KEGG   PATHWAY: uar05166
Entry
uar05166                    Pathway                                
Name
Human T-cell leukemia virus 1 infection - Ursus americanus (American black bear)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
uar05166  Human T-cell leukemia virus 1 infection
uar05166

Organism
Ursus americanus (American black bear) [GN:uar]
Gene
123793811  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
123784874  NRP1; neuropilin-1 isoform X1 [KO:K06724]
123801908  MYC; myc proto-oncogene protein [KO:K04377]
123802579  LOW QUALITY PROTEIN: transformation/transcription domain-associated protein [KO:K08874]
123778299  KAT5; histone acetyltransferase KAT5 isoform X1 [KO:K11304] [EC:2.3.1.48]
123781570  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
123784641  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
123779127  ITGB2; integrin beta-2 [KO:K06464]
123777616  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
123775506  HRAS; GTPase HRas isoform X1 [KO:K02833]
123801699  KRAS; GTPase KRas isoform X1 [KO:K07827]
123795037  NRAS; GTPase NRas [KO:K07828]
123800861  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
123796818  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
123795639  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123784602  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123781683  CD4; T-cell surface glycoprotein CD4 isoform X1 [KO:K06454]
123781159  TLN1; talin-1 [KO:K06271]
123795529  TLN2; talin-2 isoform X1 [KO:K06271]
123779031  RANBP3; ran-binding protein 3 isoform X1 [KO:K15304]
123780403  RAN; GTP-binding nuclear protein Ran [KO:K07936]
123785964  XPO1; exportin-1 isoform X1 [KO:K14290]
123777718  CALR; calreticulin [KO:K08057]
123790487  CANX; calnexin [KO:K08054]
123788880  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123782828  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123777460  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123786008  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
123781022  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
123787495  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
123799385  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
123803502  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
123795735  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
123780861  IL2RB; LOW QUALITY PROTEIN: interleukin-2 receptor subunit beta [KO:K05069]
123795350  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
123779986  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
123781848  signal transducer and activator of transcription 5A [KO:K11223]
123781849  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
123793114  IL2; interleukin-2 [KO:K05429]
123785045  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
123793445  HLA class I histocompatibility antigen, B alpha chain-like [KO:K06751]
123794160  uncharacterized protein LOC123794160 [KO:K06751]
123780238  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
123791023  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
123791025  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
123791026  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
123791029  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
123776405  B2M; beta-2-microglobulin [KO:K08055]
123789453  farnesyl pyrophosphate synthase-like [KO:K00787] [EC:2.5.1.1 2.5.1.10]
123783436  FDPS; farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
123790351  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
123793297  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
123787795  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
123802759  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
123784508  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
123788811  voltage-dependent anion-selective channel protein 2 [KO:K15040]
123782868  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
123780315  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
123780754  TSPO; translocator protein isoform X1 [KO:K05770]
123802815  TSPO2; translocator protein 2 isoform X1 [KO:K05770]
123800544  VAC14; protein VAC14 homolog [KO:K15305]
123803545  RANBP1; ran-specific GTPase-activating protein isoform X1 [KO:K15306]
123802533  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
123793319  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
123804219  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X1 [KO:K06637] [EC:2.7.11.1]
123803907  BUB3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
123799760  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
123796312  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
123802915  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
123775798  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
123779316  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
123776721  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
123779212  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
123790313  CDC23; cell division cycle protein 23 homolog [KO:K03355]
123793245  ANAPC10; anaphase-promoting complex subunit 10 [KO:K03357]
123777934  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
123788056  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
123788398  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
123782551  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
123782820  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
123793802  CDC20; cell division cycle protein 20 homolog [KO:K03363]
123788556  PTTG1; securin isoform X1 [KO:K06635]
123794703  ESPL1; LOW QUALITY PROTEIN: separin [KO:K02365] [EC:3.4.22.49]
123784090  CCNB2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
123781261  cyclin-dependent kinase 4 inhibitor B [KO:K04685]
123781143  cyclin-dependent kinase inhibitor 2A-like isoform X1 [KO:K06621]
123787201  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
123778441  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
123779180  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
123779575  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
123793313  CCNA2; cyclin-A2 [KO:K06627]
123791767  CCNA1; cyclin-A1 [KO:K06627]
123797872  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
123791375  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
123787272  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
123791847  RB1; retinoblastoma-associated protein [KO:K06618]
123798360  E2F1; transcription factor E2F1 [KO:K17454]
123782351  E2F2; transcription factor E2F2 [KO:K09389]
123791040  E2F3; LOW QUALITY PROTEIN: transcription factor E2F3 [KO:K06620]
123792533  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
123788444  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
123792711  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
123788135  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
123792132  TP53; cellular tumor antigen p53 [KO:K04451]
123800228  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123793748  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
123779926  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
123786407  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123788422  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123779078  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123793473  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123784096  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123791373  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123802097  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
123795550  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
123791076  TNF; tumor necrosis factor [KO:K03156]
123781572  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
123790179  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
123792071  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
123800287  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
123788054  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123790496  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123795376  JUN; transcription factor AP-1 [KO:K04448]
123792350  MMP7; matrilysin [KO:K01397] [EC:3.4.24.23]
123775960  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
123776050  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
123792618  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
123792617  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
123792619  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
123802932  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
123795860  CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
123780295  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
123791737  NF-kappa-B essential modulator-like [KO:K07210]
123793902  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
123788912  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
123778302  RELA; transcription factor p65 [KO:K04735]
123792157  GPS2; G protein pathway suppressor 2 isoform X1 [KO:K15307]
123781561  LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159]
123797062  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
123780818  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
123802960  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
123801972  RELB; transcription factor RelB isoform X1 [KO:K09253]
123795903  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
123784274  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
123802327  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
123793257  IL15; interleukin-15 isoform X1 [KO:K05433]
123802289  IL15RA; LOW QUALITY PROTEIN: interleukin-15 receptor subunit alpha [KO:K05074]
123788681  IL6; interleukin-6 [KO:K05405]
123790540  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
123791077  LTA; lymphotoxin-alpha [KO:K05468]
123798690  BCL2L1; bcl-2-like protein 1 [KO:K04570]
123792333  E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
123781846  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
123800112  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
123798962  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
123781069  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
123777686  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
123787367  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
123800821  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
123787394  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
123789481  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
123791264  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
123799951  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
123795737  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
123802178  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
123794794  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
123798393  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
123801897  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
123783548  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
123801768  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
123795272  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123780885  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
123794091  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
123794092  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
123790938  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
123790941  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
123790942  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
123790948  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
123790949  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
123790950  boLa class II histocompatibility antigen, DQB*0101 beta chain [KO:K06752]
123790951  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
123790953  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
123790954  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
123791051  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
123794694  SRF; serum response factor [KO:K04378]
123785675  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
123787940  ELK1; LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1 [KO:K04375]
123785023  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
123783200  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
123802652  ETS2; protein C-ets-2 isoform X1 [KO:K21932]
123800753  TBPL2; TATA box-binding protein-like 2 [KO:K03120]
123797572  TBPL1; TATA box-binding protein-like 1 [KO:K03120]
123775433  TATA-box-binding protein [KO:K03120]
123798968  FOS; proto-oncogene c-Fos [KO:K04379]
123790304  EGR1; early growth response protein 1 [KO:K09203]
123778499  FOSL1; fos-related antigen 1 [KO:K04502]
123783100  EGR2; E3 SUMO-protein ligase EGR2 isoform X1 [KO:K12496]
123798247  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
123799579  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
123781164  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
123788905  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
123796787  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
123783374  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
123794100  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
123780649  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
123789128  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
123790975  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
123779850  CRTC1; CREB-regulated transcription coactivator 1 isoform X1 [KO:K15309]
123783591  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
123802460  CRTC3; CREB-regulated transcription coactivator 3 isoform X1 [KO:K16334]
123780918  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
123783593  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
123788338  KAT2B; histone acetyltransferase KAT2B isoform X1 [KO:K06062] [EC:2.3.1.48]
123781916  KAT2A; histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
123794009  TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
123780308  POLB; DNA polymerase beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
123782388  LCK; tyrosine-protein kinase Lck isoform X1 [KO:K05856] [EC:2.7.10.2]
123776228  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
123793712  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
123799097  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
123800023  homeobox protein MSX-3-like [KO:K09341]
123788645  MSX2; homeobox protein MSX-2 [KO:K09341]
123775822  MSX1; homeobox protein MSX-1 [KO:K09341]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Sinet F.
  Title
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
  Journal
BioSciences Master Reviews, July 2013
Reference
PMID:18923409
  Authors
Sattentau Q
  Title
Avoiding the void: cell-to-cell spread of human viruses.
  Journal
Nat Rev Microbiol 6:815-26 (2008)
DOI:10.1038/nrmicro1972
Reference
PMID:15040584
  Authors
Vicente-Manzanares M, Sanchez-Madrid F
  Title
Role of the cytoskeleton during leukocyte responses.
  Journal
Nat Rev Immunol 4:110-22 (2004)
DOI:10.1038/nri1268
Reference
PMID:27334587
  Authors
Dutartre H, Claviere M, Journo C, Mahieux R
  Title
Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
  Journal
J Virol 90:7607-17 (2016)
DOI:10.1128/JVI.00407-16
Reference
PMID:15988028
  Authors
Awasthi S, Sharma A, Wong K, Zhang J, Matlock EF, Rogers L, Motloch P, Takemoto S, Taguchi H, Cole MD, Luscher B, Dittrich O, Tagami H, Nakatani Y, McGee M, Girard AM, Gaughan L, Robson CN, Monnat RJ Jr, Harrod R
  Title
A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.
  Journal
Mol Cell Biol 25:6178-98 (2005)
DOI:10.1128/MCB.25.14.6178-6198.2005
Reference
PMID:21994758
  Authors
Edwards D, Fenizia C, Gold H, de Castro-Amarante MF, Buchmann C, Pise-Masison CA, Franchini G
  Title
Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
  Journal
Viruses 3:861-85 (2011)
DOI:10.3390/v3060861
Reference
PMID:26927155
  Authors
Nakano K, Watanabe T
  Title
HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
  Journal
Viruses 8:58 (2016)
DOI:10.3390/v8030058
Reference
PMID:22783232
  Authors
Shida H
  Title
Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.
  Journal
Front Microbiol 3:179 (2012)
DOI:10.3389/fmicb.2012.00179
Reference
PMID:23248621
  Authors
Bai XT, Nicot C
  Title
Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
  Journal
Front Microbiol 3:400 (2012)
DOI:10.3389/fmicb.2012.00400
Reference
PMID:18421579
  Authors
Taylor JM, Nicot C
  Title
HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
  Journal
Apoptosis 13:733-47 (2008)
DOI:10.1007/s10495-008-0208-7
Reference
PMID:15761473
  Authors
D'Agostino DM, Silic-Benussi M, Hiraragi H, Lairmore MD, Ciminale V
  Title
The human T-cell leukemia virus type 1 p13II protein: effects on mitochondrial function and cell growth.
  Journal
Cell Death Differ 12 Suppl 1:905-15 (2005)
DOI:10.1038/sj.cdd.4401576
Reference
PMID:20332002
  Authors
Silic-Benussi M, Biasiotto R, Andresen V, Franchini G, D'Agostino DM, Ciminale V
  Title
HTLV-1 p13, a small protein with a busy agenda.
  Journal
Mol Aspects Med 31:350-8 (2010)
DOI:10.1016/j.mam.2010.03.001
Reference
PMID:23741982
  Authors
Fuentes-Gonzalez AM, Contreras-Paredes A, Manzo-Merino J, Lizano M
  Title
The modulation of apoptosis by oncogenic viruses.
  Journal
Virol J 10:182 (2013)
DOI:10.1186/1743-422X-10-182
Reference
PMID:21743832
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Qu Z, Xiao G
  Title
Human T-cell lymphotropic virus: a model of NF-kappaB-associated tumorigenesis.
  Journal
Viruses 3:714-49 (2011)
DOI:10.3390/v3060714
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PMID:21994767
  Authors
Saggioro D
  Title
Anti-apoptotic effect of Tax: an NF-kappaB path or a CREB way?
  Journal
Viruses 3:1001-14 (2011)
DOI:10.3390/v3071001
Reference
PMID:16036567
  Authors
Harhaj EW, Harhaj NS
  Title
Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
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IUBMB Life 57:83-91 (2005)
DOI:10.1080/15216540500078715
Reference
PMID:16155602
  Authors
Sun SC, Yamaoka S
  Title
Activation of NF-kappaB by HTLV-I and implications for cell transformation.
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Oncogene 24:5952-64 (2005)
DOI:10.1038/sj.onc.1208969
Reference
PMID:9710600
  Authors
Geleziunas R, Ferrell S, Lin X, Mu Y, Cunningham ET Jr, Grant M, Connelly MA, Hambor JE, Marcu KB, Greene WC
  Title
Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
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Mol Cell Biol 18:5157-65 (1998)
DOI:10.1128/MCB.18.9.5157
Reference
PMID:21315773
  Authors
Nakachi S, Nakazato T, Ishikawa C, Kimura R, Mann DA, Senba M, Masuzaki H, Mori N
  Title
Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.
  Journal
Biochim Biophys Acta 1813:731-41 (2011)
DOI:10.1016/j.bbamcr.2011.02.002
Reference
PMID:26797638
  Authors
James CD, Roberts S
  Title
Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
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Pathogens 5:E8 (2016)
DOI:10.3390/pathogens5010008
Reference
PMID:26324707
  Authors
Cherian MA, Baydoun HH, Al-Saleem J, Shkriabai N, Kvaratskhelia M, Green P, Ratner L
  Title
Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein.
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J Biol Chem 290:26270-81 (2015)
DOI:10.1074/jbc.M115.684746
Reference
PMID:11264182
  Authors
Mori N, Morishita M, Tsukazaki T, Giam CZ, Kumatori A, Tanaka Y, Yamamoto N
  Title
Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
  Journal
Blood 97:2137-44 (2001)
DOI:10.1182/blood.v97.7.2137
Reference
PMID:15310405
  Authors
Azran I, Schavinsky-Khrapunsky Y, Aboud M
  Title
Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
  Journal
Retrovirology 1:20 (2004)
DOI:10.1186/1742-4690-1-20
Reference
PMID:11244044
  Authors
Yoshida M
  Title
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
  Journal
Annu Rev Immunol 19:475-96 (2001)
DOI:10.1146/annurev.immunol.19.1.475
Reference
PMID:12802280
  Authors
Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E
  Title
Inactivation of hTERT transcription by Tax.
  Journal
Oncogene 22:3734-41 (2003)
DOI:10.1038/sj.onc.1206468
Related
pathway
uar03013  Nucleocytoplasmic transport
uar04010  MAPK signaling pathway
uar04064  NF-kappa B signaling pathway
uar04110  Cell cycle
uar04115  p53 signaling pathway
uar04151  PI3K-Akt signaling pathway
uar04210  Apoptosis
uar04350  TGF-beta signaling pathway
uar04612  Antigen processing and presentation
uar04660  T cell receptor signaling pathway
uar04668  TNF signaling pathway
KO pathway
ko05166   
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