KEGG   PATHWAY: pale05163
Entry
pale05163                   Pathway                                
Name
Human cytomegalovirus infection - Pteropus alecto (black flying fox)
Description
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
Class
Human Diseases; Infectious disease: viral
Pathway map
pale05163  Human cytomegalovirus infection
pale05163

Organism
Pteropus alecto (black flying fox) [GN:pale]
Gene
102895362  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
102889227  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102880320  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102889576  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102879163  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102891637  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X3 [KO:K02649]
102879453  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102885144  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102879337  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102898305  AKT2; LOW QUALITY PROTEIN: RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102878835  TSC1; LOW QUALITY PROTEIN: hamartin [KO:K07206]
102898762  TSC2; tuberin isoform X11 [KO:K07207]
102889101  RHEB; GTP-binding protein Rheb [KO:K07208]
102885092  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
102881655  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
102891214  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
102889369  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
102879469  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
102893261  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102880203  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102880692  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102878395  RELA; transcription factor p65 [KO:K04735]
102893495  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102878822  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
102882462  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102889597  SOS2; son of sevenless homolog 2 [KO:K03099]
102896270  HRAS; GTPase HRas isoform X3 [KO:K02833]
102895590  KRAS; GTPase KRas isoform X1 [KO:K07827]
102885950  NRAS; GTPase NRas isoform X2 [KO:K07828]
102893439  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102897122  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102879034  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102895390  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102885749  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102878877  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
102894100  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
102895440  ITGAV; integrin alpha-V [KO:K06487]
102881894  ITGB3; integrin beta-3 [KO:K06493]
102891249  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
102897644  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102885507  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102887421  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
102891515  RHOA; transforming protein RhoA [KO:K04513]
102883365  CGAS; cyclic GMP-AMP synthase isoform X1 [KO:K17834] [EC:2.7.7.86]
102888203  TMEM173; stimulator of interferon genes protein [KO:K12654]
102878859  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
102878862  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
102893886  interferon alpha-1 [KO:K05414]
102890009  interferon alpha-4 [KO:K05414]
102890512  IFNB1; interferon beta [KO:K05415]
102887632  TNF; tumor necrosis factor [KO:K03156]
102885752  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102885162  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
102893401  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
102879730  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
102889343  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
102893238  IL1B; interleukin-1 beta [KO:K04519]
102884439  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
102891056  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
102883786  C-C motif chemokine 2 [KO:K14624]
102878371  CCL5; C-C motif chemokine 5 [KO:K12499]
102892534  CXCL8; interleukin-8 [KO:K10030]
102895746  IL6; interleukin-6 [KO:K05405]
102883771  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
102882744  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
102893506  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
102890410  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
102881664  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
102886028  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
102888735  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
102889599  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
102879439  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102886041  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
112479655  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
107196679  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
102898925  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
102886682  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102877921  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
102892764  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X6 [KO:K04547]
102898674  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
102881686  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
102877919  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
102888619  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
102879238  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
102885207  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
102885781  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
102885953  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
102894982  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
102896356  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
102881783  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102894226  CALM2; calmodulin-2 isoform X1 [KO:K02183]
102897273  CALM3; calmodulin-3 [KO:K02183]
102886058  CALM1; calmodulin-1 [KO:K02183]
102884196  CALML6; calmodulin-like protein 6 [KO:K02183]
102891673  calmodulin-like [KO:K02183]
102893109  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
102881744  calmodulin-like [KO:K02183]
102880029  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102883156  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102898473  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102894471  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102895490  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
102880857  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
102886274  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
102884312  NFATC3; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
102888827  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
102886561  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
102892785  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
102885642  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
102898665  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
102884654  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X2 [KO:K04534]
102887497  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
102893265  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
102886232  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
102890575  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
102897495  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
102890588  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
102881535  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
102896789  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
102885676  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
102886679  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102877853  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102894292  C-C motif chemokine 3 [KO:K05408]
102898804  C-C motif chemokine 3 [KO:K05408]
102898551  C-C motif chemokine 4 [KO:K12964]
102884570  CX3CL1; fractalkine [KO:K05508]
102891706  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
102891607  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
102894194  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
102892639  ARHGEF11; rho guanine nucleotide exchange factor 11 [KO:K12331]
102879072  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
102879297  AKAP13; A-kinase anchor protein 13 isoform X1 [KO:K16529]
102879861  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
102897424  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
102880017  CTNNB1; LOW QUALITY PROTEIN: catenin beta-1 [KO:K02105]
102894012  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
102884861  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
102890353  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
102886026  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
102889764  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas [KO:K04632]
102884106  neuroendocrine secretory protein 55-like [KO:K04632]
102882441  GSK3B; glycogen synthase kinase-3 beta isoform X4 [KO:K03083] [EC:2.7.11.26]
102885330  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102895524  MYC; myc proto-oncogene protein [KO:K04377]
102878027  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
102880365  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
102884374  STAT3; LOW QUALITY PROTEIN: signal transducer and activator of transcription 3 [KO:K04692]
102890394  VEGFA; vascular endothelial growth factor A isoform X2 [KO:K05448]
102888822  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102895900  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102888602  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
102888845  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
102877720  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102888198  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102889014  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
102896553  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102878515  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
102894633  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
102882888  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
102886510  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
102879289  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
102884583  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
102898128  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X3 [KO:K09049]
102881363  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
102888277  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102887078  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102880663  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102888961  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102886432  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
102898998  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
102897097  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X2 [KO:K05726]
102898080  CRKL; crk-like protein [KO:K04438]
102885553  CRK; adapter molecule crk isoform X1 [KO:K04438]
102891920  PXN; paxillin isoform X2 [KO:K05760]
102890810  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
102899031  IL10RB; interleukin-10 receptor subunit beta precursor [KO:K05135]
102890894  C-C chemokine receptor type 1 [KO:K04176]
102891142  CCR3; C-C chemokine receptor type 3 [KO:K04178]
102891616  C-C chemokine receptor type 5 [KO:K04180]
102893312  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
102894050  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
102886138  TAPBP; tapasin isoform X1 [KO:K08058]
102879108  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
102881831  CALR; calreticulin [KO:K08057]
102885874  HLA class I histocompatibility antigen, B-48 alpha chain-like [KO:K06751]
102887544  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X2 [KO:K06751]
102898809  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
102896885  B2M; beta-2-microglobulin [KO:K08055]
102896422  LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 2A [KO:K06621]
102884281  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
102889604  TP53; cellular tumor antigen p53 [KO:K04451]
102894049  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
102894222  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102896272  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
102893019  RB1; retinoblastoma-associated protein [KO:K06618]
102895276  E2F1; transcription factor E2F1 [KO:K17454]
102884459  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
102887239  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
102883204  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102879561  FAS; tumor necrosis factor receptor superfamily member 6 isoform X5 [KO:K04390]
102892511  FADD; FAS-associated death domain protein [KO:K02373]
102878181  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
102887379  BID; BH3-interacting domain death agonist isoform X3 [KO:K04726]
102885135  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
102883540  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
102879159  cytochrome c [KO:K08738]
102893036  cytochrome c, testis-specific-like [KO:K08738]
102878565  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
102897289  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00584  Prostaglandin E2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:19107226
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Michaelis M, Doerr HW, Cinatl J
  Title
The story of human cytomegalovirus and cancer: increasing evidence and open questions.
  Journal
Neoplasia 11:1-9 (2009)
DOI:10.1593/neo.81178
Reference
PMID:24839861
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Roy S, Arav-Boger R
  Title
New cell-signaling pathways for controlling cytomegalovirus replication.
  Journal
Am J Transplant 14:1249-58 (2014)
DOI:10.1111/ajt.12725
Reference
PMID:14720582
  Authors
Cinatl J, Scholz M, Kotchetkov R, Vogel JU, Doerr HW
  Title
Molecular mechanisms of the modulatory effects of HCMV infection in tumor cell biology.
  Journal
Trends Mol Med 10:19-23 (2004)
DOI:10.1016/j.molmed.2003.11.002
Reference
PMID:15380778
  Authors
Evers DL, Wang X, Huang ES
  Title
Cellular stress and signal transduction responses to human cytomegalovirus infection.
  Journal
Microbes Infect 6:1084-93 (2004)
DOI:10.1016/j.micinf.2004.05.026
Reference
PMID:29547547
  Authors
Murray MJ, Peters NE, Reeves MB
  Title
Navigating the Host Cell Response during Entry into Sites of Latent Cytomegalovirus Infection.
  Journal
Pathogens 7:E30 (2018)
DOI:10.3390/pathogens7010030
Reference
PMID:27501260
  Authors
Campadelli-Fiume G, Collins-McMillen D, Gianni T, Yurochko AD
  Title
Integrins as Herpesvirus Receptors and Mediators of the Host Signalosome.
  Journal
Annu Rev Virol 3:215-236 (2016)
DOI:10.1146/annurev-virology-110615-035618
Reference
PMID:28132838
  Authors
Fu YZ, Su S, Gao YQ, Wang PP, Huang ZF, Hu MM, Luo WW, Li S, Luo MH, Wang YY, Shu HB
  Title
Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity.
  Journal
Cell Host Microbe 21:231-243 (2017)
DOI:10.1016/j.chom.2017.01.001
Reference
PMID:29082387
  Authors
Hancock MH, Nelson JA
  Title
Modulation of the NFkappab Signalling Pathway by Human Cytomegalovirus.
  Journal
Virology (Hyderabad) 1:104 (2017)
Reference
PMID:21383764
  Authors
Rahman MM, McFadden G
  Title
Modulation of NF-kappaB signalling by microbial pathogens.
  Journal
Nat Rev Microbiol 9:291-306 (2011)
DOI:10.1038/nrmicro2539
Reference
PMID:27060663
  Authors
Zhang J, Feng H, Xu S, Feng P
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pathway
pale00590  Arachidonic acid metabolism
pale03050  Proteasome
pale04010  MAPK signaling pathway
pale04064  NF-kappa B signaling pathway
pale04110  Cell cycle
pale04150  mTOR signaling pathway
pale04151  PI3K-Akt signaling pathway
pale04210  Apoptosis
pale04612  Antigen processing and presentation
pale04623  Cytosolic DNA-sensing pathway
pale04630  JAK-STAT signaling pathway
pale04668  TNF signaling pathway
pale04810  Regulation of actin cytoskeleton
KO pathway
ko05163   
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