KEGG   PATHWAY: uah05010
Entry
uah05010                    Pathway                                
Name
Alzheimer disease - Ursus arctos (brown bear)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
uah05010  Alzheimer disease
uah05010

Disease
H00056  Alzheimer disease
Organism
Ursus arctos (brown bear) [GN:uah]
Gene
113240791  [KO:K05863]
113240832  APH1B; gamma-secretase subunit APH-1B [KO:K06172]
113240885  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
113240902  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
113240981  [KO:K02264]
113241090  [KO:K02183]
113241127  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
113241128  [KO:K02183]
113241155  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
113241174  IRS4; insulin receptor substrate 4 [KO:K17446]
113241205  [KO:K02732] [EC:3.4.25.1]
113241271  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
113241285  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
113241346  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
113241361  SLC39A12; zinc transporter ZIP12 isoform X1 [KO:K14718]
113241477  CDK5; cyclin-dependent kinase 5 [KO:K02090] [EC:2.7.11.22]
113241708  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
113241758  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
113241780  CSNK1E; casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
113241827  [KO:K02270]
113241933  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
113242038  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
113242078  RYR3; ryanodine receptor 3 [KO:K04963]
113242144  [KO:K02271]
113242322  PSMA3; proteasome subunit alpha type-3 isoform X2 [KO:K02727] [EC:3.4.25.1]
113242340  [KO:K03945]
113242341  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
113242371  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
113242506  IL1B; interleukin-1 beta [KO:K04519]
113242534  [KO:K07374]
113242563  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
113242730  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X3 [KO:K03940] [EC:7.1.1.2]
113242735  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
113242741  [KO:K00420]
113242781  SLC39A3; zinc transporter ZIP3 [KO:K14709]
113242804  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
113242822  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
113242864  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
113242883  TUBB2A; tubulin beta-2A chain isoform X2 [KO:K07375]
113242904  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
113242915  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
113242935  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
113243106  MAPK8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
113243168  IDE; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
113243350  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
113243394  CALM3; calmodulin-3 [KO:K02183]
113243433  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
113243452  APOE; apolipoprotein E [KO:K04524]
113243572  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
113243578  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
113243618  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
113243711  TNF; tumor necrosis factor [KO:K03156]
113243764  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
113243792  SLC39A7; zinc transporter SLC39A7 [KO:K14713]
113243814  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
113243960  INS; insulin [KO:K04526]
113243978  FADD; FAS-associated death domain protein [KO:K02373]
113244001  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
113244009  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
113244014  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
113244076  KLC2; kinesin light chain 2 isoform X2 [KO:K10407]
113244102  RELA; LOW QUALITY PROTEIN: transcription factor p65 [KO:K04735]
113244126  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
113244147  ATG2A; autophagy-related protein 2 homolog A isoform X3 [KO:K17906]
113244175  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
113244178  BAD; bcl2-associated agonist of cell death [KO:K02158]
113244192  [KO:K02273]
113244199  RTN3; reticulon-3 isoform X2 [KO:K20723]
113244238  KIF5B; kinesin-1 heavy chain [KO:K10396]
113244264  FZD8; frizzled-8 [KO:K02375]
113244341  NOX1; NADPH oxidase 1 [KO:K08008]
113244394  NRAS; GTPase NRas isoform X2 [KO:K07828]
113244420  WNT2B; protein Wnt-2b [KO:K00182]
113244431  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
113244651  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
113244660  GRIN2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
113244743  PPP3R1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
113244841  PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]
113244843  [KO:K02267]
113244847  [KO:K02270]
113244914  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
113244929  PSMA5; proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
113245005  XBP1; X-box-binding protein 1 [KO:K09027]
113245020  [KO:K00419]
113245135  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
113245326  SLC39A1; zinc transporter ZIP1 [KO:K14709]
113245367  AXIN1; axin-1 isoform X1 [KO:K02157]
113245546  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
113245548  DKK4; dickkopf-related protein 4 [KO:K02165]
113245581  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
113245629  RTN4; reticulon-4 isoform X1 [KO:K20720]
113245850  APBB1; amyloid beta precursor protein binding family B member 1 isoform X1 [KO:K04529]
113245914  TUBB6; tubulin beta-6 chain [KO:K07375]
113245958  [KO:K07374]
113245972  CALM2; calmodulin-2 [KO:K02183]
113246085  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
113246116  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
113246142  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X2 [KO:K03029]
113246181  APH1A; gamma-secretase subunit APH-1A [KO:K06172]
113246264  PSMA1; proteasome subunit alpha type-1 isoform X1 [KO:K02725] [EC:3.4.25.1]
113246646  NCSTN; nicastrin [KO:K06171]
113246688  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
113246689  [KO:K02265]
113246718  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X2 [KO:K03935] [EC:7.1.1.2]
113246853  BECN2; beclin-2 [KO:K08334]
113246917  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
113247020  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
113247033  [KO:K07374]
113247110  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
113247157  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
113247228  [KO:K03037]
113247436  [KO:K02267]
113247437  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
113247468  WNT3A; protein Wnt-3a [KO:K00312]
113247507  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
113247518  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
113247619  [KO:K00413]
113247640  SLC39A4; zinc transporter ZIP4 [KO:K14710]
113248303  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
113248424  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X3 [KO:K05208]
113248454  TUBB4B; tubulin beta-4B chain [KO:K07375]
113248487  SLC39A2; zinc transporter ZIP2 isoform X1 [KO:K14709]
113248645  TRAF2; TNF receptor-associated factor 2 isoform X3 [KO:K03173] [EC:2.3.2.27]
113248677  WNT10A; protein Wnt-10a [KO:K01357]
113248771  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
113249115  [KO:K03939]
113249793  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
113250358  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
113250390  IRS1; insulin receptor substrate 1 [KO:K16172]
113250431  [KO:K07374]
113250444  WNT6; protein Wnt-6 [KO:K00445]
113250522  FZD5; frizzled-5 [KO:K02375]
113250544  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
113250581  FZD7; frizzled-7 isoform X1 [KO:K02432]
113250592  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
113250598  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
113250641  SLC39A10; zinc transporter ZIP10 isoform X1 [KO:K14716]
113250747  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
113250841  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
113250901  KIF5C; kinesin heavy chain [KO:K10396]
113251536  IRS2; insulin receptor substrate 2 [KO:K07187]
113251621  WNT8B; protein Wnt-8b [KO:K00714]
113251648  TUBB3; tubulin beta-3 chain [KO:K07375]
113251777  FRAT1; proto-oncogene FRAT1 [KO:K03069]
113251778  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
113251823  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
113251835  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
113251926  [KO:K03945]
113251949  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
113251972  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
113252045  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
113252181  [KO:K02263]
113252198  [KO:K00411] [EC:7.1.1.8]
113252303  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
113252334  NAE1; NEDD8-activating enzyme E1 regulatory subunit [KO:K04532]
113252438  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
113252742  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X2 [KO:K03965]
113252851  FZD6; frizzled-6 [KO:K02376]
113252908  [KO:K00417]
113253189  PSMA8; proteasome subunit alpha-type 8 [KO:K02731] [EC:3.4.25.1]
113253220  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
113253349  SLC39A6; zinc transporter ZIP6 [KO:K14712]
113253361  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X2 [KO:K00914] [EC:2.7.1.137]
113253374  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
113253816  CTNNB1; catenin beta-1 [KO:K02105]
113253924  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
113253931  [KO:K03947]
113253989  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113254091  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
113254324  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
113254396  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
113254594  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
113254727  [KO:K00416]
113254730  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
113254753  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
113254799  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
113254915  [KO:K02271]
113254991  APC; adenomatous polyposis coli protein isoform X3 [KO:K02085]
113255131  [KO:K02272]
113255266  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
113255470  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
113255536  DKK2; dickkopf-related protein 2 [KO:K02165]
113255572  [KO:K00134] [EC:1.2.1.12]
113255686  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
113255721  [KO:K02266]
113255751  [KO:K03947]
113255803  PPID; peptidyl-prolyl cis-trans isomerase D isoform X2 [KO:K05864] [EC:5.2.1.8]
113256068  [KO:K02183]
113256111  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
113256147  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
113256376  KIF5A; kinesin heavy chain [KO:K10396]
113256390  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 isoform X2 [KO:K03948]
113256392  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
113256410  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
113256429  SLC39A5; zinc transporter ZIP5 isoform X2 [KO:K14711]
113256552  [KO:K00417]
113256704  [KO:K03948]
113256705  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
113256757  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
113256842  [KO:K00414]
113256986  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
113256990  WNT5A; protein Wnt-5a [KO:K00444]
113257041  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
113257042  [KO:K03945]
113257114  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
113257190  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
113257229  WNT7A; protein Wnt-7a [KO:K00572]
113257365  WNT1; proto-oncogene Wnt-1 [KO:K03209]
113257544  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
113257592  ATG101; autophagy-related protein 101 [KO:K19730]
113257616  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
113257653  [KO:K07374]
113257654  [KO:K07374]
113257657  [KO:K07374]
113257662  WNT10B; protein Wnt-10b [KO:K01357]
113257782  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
113257792  KRAS; GTPase KRas isoform X1 [KO:K07827]
113257861  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
113257877  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
113257977  GAPDH; glyceraldehyde-3-phosphate dehydrogenase isoform X2 [KO:K00134] [EC:1.2.1.12]
113257988  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
113257995  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial isoform X1 [KO:K03953]
113258043  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
113258052  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
113258057  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
113258065  BID; BH3-interacting domain death agonist [KO:K04726]
113258067  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
113258243  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
113258346  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
113258441  CSNK2A1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
113258460  [KO:K02263]
113258771  TUBB1; LOW QUALITY PROTEIN: tubulin beta-1 chain [KO:K07375]
113258773  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
113258786  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
113258945  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
113258947  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
113258968  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
113258984  DKK1; dickkopf-related protein 1 [KO:K02165]
113259094  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
113259163  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
113259177  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X3 [KO:K04348] [EC:3.1.3.16]
113259206  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
113259219  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
113259469  [KO:K03959]
113259481  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
113259719  [KO:K04741] [EC:3.4.22.-]
113259790  FZD1; frizzled-1 [KO:K02432]
113260016  BACE1; beta-secretase 1 isoform X1 [KO:K04521] [EC:3.4.23.46]
113260378  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
113260424  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
113260540  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
113260639  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
113260769  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
113260793  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform X1 [KO:K03939]
113261105  [KO:K10881]
113261110  [KO:K02270]
113261277  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
113261280  IL6; interleukin-6 [KO:K05405]
113261548  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
113261698  [KO:K08738]
113261724  [KO:K00418]
113261734  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
113261780  WNT8A; protein Wnt-8a [KO:K00714]
113261786  [KO:K00416]
113261833  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
113262059  [KO:K02265]
113262259  CASP3; caspase-3 isoform X3 [KO:K02187] [EC:3.4.22.56]
113262270  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
113262375  [KO:K02271]
113262761  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
113262899  CAPN2; calpain-2 catalytic subunit isoform X2 [KO:K03853] [EC:3.4.22.53]
113262931  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
113262966  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113263101  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
113263102  SLC39A8; metal cation symporter ZIP8 [KO:K14714]
113263105  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
113263144  SNCA; alpha-synuclein isoform X2 [KO:K04528]
113263180  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
113263260  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
113263284  WNT2; protein Wnt-2 [KO:K00182]
113263367  [KO:K08738]
113263604  [KO:K04809]
113263804  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
113263912  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
113263933  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
113264352  TUBB; tubulin beta chain [KO:K07375]
113264790  [KO:K02267]
113264954  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X2 [KO:K03936] [EC:7.1.1.2]
113264959  PSMC3; 26S proteasome regulatory subunit 6A isoform X2 [KO:K03065]
113264960  SLC39A13; zinc transporter ZIP13 isoform X2 [KO:K14719]
113264980  ATG13; autophagy-related protein 13 isoform X3 [KO:K08331]
113264983  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
113265140  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
113265167  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
113265219  SLC39A11; zinc transporter ZIP11 isoform X4 [KO:K14717]
113265240  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
113265246  AXIN2; axin-2 isoform X1 [KO:K04385]
113265256  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
113265286  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
113265313  MAPT; microtubule-associated protein tau isoform X25 [KO:K04380]
113265349  FZD2; frizzled-2 [KO:K02235]
113265398  BECN1; beclin-1 isoform X1 [KO:K08334]
113265502  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 isoform X2 [KO:K03033]
113265544  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
113265594  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
113265667  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
113265670  WNT3; proto-oncogene Wnt-3 [KO:K00312]
113265763  [KO:K03945]
113265816  [KO:K21421] [EC:1.-.-.-]
113265845  [KO:K11352]
113265950  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
113265980  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
113265993  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
113266129  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
113266334  [KO:K02272]
113266369  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
113266397  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
113266506  WNT16; protein Wnt-16 [KO:K01558]
113266789  [KO:K02272]
113266817  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
113266853  ULK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
113266933  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
113266954  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
113266977  [KO:K03948]
113267043  [KO:K02266]
113267107  FZD10; frizzled-10 [KO:K02842]
113267167  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
113267192  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113267207  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
113267295  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
113267365  CALM1; calmodulin-1 isoform X2 [KO:K02183]
113267368  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
113267549  [KO:K00415]
113267578  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
113267625  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X2 [KO:K05853] [EC:7.2.2.10]
113267646  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
113267800  FZD9; frizzled-9 [KO:K02842]
113267858  [KO:K17445]
113267967  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
113267995  [KO:K02266]
113268105  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
113268160  IL1A; interleukin-1 alpha [KO:K04383]
113268254  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
113268305  PSMB2; proteasome subunit beta type-2 isoform X2 [KO:K02734] [EC:3.4.25.1]
113268542  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
113268761  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
113268986  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
113268987  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
113269018  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
113269168  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
113269215  APP; amyloid-beta precursor protein isoform X1 [KO:K04520]
113269338  WNT11; protein Wnt-11 [KO:K01384]
113269364  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
113269406  FZD4; frizzled-4 [KO:K02354]
113269419  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
113269421  [KO:K21423] [EC:1.6.3.-]
113269679  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
113269710  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
113269831  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
113269945  FZD3; frizzled-3 isoform X1 [KO:K02329]
113270001  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
113270002  SLC39A14; metal cation symporter ZIP14 isoform X1 [KO:K14720]
113270022  LPL; lipoprotein lipase isoform X2 [KO:K01059] [EC:3.1.1.34]
113270115  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
113270366  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
113270392  SLC39A9; zinc transporter ZIP9 [KO:K14715]
113270447  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
113270476  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
113270510  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
113270537  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113270636  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X2 [KO:K02353]
113270682  CALML6; calmodulin-like protein 6 [KO:K02183]
113270811  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
113271086  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
113271267  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
125281294  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
125281622  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
125282300  HRAS; GTPase HRas isoform X1 [KO:K02833]
130541828  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
130543483  [KO:K00134] [EC:1.2.1.12]
130544378  [KO:K05863]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Related
pathway
uah00190  Oxidative phosphorylation
uah03050  Proteasome
uah04020  Calcium signaling pathway
uah04140  Autophagy - animal
uah04141  Protein processing in endoplasmic reticulum
uah04210  Apoptosis
uah04310  Wnt signaling pathway
uah04910  Insulin signaling pathway
uah04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   

DBGET integrated database retrieval system