KEGG   PATHWAY: rkg04010
Entry
rkg04010                    Pathway                                
Name
MAPK signaling pathway - Rhinichthys klamathensis goyatoka (western speckled dace)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
rkg04010  MAPK signaling pathway
rkg04010

Other DBs
GO: 0000165
Organism
Rhinichthys klamathensis goyatoka (western speckled dace) [GN:rkg]
Gene
130083588  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b isoform X1 [KO:K04344]
130088409  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
130089818  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a isoform X1 [KO:K04849]
130072307  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
130083495  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
130082146  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
130091634  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
130099997  cacna1eb; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
130094676  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit isoform X1 [KO:K04853]
130081967  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
130088755  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
130094986  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
130077378  cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
130072686  cacna1sa; calcium channel, voltage-dependent, L type, alpha 1S subunit, a [KO:K04857]
130094579  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
130094860  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
130072221  cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a [KO:K04858]
130104010  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a [KO:K04859]
130078206  cacna2d2b; voltage-dependent calcium channel subunit alpha-2/delta-2b [KO:K04859]
130083498  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
130075707  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
130085347  cacna2d4b; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
130072288  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
130075268  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
130090468  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
130073197  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
130070787  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a isoform X1 [KO:K04864]
130101221  cacnb4b; voltage-dependent L-type calcium channel subunit beta-4b isoform X1 [KO:K04865]
130096613  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
130087203  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
130078608  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
130079653  cacng2b; calcium channel, voltage-dependent, gamma subunit 2b [KO:K04867]
130075864  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
130096870  cacng3a; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
130085573  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
130084495  cacng5b; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
130103668  cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
130097367  cacng6a; calcium channel, voltage-dependent, gamma subunit 6a [KO:K04871]
130103671  cacng7b; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
130097377  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a [KO:K04872]
130103641  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
130097368  cacng8a; calcium channel, voltage-dependent, gamma subunit 8a [KO:K04873]
130069143  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
130078098  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
130105831  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
130100399  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
130084493  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
130075873  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
130096866  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
130103639  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
130095021  gna12a; guanine nucleotide-binding protein subunit alpha-12a isoform X1 [KO:K04346]
130094484  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a [KO:K04347]
130081245  gng12b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
130082962  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
130089850  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
130084755  ppp3cb; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
130076858  protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
130095312  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
130092317  calcineurin subunit B type 1-like [KO:K06268]
130087348  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
130088825  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
130072606  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
130075900  rasgrf2a; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
130103869  rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K04350]
130072824  RAS guanyl-releasing protein 2 [KO:K12361]
130095300  rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
130097429  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
130089734  rapgef2b; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
130089535  rapgef2a; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
130105329  nf1b; neurofibromin [KO:K08052]
130105815  nf1a; neurofibromin [KO:K08052]
130069510  rasa1a; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
130073783  rasa2; ras GTPase-activating protein 2 [KO:K08053]
130078547  rap1ab; ras-related protein rap1ab [KO:K04353]
130071760  rap1aa; RAP1A, member of RAS oncogene family a isoform X1 [KO:K04353]
130072225  rap1b; ras-related protein Rap-1b [KO:K07836]
130095158  egf; pro-epidermal growth factor [KO:K04357]
130087482  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
130073612  fgf1b; fibroblast growth factor 1b [KO:K18496]
130084717  fgf1a; putative fibroblast growth factor 1 [KO:K18496]
130075364  fgf2; fibroblast growth factor 2 [KO:K18497]
130072795  fgf8a; fibroblast growth factor 8 [KO:K04358]
130082937  fgf18b; fibroblast growth factor 18b [KO:K04358]
130102292  fgf10a; fibroblast growth factor 10a [KO:K04358]
130084725  fgf24; fibroblast growth factor 24 isoform X1 [KO:K04358]
130085014  fgf5; fibroblast growth factor 5 [KO:K04358]
130085292  fgf6a; fibroblast growth factor 6a [KO:K04358]
130076782  fgf16; fibroblast growth factor 16 [KO:K04358]
130103984  fgf7; fibroblast growth factor 7 [KO:K04358]
130076874  fgf9; fibroblast growth factor 4A isoform X1 [KO:K04358]
130069584  fgf6b; fibroblast growth factor 6b [KO:K04358]
130078456  fgf18a; fibroblast growth factor 18a isoform X1 [KO:K04358]
130087868  fgf8b; fibroblast growth factor 8b [KO:K04358]
130088169  fgf10b; fibroblast growth factor 10b [KO:K04358]
130097280  fgf3; fibroblast growth factor 3 [KO:K04358]
130097282  fgf4; fibroblast growth factor 4 [KO:K04358]
130071426  fgf20b; fibroblast growth factor 20b [KO:K04358]
130081801  fgf17; fibroblast growth factor 17 [KO:K04358]
130089214  fgf22; fibroblast growth factor 22 [KO:K04358]
130089453  fgf20a; fibroblast growth factor 20a [KO:K04358]
130097283  fgf19; fibroblast growth factor 19 [KO:K22603]
130078613  fgf21; fibroblast growth factor 21 [KO:K22429]
130069552  fgf23; fibroblast growth factor 23 [KO:K22428]
130084368  ngfa; neurotrophin-7 [KO:K02582]
130103999  ngfb; nerve growth factor [KO:K02582]
130083010  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
130079956  ntf3; neurotrophin-3 [KO:K04356]
130072624  ins; insulin [KO:K04526]
130075603  insb; preproinsulin b [KO:K04526]
130088398  insulin [KO:K04526]
130072306  igf1; insulin-like growth factor I [KO:K05459]
130077039  igf2a; insulin-like growth factor 2a isoform X1 [KO:K13769]
130086013  igf2b; insulin-like growth factor 2b [KO:K13769]
130101075  pdgfbb; platelet-derived growth factor subunit B [KO:K04359]
130103468  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
130069207  pdgfab; platelet-derived growth factor alpha polypeptide b isoform X1 [KO:K04359]
130103429  si:ch211-79m20.1; adenylate cyclase, terminal-differentiation specific isoform X1 [KO:K17386]
130072480  pdgfd; platelet-derived growth factor D [KO:K05450]
130095149  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
130103579  csf1a; macrophage colony-stimulating factor 1a [KO:K05453]
130085319  kitlga; kit ligand a [KO:K05461]
130079933  kitlgb; kit ligand b [KO:K05461]
130090765  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
130069583  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
130070087  pgfa; placenta growth factor [KO:K16859]
130080186  pgfb; placenta growth factor [KO:K16859]
130085550  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
130105684  vegfc; vascular endothelial growth factor C [KO:K05449]
130094859  hepatocyte growth factor [KO:K05460]
130072301  hgfa; hepatocyte growth factor a [KO:K05460]
130076007  angpt1; angiopoietin-1 isoform X1 [KO:K05465]
130077459  angiopoietin-1-like [KO:K05465]
130089972  angpt2b; angiopoietin-2b [KO:K05466]
130084165  angpt2a; angiopoietin-2a isoform X1 [KO:K05466]
130072942  efna5b; ephrin-A5b isoform X1 [KO:K05462]
130101892  efna1b; ephrin-A1b [KO:K05462]
130101895  efna3b; ephrin-A3b [KO:K05462]
130101896  si:dkey-246i14.3; ephrin-A4 [KO:K05462]
130102398  efna1a; ephrin-A1a [KO:K05462]
130102399  efna3a; ephrin-A3 [KO:K05462]
130076043  efna2a; ephrin-A2 [KO:K05462]
130077719  efna5a; ephrin-A5b [KO:K05462]
130086598  ephrin-A2-like [KO:K05462]
130094890  gdnfa; glial cell line-derived neurotrophic factor [KO:K05452]
130088195  gdnfb; glial cell line-derived neurotrophic factor [KO:K05452]
130100898  nrtn; neurturin [KO:K25414]
130105616  uncharacterized protein LOC130105616 [KO:K25414]
130100593  neurturin [KO:K25415]
130103472  artemin [KO:K25416]
130084114  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
130097444  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
130097620  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
130080463  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
130101320  erbb3a; receptor tyrosine-protein kinase erbB-3a isoform X1 [KO:K05084] [EC:2.7.10.1]
130102117  erbb3b; receptor tyrosine-protein kinase erbB-3b [KO:K05084] [EC:2.7.10.1]
130091027  erbb4a; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
130091028  si:ch73-383l1.1; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
130096639  erbb4b; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
130077891  fgfr1b; fibroblast growth factor receptor 1b isoform X1 [KO:K04362] [EC:2.7.10.1]
130082101  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
130085075  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
130102901  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
130095534  fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
130075252  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
130070184  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
130080475  ngfrb; nerve growth factor receptor b isoform X1 [KO:K02583]
130077673  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
130099688  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b [KO:K04360] [EC:2.7.10.1]
130082074  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a [KO:K04360] [EC:2.7.10.1]
130105744  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
130071496  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
130091356  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
130088147  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
130097535  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
130086544  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
130086545  csf1ra; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
130096847  csf1rb; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
130097536  kita; mast/stem cell growth factor receptor kita isoform X1 [KO:K05091] [EC:2.7.10.1]
130089509  kitb; KIT proto-oncogene, receptor tyrosine kinase b [KO:K05091] [EC:2.7.10.1]
130083881  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
130083883  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
130069646  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
130102845  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
130097532  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
130085331  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
130076952  tek; tyrosine-protein kinase receptor Tie-2 [KO:K05121] [EC:2.7.10.1]
130102108  epha2b; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
130089099  epha2a; ephrin type-A receptor 2a [KO:K05103] [EC:2.7.10.1]
130089631  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
130075992  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
130081221  grb2a; growth factor receptor-bound protein 2a isoform X1 [KO:K04364]
130077699  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
130088251  sos2; son of sevenless homolog 2 [KO:K03099]
130091247  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
130086014  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
130075255  zgc:55558; GTPase KRas [KO:K07827]
130086042  kras; GTPase KRas isoform X1 [KO:K07827]
130091702  nras; GTPase NRas [KO:K07828]
130102615  rras2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
130088488  rras; ras-related protein R-Ras [KO:K07830]
130101066  mrasb; ras-related protein M-Ras [KO:K07831]
130089912  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
130100901  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
130094731  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
130087752  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
130089196  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
130102926  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
130090659  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
130088093  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
130086181  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
130086618  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
130079406  mknk2a; MAP kinase-interacting serine/threonine-protein kinase 2a [KO:K04372] [EC:2.7.11.1]
130083924  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
130084204  rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
130069874  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
130070697  rps6kal; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
130071246  rps6ka3a; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
130070296  atf4b; activating transcription factor 4b [KO:K04374]
130079665  atf4a; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
130099560  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
130101734  mycb; transcriptional regulator Myc-B [KO:K04377]
130087718  myca; transcriptional regulator Myc-A isoform X1 [KO:K04377]
130090381  srfb; serum response factor b [KO:K04378]
130093141  srfa; serum response factor a isoform X1 [KO:K04378]
130103126  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
130103127  si:ch211-153j24.3; protein c-Fos isoform X1 [KO:K04379]
130076711  fosaa; protein c-Fos [KO:K04379]
130070268  maptb; microtubule-associated protein tau isoform X1 [KO:K04380]
130080577  mapta; microtubule-associated protein tau isoform X1 [KO:K04380]
130073478  stmn1b; stathmin 1b [KO:K04381]
130102974  pla2g4ab; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
130070612  pla2g4f.1; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
130070613  pla2g4f.2; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
130079412  pla2g4aa; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
130088372  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
130087928  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
130094933  il1b; interleukin-1 beta [KO:K04519]
130104467  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
130096464  tgfb1b; transforming growth factor beta-1 proprotein [KO:K13375]
130084737  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
130096578  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
130077528  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
130070484  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
130076012  zmp:0000000936; interleukin-1 receptor type 1 [KO:K04386]
130077657  interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
130103408  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
130070912  tgfbr1a; TGF-beta receptor type-1a [KO:K04674] [EC:2.7.11.30]
130075527  tgfbr2a; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
130096628  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
130089558  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
130096107  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
130097413  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
130084982  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
130084983  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
130084984  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
130105874  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
130080498  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
130077386  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
130075850  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
130080630  rac3b; ras-related C3 botulinum toxin substrate 3b isoform X1 [KO:K07861]
130090848  cdc42l; cell division cycle 42, like [KO:K04393]
130101525  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
130078661  casp3b; caspase-3b [KO:K02187] [EC:3.4.22.56]
130089485  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
130089827  traf2a; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
130088204  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
130102376  daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
130083832  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
130099539  irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
130086517  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
130077123  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
130100849  gadd45ba; growth arrest and DNA-damage-inducible, beta a [KO:K04402]
130094482  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
130081244  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
130071526  gadd45bb; growth arrest and DNA-damage-inducible, beta b [KO:K04402]
130072450  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
130077856  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
130091384  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
130083599  map4k3a; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
130097477  map4k3b; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
130085470  si:zfos-2326c3.2; misshapen-like kinase 1 isoform X1 [KO:K04407] [EC:2.7.11.1]
130100435  pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
130073563  pak2b; serine/threonine-protein kinase PAK 2b isoform X1 [KO:K04410] [EC:2.7.11.1]
130071518  pak2a; serine/threonine-protein kinase PAK 2a [KO:K04410] [EC:2.7.11.1]
130069798  stk3; serine/threonine-protein kinase 3 [KO:K04412]
130091377  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
130095489  map4k6; mitogen-activated protein kinase kinase kinase kinase 6 isoform X1 [KO:K04414] [EC:2.7.11.1]
130088671  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
130069364  map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
130071061  mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
130101312  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
130072813  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
130083830  map3k22; mitogen-activated protein kinase kinase kinase 22 isoform X1 [KO:K04421] [EC:2.7.11.25]
130088268  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
130089155  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
130089693  map3k21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
130105389  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
130101304  protein kinase Npk [KO:K04424] [EC:2.7.11.25]
130078030  map3k20a; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
130090011  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
130104362  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
130091778  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
130088279  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
130101646  taok3b; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
130075218  taok2a; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
130076026  taok3a; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
130095383  taok1b; serine/threonine-protein kinase TAO1-B [KO:K04429] [EC:2.7.11.1]
130096804  taok1a; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
130080596  taok2b; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
130096659  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
130084929  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
130080158  map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
130085227  mapk8ip1a; C-Jun-amino-terminal kinase-interacting protein 1a [KO:K04434]
130082293  mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
130085428  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
130075207  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
130079656  flna; filamin-A [KO:K04437]
130102251  crkl; crk-like protein [KO:K04438]
130096780  crk; adapter molecule crk [KO:K04438]
130082899  arrb2a; arrestin, beta 2a isoform X1 [KO:K04439]
130102672  arrb2b; arrestin, beta 2b [KO:K04439]
130095945  arrb1; beta-arrestin-1 [KO:K04439]
130090761  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
130095375  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
130071353  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
130084652  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
130091708  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
130094634  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
130094797  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
130069579  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
130069580  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
130071804  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
130069091  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
130081812  mapkapk2b; MAP kinase-activated protein kinase 2b isoform X1 [KO:K04443] [EC:2.7.11.1]
130083547  mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
130080243  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
130082497  rps6ka4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
130083059  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
130085127  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
130080387  nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
130099657  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
130096106  jun; transcription factor AP-1 [KO:K04448]
130076949  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
130075338  jund; transcription factor jun-D [KO:K04449]
130076855  cellular tumor antigen p53-like [KO:K04451]
130071217  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
130072469  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
130075906  max; protein max isoform X1 [KO:K04453]
130069467  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
130076204  hspb1; heat shock protein beta-1 [KO:K04455]
130073024  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
130085687  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
130086533  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
130078309  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
130069312  ppm1aa; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
130095744  ppm1na; protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) [KO:K04457] [EC:3.1.3.16]
130096458  ppm1nb; protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) [KO:K04457] [EC:3.1.3.16]
130097554  ppm1ab; protein phosphatase, Mg2+/Mn2+ dependent, 1Ab [KO:K04457] [EC:3.1.3.16]
130092484  ptprr; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K04458] [EC:3.1.3.48]
130103613  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
130102854  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
130073803  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
130102268  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
130075333  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
130103467  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
130086023  dusp8a; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
130081885  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
130085315  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
130096153  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
130088748  dusp3a; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
130104459  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
130073029  ppm1ba; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
130088696  ppm1bb; protein phosphatase 1bb isoform X1 [KO:K04461] [EC:3.1.3.16]
130090651  heat shock 70 kDa protein [KO:K03283]
130090652  hsp70.3; heat shock cognate 70-kd protein, tandem duplicate 3 [KO:K03283]
130075539  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
130094614  hspa1b; heat shock 70 kDa protein-like [KO:K03283]
130077922  mecom; MDS1 and EVI1 complex locus protein EVI1-A isoform X1 [KO:K04462] [EC:2.1.1.367]
130099607  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
130080592  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
130075534  nr4a1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
130084161  uncharacterized protein LOC130084161 isoform X1 [KO:K04466] [EC:2.7.11.25]
130076070  map3k14a; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
130089640  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
130081706  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
130075220  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
130104575  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
130095637  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
130089719  nfkb2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
130071070  rela; transcription factor p65 [KO:K04735]
130077805  relb; transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
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Reference
PMID:23085193
  Authors
Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
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Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
rkg04070  Phosphatidylinositol signaling system
rkg04110  Cell cycle
rkg04115  p53 signaling pathway
rkg04210  Apoptosis
rkg04310  Wnt signaling pathway
KO pathway
ko04010   
LinkDB

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