KEGG   PATHWAY: ocu04360
Entry
ocu04360                    Pathway                                
Name
Axon guidance - Oryctolagus cuniculus (rabbit)
Description
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class
Organismal Systems; Development and regeneration
Pathway map
ocu04360  Axon guidance
ocu04360

Other DBs
GO: 0007411
Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100341879  NTNG1; netrin G1 [KO:K07522]
100358301  NTNG2; netrin G2 [KO:K16359]
100344455  LRRC4C; leucine rich repeat containing 4C [KO:K07523]
100342035  LRRC4; leucine rich repeat containing 4 [KO:K16351]
100340273  NTN1; netrin 1 [KO:K06843]
100347202  NTN3; netrin 3 [KO:K06844]
100356958  NTN4; netrin 4 [KO:K06845]
100344825  DCC; DCC netrin 1 receptor [KO:K06765]
100349958  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
100340139  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
100009352  TRPC1; transient receptor potential cation channel subfamily C member 1 [KO:K04964]
100343668  TRPC3; transient receptor potential cation channel subfamily C member 3 [KO:K04966]
100353818  TRPC4; transient receptor potential cation channel subfamily C member 4 [KO:K04967]
100009574  TRPC5; transient receptor potential cation channel subfamily C member 5 [KO:K04968]
100347206  TRPC6; transient receptor potential cation channel subfamily C member 6 [KO:K04969]
100356245  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
100009423  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
100009487  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
100344533  PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
100353824  NFATC2; nuclear factor of activated T-cells 2 [KO:K17332]
100008859  NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]
100347003  NFATC4; nuclear factor of activated T-cells 4 [KO:K17334]
100347455  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
100339741  FYN; FYN proto-oncogene, Src family tyrosine kinase [KO:K05703] [EC:2.7.10.2]
100341599  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
100339873  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
100356520  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
100008965  CDC42; cell division cycle 42 [KO:K04393]
100339712  ABLIM3; actin binding LIM protein family member 3 [KO:K07520]
100338590  ABLIM1; actin binding LIM protein 1 [KO:K07520]
103347329  actin-binding LIM protein 2 [KO:K07520]
100358703  NCK1; NCK adaptor protein 1 [KO:K07365]
100352056  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
100009535  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
100347273  PAK3; p21 (RAC1) activated kinase 3 [KO:K05733] [EC:2.7.11.1]
100341934  PAK4; p21 (RAC1) activated kinase 4 [KO:K05734] [EC:2.7.11.1]
100340742  PAK5; p21 (RAC1) activated kinase 5 [KO:K05736] [EC:2.7.11.1]
100348921  PAK6; p21 (RAC1) activated kinase 6 [KO:K05735] [EC:2.7.11.1]
100356250  transforming protein RhoA-like [KO:K04513]
100348967  transforming protein RhoA-like [KO:K04513]
100340661  RHOA; ras homolog family member A [KO:K04513]
100346856  transforming protein RhoA-like [KO:K04513]
100009220  ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100346837  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
100351024  UNC5C; unc-5 netrin receptor C [KO:K07521]
100338427  UNC5B; unc-5 netrin receptor B [KO:K07521]
100340738  UNC5A; unc-5 netrin receptor A [KO:K07521]
100339802  UNC5D; unc-5 netrin receptor D [KO:K07521]
100339517  PTPN11; protein tyrosine phosphatase, non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
100341130  RGMA; repulsive guidance molecule family member a [KO:K23096]
100346504  NEO1; neogenin 1 [KO:K06766]
100343384  MYL9; myosin light chain 9 [KO:K12755]
100345591  myosin regulatory light chain 12B [KO:K12757]
100346112  myosin regulatory light polypeptide 9 [KO:K12757]
100340118  ARHGEF12; Rho guanine nucleotide exchange factor 12 [KO:K07532]
100347832  LRIG2; leucine rich repeats and immunoglobulin like domains 2 [KO:K24609]
100358004  EFNA5; ephrin A5 [KO:K05462]
100344921  EFNA1; ephrin A1 [KO:K05462]
100358959  EFNA3; ephrin A3 [KO:K05462]
103350046  EFNA4; ephrin A4 [KO:K05462]
100357479  EFNB2; ephrin B2 [KO:K05463]
100352864  EFNB3; ephrin B3 [KO:K05463]
100338775  EFNB1; ephrin B1 [KO:K05463]
100338483  EPHA1; EPH receptor A1 [KO:K05102] [EC:2.7.10.1]
100343518  EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
100344496  EPHA3; EPH receptor A3 [KO:K05104] [EC:2.7.10.1]
100357064  EPHA4; EPH receptor A4 [KO:K05105] [EC:2.7.10.1]
100345523  EPHA5; EPH receptor A5 [KO:K05106] [EC:2.7.10.1]
100357849  EPHA6; EPH receptor A6 [KO:K05107] [EC:2.7.10.1]
100344577  EPHA7; EPH receptor A7 [KO:K05108] [EC:2.7.10.1]
100338073  EPHA8; EPH receptor A8 [KO:K05109] [EC:2.7.10.1]
100348083  EPHB1; EPH receptor B1 [KO:K05110] [EC:2.7.10.1]
100359223  EPHB2; EPH receptor B2 [KO:K05111] [EC:2.7.10.1]
100347330  EPHB3; EPH receptor B3 [KO:K05112] [EC:2.7.10.1]
100359286  EPHB4; EPH receptor B4 [KO:K05113] [EC:2.7.10.1]
100340354  EPHB6; EPH receptor B6 [KO:K05114] [EC:2.7.10.1]
100345909  ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase [KO:K06619] [EC:2.7.10.2]
100351936  ENAH; enabled homolog (Drosophila) [KO:K05746]
100343398  RASA1; RAS p21 protein activator 1 [KO:K04352]
103352487  NGEF; neuronal guanine nucleotide exchange factor [KO:K07525]
100347487  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
100344241  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
100347345  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100348561  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100353755  NCK2; NCK adaptor protein 2 [KO:K19862]
100356658  RGS3; regulator of G-protein signaling 3 [KO:K07524]
103345545  CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031]
100346189  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
100338391  GNAI1; G protein subunit alpha i1 [KO:K04630]
100359147  GNAI3; G protein subunit alpha i3 [KO:K04630]
100339066  GNAI2; G protein subunit alpha i2 [KO:K04630]
100350940  SLIT1; slit guidance ligand 1 [KO:K06838]
100348211  SLIT2; slit guidance ligand 2 [KO:K06839]
100338309  SLIT3; slit guidance ligand 3 [KO:K06850]
100344245  ROBO1; roundabout guidance receptor 1 [KO:K06753]
100345257  ROBO2; roundabout guidance receptor 2 [KO:K06754]
100342258  ROBO3; roundabout guidance receptor 3 [KO:K06755]
103352092  SLIT-ROBO Rho GTPase-activating protein 3 [KO:K07526]
103345512  SLIT-ROBO Rho GTPase-activating protein 3 [KO:K07526]
100345703  SRGAP2; SLIT-ROBO Rho GTPase activating protein 2 [KO:K07526]
100357985  SRGAP1; SLIT-ROBO Rho GTPase activating protein 1 [KO:K07526]
100356972  SEMA3D; semaphorin 3D [KO:K06840]
100357227  SEMA3A; semaphorin 3A [KO:K06840]
100340404  SEMA3E; semaphorin 3E [KO:K06840]
100359287  SEMA3C; semaphorin 3C [KO:K06840]
100346280  SEMA3G; semaphorin 3G [KO:K06840]
100338816  SEMA3F; semaphorin 3F [KO:K06840]
100339559  SEMA3B; semaphorin 3B [KO:K06840]
100343414  PLXNA2; plexin A2 [KO:K06820]
100328763  PLXNA3; plexin A3 [KO:K06820]
100358783  PLXNA1; plexin A1 [KO:K06820]
100346790  PLXNA4; plexin A4 [KO:K06820]
100345279  NRP1; neuropilin 1 [KO:K06724]
100328746  L1CAM; L1 cell adhesion molecule [KO:K06550]
100344018  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
100356835  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
100359205  cofilin-2 [KO:K05765]
100341589  CFL1; cofilin 1 [KO:K05765]
108178303  CFL2; cofilin 2 [KO:K05765]
103352139  RHOD; ras homolog family member D [KO:K07530]
100342531  RND1; Rho family GTPase 1 [KO:K07531]
100338780  FES; FES proto-oncogene, tyrosine kinase [KO:K07527] [EC:2.7.10.2]
100353506  DPYSL5; dihydropyrimidinase like 5 [KO:K07529]
100351135  DPYSL2; dihydropyrimidinase like 2 [KO:K07528]
100352775  CDK5; cyclin dependent kinase 5 [KO:K02090] [EC:2.7.11.22]
100348842  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
100346924  SEMA4B; semaphorin 4B [KO:K06521]
100342051  SEMA4A; semaphorin 4A [KO:K06521]
100345573  SEMA4C; semaphorin 4C [KO:K06521]
100347884  SEMA4F; ssemaphorin 4F [KO:K06521]
100348771  SEMA4G; semaphorin 4G [KO:K06521]
100346590  SEMA4D; semaphorin 4D [KO:K06521]
100340755  SEMA5A; semaphorin 5A [KO:K06841]
100354300  SEMA5B; semaphorin 5B [KO:K06841]
100353114  SEMA6D; semaphorin 6D [KO:K06842]
100328662  SEMA6C; semaphorin 6C [KO:K06842]
100355525  SEMA6A; semaphorin 6A [KO:K06842]
100355992  PLXNB3; plexin B3 [KO:K06821]
103346036  PLXNB2; plexin B2 [KO:K06821]
100342042  PLXNB1; plexin B1 [KO:K06821]
100126565  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
100347407  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
103346352  SEMA7A; semaphorin 7A (John Milton Hagen blood group) [KO:K06529]
100346617  PLXNC1; plexin C1 [KO:K06572]
100008898  ITGB1; integrin subunit beta 1 [KO:K05719]
100352774  SHH; sonic hedgehog [KO:K11988]
100345046  PTCH1; patched 1 [KO:K06225]
100352661  SMO; smoothened, frizzled class receptor [KO:K06226]
100037720  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
100355759  ILK; integrin linked kinase [KO:K06272] [EC:2.7.11.1]
100347510  BOC; BOC cell adhesion associated, oncogene regulated [KO:K20020]
100009381  WNT5A; Wnt family member 5A [KO:K00444]
100349579  WNT5B; Wnt family member 5B [KO:K00444]
100339544  FZD3; frizzled class receptor 3 [KO:K02329]
100008628  RYK; receptor-like tyrosine kinase [KO:K05128] [EC:2.7.10.1]
100342451  CAMK2B; calcium/calmodulin dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
100341507  CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
100101557  CAMK2D; calcium/calmodulin dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
100101556  CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
100303773  WNT4; Wnt family member 4 [KO:K00408]
100348663  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
100345181  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
100337822  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
100357841  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
100345250  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100347954  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
100345030  PARD3; par-3 family cell polarity regulator [KO:K04237]
100009538  PRKCZ; protein kinase C zeta [KO:K18952] [EC:2.7.11.13]
103347148  protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
100353321  PARD6B; par-6 family cell polarity regulator beta [KO:K06093]
100350899  PARD6A; par-6 family cell polarity regulator alpha [KO:K06093]
100349557  PARD6G; par-6 family cell polarity regulator gamma [KO:K06093]
100356755  SSH1; slingshot protein phosphatase 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100341119  SSH2; slingshot protein phosphatase 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100353500  SSH3; slingshot protein phosphatase 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103347033  bone morphogenetic protein 7 [KO:K16621]
100339215  GDF7; growth differentiation factor 7 [KO:K20013]
100350246  BMPR2; bone morphogenetic protein receptor type 2 [KO:K04671] [EC:2.7.11.30]
100351275  BMPR1B; bone morphogenetic protein receptor type 1B [KO:K13578] [EC:2.7.11.30]
Compound
C00076  Calcium cation
Reference
  Authors
Guan KL, Rao Y.
  Title
Signalling mechanisms mediating neuronal responses to guidance cues.
  Journal
Nat Rev Neurosci 4:941-56 (2003)
DOI:10.1038/nrn1254
Reference
  Authors
Govek EE, Newey SE, Van Aelst L.
  Title
The role of the Rho GTPases in neuronal development.
  Journal
Genes Dev 19:1-49 (2005)
DOI:10.1101/gad.1256405
Reference
  Authors
Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
  Title
Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
  Journal
Annu Rev Neurosci 26:509-63 (2003)
DOI:10.1146/annurev.neuro.26.010302.081139
Reference
  Authors
Negishi M, Oinuma I, Katoh H.
  Title
Plexins: axon guidance and signal transduction.
  Journal
Cell Mol Life Sci 62:1363-71 (2005)
DOI:10.1007/s00018-005-5018-2
Reference
  Authors
Huot J.
  Title
Ephrin signaling in axon guidance.
  Journal
Prog Neuropsychopharmacol Biol Psychiatry 28:813-8 (2004)
DOI:10.1016/j.pnpbp.2004.05.025
Reference
  Authors
Patel BN, Van Vactor DL.
  Title
Axon guidance: the cytoplasmic tail.
  Journal
Curr Opin Cell Biol 14:221-9 (2002)
DOI:10.1016/S0955-0674(02)00308-3
Reference
  Authors
Yu TW, Bargmann CI.
  Title
Dynamic regulation of axon guidance.
  Journal
Nat Neurosci 4 Suppl:1169-76 (2001)
DOI:10.1038/nn748
Reference
  Authors
Dickson BJ.
  Title
Molecular mechanisms of axon guidance.
  Journal
Science 298:1959-64 (2002)
DOI:10.1126/science.1072165
Reference
  Authors
Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
  Title
The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
  Journal
Brain Res Brain Res Rev 49:22-47 (2005)
DOI:10.1016/j.brainresrev.2004.11.003
Reference
  Authors
Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
  Title
The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
  Journal
Cell 117:157-69 (2004)
DOI:10.1016/S0092-8674(04)00303-4
Reference
  Authors
Fujita Y, Yamashita T
  Title
Axon growth inhibition by RhoA/ROCK in the central nervous system.
  Journal
Front Neurosci 8:338 (2014)
DOI:10.3389/fnins.2014.00338
Reference
  Authors
Yamashita T, Mueller BK, Hata K
  Title
Neogenin and repulsive guidance molecule signaling in the central nervous system.
  Journal
Curr Opin Neurobiol 17:29-34 (2007)
DOI:10.1016/j.conb.2006.12.001
Reference
  Authors
van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
  Title
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
  Journal
Dev Cell 35:537-552 (2015)
DOI:10.1016/j.devcel.2015.11.008
Related
pathway
ocu04010  MAPK signaling pathway
ocu04060  Cytokine-cytokine receptor interaction
ocu04310  Wnt signaling pathway
ocu04810  Regulation of actin cytoskeleton
KO pathway
ko04360   
LinkDB

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