KEGG   PATHWAY: tvc04010
Entry
tvc04010                    Pathway                                
Name
MAPK signaling pathway - Tachysurus vachellii
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
tvc04010  MAPK signaling pathway
tvc04010

Other DBs
GO: 0000165
Organism
Tachysurus vachellii [GN:tvc]
Gene
132860598  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
132839061  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b isoform X1 [KO:K04344]
132855301  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a isoform X1 [KO:K04849]
132859654  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
132858817  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
132837870  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a [KO:K04851]
132853210  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
132848965  cacna1eb; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
132853251  voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
132853295  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit isoform X1 [KO:K04853]
132853808  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
132838479  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
132863940  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
132860671  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
132844910  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
132838336  cacna1sa; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, L type, alpha 1S subunit, a [KO:K04857]
132853220  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
132851376  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
132837790  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
132844648  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
132837953  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
132853795  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
132856244  cacna2d4b; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
132861083  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
132848422  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
132862488  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
132850114  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
132844803  cacnb4b; voltage-dependent L-type calcium channel subunit beta-4b isoform X1 [KO:K04865]
132861341  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
132844849  cacng1a; calcium channel, voltage-dependent, gamma subunit 1a [KO:K04866]
132861045  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
132844908  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
132861701  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
132839185  cacng3a; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
132861058  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
132844031  cacng4a; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
132861076  voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870]
132844868  cacng5a; calcium channel, voltage-dependent, gamma subunit 5a [KO:K04870]
132842232  cacng6a; calcium channel, voltage-dependent, gamma subunit 6a [KO:K04871]
132846046  cacng6b; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
132845350  cacng7b; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
132842230  cacng8a; calcium channel, voltage-dependent, gamma subunit 8a [KO:K04873]
132845351  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
132848952  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
132837519  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
132839525  prkacab; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
132853762  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
132860690  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
132844847  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
132861454  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
132839183  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
132845349  prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
132863941  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
132861255  gng14; GGL domain-containing protein [KO:K04347]
132844071  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a [KO:K04347]
132844417  gng12b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
132848538  protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
132854617  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
132860314  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
132857438  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
132863758  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
132839253  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
132847007  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
132851086  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
132855259  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
132863344  rasgrf2a; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
132850964  rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K04350]
132851923  RAS guanyl-releasing protein 1-like [KO:K04350]
132841760  RAS guanyl-releasing protein 2-like [KO:K12361]
132859715  rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
132852002  rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
132841895  rapgef2a; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
132855978  rapgef2b; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
132863023  nf1b; neurofibromin isoform X1 [KO:K08052]
132858235  nf1a; neurofibromin isoform X1 [KO:K08052]
132855345  rasa1a; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
132851056  rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
132838122  rap1ab; ras-related protein rap1ab [KO:K04353]
132853270  rap1aa; RAP1A, member of RAS oncogene family a [KO:K04353]
132859455  rap1b; ras-related protein Rap-1b [KO:K07836]
132855618  egf; pro-epidermal growth factor [KO:K04357]
132844463  tgfa; protransforming growth factor alpha [KO:K08774]
132859949  fgf1b; fibroblast growth factor 1b isoform X1 [KO:K18496]
132861733  fgf2; fibroblast growth factor 2 [KO:K18497]
132841976  fgf22; fibroblast growth factor 22 [KO:K04358]
132854770  fgf10b; fibroblast growth factor 10b [KO:K04358]
132842596  fgf3; fibroblast growth factor 3 [KO:K04358]
132854865  fgf5; fibroblast growth factor 5 [KO:K04358]
132860325  fgf10a; fibroblast growth factor 10a [KO:K04358]
132855696  fgf6a; fibroblast growth factor 6a [KO:K04358]
132861066  fgf20a; fibroblast growth factor 20a [KO:K04358]
132855977  fgf20b; fibroblast growth factor 20b [KO:K04358]
132850564  fgf9; fibroblast growth factor 5 [KO:K04358]
132856235  fgf24; fibroblast growth factor 24 isoform X1 [KO:K04358]
132856336  fgf16; fibroblast growth factor 16 [KO:K04358]
132856647  fgf4; fibroblast growth factor 4 [KO:K04358]
132856893  fgf18a; fibroblast growth factor 18a [KO:K04358]
132851534  fgf7; fibroblast growth factor 7 [KO:K04358]
132862921  fgf18b; fibroblast growth factor 18b [KO:K04358]
132839426  fgf8b; fibroblast growth factor 8b [KO:K04358]
132846701  fgf8a; fibroblast growth factor 8 [KO:K04358]
132853629  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
132859228  fgf6b; fibroblast growth factor 6b [KO:K04358]
132842588  fgf19; fibroblast growth factor 19 [KO:K22603]
132845369  uncharacterized protein LOC132845369 [KO:K22429]
132859217  fgf23; fibroblast growth factor 23 [KO:K22428]
132855898  uncharacterized protein LOC132855898 isoform X1 [KO:K22428]
132843961  ngfb; nerve growth factor [KO:K02582]
132862089  ngfa; neurotrophin-7 [KO:K02582]
132838964  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
132859363  ntf3; neurotrophin-3 [KO:K04356]
132841226  ins; insulin [KO:K04526]
132859079  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
132856716  igf2b; insulin-like growth factor 2b [KO:K13769]
132838752  igf2a; LOW QUALITY PROTEIN: insulin-like growth factor 2a [KO:K13769]
132861009  pdgfbb; uncharacterized protein pdgfbb isoform X1 [KO:K04359]
132838686  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
132838766  pdgfba; platelet-derived growth factor beta polypeptide a isoform X1 [KO:K17386]
132856179  pdgfc; platelet-derived growth factor C [KO:K05450]
132858382  pdgfd; platelet-derived growth factor D [KO:K05450]
132838317  csf1a; macrophage colony-stimulating factor 1a [KO:K05453]
132855919  kitlga; kit ligand a [KO:K05461]
132858769  kitlgb; kit ligand b [KO:K05461]
132859982  snake venom vascular endothelial growth factor toxin HF [KO:K05448]
132859215  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
132847536  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
132842327  pgfa; snake venom vascular endothelial growth factor toxin [KO:K16859]
132852839  pgfb; snake venom vascular endothelial growth factor toxin HF isoform X1 [KO:K16859]
132847703  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
132839019  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
132851377  hgfb; hepatocyte growth factor [KO:K05460]
132837510  angpt1; angiopoietin-1 isoform X1 [KO:K05465]
132837570  angpt2b; angiopoietin-2b [KO:K05466]
132846996  angpt2a; angiopoietin-2a [KO:K05466]
132860007  efna5a; ephrin-A5b [KO:K05462]
132842243  efna3a; ephrin-A3 [KO:K05462]
132842905  efna1a; ephrin-A1a [KO:K05462]
132851825  ephrin-A2-like isoform X1 [KO:K05462]
132857666  efna2a; ephrin-A2 [KO:K05462]
132846182  si:dkey-246i14.3; ephrin-A4 [KO:K05462]
132846183  efna3b; ephrin-A3b isoform X1 [KO:K05462]
132846184  efna1b; ephrin-A1b [KO:K05462]
132853689  efna5b; ephrin-A5b isoform X1 [KO:K05462]
132863409  gdnfa; glial cell line-derived neurotrophic factor [KO:K05452]
132862534  neurturin [KO:K25414]
132852323  nrtn; neurturin [KO:K25414]
132844426  neurturin [KO:K25415]
132858138  artemin [KO:K25415]
132838640  persephin [KO:K25416]
132844608  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
132841305  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
132861807  erbb3b; receptor tyrosine-protein kinase erbB-3b [KO:K05084] [EC:2.7.10.1]
132844531  erbb3a; receptor tyrosine-protein kinase erbB-3a isoform X1 [KO:K05084] [EC:2.7.10.1]
132850488  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
132839188  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
132839428  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
132853271  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
132847035  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
132847187  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
132860291  fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
132861399  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
132845984  nradd; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
132841245  ngfrb; nerve growth factor receptor b [KO:K02583]
132839973  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
132853765  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a [KO:K04360] [EC:2.7.10.1]
132841093  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b isoform X1 [KO:K04360] [EC:2.7.10.1]
132848150  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
132854687  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
132855624  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
132851207  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
132843456  pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
132856700  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
132859942  csf1rb; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
132856529  macrophage colony-stimulating factor 1 receptor-like [KO:K05090] [EC:2.7.10.1]
132860868  kitb; KIT proto-oncogene, receptor tyrosine kinase b [KO:K05091] [EC:2.7.10.1]
132843455  kita; mast/stem cell growth factor receptor kita isoform X1 [KO:K05091] [EC:2.7.10.1]
132839919  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
132856390  kdrl; vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
132840013  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
132855494  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
132843454  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
132855469  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
132840926  tek; tyrosine-protein kinase receptor Tie-2 [KO:K05121] [EC:2.7.10.1]
132861805  epha2b; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
132844576  epha2a; ephrin type-A receptor 2a [KO:K05103] [EC:2.7.10.1]
132847389  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
132860845  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
132844070  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
132837415  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
132846808  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
132856833  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
132838753  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
132860818  zgc:55558; GTPase KRas [KO:K07827]
132856574  kras; GTPase KRas isoform X1 [KO:K07827]
132853276  nras; GTPase NRas [KO:K07828]
132849527  rras2; ras-related protein R-Ras2 [KO:K07830]
132861051  rras; ras-related protein R-Ras [KO:K07830]
132849798  mrasa; ras-related protein M-Ras [KO:K07831]
132838892  mrasb; ras-related protein M-Ras [KO:K07831]
132855403  araf; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
132858711  braf; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
132838004  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
132862286  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
132851235  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
132845593  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
132853123  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
132847176  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
132854450  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
132861356  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
132854242  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b isoform X1 [KO:K04372] [EC:2.7.11.1]
132851587  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
132858042  MAP kinase-interacting serine/threonine-protein kinase 2-like [KO:K04372] [EC:2.7.11.1]
132856425  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
132852045  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
132846990  rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
132840594  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
132840729  rps6ka3a; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
132844894  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
132853362  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
132837863  elk4; ETS domain-containing protein Elk-4 [KO:K04376]
132848371  mycb; transcriptional regulator Myc-B [KO:K04377]
132840463  myca; transcriptional regulator Myc-A [KO:K04377]
132855084  serum response factor-like isoform X1 [KO:K04378]
132847449  srfb; serum response factor b isoform X1 [KO:K04378]
132854711  si:ch211-153j24.3; protein c-Fos [KO:K04379]
132855121  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
132852110  fosaa; protein c-Fos [KO:K04379]
132841567  mapta; microtubule-associated protein tau [KO:K04380]
132842671  maptb; microtubule-associated protein tau isoform X1 [KO:K04380]
132842840  stathmin-like [KO:K04381]
132845732  stmn1b; stathmin 1b [KO:K04381]
132843521  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
132852018  cytosolic phospholipase A2 delta-like [KO:K16342] [EC:3.1.1.4]
132852019  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
132858325  pla2g4aa; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
132842187  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
132863169  interleukin-1 beta-like isoform X1 [KO:K04519]
132863177  interleukin-1 beta-like [KO:K04519]
132863678  interleukin-1 beta-like [KO:K04519]
132860460  tgfb1b; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
132849264  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
132855840  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
132845709  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
132852264  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
132845873  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
132849867  interleukin-1 receptor type 1 [KO:K04386]
132849870  zmp:0000000936; interleukin-1 receptor-like 2 isoform X1 [KO:K04386]
132839811  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
132857910  interleukin-1 receptor accessory protein [KO:K04723]
132845580  tgfbr1b; TGF-beta receptor type-1b isoform X1 [KO:K04674] [EC:2.7.11.30]
132850330  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
132856985  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
132845693  tgfbr2b; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
132842360  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
132852124  fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
132861415  rac1b; ras-related C3 botulinum toxin substrate 1b [KO:K04392]
132840369  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
132861695  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
132861572  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
132842925  cell division control protein 42 homolog [KO:K04393]
132838119  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
132862555  cdc42l2; cell division cycle 42 like 2 [KO:K04393]
132842423  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
132841980  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
132855819  casp3b; caspase-3b [KO:K02187] [EC:3.4.22.56]
132841351  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
132855231  traf2a; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
132842953  daxx; death domain-associated protein 6 [KO:K02308]
132840300  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
132853635  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
132856689  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
132838745  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
132844058  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
132844416  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
132852327  gadd45ba; growth arrest and DNA-damage-inducible, beta a [KO:K04402]
132853659  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
132859778  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
132859780  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
132844901  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
132854466  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
132848500  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
132851952  map4k3b; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
132849872  map4k4; TRAF2 and NCK-interacting protein kinase isoform X1 [KO:K04407] [EC:2.7.11.1]
132839751  mitogen-activated protein kinase kinase kinase kinase 4-like isoform X1 [KO:K04407] [EC:2.7.11.1]
132851015  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
132848157  pak2a; serine/threonine-protein kinase PAK 2a isoform X1 [KO:K04410] [EC:2.7.11.1]
132854244  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
132844689  serine/threonine-protein kinase 4-like isoform X1 [KO:K04411]
132863797  stk3; serine/threonine-protein kinase 3 [KO:K04412]
132848505  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
132859570  map4k6; mitogen-activated protein kinase kinase kinase kinase 6 isoform X1 [KO:K04414] [EC:2.7.11.1]
132864038  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
132863073  map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
132841755  mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
132844940  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
132861545  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
132839958  map3k22; mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
132850977  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
132847527  map3k21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
132853660  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
132850363  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
132850222  map3k20a; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
132854438  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
132845743  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
132854562  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
132841855  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
132841515  taok2b; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
132860047  taok1b; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
132854522  taok3a; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
132860579  taok2a; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
132858583  taok1a; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
132840880  taok3b; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
132842580  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
132840121  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
132839161  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
132862615  map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
132850579  mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
132856356  mapk8ip1a; C-Jun-amino-terminal kinase-interacting protein 1a [KO:K04434]
132851393  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
132861174  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
132862827  flna; filamin-A isoform X1 [KO:K04437]
132859920  crkl; crk-like protein [KO:K04438]
132857898  crk; adapter molecule crk [KO:K04438]
132840707  adapter molecule crk-like isoform X1 [KO:K04438]
132848620  arrb2b; arrestin, beta 2b [KO:K04439]
132863193  arrb2a; arrestin, beta 2a isoform X1 [KO:K04439]
132858363  arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
132841492  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
132860001  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
132859543  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
132847307  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
132854215  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
132837957  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
132862078  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
132851350  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
132858678  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
132853306  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
132859153  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
132854577  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
132838072  mapkapk2a; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
132838201  mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
132852635  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
132840732  rps6ka4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
132847198  cdc25b; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
132848409  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
132864289  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
132856699  nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
132838549  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
132849017  transcription factor Jun-like [KO:K04448]
132843425  jun; transcription factor AP-1 [KO:K04448]
132841102  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
132845345  jund; transcription factor jun-D [KO:K04449]
132850230  atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
132848547  cellular tumor antigen p53-like [KO:K04451]
132840785  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
132844588  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
132843049  max; protein max isoform X1 [KO:K04453]
132852755  protein max isoform X1 [KO:K04453]
132854488  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
132840872  hspb15; heat shock protein, alpha-crystallin-related, b15 [KO:K04455]
132841096  hspb1; heat shock protein beta-1 [KO:K04455]
132851059  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132852758  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132839788  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132847151  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
132860339  ppm1nb; protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) [KO:K04457] [EC:3.1.3.16]
132843320  ppm1ab; protein phosphatase, Mg2+/Mn2+ dependent, 1Ab [KO:K04457] [EC:3.1.3.16]
132858028  ppm1na; protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) isoform X1 [KO:K04457] [EC:3.1.3.16]
132846870  ppm1aa; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
132858996  ptprr; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
132839027  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
132855519  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
132860248  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132837827  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132856768  dusp8a; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132838886  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132859187  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132853997  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132855622  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
132854764  dusp10; dual specificity protein phosphatase 10 isoform X1 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
132838563  dusp3a; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
132851670  dusp3b; dual specificity protein phosphatase 3b [KO:K17614] [EC:3.1.3.16 3.1.3.48]
132849246  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
132863308  ppm1bb; protein phosphatase 1bb isoform X1 [KO:K04461] [EC:3.1.3.16]
132847144  ppm1ba; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
132860596  heat shock 70 kDa protein [KO:K03283]
132860916  heat shock 70 kDa protein-like isoform X1 [KO:K03283]
132861747  heat shock 70 kDa protein-like [KO:K03283]
132857723  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
132863039  heat shock cognate 71 kDa protein [KO:K03283]
132863113  heat shock cognate 71 kDa protein-like [KO:K03283]
132858279  hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283]
132858072  mecom; MDS1 and EVI1 complex locus protein EVI1-A isoform X1 [KO:K04462] [EC:2.1.1.367]
132838771  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
132841554  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
132838246  nuclear receptor subfamily 4 group A member 1-like [KO:K04465]
132862457  nr4a1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
132860710  map3k14a; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
132846352  uncharacterized protein LOC132846352 isoform X1 [KO:K04466] [EC:2.7.11.25]
132847409  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
132853312  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
132862050  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
132861090  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
132857770  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
132861686  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
132847508  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
132841752  rela; transcription factor p65 [KO:K04735]
132857941  relb; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
tvc04070  Phosphatidylinositol signaling system
tvc04110  Cell cycle
tvc04115  p53 signaling pathway
tvc04210  Apoptosis
tvc04310  Wnt signaling pathway
KO pathway
ko04010   
LinkDB

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