KEGG   PATHWAY: opi05161
Entry
opi05161                    Pathway                                
Name
Hepatitis B - Ochotona princeps (American pika)
Description
Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and converted into a covalently closed circular molecule cccDNA. The cccDNA is the template for transcription of all viral RNAs including the pregenomic RNA (pgRNA), encoding for 7 viral proteins: large, middle, and small envelope proteins (LHBs, MHBs, and SHBs) that form the surface antigen (HBsAg), the core antigen (HBcAg), the e antigen (HBeAg), the HBV polymerase, and the regulatory protein X (HBx). The pgRNA interacts with the viral polymerase protein to initiate the encapsidation into the core particles. Through endoplasmic reticulum, the core particles finish assembling with the envelope proteins and are released. HBV infection leads to a wide spectrum of liver diseases raging from chronic hepatitis, cirrhosis to hepatocellular carcinoma. The mechanism of liver injury is still not clear. However, HBV proteins target host proteins, involved in a variety of functions, thus regulating transcription, cellular signaling cascades, proliferation, differentiation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
opi05161  Hepatitis B
opi05161

Disease
H00412  Hepatitis B
Organism
Ochotona princeps (American pika) [GN:opi]
Gene
101516195  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
101516372  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
101516556  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
101517015  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101517070  SRC; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
101517073  [KO:K04498] [EC:2.3.1.48]
101517311  APAF1; LOW QUALITY PROTEIN: apoptotic protease-activating factor 1 [KO:K02084]
101517343  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
101517365  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
101517543  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101517612  RB1; retinoblastoma-associated protein [KO:K06618]
101517703  BAX; apoptosis regulator BAX [KO:K02159]
101517735  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101517788  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
101517982  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101518245  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
101518298  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101518442  DDB1; DNA damage-binding protein 1 [KO:K10610]
101518695  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
101518802  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
101518825  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101518842  [KO:K11224]
101518851  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101519014  [KO:K08738]
101519021  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101519172  IRF7; interferon regulatory factor 7 [KO:K09447]
101519331  [KO:K11223]
101519449  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101519504  YWHAQ; 14-3-3 protein theta [KO:K16197]
101519619  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
101519679  SLC10A1; sodium/bile acid cotransporter [KO:K14341]
101519949  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
101520034  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
101520873  CASP10; caspase-10 [KO:K04400] [EC:3.4.22.63]
101520975  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
101521104  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
101521165  EGR3; early growth response protein 3 isoform X1 [KO:K12497]
101521567  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101521668  FADD; FAS-associated death domain protein [KO:K02373]
101521685  JUN; transcription factor AP-1 [KO:K04448]
101521762  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
101522167  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:3.6.4.13]
101522285  MYC; myc proto-oncogene protein [KO:K04377]
101522332  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
101522364  [KO:K06626]
101522490  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101522542  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
101522714  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101522803  DDX3X; ATP-dependent RNA helicase DDX3X isoform X1 [KO:K11594] [EC:3.6.4.13]
101523417  YWHAZ; 14-3-3 protein zeta/delta isoform X1 [KO:K16197]
101523439  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101523446  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
101523491  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
101523549  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101523730  TLR2; toll-like receptor 2 [KO:K10159]
101524248  MYD88; myeloid differentiation primary response protein MyD88 isoform X2 [KO:K04729]
101524339  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101524465  NRAS; GTPase NRas [KO:K07828]
101524571  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101524697  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101524783  DDX58; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:3.6.4.13]
101524825  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
101524844  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101525102  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
101525120  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101525349  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101525427  [KO:K04371] [EC:2.7.11.24]
101525476  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101525561  TNF; tumor necrosis factor isoform X2 [KO:K03156]
101525575  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
101525684  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101525801  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101525829  NFATC2; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
101526067  FOS; proto-oncogene c-Fos isoform X1 [KO:K04379]
101526073  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
101526116  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101526188  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
101526211  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
101526499  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101526617  [KO:K08738]
101526626  [KO:K04802]
101526854  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
101526929  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
101527090  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
101527226  [KO:K08738]
101527767  CCNA1; cyclin-A1 [KO:K06627]
101527799  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
101527867  TLR3; toll-like receptor 3 [KO:K05401]
101527969  DDB2; DNA damage-binding protein 2 [KO:K10140]
101528030  [KO:K02649]
101528202  [KO:K03662]
101528266  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101528287  STAT3; signal transducer and activator of transcription 3 isoform X2 [KO:K04692]
101528346  TP53; cellular tumor antigen p53 [KO:K04451]
101528728  E2F2; transcription factor E2F2 [KO:K09389]
101528748  IRF3; interferon regulatory factor 3 [KO:K05411]
101528866  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
101528938  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
101529407  STAT4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
101529486  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101529588  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
101529862  E2F1; transcription factor E2F1 [KO:K17454]
101529871  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101529904  [KO:K13375]
101530066  RELA; transcription factor p65 [KO:K04735]
101530204  BID; LOW QUALITY PROTEIN: BH3-interacting domain death agonist [KO:K04726]
101530235  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
101530378  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101530701  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101531037  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101531289  CCNA2; cyclin-A2 isoform X1 [KO:K06627]
101531329  IL6; interleukin-6 precursor [KO:K05405]
101531453  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101531611  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
101531636  HRAS; GTPase HRas [KO:K02833]
101531640  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101531761  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
101531884  EGR2; E3 SUMO-protein ligase EGR2 isoform X2 [KO:K12496]
101532354  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101532574  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101532689  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101532843  [KO:K05414]
101532921  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101532937  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
101532983  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
101533024  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101533081  [KO:K05414]
101533160  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
101533296  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101533318  IFNB1; interferon beta [KO:K05415]
101533371  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
101533379  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
101533612  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101533668  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
101533713  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101533851  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
101534080  KRAS; GTPase KRas isoform X1 [KO:K07827]
101534290  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101534340  BAD; bcl2-associated agonist of cell death [KO:K02158]
101534608  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
101534610  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101534827  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101534968  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
101535293  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101535341  [KO:K05409]
101535726  CXCL8; interleukin-8 [KO:K10030]
101535976  IKBKG; NF-kappa-B essential modulator [KO:K07210]
101536073  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101536117  E2F3; transcription factor E2F3 [KO:K06620]
101536244  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
101536280  [KO:K05403]
101536420  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101536535  TLR4; toll-like receptor 4 [KO:K10160]
101536651  [KO:K04802]
101536685  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
105941493  [KO:K08738]
105941968  [KO:K08738]
105942099  [KO:K04369] [EC:2.7.12.2]
Compound
C00076  Calcium cation
Reference
PMID:30059722
  Authors
Caballero A, Tabernero D, Buti M, Rodriguez-Frias F
  Title
Hepatitis B virus: The challenge of an ancient virus with multiple faces and a remarkable replication strategy.
  Journal
Antiviral Res 158:34-44 (2018)
DOI:10.1016/j.antiviral.2018.07.019
Reference
PMID:22869468
  Authors
Walsh R, Locarnini S
  Title
Hepatitis B precore protein: pathogenic potential and therapeutic promise.
  Journal
Yonsei Med J 53:875-85 (2012)
DOI:10.3349/ymj.2012.53.5.875
Reference
PMID:26239691
  Authors
Liang TJ, Block TM, McMahon BJ, Ghany MG, Urban S, Guo JT, Locarnini S, Zoulim F, Chang KM, Lok AS
  Title
Present and future therapies of hepatitis B: From discovery to cure.
  Journal
Hepatology 62:1893-908 (2015)
DOI:10.1002/hep.28025
Reference
PMID:26776362
  Authors
Morikawa K, Suda G, Sakamoto N
  Title
Viral life cycle of hepatitis B virus: Host factors and druggable targets.
  Journal
Hepatol Res 46:871-7 (2016)
DOI:10.1111/hepr.12650
Reference
PMID:19201080
  Authors
Feitelson MA, Reis HM, Tufan NL, Sun B, Pan J, Lian Z
  Title
Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease.
  Journal
Cancer Lett 286:69-79 (2009)
DOI:10.1016/j.canlet.2008.12.010
Reference
PMID:19263472
  Authors
Murata M, Matsuzaki K, Yoshida K, Sekimoto G, Tahashi Y, Mori S, Uemura Y, Sakaida N, Fujisawa J, Seki T, Kobayashi K, Yokote K, Koike K, Okazaki K
  Title
Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-beta signaling from tumor suppression to oncogenesis in early chronic hepatitis B.
  Journal
Hepatology 49:1203-17 (2009)
DOI:10.1002/hep.22765
Reference
PMID:15173177
  Authors
Yoo YG, Lee MO
  Title
Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.
  Journal
J Biol Chem 279:36242-9 (2004)
DOI:10.1074/jbc.M401290200
Reference
PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
  Journal
J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:19854353
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
PMID:21994562
  Authors
Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
  Journal
Viruses 1:630-46 (2009)
DOI:10.3390/v1030630
Reference
PMID:11099494
  Authors
Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD
  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
  Journal
J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:16891440
  Authors
Park NH, Song IH, Chung YH
  Title
Chronic hepatitis B in hepatocarcinogenesis.
  Journal
Postgrad Med J 82:507-15 (2006)
DOI:10.1136/pgmj.2006.047431
Reference
PMID:28820498
  Authors
Lin S, Zhang YJ
  Title
Interference of Apoptosis by Hepatitis B Virus.
  Journal
Viruses 9:230 (2017)
DOI:10.3390/v9080230
Reference
PMID:16173017
  Authors
Zhang X, Dong N, Yin L, Cai N, Ma H, You J, Zhang H, Wang H, He R, Ye L
  Title
Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues.
  Journal
J Med Virol 77:374-81 (2005)
DOI:10.1002/jmv.20466
Reference
PMID:18481805
  Authors
Kim HJ, Kim SY, Kim J, Lee H, Choi M, Kim JK, Ahn JK
  Title
Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria.
  Journal
IUBMB Life 60:473-80 (2008)
DOI:10.1002/iub.68
Reference
PMID:21647825
  Authors
Ng SA, Lee C
  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
  Journal
J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9
Reference
PMID:9195957
  Authors
Cong YS, Yao YL, Yang WM, Kuzhandaivelu N, Seto E
  Title
The hepatitis B virus X-associated protein, XAP3, is a protein kinase C-binding protein.
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J Biol Chem 272:16482-9 (1997)
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Reference
PMID:12686421
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Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:9738022
  Authors
Lee YH, Yun Y
  Title
HBx protein of hepatitis B virus activates Jak1-STAT signaling.
  Journal
J Biol Chem 273:25510-5 (1998)
DOI:10.1074/jbc.273.39.25510
Reference
PMID:18251977
  Authors
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  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
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Reference
PMID:17059849
  Authors
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  Title
Cytobiological consequences of calcium-signaling alterations induced by human viral proteins.
  Journal
Biochim Biophys Acta 1763:1344-62 (2006)
DOI:10.1016/j.bbamcr.2006.09.025
Reference
PMID:11743185
  Authors
Ganem D
  Title
Virology. The X files--one step closer to closure.
  Journal
Science 294:2299-300 (2001)
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Reference
PMID:15132991
  Authors
Chung TW, Lee YC, Kim CH
  Title
Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential.
  Journal
FASEB J 18:1123-5 (2004)
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Reference
PMID:18605975
  Authors
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  Title
Human oncogenic viruses: hepatitis B and hepatitis C viruses and their role in hepatocarcinogenesis.
  Journal
Biochemistry (Mosc) 73:504-13 (2008)
DOI:10.1134/S0006297908050039
Reference
PMID:21994545
  Authors
Schadler S, Hildt E
  Title
HBV life cycle: entry and morphogenesis.
  Journal
Viruses 1:185-209 (2009)
DOI:10.3390/v1020185
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:28704708
  Authors
Nosratabadi R, Alavian SM, Zare-Bidaki M, Shahrokhi VM, Arababadi MK
  Title
Innate immunity related pathogen recognition receptors and chronic hepatitis B infection.
  Journal
Mol Immunol 90:64-73 (2017)
DOI:10.1016/j.molimm.2017.07.002
Reference
PMID:24530748
  Authors
Bagheri V, Askari A, Arababadi MK, Kennedy D
  Title
Can Toll-Like Receptor (TLR) 2 be considered as a new target for immunotherapy against hepatitis B infection?
  Journal
Hum Immunol 75:549-54 (2014)
DOI:10.1016/j.humimm.2014.02.018
Reference
PMID:25550115
  Authors
Zhang E, Lu M
  Title
Toll-like receptor (TLR)-mediated innate immune responses in the control of hepatitis B virus (HBV) infection.
  Journal
Med Microbiol Immunol 204:11-20 (2015)
DOI:10.1007/s00430-014-0370-1
Reference
PMID:20375222
  Authors
Yu S, Chen J, Wu M, Chen H, Kato N, Yuan Z
  Title
Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3.
  Journal
J Gen Virol 91:2080-90 (2010)
DOI:10.1099/vir.0.020552-0
Reference
PMID:23363957
  Authors
Revill P, Yuan Z
  Title
New insights into how HBV manipulates the innate immune response to establish acute and persistent infection.
  Journal
Antivir Ther 18:1-15 (2013)
DOI:10.3851/IMP2542
Reference
PMID:28893934
  Authors
Hopcraft SE, Damania B
  Title
Tumour viruses and innate immunity.
  Journal
Philos Trans R Soc Lond B Biol Sci 372:20160267 (2017)
DOI:10.1098/rstb.2016.0267
Reference
PMID:22504921
  Authors
Dandri M, Locarnini S
  Title
New insight in the pathobiology of hepatitis B virus infection.
  Journal
Gut 61 Suppl 1:i6-17 (2012)
DOI:10.1136/gutjnl-2012-302056
Related
pathway
opi04010  MAPK signaling pathway
opi04064  NF-kappa B signaling pathway
opi04110  Cell cycle
opi04115  p53 signaling pathway
opi04151  PI3K-Akt signaling pathway
opi04210  Apoptosis
opi04620  Toll-like receptor signaling pathway
opi04622  RIG-I-like receptor signaling pathway
opi04630  JAK-STAT signaling pathway
KO pathway
ko05161   

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