KEGG   PATHWAY: pleu05170
Entry
pleu05170                   Pathway                                
Name
Human immunodeficiency virus 1 infection - Peromyscus leucopus (white-footed mouse)
Description
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency syndrome), is a lentivirus belonging to the Retroviridae family. The primary cell surface receptor for HIV-1, the CD4 protein, and the co-receptor for HIV-1, either CCR5 or CXCR4, are found on macrophages and T lymphocytes. At the earliest step, sequential binding of virus envelope (Env) glycoprotein gp120 to CD4 and the co-receptor CCR5 or CXCR4 facilitates HIV-1 entry and has the potential to trigger critical signaling that may favor viral replication. At advanced stages of the disease, HIV-1 infection results in dramatic induction of T-cell (CD4+ T and CD8+ T cell) apoptosis both in infected and uninfected bystander T cells, a hallmark of HIV-1 pathogenesis. On the contrary, macrophages are resistant to the cytopathic effect of HIV-1 and produce virus for longer periods of time.
Class
Human Diseases; Infectious disease: viral
Pathway map
pleu05170  Human immunodeficiency virus 1 infection
pleu05170

Disease
H00406  Acquired immunodeficiency syndrome (AIDS)
H01563  HIV infection
Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114680645  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
114680676  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
114680792  Elob; elongin-B [KO:K03873]
114681035  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
114681076  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
114681254  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
114681403  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
114681418  Calm3; calmodulin-3 [KO:K02183]
114681520  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
114681524  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114681847  Samhd1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [KO:K22544] [EC:3.1.5.-]
114682099  Rela; transcription factor p65 [KO:K04735]
114682128  Bst2; bone marrow stromal antigen 2 [KO:K06731]
114682503  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
114682519  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
114682605  Pxn; paxillin isoform X1 [KO:K05760]
114682640  [KO:K06751]
114682644  [KO:K06751]
114682645  [KO:K06751]
114682649  [KO:K06751]
114682653  [KO:K06751]
114682654  [KO:K06751]
114682655  [KO:K06751]
114682656  [KO:K06751]
114682666  [KO:K06751]
114682671  [KO:K06751]
114682672  [KO:K06751]
114682673  [KO:K06751]
114682677  [KO:K06751]
114682685  [KO:K06751]
114682688  [KO:K06751]
114682714  Crkl; crk-like protein [KO:K04438]
114682732  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114683050  Skp1; S-phase kinase-associated protein 1 [KO:K03094]
114683205  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
114683255  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
114683276  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
114683462  [KO:K03872]
114683476  Fbxw11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
114683622  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
114684003  Chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
114684032  Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
114684433  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
114684461  Wee2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
114684495  [KO:K03873]
114684638  Pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
114684640  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
114685127  [KO:K02833]
114685139  Ifnb1; interferon beta [KO:K05415]
114685140  [KO:K05414]
114685141  [KO:K05414]
114685144  [KO:K05414]
114685147  [KO:K05414]
114685149  [KO:K05414]
114685150  [KO:K05414]
114685151  [KO:K05414]
114685152  [KO:K05414]
114685154  [KO:K05414]
114685155  [KO:K05414]
114685202  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
114685523  Tnfrsf1b; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
114685999  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
114686066  Map2k7; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
114686350  Tap1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
114686351  Tap2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
114686366  [KO:K06751]
114686371  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
114686570  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
114686598  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
114686769  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
114686791  Cgas; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
114686891  [KO:K10648] [EC:2.3.2.27]
114686894  [KO:K10648] [EC:2.3.2.27]
114686895  [KO:K10648] [EC:2.3.2.27]
114686898  [KO:K10648] [EC:2.3.2.27]
114687018  [KO:K06751]
114687019  [KO:K06751]
114687020  [KO:K06751]
114687039  [KO:K07826]
114687088  Calr; calreticulin [KO:K08057]
114687156  Irf3; interferon regulatory factor 3 isoform X1 [KO:K05411]
114687523  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
114687652  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
114687933  [KO:K06751]
114687935  [KO:K06751]
114688000  [KO:K10609]
114688121  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
114688160  Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
114688303  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
114688340  [KO:K04545]
114688345  [KO:K03873]
114688453  [KO:K05414]
114688454  [KO:K05414]
114688456  [KO:K05414]
114688459  [KO:K05414]
114688460  [KO:K05414]
114688461  [KO:K05414]
114688462  [KO:K05414]
114688463  [KO:K05414]
114688482  [KO:K06751]
114688488  [KO:K02833]
114688490  [KO:K06751]
114688492  [KO:K06751]
114688790  [KO:K06751]
114688816  [KO:K06751]
114688817  [KO:K06751]
114688966  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
114689282  [KO:K03873]
114689321  [KO:K05414]
114689322  [KO:K05414]
114689636  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114689745  [KO:K08738]
114689925  Cd247; T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453]
114689971  Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
114690123  Eloc; elongin-C [KO:K03872]
114690277  Atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
114690280  Cul5; cullin-5 [KO:K10612]
114690390  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
114690439  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
114690458  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
114690660  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114690838  Ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
114690969  Atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
114690975  Rnf7; RING-box protein 2 isoform X1 [KO:K10611]
114691293  Cd3g; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
114691294  Cd3d; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
114691295  Cd3e; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
114691441  Crk; adapter molecule crk isoform X1 [KO:K04438]
114691448  [KO:K08056] [EC:5.3.4.1]
114691497  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
114691640  Calml4; calmodulin-like protein 4 isoform X2 [KO:K02183]
114691777  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114691978  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
114692175  [KO:K03872]
114692203  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
114692290  [KO:K03873]
114692579  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
114692795  Traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
114692919  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
114693019  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
114693020  Mapk11; mitogen-activated protein kinase 11 isoform X5 [KO:K04441] [EC:2.7.11.24]
114693067  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
114693293  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
114693369  Cfl2; cofilin-2 [KO:K05765]
114693378  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
114693442  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
114693493  [KO:K02833]
114693495  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
114693559  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
114693595  Hras; GTPase HRas isoform X1 [KO:K02833]
114693645  Limk1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
114693768  Jun; transcription factor AP-1 [KO:K04448]
114693817  Casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
114693819  [KO:K08738]
114694000  Ap1b1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
114694032  Limk2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
114694231  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
114694280  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2 [KO:K04403]
114694298  Rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
114694361  [KO:K18750] [EC:3.5.4.-]
114694438  Fadd; FAS-associated death domain protein [KO:K02373]
114694517  Gnao1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
114694913  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
114695300  Ap1m2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
114695335  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114695341  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
114695408  [KO:K08738]
114695419  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
114696553  [KO:K02833]
114696911  [KO:K04634]
114696964  Cxcr4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
114697457  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
114697928  [KO:K08738]
114698005  Cul1; cullin-1 [KO:K03347]
114698038  Fos; proto-oncogene c-Fos [KO:K04379]
114698273  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
114698321  Pak3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
114698532  Cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
114698582  Nras; GTPase NRas [KO:K07828]
114698679  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
114698768  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
114698806  [KO:K04348] [EC:3.1.3.16]
114699281  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
114699340  [KO:K03094]
114699348  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
114699590  Pdia3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
114699604  B2m; beta-2-microglobulin [KO:K08055]
114699988  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
114700198  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
114700736  Bid; BH3-interacting domain death agonist [KO:K04726]
114700813  [KO:K08738]
114700859  Casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
114700920  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
114701247  Cul4a; cullin-4A isoform X1 [KO:K10609]
114701254  Ripk1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
114701918  [KO:K03873]
114702410  Traf5; TNF receptor-associated factor 5 [KO:K09849]
114702810  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
114703046  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114703309  Ap1s3; AP-1 complex subunit sigma-3 isoform X2 [KO:K12395]
114703417  Ddb1; DNA damage-binding protein 1 isoform X2 [KO:K10610]
114703574  [KO:K08738]
114703664  Pak5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
114703850  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114703855  Ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
114704332  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114704437  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
114704659  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
114704673  [KO:K11789] [EC:2.7.11.1]
114704956  [KO:K05765]
114705020  Calm1; calmodulin-1 [KO:K02183]
114705113  Cdc25c; M-phase inducer phosphatase 3 isoform X1 [KO:K05867] [EC:3.1.3.48]
114705142  Sting1; stimulator of interferon genes protein [KO:K12654]
114705519  Ppp3r1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
114705602  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
114705708  Ap1s2; AP-1 complex subunit sigma-2 isoform X2 [KO:K12394]
114705738  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
114705782  Tlr4; toll-like receptor 4 isoform X2 [KO:K10160]
114705817  Tnf; tumor necrosis factor [KO:K03156]
114705846  [KO:K06751]
114705916  Pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
114706123  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
114706134  [KO:K08058]
114706143  Bak1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
114706162  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
114706165  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
114706175  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
114706205  Irak1; interleukin-1 receptor-associated kinase 1 isoform X3 [KO:K04730] [EC:2.7.11.1]
114706431  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
114706924  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
114707186  [KO:K03868] [EC:2.3.2.32]
114707316  Ptk2b; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
114707535  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
114707623  [KO:K08057]
114708088  Ap1g1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
114708125  Btrc; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
114708228  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
114708260  Calml6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
114708288  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
114708393  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
114708477  Kras; GTPase KRas isoform X2 [KO:K07827]
114708726  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
114708731  Ap1g2; AP-1 complex subunit gamma-like 2 [KO:K12391]
114708768  [KO:K02183]
114708779  Calml3; calmodulin-like protein 3 [KO:K02183]
114708799  Tnfrsf1a; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158]
114708812  Tapbpl; tapasin-related protein [KO:K28445]
114708820  Cd4; T-cell surface glycoprotein CD4 isoform X2 [KO:K06454]
114708827  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
114709020  [KO:K08738]
114709086  [KO:K04542]
114709166  Cfl1; cofilin-1 [KO:K05765]
114709209  Calm2; calmodulin-2 [KO:K02183]
114709573  Ap1m1; AP-1 complex subunit mu-1 isoform X2 [KO:K12393]
114709670  Mtor; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
114709744  Cul4b; cullin-4B isoform X1 [KO:K10609]
114709997  Ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
114710030  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
114710188  Tlr2; toll-like receptor 2 [KO:K10159]
114710287  [KO:K08738]
114710321  Ap1s1; AP-1 complex subunit sigma-1A [KO:K12394]
114710459  Wee1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
114710523  [KO:K04371] [EC:2.7.11.24]
114710754  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
114710969  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
114711006  Dcaf1; DDB1- and CUL4-associated factor 1 isoform X5 [KO:K11789] [EC:2.7.11.1]
119086094  [KO:K10648] [EC:2.3.2.27]
119088838  [KO:K04438]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:22749173
  Authors
Evans VA, Khoury G, Saleh S, Cameron PU, Lewin SR
  Title
HIV persistence: chemokines and their signalling pathways.
  Journal
Cytokine Growth Factor Rev 23:151-7 (2012)
DOI:10.1016/j.cytogfr.2012.05.002
Reference
PMID:23806647
  Authors
Abbas W, Herbein G
  Title
Plasma membrane signaling in HIV-1 infection.
  Journal
Biochim Biophys Acta 1838:1132-42 (2014)
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Front Microbiol 4:34 (2013)
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Philos Trans R Soc Lond B Biol Sci 364:675-87 (2009)
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J Virol 85:11220-34 (2011)
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Related
pathway
pleu03050  Proteasome
pleu04010  MAPK signaling pathway
pleu04020  Calcium signaling pathway
pleu04064  NF-kappa B signaling pathway
pleu04110  Cell cycle
pleu04141  Protein processing in endoplasmic reticulum
pleu04142  Lysosome biogenesis
pleu04150  mTOR signaling pathway
pleu04151  PI3K-Akt signaling pathway
pleu04210  Apoptosis
pleu04612  Antigen processing and presentation
pleu04620  Toll-like receptor signaling pathway
pleu04623  Cytosolic DNA-sensing pathway
pleu04668  TNF signaling pathway
pleu04810  Regulation of actin cytoskeleton
KO pathway
ko05170   

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