KEGG ORTHOLOGY: K04353

ORTHOLOGY: K04353

Entry

K04353                      KO

Symbol

RAP1A

Name

Ras-related protein Rap-1A

Pathway

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04024

cAMP signaling pathway

map04062

Chemokine signaling pathway

map04510

Focal adhesion

map04520

Adherens junction

map04530

Tight junction

map04611

Platelet activation

map04670

Leukocyte transendothelial migration

map04720

Long-term potentiation

map04722

Neurotrophin signaling pathway

map04934

Cushing syndrome

map04972

Pancreatic secretion

map05211

Renal cell carcinoma

map05417

Lipid and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04353  RAP1A; Ras-related protein Rap-1A
   04014 Ras signaling pathway
    K04353  RAP1A; Ras-related protein Rap-1A
   04015 Rap1 signaling pathway
    K04353  RAP1A; Ras-related protein Rap-1A
   04024 cAMP signaling pathway
    K04353  RAP1A; Ras-related protein Rap-1A
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04353  RAP1A; Ras-related protein Rap-1A
   04520 Adherens junction
    K04353  RAP1A; Ras-related protein Rap-1A
   04530 Tight junction
    K04353  RAP1A; Ras-related protein Rap-1A
09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K04353  RAP1A; Ras-related protein Rap-1A
   04670 Leukocyte transendothelial migration
    K04353  RAP1A; Ras-related protein Rap-1A
   04062 Chemokine signaling pathway
    K04353  RAP1A; Ras-related protein Rap-1A
  09154 Digestive system
   04972 Pancreatic secretion
    K04353  RAP1A; Ras-related protein Rap-1A
  09156 Nervous system
   04720 Long-term potentiation
    K04353  RAP1A; Ras-related protein Rap-1A
   04722 Neurotrophin signaling pathway
    K04353  RAP1A; Ras-related protein Rap-1A
09160 Human Diseases
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    K04353  RAP1A; Ras-related protein Rap-1A
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04353  RAP1A; Ras-related protein Rap-1A
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04353  RAP1A; Ras-related protein Rap-1A
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins
    K04353  RAP1A; Ras-related protein Rap-1A
GTP-binding proteins [BR:ko04031]
Small (monomeric) G-proteins
  Ras Family
   Rap [OT]
    K04353  RAP1A; Ras-related protein Rap-1A

Genes

HSA:	5906(RAP1A)

PTR:	469408(RAP1A)

PPS:	100980934(RAP1A)

GGO:	101125618(RAP1A)

PON:	100433839(RAP1A)

PPYG:

129021306(RAP1A)

NLE:	100603891(RAP1A)

HMH:	116469612(RAP1A)

SSYN:

134734151(RAP1A)

MCC:	704404(RAP1A)

MCF:	102144586(RAP1A)

MTHB:

126930173

MNI:	105479203(RAP1A)

CSAB:

103224221(RAP1A)

CATY:

105594391(RAP1A)

PANU:

101002054(RAP1A)

TGE:	112626061(RAP1A)

MLEU:

105554311(RAP1A)

RRO:	104658932(RAP1A)

RBB:	108525739 108528085(RAP1A)

TFN:	117076028(RAP1A)

PTEH:

111556041(RAP1A)

CANG:

105505360(RAP1A)

CJC:	100393183(RAP1A)

SBQ:	101048450(RAP1A)

CIMI:

108301226(RAP1A)

ANAN:

105727940(RAP1A)

CSYR:

103271454(RAP1A)

MMUR:

105878770(RAP1A)

LCAT:

123635037(RAP1A)

PCOQ:

105809043 105822091(RAP1A)

OGA:	100962069(RAP1A)

MMU:	109905(Rap1a)

MCAL:

110290796(Rap1a)

MPAH:

110319932(Rap1a)

RNO:	295347(Rap1a)

MCOC:

116092927 116093571(Rap1a)

ANU:	117707587(Rap1a)

MUN:	110549551(Rap1a)

CGE:	100751497(Rap1a)

MAUA:

101841364(Rap1a)

PROB:

127233056(Rap1a)

PLEU:

114707256(Rap1a)

MORG:

121437958 121449757

MFOT:

126495237

AAMP:

119800929(Rap1a)

NGI:	103734905(Rap1a)

HGL:	101698757(Rap1a)

CPOC:

100713608(Rap1a)

CCAN:

109695156(Rap1a)

DORD:

105991859(Rap1a)

DSP:	122104391(Rap1a)

PLOP:

125355399(Rap1a)

NCAR:

124978224

MMMA:

107156138(Rap1a)

OCU:

100351588

OPI:	101516340(RAP1A)

TUP:	102475072(RAP1A)

GVR:	103589910(RAP1A)

CFA:	483225(RAP1A)

CLUD:

112663891(RAP1A)

VVP:	112907935(RAP1A)

VLG:	121490661(RAP1A)

NPO:	129501387(RAP1A)

AML:	100471801(RAP1A)

UMR:	103675043(RAP1A)

UAH:	113244427(RAP1A)

UAR:	123795072(RAP1A)

ELK:

111143648

LLV:

125096746

MPUF:

101684587(RAP1A)

MNP:	132001295(RAP1A)

MLK:	131810068(RAP1A)

NVS:	122900324(RAP1A)

ORO:	101375466(RAP1A)

EJU:	114207895(RAP1A)

ZCA:	113928623(RAP1A)

MLX:	118010439 118019003(RAP1A)

NSU:	110580572(RAP1A)

LWW:	102742414(RAP1A)

FCA:	101094942(RAP1A)

PYU:	121027680(RAP1A)

PCOO:

112848655(RAP1A)

PBG:	122480933(RAP1A)

PVIV:

125172327(RAP1A)

LRUF:

124516472

PTG:	102963243(RAP1A)

PPAD:

109272045(RAP1A)

PUC:

125912252

AJU:

106969628

HHV:	120247125(RAP1A)

BTA:	282031(RAP1A)

BOM:	102286224(RAP1A)

BIU:	109555931(RAP1A)

BBUB:

102394947(RAP1A)

BBIS:

104981626(RAP1A)

CHX:	102176930(RAP1A)

OAS:	101115080(RAP1A)

BTAX:

128044450(RAP1A) 128061218

ODA:	120856682(RAP1A)

CCAD:

122436539(RAP1A)

MBEZ:

129541434 129541813(RAP1A)

SSC:	100153199(RAP1A)

CFR:	102516450(RAP1A)

CBAI:

105063692(RAP1A)

CDK:	105102039(RAP1A)

VPC:	102544212(RAP1A)

BACU:

103017880(RAP1A)

BMUS:

118897636(RAP1A)

LVE:	103069239(RAP1A)

OOR:	101287340(RAP1A)

DLE:	111180034(RAP1A)

PCAD:

102985661(RAP1A)

PSIU:

116755898(RAP1A)

NASI:

112413011(RAP1A)

ECB:	100049912 100058930(RAP1A)

EPZ:	103547802(RAP1A)

EAI:	106828599(RAP1A)

MYB:	102258771(RAP1A)

MYD:	102774675(RAP1A)

MMYO:

118672699(RAP1A)

MLF:	102418362(RAP1A)

MDT:	132220747(RAP1A)

PKL:	118727506(RAP1A) 118731567

EFUS:

103291183(RAP1A)

MNA:	107545324(RAP1A)

DRO:	112313714(RAP1A)

SHON:

118982036(RAP1A)

AJM:	119054595(RAP1A)

PDIC:

114488957(RAP1A)

PHAS:

123804635(RAP1A)

MMF:	118637043(RAP1A)

PPAM:

129063844(RAP1A)

HAI:	109373546(RAP1A)

RFQ:	117014781(RAP1A)

PALE:

102879271(RAP1A)

PGIG:

120585025(RAP1A)

PVP:	105296884(RAP1A)

RAY:	107499843(RAP1A)

MJV:	108395546(RAP1A)

TOD:	119235568(RAP1A)

SARA:

101543770(RAP1A)

SETR:

125997373(RAP1A)

LAV:	100676220(RAP1A)

TMU:

101352801

ETF:	101661777(RAP1A)

DNM:	101412472 101431654(RAP1A)

MDO:	100033128(RAP1A)

GAS:	123244057(RAP1A)

SHR:	100935403(RAP1A)

AFZ:

127559326

PCW:	110218764(RAP1A)

TVP:	118857384(RAP1A)

OAA:	100076731(RAP1A)

GGA:	419867(RAP1A)

PCOC:

116237094(RAP1A)

MGP:	100151696(RAP1A)

CJO:	107324916(RAP1A)

TPAI:

128088024(RAP1A)

LMUT:

125684074(RAP1A)

NMEL:

110388047(RAP1A)

APLA:

101800296(RAP1A)

ACYG:

106041314(RAP1A)

CATA:

118255454(RAP1A)

AFUL:

116498770(RAP1A)

TGU:	100151697(RAP1A)

LSR:	110475399(RAP1A)

SCAN:

103823268(RAP1A)

PMOA:

120495847(RAP1A)

OTC:	121348043(RAP1A)

PRUF:

121353155(RAP1A)

GFR:	102036447(RAP1A)

FAB:	101806584(RAP1A)

OMA:	130263651(RAP1A)

PHI:	102112636(RAP1A)

PMAJ:

107214847(RAP1A)

CCAE:

111939824(RAP1A)

CCW:	104692321(RAP1A)

CBRC:

103620353(RAP1A)

ETL:	114063112(RAP1A)

ZAB:	102070962(RAP1A)

ZLE:	135458042(RAP1A)

ACHL:

103805174(RAP1A)

SVG:	106863035(RAP1A)

MMEA:

130586108(RAP1A)

HRT:	120762694(RAP1A)

SATI:

136371649(RAP1A)

FPG:	101924077(RAP1A)

FCH:	102052801(RAP1A)

CCRI:

104159090(RAP1A)

NNT:	104410007(RAP1A)

SHAB:

115602460(RAP1A)

ACUN:

113488776(RAP1A)

TALA:

104360909(RAP1A)

ACHC:

115335056(RAP1A)

HALD:

104322485

HLE:	104838887(RAP1A)

AGEN:

126051975

GCL:

127026377

CSTI:

104553928

LDI:	104353529(RAP1A)

MNB:	103772591(RAP1A)

DPUB:

104296422(RAP1A)

AVIT:

104277180(RAP1A)

BRHI:

104495579(RAP1A)

EGZ:	104126794(RAP1A)

NNI:	104010315(RAP1A)

PCRI:

104036618

PCAO:

104049545

PADL:

103923560(RAP1A)

AFOR:

103893569(RAP1A)

FGA:	104082410(RAP1A)

GSTE:

104264980

CLV:	102089030(RAP1A)

MUI:	104542974(RAP1A)

PGUU:

104460010

PLET:

104618860(RAP1A)

EHS:	104513138(RAP1A)

CMAC:

104485325

CUCA:

104060011(RAP1A)

TEO:

104382934

BREG:

104637821(RAP1A)

OHA:	104333159(RAP1A)

ACAR:

104527015

CPEA:

104392402(RAP1A)

CVF:	104289481(RAP1A)

RTD:	128900238(RAP1A)

AAM:	106485263(RAP1A)

AROW:

112971578(RAP1A)

NPD:	112944571(RAP1A)

TGT:	104569825(RAP1A)

DNE:	112990243(RAP1A)

SCAM:

104142306(RAP1A)

ASN:	102385556(RAP1A)

AMJ:	102571106(RAP1A)

CPOO:

109317882(RAP1A)

GGN:	109295298(RAP1A)

PSS:	102461781(RAP1A)

CMY:	102948045(RAP1A)

CCAY:

125625088(RAP1A)

DCC:	119846364(RAP1A)

CPIC:

101952443(RAP1A)

TST:	117877457(RAP1A)

MRV:	120404195(RAP1A)

ACS:	100556443(rap1a)

ASAO:

132773551(RAP1A)

PVT:	110072354(RAP1A)

SUND:

121928393(RAP1A)

PBI:	103065471(RAP1A)

PMUR:

107292543(RAP1A)

CTIG:

120316127(RAP1A)

TSR:

106550518

PGUT:

117663826(RAP1A)

PTEX:

113444272(RAP1A)

NSS:	113417007(RAP1A)

VKO:	123031805(RAP1A)

PMUA:

114599364(RAP1A)

PRAF:

128403464 128416171(RAP1A)

ZVI:	118089490(RAP1A)

HCG:	128325184(RAP1A)

GJA:	107112269(RAP1A)

STOW:

125433058(RAP1A)

EMC:	129330698(RAP1A)

XLA:	414290(rap1a.S) 779127(rap1a.L)

XTR:	100124947(rap1a)

NPR:	108789680(RAP1A)

RTEM:

120927068(RAP1A)

BBUF:

120994960(RAP1A)

BGAR:

122930275 122930276

MUO:	115481761(RAP1A)

GSH:	117347209(RAP1A)

DRE:	406714(rap1ab) 415242(rap1aa)

SRX:	107711849 107742898 107745329 107751450

SANH:

107669014 107669591 107679791

SGH:	107556321 107557907 107560426 107591033 107594522

CCAR:

109078070 109103832

CAUA:

113054957 113069357 113072089 113107537 113107754

CGIB:

127963784 127967988 128018570 128022638

PTET:

122350014(rap1aa) 122354231(rap1ab)

LROH:

127169813(rap1aa) 127173149(rap1ab)

OMC:	131545529(rap1aa) 131549384(rap1ab)

PPRM:

120484123(rap1aa)

RKG:	130071760(rap1aa) 130078547(rap1ab)

MAMB:

125256596 125279745(rap1aa)

CIDE:

127517991 127522029

CERY:

137021690(rap1ab) 137027107(rap1aa)

MASI:

127415307 127424268 127426452 127427682

TROS:

130568370(rap1aa) 130571211(rap1ab)

TDW:	130410783(rap1ab) 130439797(rap1aa)

MANU:

129414019(rap1aa) 129428243(rap1ab)

IPU:	108255244(rap1ab) 108265690(rap1aa)

IFU:	128608011(rap1aa) 128625092(rap1ab)

PHYP:

113526347(rap1a) 113538035

SMEO:

124399916(rap1aa)

TFD:	113655771(rap1aa) 113656435(rap1ab)

TVC:	132838122(rap1ab) 132853270(rap1aa)

TRN:	134301457(rap1ab) 134318224(rap1aa)

AMEX:

103022868(rap1ab) 103047011(rap1aa)

CMAO:

118799483(rap1ab) 118813406(rap1aa)

EEE:	113572077(rap1a) 113586523

CHAR:

105901888 105902222(rap1aa)

TRU:	101064935 101074250

TFS:	130523547 130530732

TNG:	GSTEN00013536G001 GSTEN00023474G001

LCO:	104919934 104924467

NCC:

104961557

TBEN:

117489544

CGOB:

115004964 115006261 115007899

PGEO:

117446294

GACU:

117534181

EMAC:

134862380 134883005

ELY:	117256736 117258625

EFO:	125891517 125896957

PLEP:

121946624 121957019

SLUC:

116043610(rap1aa) 116051393

ECRA:

117943332 117947038

ESP:	116688344 116692093

PFLV:

114553888 114558435

GAT:	120829663 120835153

PPUG:

119222818 119229933

AFB:	129099265(rap1aa) 129105212

CLUM:

117730340 117733308(rap1aa)

PSWI:

130199451 130207780

MSAM:

119885910 119905851

SCHU:

122866755 122882912

CUD:	121517480 121528659

ALAT:

119021110 119022741

MZE:	101466020 101483640

ONL:	100690250 100692376

OAU:	116317168(rap1aa) 116320713

OLA:	101167529 101171247

OML:	112144686 112158849

CSAI:

133448333 133456732

XMA:	102226994 102235995

XCO:	114135748 114140864

XHE:	116710773(rap1a) 116712138

PRET:

103464617 103467749

PFOR:

103135492(rap1a) 103139095

PLAI:

106952760 106955536(rap1a)

PMEI:

106903419 106916736

GAF:	122833974 122838766(rap1aa)

PPRL:

129358132 129370163

CVG:	107090729 107103249

CTUL:

119794231 119799404(rap1aa)

GMU:	124856820 124875123

NFU:	107385357 107389464 107390354

KMR:	108231658 108232056

ALIM:

106515116(rap1a) 106527728 106531700

NWH:	119411850 119417490

AOCE:

111572080 111585086

MCEP:

125006269 125006718

CSEM:

103385603 103386699(rap1a)

POV:	109635540 109642729

SSEN:

122768573 122775382 122776902

HHIP:

117761319 117764251

HSP:	118104695 118111396

PPLT:

128443038 128453004

SMAU:

118309303 118316864

LCF:	108884107 108890490

SDU:	111224024 111234902

SLAL:

111650973 111661945

XGL:	120803735 120807409

HCQ:	109526885 109529211

SSCV:

125977858 125989090

SBIA:

133507432 133514827(rap1aa)

PEE:	133401618 133408301

PTAO:

133477705(rap1aa) 133483430

BPEC:

110164509 110170275

MALB:

109954071 109959359 109970312

BSPL:

114855366 114858554(rap1aa)

SJO:	128354919 128357403(rap1aa)

SASA:

106566052(RAP1A) 106567206(RAP1B) 106572472(RAP1B) 106582744(RAP1B)

STRU:

115150983 115165695 115168039 115207441

OTW:	112216212 112221097 112221873 112254221

OMY:	100305315(rap1b) 110492737 110494688 110532523

OGO:	124003093 124031583 124032134 124045946

ONE:	115102395 115132366 115136059 115143474

OKI:	109869058 109890855 109899027 109908184

OKE:	118359921 118360805 118388258 118399980

SALP:

111966669 111969753 111976890

SNH:	120058606 120059240 120061134 120065036

CCLU:

121538058 121545693 121574894 121578376

ELS:	105022336(rap1b) 105023688(rap1a)

SFM:	108928254(rap1a) 108930477

PKI:	111839862 111851087(rap1a)

AANG:

118208143(rap1aa) 118211443

LOC:	102690385(rap1a)

PSPA:

121299977 121300003

ARUT:

117417594 117431526

PSEX:

120526306

LCM:	102354992(RAP1A)

CMK:	103182425(rap1a)

CPLA:

122563040(rap1aa)

HOC:	132828310(rap1aa)

LERI:

129708836(rap1aa)

PMRN:

116951296

LRJ:

133356608

BFO:	118409875 118415225 118415323

BBEL:

109487627 109487934

CIN:	445785(rap1b)

SPU:	115919354 580151

LPIC:

129256657

APLC:

110982135

ARUN:

117306896

DME:	Dmel_CG1956(Rap1)

DER:

6546030

DSE:

6610415

DSI:	Dsimw501_GD13432(Dsim_R)

DYA:	Dyak_GE20907

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI16691

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108360732 108369662

AOQ:

129240985

TDA:	119668424 119668632

MDE:	101892158 131806690

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ008396

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105667796(Rap1)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

DCOR:

135797739(Rap1)

APLN:

108741848

PPYR:

116166698

OTU:

111425166

BMOR:

692519(Ras3)

BMAN:

114253491

MSEX:

115440159 119192034 119193570

DPL:	KGM_210727

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:	119836534 119836566

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106680081(Rap1)

NLU:

120354428

HVI:

124369099

MQU:

128998000

PHU:	Phum_PHUM226110

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

126297669 126322411 126325535

BROR:

134529332

IEL:

124170962

FCD:	110845442 110851148

DPX:	DAPPUDRAFT_231811

DMK:

116925683

DPZ:

124317221

PVM:	113809417 113824747

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:	126986306 127003069

MNZ:

135221907

HAZT:

108680208

EAF:	111704710 111714711

LSM:	121116213 121116596

TCF:	131886796 131886797

PPOI:

119091908

ISC:

115313968

DSV:	119446291 119466408

RSAN:

119407116

RMP:

119163534

VDE:	111245746 111255224

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136980458(Rap1) 136980866

PTEP:

ABRU:

UDV:

SDM:

LPOL:

106462065 106462951 106469156 106471875 106473453 106478101

PMEO:

129584450

CEL:	CELE_C27B7.8(rap-1)

CBR:	CBG_21720(Cbr-rap-1)

CRQ:	GCK72_013389

NAI:	NECAME_08250 NECAME_08256 NECAME_15432

BMY:	BM_BM2428(Bma-rap-1)

LOA:	LOAG_05207

TSP:

Tsp_02666

HRO:	HELRODRAFT_77994

LGI:	LOTGIDRAFT_226838

PVUL:

126828736

PCAN:

112572369

BGT:	106064066 106075417

GAE:	121367998 121381407

HRF:

124125080

HRJ:	124265142 124288595

CRG:

105347969

CANU:

128159508

CVN:	111108653 111132147

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:	115209907 115228804

LJP:

135471891

LAK:	106163156 106163157

SMM:	Smp_142450

SHX:	MS3_00006964(RAP1B_1)

LLON:

135483634 135483645 135490640

NVE:	5510684 5517110

EPA:	110236317 110236776

ATEN:

116291898 116295677

ADF:	107340152 107354004

AMIL:

114955013 114961376 114962244 114964104

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:	130625292 130662657

RES:	135687292 135692624 135694436

PCHM:

VFPPC_08273

CDEP:

91089948(L203_105739)

KMG:	30162616(I203_101169)

TMS:	TREMEDRAFT_62789

TASA:

A1Q1_04105

SHS:	STEHIDRAFT_91025

FME:	FOMMEDRAFT_131416

LBC:	LACBIDRAFT_190473

CCI:	CC1G_14380

PCUB:

JR316_0006052

MRR:	Moror_1237

E1B28_011332

SCM:	SCHCO_02625881(SCHCODRAFT_02625881)

WSE:	WALSEDRAFT_41564

MBR:	MONBRDRAFT_37080

SRE:	PTSG_11774

DDI:	DDB_G0272857(rapB)

DPP:	DICPUDRAFT_26434(rapB)

DFA:

DFA_02753

EHI:	EHI_004860(203.t00010) EHI_049030 EHI_058090(179.t00009) EHI_101260(5.t00090)

EDI:	EDI_041020 EDI_090510 EDI_120240 EDI_216290 EDI_234890 EDI_244910 EDI_278170

EIV:	EIN_002150 EIN_051510 EIN_075710 EIN_082730 EIN_114190 EIN_125800 EIN_181310 EIN_184940 EIN_249710 EIN_346100 EIN_362190 EIN_400010 EIN_408950

ACAN:

ACA1_095980 ACA1_384830 ACA1_396120

NGR:	NAEGRDRAFT_55569

TVA:	TVAG_2v0214390 TVAG_2v0750270 TVAG_2v0996810

» show all

Reference

PMID:2642744

Authors

Kitayama H, Sugimoto Y, Matsuzaki T, Ikawa Y, Noda M

Title

A ras-related gene with transformation suppressor activity.

Journal

Cell 56:77-84 (1989)
DOI:10.1016/0092-8674(89)90985-9

Sequence

[hsa:5906]

LinkDB

ORTHOLOGY: K07836

Entry

K07836                      KO

Symbol

RAP1B

Name

Ras-related protein Rap-1B

Pathway

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04024

cAMP signaling pathway

map04062

Chemokine signaling pathway

map04510

Focal adhesion

map04520

Adherens junction

map04611

Platelet activation

map04670

Leukocyte transendothelial migration

map04720

Long-term potentiation

map04722

Neurotrophin signaling pathway

map04934

Cushing syndrome

map04972

Pancreatic secretion

map05211

Renal cell carcinoma

map05417

Lipid and atherosclerosis

Disease

H00978

Thrombocytopenia (THC)

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K07836  RAP1B; Ras-related protein Rap-1B
   04014 Ras signaling pathway
    K07836  RAP1B; Ras-related protein Rap-1B
   04015 Rap1 signaling pathway
    K07836  RAP1B; Ras-related protein Rap-1B
   04024 cAMP signaling pathway
    K07836  RAP1B; Ras-related protein Rap-1B
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K07836  RAP1B; Ras-related protein Rap-1B
   04520 Adherens junction
    K07836  RAP1B; Ras-related protein Rap-1B
09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K07836  RAP1B; Ras-related protein Rap-1B
   04670 Leukocyte transendothelial migration
    K07836  RAP1B; Ras-related protein Rap-1B
   04062 Chemokine signaling pathway
    K07836  RAP1B; Ras-related protein Rap-1B
  09154 Digestive system
   04972 Pancreatic secretion
    K07836  RAP1B; Ras-related protein Rap-1B
  09156 Nervous system
   04720 Long-term potentiation
    K07836  RAP1B; Ras-related protein Rap-1B
   04722 Neurotrophin signaling pathway
    K07836  RAP1B; Ras-related protein Rap-1B
09160 Human Diseases
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    K07836  RAP1B; Ras-related protein Rap-1B
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K07836  RAP1B; Ras-related protein Rap-1B
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K07836  RAP1B; Ras-related protein Rap-1B
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K07836  RAP1B; Ras-related protein Rap-1B
   04031 GTP-binding proteins
    K07836  RAP1B; Ras-related protein Rap-1B
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K07836  RAP1B; Ras-related protein Rap-1B
  Exosomal proteins of other body fluids (saliva and urine)
   K07836  RAP1B; Ras-related protein Rap-1B
  Exosomal proteins of colorectal cancer cells
   K07836  RAP1B; Ras-related protein Rap-1B
GTP-binding proteins [BR:ko04031]
Small (monomeric) G-proteins
  Ras Family
   Rap [OT]
    K07836  RAP1B; Ras-related protein Rap-1B

Genes

HSA:	5908(RAP1B)

PTR:	452065(RAP1B)

PPS:	100995578(RAP1B)

GGO:	101125880(RAP1B)

PON:	100171907(RAP1B)

PPYG:

129009944(RAP1B)

NLE:	100593411(RAP1B)

HMH:	116478979(RAP1B)

SSYN:

129461142(RAP1B) 129490367

MCC:	693750 718171(RAP1B)

MCF:	102133022(RAP1B)

MTHB:

126930986 126937705

MNI:	105473408(RAP1B)

CSAB:

103215555 103238680(RAP1B)

CATY:

105600503(RAP1B)

PANU:

101013495(RAP1B)

TGE:	112635460(RAP1B)

MLEU:

105537110(RAP1B)

RRO:	104658672(RAP1B)

RBB:	108532250(RAP1B)

TFN:	117089777(RAP1B) 117098609

PTEH:

111528626(RAP1B) 111532119

CANG:

105502654(RAP1B)

CJC:	100411763 100413220(RAP1B)

SBQ:	101036065(RAP1B)

CIMI:

108300232(RAP1B)

ANAN:

105711998(RAP1B)

CSYR:

103250369 103253054 103253055 103268438

MMUR:

105880992(RAP1B)

LCAT:

123639540(RAP1B)

PCOQ:

105808407(RAP1B)

OGA:	100941765 100959791(RAP1B)

MMU:	215449(Rap1b)

MCAL:

110303320(Rap1b)

MPAH:

110326460(Rap1b)

RNO:	171337(Rap1b)

MCOC:

116075736(Rap1b)

ANU:	117696422(Rap1b)

MUN:	110562151(Rap1b)

CGE:	100769542(Rap1b)

MAUA:

101823756(Rap1b)

PROB:

127215719(Rap1b)

PLEU:

114693311(Rap1b)

MORG:

121461538(Rap1b)

MFOT:

126515662

AAMP:

119803252(Rap1b)

NGI:	103745076(Rap1b)

HGL:	101714409 101726671(Rap1b)

CPOC:

100713271 100734094(Rap1b)

CCAN:

109699305

DORD:

105989638(Rap1b)

DSP:	122124042(Rap1b)

PLOP:

125345750 125361483(Rap1b)

NCAR:

124982482

MMMA:

107140075(Rap1b) 107140230

OCU:

100339891

OPI:	101518056(RAP1B)

TUP:	102472381(RAP1B)

GVR:	103595400(RAP1B)

CFA:	608981(RAP1B)

CLUD:

112677882(RAP1B)

VVP:	112922290(RAP1B)

VLG:	121476667 121491095(RAP1B)

NPO:	129511430(RAP1B)

AML:	100480240(RAP1B)

UMR:	103656863(RAP1B) 103659828

UAH:	113256300(RAP1B) 123000663

UAR:	123787151(RAP1B)

ELK:

111141969

LLV:	125106325 125107556

MPUF:

101691404(RAP1B)

MNP:	132019439(RAP1B)

MLK:	131839131(RAP1B)

NVS:	122892522(RAP1B)

ORO:	101383971(RAP1B)

EJU:	114214898(RAP1B)

ZCA:	113921540(RAP1B)

MLX:	118008596(RAP1B)

NSU:	110570611(RAP1B)

LWW:	102732389(RAP1B)

FCA:	101095993(RAP1B)

PYU:	121040776(RAP1B)

PCOO:

112863816(RAP1B)

PBG:	122474003(RAP1B)

PVIV:

125169828(RAP1B)

LRUF:

124502483

PTG:	102965011(RAP1B)

PPAD:

109259557 109270479(RAP1B)

PUC:

125919321

AJU:

106966345

HHV:	120240794(RAP1B)

BTA:	327708(RAP1B) 789148

BOM:	102265384(RAP1B) 102269967 102277019

BIU:	109559248(RAP1B)

BBUB:

102400135(RAP1B)

BBIS:

104989774(RAP1B)

CHX:	102174543(RAP1B)

OAS:	101106317(RAP1B) 114113232

BTAX:

128047462(RAP1B)

ODA:	120857713(RAP1B)

CCAD:

122427076(RAP1B)

MBEZ:

129537257(RAP1B)

SSC:	100152555(RAP1B)

CFR:	102524037(RAP1B)

CBAI:

105081341(RAP1B)

CDK:	105101089(RAP1B)

VPC:	102535500(RAP1B)

BACU:

103018737 103019004(RAP1B)

BMUS:

118898513 118900105 118901719(RAP1B)

LVE:	103083426(RAP1B) 103088976

OOR:	101284281(RAP1B)

DLE:	111173766(RAP1B)

PCAD:

102980344(RAP1B) 102989853

PSIU:

116753261 116757757 116760187(RAP1B)

NASI:

112393952(RAP1B) 112407608

ECB:	100052025(RAP1B)

EPZ:	103558687(RAP1B)

EAI:	106843586(RAP1B)

MYB:	102254910(RAP1B)

MYD:	102772411(RAP1B)

MMYO:

118651809(RAP1B)

MLF:	102441232(RAP1B)

MDT:	132225178 132227892(RAP1B)

PKL:	118724188 118729245(RAP1B)

EFUS:

103292519(RAP1B)

MNA:	107526932(RAP1B)

DRO:	112318977(RAP1B)

SHON:

118989371(RAP1B)

AJM:	119036470 119042914(RAP1B)

PDIC:

114512692(RAP1B)

PHAS:

123812719(RAP1B)

MMF:	118624733(RAP1B)

PPAM:

129075864(RAP1B)

HAI:	109381707(RAP1B)

RFQ:	117028675(RAP1B)

PALE:

102883778(RAP1B)

PGIG:

120605040(RAP1B)

PVP:	105302160(RAP1B)

RAY:	107512678(RAP1B)

MJV:	108392641 108407356(RAP1B)

TOD:	119247531(RAP1B)

SARA:

101545287(RAP1B)

SETR:

126006387 126021897(RAP1B)

LAV:	100665185(RAP1B)

TMU:

101348129

ETF:	101641765 101659498(RAP1B) 101664314

DNM:	101421103(RAP1B) 101431477

MDO:	100014092(RAP1B)

GAS:	123233503 123234910 123248572(RAP1B)

SHR:	100920135(RAP1B)

AFZ:	127538164 127541432

PCW:	110211041(RAP1B)

TVP:	118847569 118850626(RAP1B)

OAA:	100079331(RAP1B)

GGA:	417840(RAP1B)

PCOC:

116226600(RAP1B)

MGP:	100543810(RAP1B)

CJO:	107310547(RAP1B)

TPAI:

128073883(RAP1B)

LMUT:

125688069(RAP1B)

NMEL:

110392786(RAP1B)

APLA:

101789925(RAP1B)

ACYG:

106046993(RAP1B)

CATA:

118246831(RAP1B)

AFUL:

116487830(RAP1B)

TGU:	100223739(RAP1B)

LSR:	110477997(RAP1B)

SCAN:

103813454(RAP1B)

PMOA:

120499794(RAP1B)

OTC:	121339432(RAP1B)

PRUF:

121352517(RAP1B)

GFR:	102042554(RAP1B)

FAB:	101812484(RAP1B)

OMA:	130264553(RAP1B)

PHI:	102099438(RAP1B)

PMAJ:

107204636(RAP1B)

CCAE:

111932715(RAP1B)

CCW:	104698372(RAP1B)

CBRC:

103614815(RAP1B)

ETL:	114062143(RAP1B)

ZAB:	102063354(RAP1B)

ZLE:	135442277(RAP1B)

ACHL:

103797087(RAP1B)

SVG:	106855333(RAP1B)

MMEA:

130580110(RAP1B)

HRT:	120751456(RAP1B)

SATI:

136361331(RAP1B)

FPG:	101924298(RAP1B)

FCH:	102047995(RAP1B)

CCRI:

104166782(RAP1B)

NNT:

104411965

SHAB:

115605366(RAP1B)

ACUN:

113487398(RAP1B)

TALA:

104364250(RAP1B)

ACHC:

115336097(RAP1B)

HALD:

104323997(RAP1B)

HLE:	104828219(RAP1B)

AGEN:

126034345

GCL:

127015780

CSTI:

104563621(RAP1B)

LDI:	104341426(RAP1B)

MNB:	103774779(RAP1B)

DPUB:

104305542(RAP1B)

AVIT:

104270664(RAP1B)

BRHI:

104495704(RAP1B)

EGZ:	104132908(RAP1B)

NNI:	104011007(RAP1B)

PCRI:

104030981(RAP1B)

PCAO:

104051011(RAP1B)

PADL:

103919959(RAP1B)

AFOR:

103893929(RAP1B)

FGA:	104084036(RAP1B)

GSTE:

104254385(RAP1B)

CLV:	102083646(RAP1B)

MUI:	104537576(RAP1B)

PGUU:

104465991(RAP1B)

PLET:

104615422(RAP1B)

EHS:	104504649(RAP1B)

CMAC:

104474756(RAP1B)

CUCA:

104061349(RAP1B)

TEO:	104373969(RAP1B)

BREG:

104630904(RAP1B)

OHA:	104326768(RAP1B)

ACAR:

104527054(RAP1B)

CPEA:

104388816(RAP1B)

CVF:	104288923(RAP1B)

RTD:	128911066(RAP1B)

AAM:	106488632(RAP1B)

AROW:

112970437(RAP1B)

NPD:	112958867(RAP1B)

TGT:	104574441(RAP1B)

DNE:	112983294(RAP1B)

SCAM:

104142047(RAP1B)

ASN:	102382819(RAP1B)

AMJ:	102561548(RAP1B)

CPOO:

109315520(RAP1B)

GGN:	109295712(RAP1B)

PSS:	102444055(RAP1B)

CMY:	102947916(RAP1B)

CCAY:

125630229(RAP1B)

DCC:	119859043(RAP1B)

CPIC:

101935007(RAP1B)

TST:	117877671(RAP1B)

CABI:

116834442(RAP1B)

MRV:	120383281(RAP1B)

ACS:	100553457(rap1b)

ASAO:

132776179(RAP1B)

PVT:	110075099(RAP1B)

SUND:

121930868(RAP1B)

PBI:	103064511(RAP1B)

PMUR:

107284411(RAP1B)

CTIG:

120307687(RAP1B)

TSR:	106545246(RAP1B)

PGUT:

117655710(RAP1B)

APRI:

131201824(RAP1B)

PTEX:

113435814(RAP1B)

NSS:	113412267(RAP1B)

VKO:	123033326(RAP1B)

PMUA:

114605252(RAP1B)

PRAF:

128422090(RAP1B)

ZVI:	118090625(RAP1B)

HCG:	128327323(RAP1B)

GJA:	107105721(RAP1B)

STOW:

125434778(RAP1B)

EMC:	129335857(RAP1B)

XLA:	108713157 379883(rap1b.L)

XTR:	493557(rap1b)

NPR:	108804561(RAP1B)

RTEM:

120931994(RAP1B)

BBUF:

120980486(RAP1B)

BGAR:

122928017(RAP1B)

MUO:	115478180(RAP1B)

GSH:	117363953(RAP1B)

DRE:	321107(rap1b)

SRX:	107725524 107732995(rap1b)

SANH:

107664881 107695907

SGH:	107553881(rap1b)

CCAR:

109067672 109072174(rap1b)

CAUA:

113048121 113063276

CGIB:

127956746 127974411

PTET:

122343501(rap1b)

LROH:

127163881(rap1b)

OMC:	131539666(rap1b)

PPRM:

120476984(rap1b)

RKG:	130072225(rap1b)

MAMB:

125246225(rap1b)

CIDE:

127511385

CERY:

137024478(rap1b)

MASI:

127434844 127436684

TROS:

130547968(rap1b)

TDW:	130420368(rap1b)

MANU:

129432000(rap1b)

IPU:	100528315(rap1b)

IFU:	128623063(rap1b)

PHYP:

113532015(rap1b)

SMEO:

124400808(rap1b)

TFD:	113645502(rap1b)

TVC:	132859455(rap1b)

TRN:	134315052(rap1b)

AMEX:

103035254(rap1b)

CMAO:

118812483(rap1b)

EEE:	113572528(rap1b)

CHAR:

105892499

TRU:

101070080

TFS:

130519413

TNG:	GSTEN00012332G001

LCO:	104935802(rap1b)

TBEN:

PGEO:

EMAC:

ELY:

EFO:

SLUC:

PFLV:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:

ONL:	100707998(rap1b)

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:	116736693(rap1b)

PRET:

103459326(rap1b)

PFOR:

103133068 103154285(rap1b)

PLAI:

106940239 106941801

PMEI:

106917317(rap1b)

GAF:

122826820

PPRL:

129352835

CVG:	107089072(rap1b)

CTUL:

119796580

GMU:

124882697

NFU:	107387503(rap1b)

NWH:

AOCE:

MCEP:

CSEM:

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:	111225046(rap1b)

SLAL:

111661323

XGL:

120803527

HCQ:	109532657(rap1b)

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110161898(rap1b)

MALB:

109974612

BSPL:

114862548

SJO:

128385170

SASA:

106576640 106593497(RAP1B)

STRU:

115182047 115182953

OTW:	121842780 121845253

OMY:	110490689 118936571

OGO:	124020931 124020932 124022472

OKI:

116360631

OKE:	127927760 127927765

SNH:

120050139

CCLU:

121553840

ELS:	105017798(rap1b)

SFM:	108920959 108936546(rap1b)

PKI:	111844324 111851234(rap1b)

AANG:

118218837 118231987

LOC:	102697231(rap1b)

PSPA:

121317980 121320084

ARUT:

117415871 117419830

PSEX:

120539577(rap1b)

LCM:	102354357(RAP1B)

CMK:

RTP:

CPLA:

HOC:

LERI:

BBEL:

CIN:

SCLV:

SKO:

LDC:

HAME:

ESN:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

GAE:

HRF:

SMM:	Smp_071250

OVI:	T265_00309 T265_07457

EGL:	EGR_01616 EGR_03026

ATEN:

116301360

TAD:	TRIADDRAFT_55369

AQU:

105313915

SCE:	YGR152C(RSR1)

SEUB:

DI49_2116

SPAO:

SPAR_G03670

AGO:	AGOS_AFR464W

ERC:

Ecym_1407

KLA:	KLLA0_C12001g

KMX:	KLMA_60196(RSR1)

LTH:	KLTH0H09042g

VPO:	Kpol_1026p12

ZRO:	ZYRO0G07018g

CGR:	2887368(GVI51_E02871)

NCS:	NCAS_0A01890(NCAS0A01890)

NDI:	NDAI_0D03820(NDAI0D03820)

TPF:	TPHA_0K01820(TPHA0K01820)

TBL:	TBLA_0B00370(TBLA0B00370)

TGB:	HG536_0D04840

TDL:	TDEL_0F02770(TDEL0F02770)

KAF:	KAFR_0F03670(KAFR0F03670)

KNG:	KNAG_0D03780(KNAG0D03780)

ZMK:	HG535_0B05640

SLUD:

SCDLUD_001545

DHA:	DEHA2C16544g

PIC:	PICST_57530

PGU:	PGUG_03860

SPAA:

SPAPADRAFT_49461

LBG:	92206220(LODBEIA_P10240)

CAL:	CAALFM_CR02140WA(RSR1)

CTP:	CTRG_00897

COT:	CORT_0A00810

CDU:	CD36_27060(RSR1)

CTEN:

18250026(RSR1)

CLU:	CLUG_03767

CLUS:

A9F13_01g03751

CAUR:

CJI96_0002950

PPA:	PAS_chr2-2_0347

PKZ:	C5L36_0A11320

BNN:	FOA43_004055(RSR1)

BBRX:

BRETT_002898(RSR1)

OPA:	HPODL_05361

YLI:	2908782(YALI2_E01056g)

SLB:	AWJ20_3825(RSR1)

SMP:	10801369(SMAC4_09077)

PAN:	PODANSg4399

MGR:

MGG_02727

TMN:	UCRPA7_2837

FGR:	FGSG_08817

FPU:	FPSE_11987

FPOA:

FPOAC1_004955(RSR1)

FVN:	FVRRES_05473

FVR:	FVEG_02390

FOX:	FOXG_03523

NHE:	NECHADRAFT_92074

FFC:	NCS54_00423400

FKR:	NCS57_00428700

TRE:	TRIREDRAFT_76880(rsr1)

TRR:	M419DRAFT_97568

TATV:

25781841(TrAtP1_001989)

MAW:	19245284(RSR1_1)

MAJ:

MAA_10959

MBRN:

26245536(RSR1)

PCHM:

VFPPC_13713

CMT:

CCM_00788

AMUS:

LMH87_002062

PLJ:	28882579(PLICBS_001407)

PTKZ:

JDV02_010060(RSR1)

CFJ:	CFIO01_12692

SAPO:

SAPIO_CDS5131

PFY:	PFICI_03039

SSL:	SS1G_03294

BFU:	BCIN_08g02920(Bcrsr1)

MBE:

MBM_09336

PSCO:

LY89DRAFT_278291

GLZ:	GLAREA_09150

ACT:	ACLA_011600

NFI:	NFIA_078360

AOR:	AO090020000491

ANG:	An07g04240

TRG:	TRUGW13939_10630

CIM:	CIMG_06722

CPW:	CPC735_031650

URE:	UREG_03736

ABE:

ARB_00736

TVE:

TRV_08011

PBN:	PADG_07371

AJE:	HCAG_00675

BGH:	BDBG_01197

PNO:	SNOG_09547

PTE:

PTT_20340

BZE:	COCCADRAFT_39940

BSC:	COCSADRAFT_91616

BOR:	COCMIDRAFT_37929

AALT:

CC77DRAFT_1032527

ZTR:	MYCGRDRAFT_30706 MYCGRDRAFT_69392

PFJ:	MYCFIDRAFT_152766

BCOM:

BAUCODRAFT_141164

TML:	GSTUM_00000073001

CCAC:

CcaHIS019_0303840(CcaverHIS019_0303840)

PPL:	POSPLDRAFT_27587

PCO:	PHACADRAFT_251819

UMA:	UMAG_11909

PFP:	PFL1_00443

PGR:	PGTG_12740

MLR:	MELLADRAFT_35390

DDI:	DDB_G0291237(rapA)

DPP:	DICPUDRAFT_59134(rapA)

DFA:	DFA_03257 DFA_12095(rapA)

ACAN:

ACA1_215900 ACA1_278840

NGR:	NAEGRDRAFT_69615

TVA:	TVAG_2v0675690 TVAG_2v0820100 TVAG_2v0874390

» show all

Reference

PMID:10579920

Authors

Zwartkruis FJ, Bos JL

Title

Ras and Rap1: two highly related small GTPases with distinct function.

Journal

Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695

Reference

PMID:3137530

Authors

Pizon V, Lerosey I, Chardin P, Tavitian A

Title

Nucleotide sequence of a human cDNA encoding a ras-related protein (rap1B).

Journal

Nucleic Acids Res 16:7719 (1988)
DOI:10.1093/nar/16.15.7719

Sequence

[hsa:5908]

LinkDB

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