KEGG   PATHWAY: mni04151
Entry
mni04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Macaca nemestrina (pig-tailed macaque)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
mni04151  PI3K-Akt signaling pathway
mni04151

Other DBs
GO: 0043491
Organism
Macaca nemestrina (pig-tailed macaque) [GN:mni]
Gene
105486254  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
105465222  TGFA; protransforming growth factor alpha [KO:K08774]
105477283  EREG; proepiregulin [KO:K09784]
105477282  AREG; amphiregulin isoform X1 [KO:K09782]
105466960  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
105486416  FGF2; fibroblast growth factor 2 [KO:K18497]
105464242  FGF16; fibroblast growth factor 16 [KO:K04358]
105463317  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
105463744  FGF20; fibroblast growth factor 20 [KO:K04358]
105486552  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
105487492  FGF10; fibroblast growth factor 10 [KO:K04358]
105490268  FGF9; fibroblast growth factor 9 [KO:K04358]
105490607  FGF7; fibroblast growth factor 7 [KO:K04358]
105480865  FGF18; fibroblast growth factor 18 [KO:K04358]
105478366  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
105469729  FGF4; fibroblast growth factor 4 [KO:K04358]
105469730  FGF3; fibroblast growth factor 3 [KO:K04358]
105482098  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105484151  FGF6; fibroblast growth factor 6 [KO:K04358]
105469728  FGF19; fibroblast growth factor 19 [KO:K22603]
105478658  FGF21; fibroblast growth factor 21 [KO:K22429]
105484150  FGF23; fibroblast growth factor 23 [KO:K22428]
105479138  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
105463281  BDNF; brain-derived neurotrophic factor isoform X2 [KO:K04355]
105484167  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
105497222  NTF4; neurotrophin-4 [KO:K12457]
105469786  INS; insulin isoform X1 [KO:K04526]
105493817  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
105469784  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
105483431  PDGFA; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
105464425  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
105488621  PDGFC; platelet-derived growth factor C [KO:K05450]
105493695  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
105479257  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
105483765  KITLG; kit ligand isoform X1 [KO:K05461]
105497202  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
105489557  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
105469816  VEGFB; vascular endothelial growth factor B [KO:K16858]
105495787  PGF; placenta growth factor isoform X1 [KO:K16859]
105478154  VEGFD; vascular endothelial growth factor D [KO:K05449]
105466632  VEGFC; vascular endothelial growth factor C [KO:K05449]
105475398  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105475992  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
105464176  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
105496121  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
105486219  EFNA2; ephrin-A2 [KO:K05462]
105497987  EFNA4; ephrin-A4 [KO:K05462]
105497995  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
105497996  EFNA1; ephrin-A1 [KO:K05462]
105471088  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
105473093  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
105484888  NRTN; neurturin [KO:K25414]
105494888  ARTN; artemin [KO:K25415]
105484731  PSPN; persephin [KO:K25416]
105493061  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105472243  ERBB2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105474161  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
105481143  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
105476567  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105469674  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
105483839  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105484062  FGFR4; fibroblast growth factor receptor 4 isoform X5 [KO:K05095] [EC:2.7.10.1]
105472349  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
105498076  NTRK1; high affinity nerve growth factor receptor isoform X2 [KO:K03176] [EC:2.7.10.1]
105498757  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
105487005  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
105479398  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
105463522  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105466873  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
105466874  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
105463525  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
105490198  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
105490192  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
105483981  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
105463529  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
105475620  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
105493864  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
105473227  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
105486614  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
105469160  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105465416  SOS1; son of sevenless homolog 1 [KO:K03099]
105481847  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
105494134  HRAS; GTPase HRas isoform X1 [KO:K02833]
105492133  KRAS; GTPase KRas isoform X1 [KO:K07827]
105479146  NRAS; GTPase NRas [KO:K07828]
105477727  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105488275  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105485357  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
105480656  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105482882  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105473988  IRS1; insulin receptor substrate 1 [KO:K16172]
105463507  TLR2; toll-like receptor 2 [KO:K10159]
105487117  TLR4; toll-like receptor 4 precursor [KO:K10160]
105497946  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105489886  immunoglobulin heavy variable 4-4 [KO:K06856]
105498823  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
105482863  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
105478460  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
105468986  somatotropin isoform X1 [KO:K05438]
105468988  GH1; somatotropin isoform X1 [KO:K05438]
105469367  somatotropin-like [KO:K05438]
105483028  somatotropin-like isoform X1 [KO:K05438]
105483030  LOW QUALITY PROTEIN: somatotropin-like [KO:K05438]
105482522  PRL; prolactin isoform X1 [KO:K05439]
105487244  OSM; oncostatin-M isoform X2 [KO:K05418]
105486135  IL2; interleukin-2 precursor [KO:K05429]
105467189  IL3; interleukin-3 [KO:K04736]
105475680  IL6; interleukin-6 isoform X1 [KO:K05405]
105467168  IL4; interleukin-4 isoform X1 [KO:K05430]
105483548  IL7; interleukin-7 isoform X1 [KO:K05431]
105465888  IFNA21; LOW QUALITY PROTEIN: interferon alpha-21 [KO:K05414]
105498418  interferon alpha-1/13-like [KO:K05414]
105498422  IFNA8; interferon alpha-8 [KO:K05414]
105498424  interferon alpha-6 [KO:K05414]
105498425  interferon alpha-1/13 [KO:K05414]
105498426  interferon alpha-2 [KO:K05414]
105498430  interferon alpha-4 [KO:K05414]
105465886  IFNB1; interferon beta [KO:K05415]
105498043  EPO; erythropoietin isoform X2 [KO:K05437]
105472231  CSF3; granulocyte colony-stimulating factor isoform X2 [KO:K05423]
105487459  GHR; growth hormone receptor isoform X1 [KO:K05080]
105473061  PRLR; prolactin receptor [KO:K05081]
105473105  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
105494366  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
105464497  IL2RB; interleukin-2 receptor subunit beta isoform X2 [KO:K05069]
105476651  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
105497972  IL6R; LOW QUALITY PROTEIN: interleukin-6 receptor subunit alpha [KO:K05055]
105463220  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
105473067  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
105472707  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
105472438  EPOR; erythropoietin receptor [KO:K05079]
105494725  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
105498461  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
105491847  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
105486722  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
105475526  COL1A2; collagen alpha-2(I) chain [KO:K06236]
105472370  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
105470054  COL2A1; collagen alpha-1(II) chain isoform X2 [KO:K19719]
105485298  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
105485301  COL4A1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain [KO:K06237]
105473978  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
105473981  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
105490453  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
105490456  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
105490394  COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
105490396  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
105490397  collagen alpha-4(VI) chain-like isoform X1 [KO:K06238]
105472481  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
105472484  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
105479481  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
105470727  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
105494804  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
105465590  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
105478856  LAMA1; laminin subunit alpha-1 isoform X2 [KO:K05637]
105465071  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
105470533  LAMA5; laminin subunit alpha-5 [KO:K06240]
105499731  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
105475300  LAMB1; laminin subunit beta-1 [KO:K05636]
105480428  LAMB2; laminin subunit beta-2 [KO:K06243]
105484900  LAMB3; laminin subunit beta-3 [KO:K06244]
105475298  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
105484563  LAMC1; laminin subunit gamma-1 isoform X1 [KO:K05635]
105484564  LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246]
105464043  LAMC3; LOW QUALITY PROTEIN: laminin subunit gamma-3 [KO:K06247]
105472380  CHAD; chondroadherin [KO:K06248]
105475346  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
105492481  THBS1; thrombospondin-1 [KO:K16857]
105475080  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
105487598  THBS2; thrombospondin-2 [KO:K04659]
105498006  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
105486691  COMP; cartilage oligomeric matrix protein [KO:K04659]
105481166  FN1; fibronectin isoform X1 [KO:K05717]
105479646  SPP1; osteopontin [KO:K06250]
105476149  VTN; vitronectin [KO:K06251]
105487096  TNC; tenascin isoform X1 [KO:K06252]
105497656  TNXB; tenascin-X isoform X1 [KO:K06252]
105484458  TNN; tenascin-N isoform X1 [KO:K06252]
105484466  TNR; tenascin-R isoform X1 [KO:K06252]
105484247  VWF; LOW QUALITY PROTEIN: von Willebrand factor [KO:K03900]
105479650  IBSP; bone sialoprotein 2 [KO:K06253]
105499359  ITGA1; integrin alpha-1 [KO:K06480]
105499361  ITGA2; integrin alpha-2 [KO:K06481]
105469039  ITGA2B; integrin alpha-IIb [KO:K06476]
105472360  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
105499538  ITGA4; integrin alpha-4 [KO:K06483]
105474221  ITGA5; integrin alpha-5 [KO:K06484]
105483230  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
105474183  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
105488206  ITGA8; integrin alpha-8 [KO:K06584]
105480186  ITGA9; integrin alpha-9 [KO:K06585]
105479040  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
105487976  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
105468297  ITGAV; LOW QUALITY PROTEIN: integrin alpha-V [KO:K06487]
105479922  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
105483061  ITGB3; integrin beta-3 [KO:K06493]
105469171  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
105470255  ITGB5; integrin beta-5 [KO:K06588]
105493177  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
105474288  ITGB7; integrin beta-7 [KO:K06590]
105475918  ITGB8; LOW QUALITY PROTEIN: integrin beta-8 [KO:K06591]
105488506  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105478978  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105489973  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105469947  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105475205  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105488082  PIK3R2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105494953  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105475117  F2R; proteinase-activated receptor 1 [KO:K03914]
105469478  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
105471325  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
105475951  lysophosphatidic acid receptor 1 [KO:K04289]
105481062  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
105492735  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
105482759  LPAR3; lysophosphatidic acid receptor 3 isoform X1 [KO:K04294]
105464349  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
105484191  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
105490693  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
105496719  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
105497010  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
105484206  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
105489969  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
105490201  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105481826  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
105469457  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1 [KO:K04540]
105474606  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
105463427  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
112426886  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
105485776  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
105478587  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
105481072  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
105475520  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
105498434  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
112427422  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
105475518  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
105472342  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
105475319  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
105474167  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
105474202  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
105485792  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X3 [KO:K06276] [EC:2.7.11.1]
105486273  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
105487437  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
105495129  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
105466044  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
105464069  TSC1; LOW QUALITY PROTEIN: hamartin [KO:K07206]
105485816  TSC2; tuberin isoform X13 [KO:K07207]
105474923  RHEB; GTP-binding protein Rheb [KO:K07208]
105485809  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
105473151  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105469284  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
105476575  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
105473911  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
105486387  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
105480946  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
105476846  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
105469679  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
105474393  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
105484230  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4B-like [KO:K03258]
105487991  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
105489172  RPS6; LOW QUALITY PROTEIN: 40S ribosomal protein S6 [KO:K02991]
105469029  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105497360  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
105482800  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
105463990  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
105465645  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
105496377  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
105482178  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
105474669  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105489842  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105495343  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105483536  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
105475378  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
105480917  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105497868  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X2 [KO:K16339] [EC:3.1.2.2]
105467143  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
105481960  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
105497074  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
105493624  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
105466919  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
105482032  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
105470886  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
105483910  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
105477973  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
105478255  PPP2R3B; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
105469910  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
105473681  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
105467393  PPP2R5C; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [KO:K11584]
105489585  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
105469541  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
105493556  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
105466741  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
105467389  heat shock protein HSP 90-alpha [KO:K04079]
105489542  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
105497727  HSP90B1; endoplasmin [KO:K09487]
105475808  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
105497954  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
105477008  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
105491314  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
105467468  TCL1B; T-cell leukemia/lymphoma protein 1B isoform X1 [KO:K16836]
105468352  MTCP1; protein p13 MTCP-1 [KO:K16837]
105474900  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
105472075  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
105470323  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105478667  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
105492101  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
105477850  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
105470606  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
105469320  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
105483371  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
105472085  G6PC; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
105492792  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
105469727  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
105474528  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
105482108  CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X1 [KO:K06624]
105474169  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
105474081  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
105475503  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
105484147  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
105489611  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
105497230  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
105487658  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
105492041  FOXO3; forkhead box protein O3 [KO:K09408]
105494099  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
105484428  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105471817  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
105476048  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
105486509  YWHAQ; 14-3-3 protein theta [KO:K16197]
105496419  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
105498986  LOW QUALITY PROTEIN: 14-3-3 protein beta/alpha [KO:K16197]
105471598  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
105487193  YWHAH; 14-3-3 protein eta [KO:K16198]
105492763  YWHAG; 14-3-3 protein gamma [KO:K16198]
105469512  BAD; bcl2-associated agonist of cell death [KO:K02158]
105496162  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
105477002  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
105473212  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
105468005  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
105483203  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
105464416  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105485736  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
105487183  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
105497957  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
105471318  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
105471659  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X3 [KO:K09048]
105475779  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
105497591  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
105497810  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
105471885  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
105474331  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X2 [KO:K04465]
105471007  LOW QUALITY PROTEIN: NF-kappa-B essential modulator-like [KO:K07210]
105478402  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105476527  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105469585  RELA; transcription factor p65 isoform X1 [KO:K04735]
105486337  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
105465658  MYB; transcriptional activator Myb isoform X3 [KO:K09420]
105473404  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
105473688  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
mni00010  Glycolysis / Gluconeogenesis
mni04010  MAPK signaling pathway
mni04012  ErbB signaling pathway
mni04062  Chemokine signaling pathway
mni04064  NF-kappa B signaling pathway
mni04068  FoxO signaling pathway
mni04110  Cell cycle
mni04115  p53 signaling pathway
mni04150  mTOR signaling pathway
mni04210  Apoptosis
mni04370  VEGF signaling pathway
mni04510  Focal adhesion
mni04620  Toll-like receptor signaling pathway
mni04630  JAK-STAT signaling pathway
mni04662  B cell receptor signaling pathway
mni04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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