KEGG   PATHWAY: mpuf05170
Entry
mpuf05170                   Pathway                                
Name
Human immunodeficiency virus 1 infection - Mustela putorius furo (domestic ferret)
Description
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency syndrome), is a lentivirus belonging to the Retroviridae family. The primary cell surface receptor for HIV-1, the CD4 protein, and the co-receptor for HIV-1, either CCR5 or CXCR4, are found on macrophages and T lymphocytes. At the earliest step, sequential binding of virus envelope (Env) glycoprotein gp120 to CD4 and the co-receptor CCR5 or CXCR4 facilitates HIV-1 entry and has the potential to trigger critical signaling that may favor viral replication. At advanced stages of the disease, HIV-1 infection results in dramatic induction of T-cell (CD4+ T and CD8+ T cell) apoptosis both in infected and uninfected bystander T cells, a hallmark of HIV-1 pathogenesis. On the contrary, macrophages are resistant to the cytopathic effect of HIV-1 and produce virus for longer periods of time.
Class
Human Diseases; Infectious disease: viral
Pathway map
mpuf05170  Human immunodeficiency virus 1 infection
mpuf05170

Disease
H00406  Acquired immunodeficiency syndrome (AIDS)
H01563  HIV infection
Organism
Mustela putorius furo (domestic ferret) [GN:mpuf]
Gene
101669959  WEE2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
101670116  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
101670335  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
101670448  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101670597  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
101670617  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101670774  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
101670820  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
101671054  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
101671073  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101671422  CCNB3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
101671536  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101671644  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
101671648  IKBKG; NF-kappa-B essential modulator [KO:K07210]
101671860  FADD; FAS-associated death domain protein [KO:K02373]
101672027  AP1G2; AP-1 complex subunit gamma-like 2 isoform X1 [KO:K12391]
101672072  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101672171  BST2; bone marrow stromal antigen 2 isoform X1 [KO:K06731]
101672230  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
101672273  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
101672371  AP1G1; AP-1 complex subunit gamma-1 isoform X2 [KO:K12391]
101672676  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
101672818  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
101672877  CFL2; cofilin-2 [KO:K05765]
101673044  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
101673428  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
101673776  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
101673914  SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 [KO:K22544] [EC:3.1.5.-]
101673919  CFL1; cofilin-1 isoform X1 [KO:K05765]
101673939  B2M; beta-2-microglobulin [KO:K08055]
101674042  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X2 [KO:K17334]
101674115  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
101674179  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
101674199  TAP1; antigen peptide transporter 1 isoform X2 [KO:K05653] [EC:7.4.2.14]
101674297  BCL2L1; bcl-2-like protein 1 [KO:K04570]
101674354  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
101674862  CALM3; calmodulin [KO:K02183]
101674924  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
101674940  [KO:K05414]
101675243  [KO:K05414]
101675302  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101675380  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101675500  WEE1; wee1-like protein kinase isoform X1 [KO:K06632] [EC:2.7.11.1]
101675553  CUL5; cullin-5 [KO:K10612]
101675609  RNF7; RING-box protein 2 isoform X1 [KO:K10611]
101675629  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
101675758  [KO:K05414]
101675854  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101675922  [KO:K10648] [EC:2.3.2.27]
101675984  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101676004  PXN; paxillin isoform X1 [KO:K05760]
101676085  CALR; calreticulin [KO:K08057]
101676091  CD3E; T-cell surface glycoprotein CD3 epsilon chain isoform X1 [KO:K06451]
101676200  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
101676245  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101676370  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101676392  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
101676423  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101676486  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101676559  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101676562  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101676567  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101676633  [KO:K05414]
101676687  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
101676895  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101676957  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
101676992  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101677157  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
101677174  AP1M2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
101677354  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101677422  [KO:K05414]
101677799  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
101677959  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X2 [KO:K04543]
101677976  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
101678023  CDC25C; M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
101678102  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
101678181  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101678184  [KO:K05414]
101678308  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
101678496  [KO:K05414]
101678599  CUL4B; cullin-4B isoform X1 [KO:K10609]
101678743  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101678795  [KO:K05414]
101678913  CRKL; crk-like protein [KO:K04438]
101679100  IFNB1; interferon beta [KO:K05415]
101679339  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101679748  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101679776  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101679855  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
101680223  [KO:K18750] [EC:3.5.4.-]
101680239  RELA; transcription factor p65 [KO:K04735]
101680348  JUN; transcription factor AP-1 [KO:K04448]
101680372  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101680399  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101680542  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101680658  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101680687  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
101680975  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101681070  [KO:K04726]
101681131  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
101681141  PAK7; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
101681170  [KO:K02183]
101681290  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101681308  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101681333  KRAS; GTPase KRas isoform X3 [KO:K07827]
101681349  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101681355  HRAS; GTPase HRas isoform X1 [KO:K02833]
101681446  [KO:K02183]
101681595  TLR2; toll-like receptor 2 [KO:K10159]
101681650  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101681759  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101681868  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
101682439  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101682554  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101682835  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101682868  [KO:K03094]
101682916  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
101683038  NRAS; GTPase NRas [KO:K07828]
101683116  CCNB1; LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B1 [KO:K05868]
101683200  [KO:K05414]
101683594  [KO:K02649]
101683633  TAPBP; tapasin [KO:K08058]
101683659  CALM2; calmodulin [KO:K02183]
101683710  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101683736  CRK; adapter molecule crk isoform X1 [KO:K04438]
101684009  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101684074  [KO:K05414]
101684109  CUL1; cullin-1 [KO:K03347]
101684131  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101684365  [KO:K05414]
101684443  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101684485  LIMK2; LIM domain kinase 2 isoform X2 [KO:K05744] [EC:2.7.11.1]
101684487  CD4; T-cell surface glycoprotein CD4 isoform X1 [KO:K06454]
101684645  [KO:K05414]
101684873  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
101685123  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
101685236  FOS; proto-oncogene c-Fos [KO:K04379]
101685356  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101685422  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
101685502  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
101685546  [KO:K05414]
101685590  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
101685765  DDB1; DNA damage-binding protein 1 [KO:K10610]
101685801  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101686008  [KO:K10785]
101686116  [KO:K05414]
101686218  TCEB1; transcription elongation factor B polypeptide 1 [KO:K03872]
101686271  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101686427  BAD; bcl2-associated agonist of cell death [KO:K02158]
101686492  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
101686636  BID; BH3-interacting domain death agonist [KO:K04726]
101686802  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
101686932  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101687148  TNF; tumor necrosis factor isoform X1 [KO:K03156]
101687227  [KO:K03347]
101687324  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101687517  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101687579  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
101687674  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
101687874  MB21D1; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
101687914  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
101687979  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
101688079  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101688102  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
101688258  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101688438  CUL4A; cullin-4A [KO:K10609]
101688546  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
101688570  CD247; T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453]
101688800  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101688837  TCEB2; transcription elongation factor B polypeptide 2 [KO:K03873]
101688882  [KO:K10610]
101688912  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
101688916  BAK1; bcl-2 homologous antagonist/killer isoform X3 [KO:K14021]
101689041  [KO:K06751]
101689227  VPRBP; protein VPRBP isoform X1 [KO:K11789] [EC:2.7.11.1]
101689344  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
101690347  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
101690408  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
101690482  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101690488  [KO:K08738]
101690549  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X2 [KO:K04404]
101690568  [KO:K06751]
101690739  [KO:K10784]
101690759  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101690814  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
101690858  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
101691230  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
101691234  [KO:K05868]
101691254  CALM1; calmodulin [KO:K02183]
101691280  TMEM173; stimulator of interferon genes protein isoform X1 [KO:K12654]
101691468  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101691506  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101691734  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101691741  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
101692143  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101692220  BTRC; F-box/WD repeat-containing protein 1A isoform X7 [KO:K03362]
101692743  CCR5; C-C chemokine receptor type 5 [KO:K04180]
101693321  [KO:K06751]
101693423  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
101693829  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101693834  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
101693860  [KO:K06751]
106003371  [KO:K08738]
106004724  [KO:K06751]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:22749173
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Evans VA, Khoury G, Saleh S, Cameron PU, Lewin SR
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HIV persistence: chemokines and their signalling pathways.
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Cytokine Growth Factor Rev 23:151-7 (2012)
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Reference
PMID:23806647
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Abbas W, Herbein G
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Plasma membrane signaling in HIV-1 infection.
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Biochim Biophys Acta 1838:1132-42 (2014)
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Reference
PMID:20041213
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Wu Y, Yoder A
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Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
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PLoS Pathog 5:e1000520 (2009)
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Reference
PMID:22085380
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Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).
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J Med Chem 55:977-94 (2012)
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Reference
PMID:21321123
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Vorster PJ, Guo J, Yoder A, Wang W, Zheng Y, Xu X, Yu D, Spear M, Wu Y
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LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection.
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J Biol Chem 286:12554-64 (2011)
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Reference
PMID:15817946
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Das SR, Jameel S
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Biology of the HIV Nef protein.
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Indian J Med Res 121:315-32 (2005)
Reference
PMID:24822052
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Roy N, Pacini G, Berlioz-Torrent C, Janvier K
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Mechanisms underlying HIV-1 Vpu-mediated viral egress.
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Front Microbiol 5:177 (2014)
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Reference
PMID:22090097
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Magadan JG, Bonifacino JS
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Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.
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J Virol 86:757-72 (2012)
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Reference
PMID:26056579
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Kumar A, Herbein G
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The macrophage: a therapeutic target in HIV-1 infection.
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Mol Cell Ther 2:10 (2014)
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Reference
PMID:20672047
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Yokota S, Okabayashi T, Fujii N
  Title
The battle between virus and host: modulation of Toll-like receptor signaling pathways by virus infection.
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Mediators Inflamm 2010:184328 (2010)
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Reference
PMID:26628325
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Sauter D, Kirchhoff F
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HIV replication: a game of hide and sense.
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Curr Opin HIV AIDS 11:173-81 (2016)
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Reference
PMID:25988887
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Altfeld M, Gale M Jr
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Innate immunity against HIV-1 infection.
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Nat Immunol 16:554-62 (2015)
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Reference
PMID:28358311
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Pasquereau S, Kumar A, Herbein G
  Title
Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs.
  Journal
Viruses 9:E64 (2017)
DOI:10.3390/v9040064
Reference
PMID:18178131
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Herbein G, Khan KA
  Title
Is HIV infection a TNF receptor signalling-driven disease?
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Trends Immunol 29:61-7 (2008)
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Reference
PMID:24453421
  Authors
Kumar A, Abbas W, Herbein G
  Title
TNF and TNF receptor superfamily members in HIV infection: new cellular targets for therapy?
  Journal
Mediators Inflamm 2013:484378 (2013)
DOI:10.1155/2013/484378
Reference
PMID:23986795
  Authors
Abbas W, Herbein G
  Title
T-Cell Signaling in HIV-1 Infection.
  Journal
Open Virol J 7:57-71 (2013)
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Reference
PMID:21368875
  Authors
Cummins NW, Badley AD
  Title
Mechanisms of HIV-associated lymphocyte apoptosis: 2010.
  Journal
Cell Death Dis 1:e99 (2010)
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Reference
PMID:12766761
  Authors
Gougeon ML
  Title
Apoptosis as an HIV strategy to escape immune attack.
  Journal
Nat Rev Immunol 3:392-404 (2003)
DOI:10.1038/nri1087
Reference
PMID:21994747
  Authors
Fevrier M, Dorgham K, Rebollo A
  Title
CD4+ T cell depletion in human immunodeficiency virus (HIV) infection: role of apoptosis.
  Journal
Viruses 3:586-612 (2011)
DOI:10.3390/v3050586
Reference
PMID:11237054
  Authors
Ross TM
  Title
Using death to one's advantage: HIV modulation of apoptosis.
  Journal
Leukemia 15:332-41 (2001)
DOI:10.1038/sj.leu.2402028
Reference
PMID:22767237
  Authors
Hurley JH, Bonifacino JS
  Title
Nef-arious goings-on at the Golgi.
  Journal
Nat Struct Mol Biol 19:661-2 (2012)
DOI:10.1038/nsmb.2304
Reference
PMID:21762823
  Authors
Wonderlich ER, Leonard JA, Collins KL
  Title
HIV immune evasion disruption of antigen presentation by the HIV Nef protein.
  Journal
Adv Virus Res 80:103-27 (2011)
DOI:10.1016/B978-0-12-385987-7.00005-1
Reference
PMID:20594957
  Authors
Laguette N, Bregnard C, Benichou S, Basmaciogullari S
  Title
Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins.
  Journal
Mol Aspects Med 31:418-33 (2010)
DOI:10.1016/j.mam.2010.05.003
Reference
PMID:27161574
  Authors
Pereira EA, daSilva LL
  Title
HIV-1 Nef: Taking Control of Protein Trafficking.
  Journal
Traffic 17:976-96 (2016)
DOI:10.1111/tra.12412
Reference
PMID:26950141
  Authors
Sugden SM, Bego MG, Pham TN, Cohen EA
  Title
Remodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and Persistence.
  Journal
Viruses 8:67 (2016)
DOI:10.3390/v8030067
Reference
PMID:24906315
  Authors
Bagga S, Bouchard MJ
  Title
Cell cycle regulation during viral infection.
  Journal
Methods Mol Biol 1170:165-227 (2014)
DOI:10.1007/978-1-4939-0888-2_10
Reference
PMID:15638722
  Authors
Andersen JL, Planelles V
  Title
The role of Vpr in HIV-1 pathogenesis.
  Journal
Curr HIV Res 3:43-51 (2005)
DOI:10.2174/1570162052772988
Reference
PMID:17140287
  Authors
Andersen JL, DeHart JL, Zimmerman ES, Ardon O, Kim B, Jacquot G, Benichou S, Planelles V
  Title
HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT.
  Journal
PLoS Pathog 2:e127 (2006)
DOI:10.1371/journal.ppat.0020127
Reference
PMID:23430691
  Authors
Takaori-Kondo A, Shindo K
  Title
HIV-1 Vif: a guardian of the virus that opens up a new era in the research field of restriction factors.
  Journal
Front Microbiol 4:34 (2013)
DOI:10.3389/fmicb.2013.00034
Reference
PMID:19038776
  Authors
Malim MH
  Title
APOBEC proteins and intrinsic resistance to HIV-1 infection.
  Journal
Philos Trans R Soc Lond B Biol Sci 364:675-87 (2009)
DOI:10.1098/rstb.2008.0185
Reference
PMID:21835787
  Authors
Hultquist JF, Lengyel JA, Refsland EW, LaRue RS, Lackey L, Brown WL, Harris RS
  Title
Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1.
  Journal
J Virol 85:11220-34 (2011)
DOI:10.1128/JVI.05238-11
Related
pathway
mpuf03050  Proteasome
mpuf04010  MAPK signaling pathway
mpuf04020  Calcium signaling pathway
mpuf04064  NF-kappa B signaling pathway
mpuf04110  Cell cycle
mpuf04141  Protein processing in endoplasmic reticulum
mpuf04142  Lysosome
mpuf04150  mTOR signaling pathway
mpuf04151  PI3K-Akt signaling pathway
mpuf04210  Apoptosis
mpuf04612  Antigen processing and presentation
mpuf04620  Toll-like receptor signaling pathway
mpuf04623  Cytosolic DNA-sensing pathway
mpuf04668  TNF signaling pathway
mpuf04810  Regulation of actin cytoskeleton
KO pathway
ko05170   

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