KEGG   PATHWAY: uar05167
Entry
uar05167                    Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Ursus americanus (American black bear)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
uar05167  Kaposi sarcoma-associated herpesvirus infection
uar05167

Organism
Ursus americanus (American black bear) [GN:uar]
Gene
123779001  C3; complement C3 [KO:K03990]
123784495  TLR3; toll-like receptor 3 [KO:K05401]
123796797  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
123779266  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
123785662  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
123787173  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
123775465  IRF7; interferon regulatory factor 7 [KO:K09447]
123781241  interferon alpha-1/2-like [KO:K05414]
123781249  interferon alpha-1/2-like [KO:K05414]
123781251  interferon alpha-1/2-like [KO:K05414]
123781252  interferon alpha-1/2-like [KO:K05414]
123781255  interferon alpha-1/2-like [KO:K05414]
123781256  interferon alpha-1/2-like [KO:K05414]
123781260  interferon alpha-1/2-like [KO:K05414]
123781283  interferon alpha-1/2-like [KO:K05414]
123781329  interferon alpha-2-like [KO:K05414]
123776252  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
123780918  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
123783593  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
123781031  IFNB1; interferon beta [KO:K05415]
123784206  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
123795350  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
123777576  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
123798145  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
123787247  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
123795756  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
123799832  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
123803776  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
123803793  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
123776209  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
123776212  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
123785786  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
123803240  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
123784274  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
123788681  IL6; interleukin-6 [KO:K05405]
123790540  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
123780036  C-C chemokine receptor type 3 [KO:K04178]
123780012  C-C chemokine receptor type 5 [KO:K04180]
123780046  C-C chemokine receptor type 1-like [KO:K04176]
123792792  CCR4; C-C chemokine receptor type 4 [KO:K04179]
123792786  CCR8; C-C chemokine receptor type 8 [KO:K04183]
123795545  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
123778464  FADD; FAS-associated death domain protein [KO:K02373]
123798200  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
123778036  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
123776228  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
123790912  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
123782054  cytochrome c-like [KO:K08738]
123789159  cytochrome c [KO:K08738]
123798082  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
123777792  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
123784520  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
123781572  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
123803514  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
123796334  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
123795860  CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
123780295  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
123791737  NF-kappa-B essential modulator-like [KO:K07210]
123793902  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
123788912  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
123778302  RELA; transcription factor p65 [KO:K04735]
123792132  TP53; cellular tumor antigen p53 [KO:K04451]
123779575  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
123787201  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
123789288  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
123791847  RB1; retinoblastoma-associated protein [KO:K06618]
123798360  E2F1; transcription factor E2F1 [KO:K17454]
123782351  E2F2; transcription factor E2F2 [KO:K09389]
123791040  E2F3; LOW QUALITY PROTEIN: transcription factor E2F3 [KO:K06620]
123785045  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
123793445  HLA class I histocompatibility antigen, B alpha chain-like [KO:K06751]
123794160  uncharacterized protein LOC123794160 [KO:K06751]
123780238  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
123791023  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
123791025  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
123791026  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
123791029  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
123803346  IFNGR1; interferon gamma receptor 1 [KO:K05132]
123777616  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
123802090  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
123781688  CLEC2B; C-type lectin domain family 2 member B isoform X1 [KO:K10071]
123779925  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
123795660  ubiquitin-60S ribosomal protein L40 [KO:K02927]
123785937  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
123779762  UBB; polyubiquitin-B [KO:K04551]
123798227  LOW QUALITY PROTEIN: polyubiquitin-like [KO:K04551]
123780227  UBC; polyubiquitin-C [KO:K08770]
123781873  BECN1; beclin-1 isoform X1 [KO:K08334]
123790998  BECN2; beclin-2 [KO:K08334]
123800612  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
123787345  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
123784066  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
123790991  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
123798215  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
123791286  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
123776674  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
123796116  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
123777259  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
123781583  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
123786411  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
123801797  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
123800611  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
123789819  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
123783123  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
123787748  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
123795269  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
123793984  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
123778756  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
123803383  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
123776695  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
123789281  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
123795327  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
123777697  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
123783660  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
123789282  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
123802847  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
123775506  HRAS; GTPase HRas isoform X1 [KO:K02833]
123801699  KRAS; GTPase KRas isoform X1 [KO:K07827]
123795037  NRAS; GTPase NRas [KO:K07828]
123802053  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123800861  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
123796818  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
123795639  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123784602  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123800588  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
123795376  JUN; transcription factor AP-1 [KO:K04448]
123798968  FOS; proto-oncogene c-Fos [KO:K04379]
123789397  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
123792094  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
123792093  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
123786407  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123788422  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123779078  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123800228  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123793748  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
123779926  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
123793473  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123784096  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123791373  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123779112  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
123775945  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
123802589  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123800287  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
123788054  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123790496  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123784061  CD200R1; LOW QUALITY PROTEIN: cell surface glycoprotein CD200 receptor 1 [KO:K21668]
123784062  cell surface glycoprotein CD200 receptor 2-like isoform X1 [KO:K21668]
123784295  cell surface glycoprotein CD200 receptor 1-like [KO:K21668]
123776440  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
123796968  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
123798585  HCK; tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
123786722  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
123792071  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
123777544  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
123791349  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
123796994  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
123799165  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
123801684  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
123790908  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
123785908  CALM2; calmodulin-2 [KO:K02183]
123800842  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
123802291  calmodulin-like [KO:K02183]
123802321  CALML3; calmodulin-like protein 3 [KO:K02183]
123796079  CALML6; calmodulin-like protein 6 [KO:K02183]
123798898  CALM1; calmodulin-1 [KO:K02183]
123778741  CALM3; calmodulin-3 [KO:K02183]
123788880  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123782828  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123777460  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123786008  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
123781022  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
123787495  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
123799385  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
123803502  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
123795735  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
123789115  CXCL8; interleukin-8 [KO:K10030]
123801412  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
123787104  growth-regulated alpha protein-like [KO:K05505]
123789130  growth-regulated protein homolog gamma-like isoform X1 [KO:K05505]
123789142  growth-regulated alpha protein-like [KO:K05505]
123784222  RCAN1; calcipressin-1 isoform X1 [KO:K17901]
123793143  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
123796996  VEGFA; vascular endothelial growth factor A [KO:K05448]
123780665  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
123800895  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
123790182  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
123776417  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
123781851  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
123784023  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
123792803  CTNNB1; catenin beta-1 [KO:K02105]
123790349  TCF7; transcription factor 7 isoform X1 [KO:K02620]
123799645  TCF7L1; LOW QUALITY PROTEIN: transcription factor 7-like 1 [KO:K04490]
123795969  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
123793375  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
123798247  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
123778441  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
123801908  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
  Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
  Journal
Blood 95:1151-7 (2000)
Reference
PMID:26431609
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
PMID:10377196
  Authors
Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
  Title
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
  Journal
J Exp Med 189:1993-8 (1999)
DOI:10.1084/jem.189.12.1993
Reference
PMID:18434408
  Authors
Choi YB, Nicholas J
  Title
Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines.
  Journal
J Virol 82:6501-13 (2008)
DOI:10.1128/JVI.02396-07
Reference
PMID:15692053
  Authors
McCormick C, Ganem D
  Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
Reference
PMID:15967719
  Authors
Wang HW, Boshoff C
  Title
Linking Kaposi virus to cancer-associated cytokines.
  Journal
Trends Mol Med 11:309-12 (2005)
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EMBO J 21:2602-15 (2002)
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J Virol 74:5300-9 (2000)
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Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
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Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus.
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KO pathway
ko05167   
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