KEGG   PATHWAY: mcc05169
Entry
mcc05169                    Pathway                                
Name
Epstein-Barr virus infection - Macaca mulatta (rhesus monkey)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
mcc05169  Epstein-Barr virus infection
mcc05169

Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
714202  CR2; complement receptor type 2 isoform X1 [KO:K04012]
705211  CD19; B-lymphocyte antigen CD19 isoform X3 [KO:K06465]
692100  MAMU-DRB1; major histocompatibility complex, class II, DR beta 1 precursor [KO:K06752]
717870  MAMU-DMA; major histocompatibility complex, class II, DM alpha precursor [KO:K06752]
717969  MAMU-DPB; major histocompatibility complex, class II, DP beta [KO:K06752]
717947  MAMU-DOA; major histocompatibility complex, class II, DO alpha precursor [KO:K06752]
717992  MAMU-DPA; major histocompatibility complex, class II, DP alpha [KO:K06752]
717702  MAMU-DOB; major histocompatibility complex, class II, DO beta precursor [KO:K06752]
100187587  MAMU-DRA; mamu class II histocompatibility antigen, DR alpha chain precursor [KO:K06752]
720582  MAMU-DQA1; major histocompatibility complex, class II, DQ alpha 1 precursor [KO:K06752]
716823  MAMU-DQB1; major histocompatibility complex, class II, DQ beta 1 precursor [KO:K06752]
100429857  MAMU-DMB; major histocompatibility complex, class II, DM beta precursor [KO:K06752]
100428228  MAMU-DRB5; LOW QUALITY PROTEIN: MHC class II antigen, Mamu-DRB5 [KO:K06752]
100428435  HLA class II histocompatibility antigen, DRB1-3 chain [KO:K06752]
114669810  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
114675357  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
106997902  DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X1 [KO:K06752]
574290  TLR2; toll-like receptor 2 precursor [KO:K10159]
696494  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
700568  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
699919  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
716907  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
703409  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
696875  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
703101  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
709511  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3 [KO:K04467] [EC:2.7.11.10]
704683  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
701237  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
695335  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
710324  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
715919  RELA; transcription factor p65 isoform X1 [KO:K04735]
715467  TNF; tumor necrosis factor [KO:K03156]
705819  IL6; interleukin-6 precursor [KO:K05405]
704638  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
717616  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
693961  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
717427  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
695607  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
699578  IRF7; interferon regulatory factor 7 [KO:K09447]
718970  IRF3; interferon regulatory factor 3 [KO:K05411]
709948  IFNA2; interferon alpha-2 precursor [KO:K05414]
709755  IFNA8; interferon alpha-8 [KO:K05414]
710751  interferon alpha-17-like [KO:K05414]
694631  interferon alpha-1/13-like [KO:K05414]
710487  interferon alpha-14 [KO:K05414]
710528  interferon alpha-1/13 [KO:K05414]
710568  interferon alpha-4-like [KO:K05414]
710654  IFNA10; interferon alpha-4 precursor [KO:K05414]
711252  IFNA21; interferon alpha-21 [KO:K05414]
709559  IFNA13; interferon alpha-1/13 precursor [KO:K05414]
711088  interferon alpha-17-like [KO:K05414]
106992322  interferon alpha-17 [KO:K05414]
710848  interferon alpha-17 [KO:K05414]
106995851  IFNA6; interferon alpha-6 [KO:K05414]
114672663  interferon alpha-17-like [KO:K05414]
114672664  interferon alpha-17-like [KO:K05414]
711414  IFNB1; interferon beta precursor [KO:K05415]
699604  IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130]
699726  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
677689  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
574130  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
693650  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
712694  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
715335  IRF9; interferon regulatory factor 9 [KO:K04693]
708912  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
712265  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
712401  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
712342  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
574243  CXCL10; C-X-C motif chemokine 10 precursor [KO:K12671]
700141  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
574332  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
708606  FADD; FAS-associated death domain protein [KO:K02373]
702781  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100426724  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
697082  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
707407  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
718948  BAX; apoptosis regulator BAX [KO:K02159]
706534  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
114675515  bcl-2 homologous antagonist/killer-like [KO:K14021]
705449  cytochrome c-like [KO:K08738]
716056  cytochrome c-like [KO:K08738]
711309  cytochrome c-like [KO:K08738]
698225  cytochrome c-like [KO:K08738]
701246  cytochrome c-like [KO:K08738]
699951  cytochrome c-like [KO:K08738]
702488  cytochrome c-like [KO:K08738]
100425223  CYCS; cytochrome c [KO:K08738]
106995399  cytochrome c-like [KO:K08738]
712148  cytochrome c-like [KO:K08738]
694164  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
694544  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
694473  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
710149  uncharacterized protein LOC710149 [KO:K10784]
698785  LOW QUALITY PROTEIN: uncharacterized protein LOC698785 [KO:K10785]
696306  T cell receptor beta variable 3-1 [KO:K10785]
697904  uncharacterized protein LOC697904 [KO:K10785]
703029  immunoglobulin lambda-1 light chain-like [KO:K10785]
699467  CD3E; T-cell surface glycoprotein CD3 epsilon chain isoform X1 [KO:K06451]
705270  CD3G; T-cell surface glycoprotein CD3 gamma chain precursor [KO:K06452]
699582  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
697814  CD247; T-cell surface glycoprotein CD3 zeta chain precursor [KO:K06453]
722117  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
697799  PSMC1; proteasome (prosome, macropain) 26S subunit, ATPase, 1 [KO:K03062]
699847  PSMC4; 26S protease regulatory subunit 6B [KO:K03063]
710822  PSMC6; 26S proteasome regulatory subunit 10B isoform X2 [KO:K03064]
693577  26S proteasome regulatory subunit 10B [KO:K03064]
713356  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
717437  PSMC5; 26S protease regulatory subunit 8 [KO:K03066]
705035  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
711724  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
698712  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
718756  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
717953  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
698601  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
705581  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
696966  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
100192390  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
701063  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
721897  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
699928  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
698349  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
717726  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
717742  TAP2; antigen peptide transporter 2 isoform X1 [KO:K05654] [EC:7.4.2.14]
718235  TAPBP; tapasin precursor [KO:K08058]
711029  PDIA3; protein disulfide-isomerase A3 precursor [KO:K08056] [EC:5.3.4.1]
114672113  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
716910  CALR; calreticulin precursor [KO:K08057]
694372  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like isoform X1 [KO:K06751]
709076  MAMU-F; mamu class I histocompatibility antigen, alpha chain F precursor [KO:K06751]
711832  MAMU-A; major histocompatibility complex, class I, A isoform X1 [KO:K06751]
723473  patr class I histocompatibility antigen, B-1 alpha chain-like precursor [KO:K06751]
711532  MAMU-E; major histocompatibility complex, class I, E precursor [KO:K06751]
699243  MAMU-A3; major histocompatibility complex, class I, A isoform X1 [KO:K06751]
714964  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-67 alpha chain-like [KO:K06751]
719702  HLA class I histocompatibility antigen, B-46 alpha chain-like precursor [KO:K06751]
100187576  MAMU-AG; major histocompatibility complex, class I, AG precursor [KO:K06751]
719250  HLA class I histocompatibility antigen, B-14 alpha chain isoform X7 [KO:K06751]
106995452  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
100426197  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
100424348  HLA class I histocompatibility antigen, B-14 alpha chain isoform X1 [KO:K06751]
106996676  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-46 alpha chain-like [KO:K06751]
106996627  HLA class I histocompatibility antigen, B-15 alpha chain-like isoform X1 [KO:K06751]
114676051  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-14 alpha chain-like [KO:K06751]
106997893  HLA class I histocompatibility antigen, B-15 alpha chain-like isoform X1 [KO:K06751]
114677644  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
720132  HLA class I histocompatibility antigen, B-38 alpha chain-like [KO:K06751]
712428  B2M; beta-2-microglobulin precursor [KO:K08055]
641448  SNW1; SNW domain-containing protein 1 isoform X1 [KO:K06063]
705719  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
708441  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
694662  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
706261  NCOR2; nuclear receptor corepressor 2 isoform X8 [KO:K06065]
696519  SAP30; histone deacetylase complex subunit SAP30 [KO:K19202]
714400  SAP30L; histone deacetylase complex subunit SAP30L [KO:K19202]
698068  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
694601  RBPJ; recombining binding protein suppressor of hairless [KO:K06053]
717625  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
707140  HES1; transcription factor HES-1 [KO:K06054]
708980  FCER2; low affinity immunoglobulin epsilon Fc receptor isoform X1 [KO:K06468]
719447  RUNX3; runt-related transcription factor 3 [KO:K09279]
694626  MYC; myc proto-oncogene protein [KO:K04377]
714625  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X2 [KO:K11838] [EC:3.4.19.12]
718284  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
716170  TP53; cellular tumor antigen p53 [KO:K04451]
719199  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
697835  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
701054  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
711257  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
713813  DDB2; DNA damage-binding protein 2 [KO:K10140]
114672263  LOW QUALITY PROTEIN: DNA damage-binding protein 2-like [KO:K10140]
705713  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
711879  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
716098  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
709959  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
710552  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
707310  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
719367  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
698996  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
714717  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
697747  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
700591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
716258  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
714677  RELB; transcription factor RelB isoform X1 [KO:K09253]
714689  nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
114669860  NFKB2; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p100 subunit [KO:K04469]
698160  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
694844  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
702498  NFKBIE; LOW QUALITY PROTEIN: NF-kappa-B inhibitor epsilon [KO:K05872]
718155  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
710077  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
699736  MAPK10; mitogen-activated protein kinase 10 isoform 1 [KO:K04440] [EC:2.7.11.24]
711115  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
715782  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
708391  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
708013  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X2 [KO:K02861] [EC:2.7.11.1]
705195  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
693914  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
715745  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
715794  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
718976  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
719085  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
716452  JUN; transcription factor AP-1 [KO:K04448]
704424  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X2 [KO:K01510] [EC:3.6.1.5]
718311  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
707749  CD40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160]
717204  CD44; CD44 antigen isoform X1 [KO:K06256]
711945  ITGAL; integrin alpha-L isoform X2 [KO:K05718]
710732  CD58; lymphocyte function-associated antigen 3 [KO:K06492]
712280  ICAM1; intercellular adhesion molecule 1 precursor [KO:K06490]
705289  VIM; vimentin [KO:K07606]
704130  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
720040  JAK3; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
114669853  LOW QUALITY PROTEIN: tyrosine-protein kinase JAK3-like [KO:K11218] [EC:2.7.10.2]
574128  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
698553  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
704102  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
699550  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
717755  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
721002  LOW QUALITY PROTEIN: immunoglobulin heavy variable 4-39 [KO:K06856]
106999628  immunoglobulin heavy variable 4-4 [KO:K06856]
114675805  uncharacterized protein LOC114675805 [KO:K06856]
720935  immunoglobulin heavy variable 4-61 [KO:K06856]
720985  immunoglobulin heavy variable 4-59 [KO:K06856]
714419  uncharacterized protein LOC714419 [KO:K06856]
721083  LOW QUALITY PROTEIN: immunoglobulin heavy variable 4-28 [KO:K06856]
722278  immunoglobulin heavy variable 4-59 [KO:K06856]
106996003  immunoglobulin heavy variable 4-38-2 [KO:K06856]
720452  Ig heavy chain V region MOPC 315 isoform X1 [KO:K06856]
720904  immunoglobulin heavy variable 4-59 isoform X1 [KO:K06856]
114679736  uncharacterized protein LOC114679736 [KO:K06856]
703000  BTK; tyrosine-protein kinase BTK isoform X2 [KO:K07370] [EC:2.7.10.2]
704363  BLNK; B-cell linker protein isoform X2 [KO:K07371]
714173  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
700617  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
697188  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
574320  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
710379  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
695215  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
715650  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
701822  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
707259  CCNA2; cyclin-A2 [KO:K06627]
693797  CCNA1; cyclin-A1 isoform X3 [KO:K06627]
700589  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
700382  CCNE2; G1/S-specific cyclin-E2 isoform X2 [KO:K06626]
711002  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
704871  RB1; retinoblastoma-associated protein [KO:K06618]
714126  E2F1; transcription factor E2F1 [KO:K17454]
710200  E2F2; transcription factor E2F2 [KO:K09389]
713904  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
  Journal
Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
  Journal
Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
mcc03050  Proteasome
mcc04010  MAPK signaling pathway
mcc04020  Calcium signaling pathway
mcc04064  NF-kappa B signaling pathway
mcc04110  Cell cycle
mcc04115  p53 signaling pathway
mcc04210  Apoptosis
mcc04612  Antigen processing and presentation
mcc04620  Toll-like receptor signaling pathway
mcc04622  RIG-I-like receptor signaling pathway
mcc04630  JAK-STAT signaling pathway
mcc04662  B cell receptor signaling pathway
KO pathway
ko05169   
LinkDB

DBGET integrated database retrieval system