KEGG   PATHWAY: sara05417
Entry
sara05417                   Pathway                                
Name
Lipid and atherosclerosis - Sorex araneus (European shrew)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
sara05417  Lipid and atherosclerosis
sara05417

Organism
Sorex araneus (European shrew) [GN:sara]
Gene
101550503  APOB; LOW QUALITY PROTEIN: apolipoprotein B-100 [KO:K14462]
101541684  apolipoprotein A-IV [KO:K08760]
101541159  apolipoprotein A-IV-like [KO:K08760]
101541425  apolipoprotein A-IV-like [KO:K08760]
101542214  APOA1; apolipoprotein A-I [KO:K08757]
101552750  LDLR; low-density lipoprotein receptor [KO:K12473]
101556317  OLR1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
101542367  ARHGEF1; rho guanine nucleotide exchange factor 1 [KO:K12330]
101545391  MMP1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
101544191  transforming protein RhoA [KO:K04513]
101557527  LOW QUALITY PROTEIN: transforming protein RhoA-like [KO:K04513]
101539253  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
101547011  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
101542917  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101556597  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101548304  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101547106  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101541868  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101540938  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101543096  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101559009  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101543371  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101540951  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
101549930  BAD; bcl2-associated agonist of cell death [KO:K02158]
101542397  bcl-2-like protein 1 isoform X1 [KO:K04570]
101558524  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
101545820  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101538553  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101556557  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101556063  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101537605  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
101551961  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101548626  POU2F2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
101550140  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
101559154  POU2F1; POU domain, class 2, transcription factor 1 [KO:K09364]
101546061  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
101552082  CD40LG; CD40 ligand [KO:K03161]
101550604  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
101547677  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101558147  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101558420  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101547147  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101547409  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101547951  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101545016  AGER; advanced glycosylation end product-specific receptor isoform X3 [KO:K19722]
101542682  cytochrome b-245 heavy chain isoform X1 [KO:K21421] [EC:1.-.-.-]
101546517  NCF1; neutrophil cytosol factor 1 [KO:K08011]
101540075  cytochrome b-245 light chain [KO:K08009]
101547168  NCF2; neutrophil cytosol factor 2 [KO:K08010]
101554314  NCF4; neutrophil cytosol factor 4 [KO:K08012]
101557373  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101559065  SRC; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
101550196  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
101552896  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
101540617  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101542924  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
101554595  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101545059  FOS; proto-oncogene c-Fos isoform X1 [KO:K04379]
101545218  C-C motif chemokine 2-like [KO:K14624]
101542043  C-C motif chemokine 2-like [KO:K14624]
101549044  ICAM1; LOW QUALITY PROTEIN: intercellular adhesion molecule 1 [KO:K06490]
101559441  CXCL8; interleukin-8 [KO:K10030]
101555912  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
101542881  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
101536977  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101537598  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101554044  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101545321  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101546777  HRAS; GTPase HRas [KO:K02833]
101557531  KRAS; GTPase KRas isoform X1 [KO:K07827]
101559343  NRAS; GTPase NRas [KO:K07828]
101559341  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101541587  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
101545848  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
101543163  RELA; transcription factor p65 [KO:K04735]
101549580  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
101541535  SELE; E-selectin [KO:K06494]
101541271  SELP; P-selectin [KO:K06496]
101545075  VCAM1; vascular cell adhesion protein 1 isoform X1 [KO:K06527]
101545129  stromelysin-1 [KO:K01394] [EC:3.4.24.17]
101545527  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
101550075  IL1B; interleukin-1 beta [KO:K04519]
101540363  IL6; interleukin-6 [KO:K05405]
101558664  TNF; tumor necrosis factor [KO:K03156]
101558735  HSPD1; 60 kDa heat shock protein, mitochondrial isoform X1 [KO:K04077] [EC:5.6.1.7]
101554325  LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
101540963  heat shock 70 kDa protein 1-like [KO:K03283]
101549601  heat shock 70 kDa protein 1 [KO:K03283]
101555362  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
101556811  HSPA2; heat shock-related 70 kDa protein 2 isoform X2 [KO:K26598]
101556889  HSPA4; heat shock 70 kDa protein 4 isoform X2 [KO:K09489]
101538241  HSP90AA1; heat shock protein HSP 90-alpha isoform X1 [KO:K04079]
101549543  HSP90AB1; heat shock protein HSP 90-beta isoform X1 [KO:K04079]
101555614  HSP90B1; LOW QUALITY PROTEIN: endoplasmin [KO:K09487]
101542483  TLR2; toll-like receptor 2 [KO:K10159]
101549027  uncharacterized protein LOC101549027 [KO:K05399]
101551488  CD14; monocyte differentiation antigen CD14 [KO:K04391]
101542285  LY96; lymphocyte antigen 96 [KO:K05400]
101548691  TLR4; toll-like receptor 4 [KO:K10160]
101552741  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
101547526  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
101539504  IRAK1; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
101543216  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101547502  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
101539336  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101546102  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101538389  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101540472  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101536840  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101556810  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101539539  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
101557102  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
101538970  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101545842  MIB1; E3 ubiquitin-protein ligase MIB1 [KO:K10645] [EC:2.3.2.27]
101542398  MIB2; E3 ubiquitin-protein ligase MIB2 [KO:K10645] [EC:2.3.2.27]
101538094  TANK; TRAF family member-associated NF-kappa-B activator [KO:K12650]
101552901  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
101542553  TBK1; serine/threonine-protein kinase TBK1 isoform X2 [KO:K05410] [EC:2.7.11.10]
101545292  IRF7; interferon regulatory factor 7 [KO:K09447]
101542890  IRF3; interferon regulatory factor 3 [KO:K05411]
101549593  LOW QUALITY PROTEIN: interferon alpha-14 [KO:K05414]
101548268  IFNB1; interferon beta [KO:K05415]
101545905  platelet glycoprotein 4-like [KO:K06259]
101546427  platelet glycoprotein 4-like isoform X1 [KO:K06259]
101544894  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
101553357  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
101542702  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
101549211  RXRG; retinoic acid receptor RXR-gamma [KO:K08526]
101544577  LYN; tyrosine-protein kinase Lyn isoform X2 [KO:K05854] [EC:2.7.10.2]
101540332  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
101549936  VAV1; LOW QUALITY PROTEIN: proto-oncogene vav [KO:K05730]
101550254  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
101549098  TLR6; toll-like receptor 6 [KO:K10169]
101543770  RAP1A; ras-related protein Rap-1A [KO:K04353]
101545287  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
101548921  CCL5; C-C motif chemokine 5 [KO:K12499]
101547856  C-C motif chemokine 3-like [KO:K05408]
101548395  C-C motif chemokine 3-like [KO:K05408]
101548127  C-C motif chemokine 3-like [KO:K05408]
101544994  growth-regulated protein homolog [KO:K05505]
101545791  growth-regulated protein homolog gamma-like [KO:K05505]
101539403  IL12A; interleukin-12 subunit alpha [KO:K05406]
101542768  IL12B; interleukin-12 subunit beta [KO:K05425]
101559035  IL18; interleukin-18 [KO:K05482]
101546566  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
101552652  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
101555958  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101538155  ERO1L; ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
101556467  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
101545625  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101542258  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
101549665  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
101549827  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
101552290  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
101555179  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
101552557  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101539159  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101546144  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
101550002  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101547499  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101550010  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
101543604  ABCA1; ATP-binding cassette sub-family A member 1 [KO:K05641]
101541225  ABCG1; ATP-binding cassette sub-family G member 1 [KO:K05679]
101542637  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
101546398  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
101552446  caspase-1-like [KO:K01370] [EC:3.4.22.36]
101547008  VLDLR; very low-density lipoprotein receptor isoform X1 [KO:K20053]
101540891  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
101538779  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
101536841  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101554287  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101555053  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
101549236  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101551223  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
101546811  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101547690  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101559179  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
101545860  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
101554401  CALM1; calmodulin isoform X1 [KO:K02183]
101552535  CALML3; calmodulin-like protein 3 [KO:K02183]
101545302  CALML5; calmodulin-like protein 5 [KO:K02183]
101546941  CALML4; calmodulin-like protein 4 [KO:K02183]
101541555  CALM2; calmodulin [KO:K02183]
101543973  calmodulin-like [KO:K02183]
101559307  CALM3; calmodulin [KO:K02183]
101557366  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101558512  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
101555223  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
101556800  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101541742  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101536897  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
101537204  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B [KO:K04722]
101541261  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101543078  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
101546492  BID; BH3-interacting domain death agonist [KO:K04726]
101558408  cytochrome c, somatic [KO:K08738]
101538879  cytochrome c-like [KO:K08738]
101549686  cytochrome c, somatic [KO:K08738]
101543860  cytochrome c 2 [KO:K08738]
101537432  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
101537803  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101557941  caspase-6-like [KO:K04396] [EC:3.4.22.59]
101538110  caspase-6-like [KO:K04396] [EC:3.4.22.59]
101539439  caspase-6-like [KO:K04396] [EC:3.4.22.59]
101540223  caspase-6-like [KO:K04396] [EC:3.4.22.59]
101538373  caspase-6-like [KO:K04396] [EC:3.4.22.59]
101538645  caspase-6-like [KO:K04396] [EC:3.4.22.59]
101538911  caspase-6-like [KO:K04396] [EC:3.4.22.59]
101539695  caspase-6-like [KO:K04396] [EC:3.4.22.59]
101539962  caspase-6-like [KO:K04396] [EC:3.4.22.59]
101539340  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
101536946  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
101558045  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:E218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
DOI:10.1016/s0735-1097(02)01803-x
Reference
PMID:19286611
  Authors
Li D, Mehta JL
  Title
Intracellular signaling of LOX-1 in endothelial cell apoptosis.
  Journal
Circ Res 104:566-8 (2009)
DOI:10.1161/CIRCRESAHA.109.194209
Reference
PMID:24886290
  Authors
Lubrano V, Balzan S
  Title
LOX-1 and ROS, inseparable factors in the process of endothelial damage.
  Journal
Free Radic Res 48:841-8 (2014)
DOI:10.3109/10715762.2014.929122
Reference
PMID:23124189
  Authors
Xu S, Ogura S, Chen J, Little PJ, Moss J, Liu P
  Title
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers.
  Journal
Cell Mol Life Sci 70:2859-72 (2013)
DOI:10.1007/s00018-012-1194-z
Reference
PMID:21947818
  Authors
Mitra S, Goyal T, Mehta JL
  Title
Oxidized LDL, LOX-1 and atherosclerosis.
  Journal
Cardiovasc Drugs Ther 25:419-29 (2011)
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Related
pathway
sara04020  Calcium signaling pathway
sara04115  p53 signaling pathway
sara04141  Protein processing in endoplasmic reticulum
sara04151  PI3K-Akt signaling pathway
sara04210  Apoptosis
sara04620  Toll-like receptor signaling pathway
sara04621  NOD-like receptor signaling pathway
sara04668  TNF signaling pathway
sara04670  Leukocyte transendothelial migration
sara04975  Fat digestion and absorption
sara04979  Cholesterol metabolism
sara05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   
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