KEGG   PATHWAY: lww05163
Entry
lww05163                    Pathway                                
Name
Human cytomegalovirus infection - Leptonychotes weddellii (Weddell seal)
Description
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
Class
Human Diseases; Infectious disease: viral
Pathway map
lww05163  Human cytomegalovirus infection
lww05163

Organism
Leptonychotes weddellii (Weddell seal) [GN:lww]
Gene
102746830  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
102743753  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4 [KO:K00922] [EC:2.7.1.153]
102749194  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102738988  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102751021  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102726443  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102728383  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
102747309  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102749871  AKT1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
102734291  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102740017  TSC1; hamartin isoform X1 [KO:K07206]
102736702  TSC2; tuberin [KO:K07207]
102739066  RHEB; GTP-binding protein Rheb [KO:K07208]
102739884  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
102729820  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
102729360  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
102729021  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
102728853  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102750184  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
102742694  IKBKG; NF-kappa-B essential modulator [KO:K07210]
102732435  nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
102739707  RELA; transcription factor p65 [KO:K04735]
102743972  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102745822  SOS1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
102741455  son of sevenless homolog 2 [KO:K03099]
115936553  GTPase HRas-like [KO:K02833]
102735541  HRAS; GTPase HRas [KO:K02833]
102727145  KRAS; GTPase KRas [KO:K07827]
102746431  NRAS; GTPase NRas [KO:K07828]
102726914  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102750302  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102745982  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102727849  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102730012  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102734763  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
102750952  SP1; transcription factor Sp1 [KO:K04684]
102735999  ITGAV; integrin alpha-V [KO:K06487]
102740981  ITGB3; integrin beta-3 [KO:K06493]
102734775  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
102733229  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
102731700  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
102746808  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
102739474  transforming protein RhoA-like [KO:K04513]
102738654  LOW QUALITY PROTEIN: transforming protein RhoA-like [KO:K04513]
102733539  CGAS; cyclic GMP-AMP synthase isoform X1 [KO:K17834] [EC:2.7.7.86]
102733154  STING1; stimulator of interferon genes protein isoform X1 [KO:K12654]
102749350  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
102732139  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
102748540  LOW QUALITY PROTEIN: interferon alpha-14 [KO:K05414]
102747471  interferon alpha-1/2-like [KO:K05414]
102747757  interferon alpha-1/2-like [KO:K05414]
102750324  interferon alpha-2-like [KO:K05414]
102727550  interferon alpha-1/2-like [KO:K05414]
102749740  LOW QUALITY PROTEIN: interferon alpha-2-like [KO:K05414]
102748842  IFNB1; interferon beta [KO:K05415]
102743506  TNF; tumor necrosis factor [KO:K03156]
102739000  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102727515  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
102750365  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
102740611  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
102736169  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
102738552  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
102739919  IL1B; interleukin-1 beta [KO:K04519]
102741586  IL1R1; LOW QUALITY PROTEIN: interleukin-1 receptor type 1 [KO:K04386]
102725682  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
102740920  CCL5; C-C motif chemokine 5 [KO:K12499]
102737756  CXCL8; interleukin-8 [KO:K10030]
102745902  IL6; interleukin-6 isoform X1 [KO:K05405]
102733062  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
102745475  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
102740677  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
102732783  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
102733448  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
102725604  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
102725746  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
102744808  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
102747228  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
102748197  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102732481  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102735164  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102749236  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
102731100  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
102729125  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
102742669  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
102748147  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
102736718  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102739395  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X2 [KO:K04547]
102743177  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
102735798  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X2 [KO:K04549]
102731450  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
102732710  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
102739019  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
102736489  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
102750198  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
102751213  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
102739407  inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
102735685  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
102745629  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102730620  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
102738071  calmodulin-like [KO:K02183]
102736921  calmodulin-like [KO:K02183]
102731712  CALM3; calmodulin-3 [KO:K02183]
102738351  calmodulin-like [KO:K02183]
102736922  calmodulin-like [KO:K02183]
102738889  CALM2; calmodulin-2 [KO:K02183]
102732458  CALML6; calmodulin-like protein 6 [KO:K02183]
102735924  CALM1; calmodulin-1 [KO:K02183]
102726280  CALML5; calmodulin-like protein 5 [KO:K02183]
102750042  calmodulin-like protein 3 [KO:K02183]
102726108  calmodulin-like [KO:K02183]
102739246  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
102743467  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
102747867  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102732630  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
102749914  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102730825  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102748078  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
102726761  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
102750373  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
102726697  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
102749575  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
102737331  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
102739347  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
102741598  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
102729355  adenylate cyclase type 4-like isoform X1 [KO:K08044] [EC:4.6.1.1]
102750941  adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
102734024  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
102732736  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
102733005  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
102728665  adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
102735449  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
102729236  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102735431  C-C motif chemokine 3 [KO:K05408]
102725792  CCL4; C-C motif chemokine 4 [KO:K12964]
102747754  fractalkine-like [KO:K05508]
102735043  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
102751138  guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
102742664  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X4 [KO:K12330]
102738217  ARHGEF11; rho guanine nucleotide exchange factor 11 [KO:K12331]
102744485  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X3 [KO:K07532]
102737632  A-kinase anchor protein 13-like [KO:K16529]
102734862  ROCK1; rho-associated protein kinase 1 isoform X3 [KO:K04514] [EC:2.7.11.1]
102747780  rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
102750710  catenin beta-1 [KO:K02105]
102734368  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
102741125  prostaglandin E2 receptor EP3 subtype [KO:K04260]
102731769  PTGER4; prostaglandin E2 receptor EP4 subtype isoform X1 [KO:K04261]
102743109  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
102742813  neuroendocrine secretory protein 55 [KO:K04632]
102742516  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
102747216  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102739954  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
102746903  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
102736730  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
102748936  signal transducer and activator of transcription 3 [KO:K04692]
102740057  vascular endothelial growth factor A isoform X1 [KO:K05448]
102743800  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X2 [KO:K04433] [EC:2.7.12.2]
102746987  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
115942902  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102738377  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102725695  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102748542  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102746508  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
102744591  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102735888  cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
102744352  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
102743115  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
102750583  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
102746287  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X2 [KO:K09048]
102746490  cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
102749610  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
102747594  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102732903  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102741890  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102736119  protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
102734509  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
102726881  breast cancer anti-estrogen resistance protein 1-like isoform X1 [KO:K05726]
102741313  CRKL; crk-like protein [KO:K04438]
102728775  PXN; paxillin isoform X1 [KO:K05760]
102738815  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
102734341  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
102733354  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
102742656  CCR1; C-C chemokine receptor type 1 [KO:K04176]
102742365  CCR3; C-C chemokine receptor type 3 [KO:K04178]
102744296  CCR5; C-C chemokine receptor type 5 [KO:K04180]
102749278  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
102733853  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
102730147  TAPBP; tapasin [KO:K08058]
102733223  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
102740350  CALR; calreticulin [KO:K08057]
102749162  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
102735909  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
102746195  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
102730025  HLA class I histocompatibility antigen, A-24 alpha chain-like [KO:K06751]
102736667  patr class I histocompatibility antigen, A-2 alpha chain [KO:K06751]
102728163  B2M; beta-2-microglobulin [KO:K08055]
102727854  cyclin-dependent kinase inhibitor 2A isoform X3 [KO:K06621]
102730468  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
102726420  TP53; cellular tumor antigen p53 [KO:K04451]
102737261  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
102746891  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
102737670  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
102737296  RB1; retinoblastoma-associated protein [KO:K06618]
102743808  E2F1; transcription factor E2F1 [KO:K17454]
102749663  E2F2; transcription factor E2F2 [KO:K09389]
102736623  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
102745146  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
102738718  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
102737084  FADD; FAS-associated death domain protein [KO:K02373]
102733039  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
115943885  BH3-interacting domain death agonist-like [KO:K04726]
102729504  apoptosis regulator BAX-like isoform X1 [KO:K02159]
102731986  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
102725978  cytochrome c 2-like [KO:K08738]
102750923  cytochrome c [KO:K08738]
102726669  cytochrome c [KO:K08738]
102725545  caspase-9-like [KO:K04399] [EC:3.4.22.62]
102735000  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00584  Prostaglandin E2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:19107226
  Authors
Michaelis M, Doerr HW, Cinatl J
  Title
The story of human cytomegalovirus and cancer: increasing evidence and open questions.
  Journal
Neoplasia 11:1-9 (2009)
DOI:10.1593/neo.81178
Reference
PMID:24839861
  Authors
Roy S, Arav-Boger R
  Title
New cell-signaling pathways for controlling cytomegalovirus replication.
  Journal
Am J Transplant 14:1249-58 (2014)
DOI:10.1111/ajt.12725
Reference
PMID:14720582
  Authors
Cinatl J, Scholz M, Kotchetkov R, Vogel JU, Doerr HW
  Title
Molecular mechanisms of the modulatory effects of HCMV infection in tumor cell biology.
  Journal
Trends Mol Med 10:19-23 (2004)
DOI:10.1016/j.molmed.2003.11.002
Reference
PMID:15380778
  Authors
Evers DL, Wang X, Huang ES
  Title
Cellular stress and signal transduction responses to human cytomegalovirus infection.
  Journal
Microbes Infect 6:1084-93 (2004)
DOI:10.1016/j.micinf.2004.05.026
Reference
PMID:29547547
  Authors
Murray MJ, Peters NE, Reeves MB
  Title
Navigating the Host Cell Response during Entry into Sites of Latent Cytomegalovirus Infection.
  Journal
Pathogens 7:E30 (2018)
DOI:10.3390/pathogens7010030
Reference
PMID:27501260
  Authors
Campadelli-Fiume G, Collins-McMillen D, Gianni T, Yurochko AD
  Title
Integrins as Herpesvirus Receptors and Mediators of the Host Signalosome.
  Journal
Annu Rev Virol 3:215-236 (2016)
DOI:10.1146/annurev-virology-110615-035618
Reference
PMID:28132838
  Authors
Fu YZ, Su S, Gao YQ, Wang PP, Huang ZF, Hu MM, Luo WW, Li S, Luo MH, Wang YY, Shu HB
  Title
Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity.
  Journal
Cell Host Microbe 21:231-243 (2017)
DOI:10.1016/j.chom.2017.01.001
Reference
PMID:29082387
  Authors
Hancock MH, Nelson JA
  Title
Modulation of the NFkappab Signalling Pathway by Human Cytomegalovirus.
  Journal
Virology (Hyderabad) 1:104 (2017)
Reference
PMID:21383764
  Authors
Rahman MM, McFadden G
  Title
Modulation of NF-kappaB signalling by microbial pathogens.
  Journal
Nat Rev Microbiol 9:291-306 (2011)
DOI:10.1038/nrmicro2539
Reference
PMID:27060663
  Authors
Zhang J, Feng H, Xu S, Feng P
  Title
Hijacking GPCRs by viral pathogens and tumor.
  Journal
Biochem Pharmacol 114:69-81 (2016)
DOI:10.1016/j.bcp.2016.03.021
Reference
PMID:28035083
  Authors
Lee S, Chung YH, Lee C
  Title
US28, a Virally-Encoded GPCR as an Antiviral Target for Human Cytomegalovirus Infection.
  Journal
Biomol Ther (Seoul) 25:69-79 (2017)
DOI:10.4062/biomolther.2016.208
Reference
PMID:23145028
  Authors
Langemeijer EV, Slinger E, de Munnik S, Schreiber A, Maussang D, Vischer H, Verkaar F, Leurs R, Siderius M, Smit MJ
  Title
Constitutive beta-catenin signaling by the viral chemokine receptor US28.
  Journal
PLoS One 7:e48935 (2012)
DOI:10.1371/journal.pone.0048935
Reference
PMID:15990176
  Authors
Couty JP, Gershengorn MC
  Title
G-protein-coupled receptors encoded by human herpesviruses.
  Journal
Trends Pharmacol Sci 26:405-11 (2005)
DOI:10.1016/j.tips.2005.06.004
Reference
PMID:25549333
  Authors
Fiallos E, Judkins J, Matlaf L, Prichard M, Dittmer D, Cobbs C, Soroceanu L
  Title
Human cytomegalovirus gene expression in long-term infected glioma stem cells.
  Journal
PLoS One 9:e116178 (2014)
DOI:10.1371/journal.pone.0116178
Reference
PMID:24445563
  Authors
Vischer HF, Siderius M, Leurs R, Smit MJ
  Title
Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
  Journal
Nat Rev Drug Discov 13:123-39 (2014)
DOI:10.1038/nrd4189
Reference
PMID:20398729
  Authors
Slinger E, Langemeijer E, Siderius M, Vischer HF, Smit MJ
  Title
Herpesvirus-encoded GPCRs rewire cellular signaling.
  Journal
Mol Cell Endocrinol 331:179-84 (2011)
DOI:10.1016/j.mce.2010.04.007
Reference
PMID:11175803
  Authors
Murphy PM
  Title
Viral exploitation and subversion of the immune system through chemokine mimicry.
  Journal
Nat Immunol 2:116-22 (2001)
DOI:10.1038/84214
Reference
PMID:16352349
  Authors
Vischer HF, Leurs R, Smit MJ
  Title
HCMV-encoded G-protein-coupled receptors as constitutively active modulators of cellular signaling networks.
  Journal
Trends Pharmacol Sci 27:56-63 (2006)
DOI:10.1016/j.tips.2005.11.006
Reference
PMID:25805993
  Authors
de Munnik SM, Smit MJ, Leurs R, Vischer HF
  Title
Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors.
  Journal
Front Pharmacol 6:40 (2015)
DOI:10.3389/fphar.2015.00040
Reference
PMID:15172446
  Authors
Michelson S
  Title
Consequences of human cytomegalovirus mimicry.
  Journal
Hum Immunol 65:465-75 (2004)
DOI:10.1016/j.humimm.2004.02.002
Reference
PMID:29237840
  Authors
Tu CC, Arnolds KL, O'Connor CM, Spencer JV
  Title
Human Cytomegalovirus UL111A and US27 Gene Products Enhance the CXCL12/CXCR4 Signaling Axis via Distinct Mechanisms.
  Journal
J Virol 92:e01981-17 (2018)
DOI:10.1128/JVI.01981-17
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:22454101
  Authors
Noriega V, Redmann V, Gardner T, Tortorella D
  Title
Diverse immune evasion strategies by human cytomegalovirus.
  Journal
Immunol Res 54:140-51 (2012)
DOI:10.1007/s12026-012-8304-8
Reference
PMID:17145306
  Authors
Loureiro J, Ploegh HL
  Title
Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions.
  Journal
Adv Immunol 92:225-305 (2006)
DOI:10.1016/S0065-2776(06)92006-9
Reference
PMID:10707064
  Authors
Fortunato EA, McElroy AK, Sanchez I, Spector DH
  Title
Exploitation of cellular signaling and regulatory pathways by human cytomegalovirus.
  Journal
Trends Microbiol 8:111-9 (2000)
DOI:10.1016/S0966-842X(00)01699-1
Reference
PMID:15389728
  Authors
Cinatl J Jr, Scholz M, Doerr HW
  Title
Role of tumor cell immune escape mechanisms in cytomegalovirus-mediated oncomodulation.
  Journal
Med Res Rev 25:167-85 (2005)
DOI:10.1002/med.20018
Reference
PMID:14975530
  Authors
Cinatl J Jr, Vogel JU, Kotchetkov R, Wilhelm Doerr H
  Title
Oncomodulatory signals by regulatory proteins encoded by human cytomegalovirus: a novel role for viral infection in tumor progression.
  Journal
FEMS Microbiol Rev 28:59-77 (2004)
DOI:10.1016/j.femsre.2003.07.005
Reference
PMID:12062798
  Authors
Castillo JP, Kowalik TF
  Title
Human cytomegalovirus immediate early proteins and cell growth control.
  Journal
Gene 290:19-34 (2002)
DOI:10.1016/S0378-1119(02)00566-8
Reference
PMID:15352160
  Authors
Kalejta RF
  Title
Human cytomegalovirus pp71: a new viral tool to probe the mechanisms of cell cycle progression and oncogenesis controlled by the retinoblastoma family of tumor suppressors.
  Journal
J Cell Biochem 93:37-45 (2004)
DOI:10.1002/jcb.20177
Reference
PMID:20969904
  Authors
Brune W
  Title
Inhibition of programmed cell death by cytomegaloviruses.
  Journal
Virus Res 157:144-50 (2011)
DOI:10.1016/j.virusres.2010.10.012
Reference
PMID:28869497
  Authors
Brune W, Andoniou CE
  Title
Die Another Day: Inhibition of Cell Death Pathways by Cytomegalovirus.
  Journal
Viruses 9:E249 (2017)
DOI:10.3390/v9090249
Reference
PMID:27160907
  Authors
Yamin R, Lecker LSM, Weisblum Y, Vitenshtein A, Le-Trilling VTK, Wolf DG, Mandelboim O
  Title
HCMV vCXCL1 Binds Several Chemokine Receptors and Preferentially Attracts Neutrophils over NK Cells by Interacting with CXCR2.
  Journal
Cell Rep 15:1542-1553 (2016)
DOI:10.1016/j.celrep.2016.04.042
Reference
PMID:28488292
  Authors
Wang X, Sanchez J, Stone MJ, Payne RJ
  Title
Sulfation of the Human Cytomegalovirus Protein UL22A Enhances Binding to the Chemokine RANTES.
  Journal
Angew Chem Int Ed Engl 56:8490-8494 (2017)
DOI:10.1002/anie.201703059
Related
pathway
lww00590  Arachidonic acid metabolism
lww03050  Proteasome
lww04010  MAPK signaling pathway
lww04064  NF-kappa B signaling pathway
lww04110  Cell cycle
lww04150  mTOR signaling pathway
lww04151  PI3K-Akt signaling pathway
lww04210  Apoptosis
lww04612  Antigen processing and presentation
lww04623  Cytosolic DNA-sensing pathway
lww04630  JAK-STAT signaling pathway
lww04668  TNF signaling pathway
lww04810  Regulation of actin cytoskeleton
KO pathway
ko05163   
LinkDB

DBGET integrated database retrieval system