID:21321123
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Vorster PJ, Guo J, Yoder A, Wang W, Zheng Y, Xu X, Yu D, Spear M, Wu Y
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LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection.
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J Biol Chem 286:12554-64 (2011)
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Reference
PMID:15817946
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Das SR, Jameel S
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Biology of the HIV Nef protein.
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Indian J Med Res 121:315-32 (2005)
Reference
PMID:24822052
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Roy N, Pacini G, Berlioz-Torrent C, Janvier K
  Title
Mechanisms underlying HIV-1 Vpu-mediated viral egress.
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Front Microbiol 5:177 (2014)
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Reference
PMID:22090097
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Magadan JG, Bonifacino JS
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Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.
  Journal
J Virol 86:757-72 (2012)
DOI:10.1128/JVI.05933-11
Reference
PMID:26056579
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Kumar A, Herbein G
  Title
The macrophage: a therapeutic target in HIV-1 infection.
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Mol Cell Ther 2:10 (2014)
DOI:10.1186/2052-8426-2-10
Reference
PMID:20672047
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Yokota S, Okabayashi T, Fujii N
  Title
The battle between virus and host: modulation of Toll-like receptor signaling pathways by virus infection.
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Mediators Inflamm 2010:184328 (2010)
DOI:10.1155/2010/184328
Reference
PMID:26628325
  Authors
Sauter D, Kirchhoff F
  Title
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Related
pathway
hhv03050  Proteasome
hhv04010  MAPK signaling pathway
hhv04020  Calcium signaling pathway
hhv04064  NF-kappa B signaling pathway
hhv04110  Cell cycle
hhv04141  Protein processing in endoplasmic reticulum
hhv04142  Lysosome
hhv04150  mTOR signaling pathway
hhv04151  PI3K-Akt signaling pathway
hhv04210  Apoptosis
hhv04612  Antigen processing and presentation
hhv04620  Toll-like receptor signaling pathway
hhv04623  Cytosolic DNA-sensing pathway
hhv04668  TNF signaling pathway
hhv04810  Regulation of actin cytoskeleton
KO pathway
ko05170   
LinkDB

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