KEGG   PATHWAY: tdw04010
Entry
tdw04010                    Pathway                                
Name
MAPK signaling pathway - Triplophysa dalaica
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
tdw04010  MAPK signaling pathway
tdw04010

Other DBs
GO: 0000165
Organism
Triplophysa dalaica [GN:tdw]
Gene
130426178  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
130410129  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b isoform X1 [KO:K04344]
130408099  cacna1bb; probable voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
130418819  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a isoform X1 [KO:K04849]
130420342  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
130439975  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
130410399  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
130439922  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
130417284  cacna1eb; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
130407254  cacna1fa; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
130440415  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
130438622  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
130425686  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
130426285  cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
130430334  cacna1sa; calcium channel, voltage-dependent, L type, alpha 1S subunit, a [KO:K04857]
130440240  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
130420600  cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a [KO:K04858]
130435603  voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
130430101  cacna2d2b; voltage-dependent calcium channel subunit alpha-2/delta-2b [KO:K04859]
130424337  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
130407095  cacna2d3a; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
130410662  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
130420343  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
130413756  cacna2d4b; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
130426347  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
130416456  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
130408762  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a isoform X1 [KO:K04864]
130409686  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
130424532  cacnb4b; voltage-dependent L-type calcium channel subunit beta-4b isoform X1 [KO:K04865]
130427441  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
130425098  cacng1a; calcium channel, voltage-dependent, gamma subunit 1a [KO:K04866]
130425689  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
130424221  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
130426302  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
130426901  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
130410062  cacng3a; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
130427007  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
130426351  cacng5b; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
130433513  cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
130416097  cacng6a; calcium channel, voltage-dependent, gamma subunit 6a isoform X1 [KO:K04871]
130415497  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a [KO:K04872]
130433505  cacng7b; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
130415496  cacng8a; calcium channel, voltage-dependent, gamma subunit 8a [KO:K04873]
130433497  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
130413532  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
130425532  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a [KO:K04345] [EC:2.7.11.11]
130417496  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
130410614  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
130426945  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
130439103  prkcba; protein kinase C, beta a [KO:K19662] [EC:2.7.11.13]
130425692  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
130433482  prkcg; LOW QUALITY PROTEIN: protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
130425677  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
130418347  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a [KO:K04347]
130412145  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
130437608  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
130407491  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
130426938  protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
130418789  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
130412879  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
130431560  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
130435492  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
130411588  rasgrf2a; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
130435720  rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K04350]
130407549  rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
130436652  rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
130436675  rapgef2a; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
130437668  rapgef2b; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
130411480  nf1b; neurofibromin isoform X1 [KO:K08052]
130429298  nf1a; neurofibromin isoform X1 [KO:K08052]
130435664  rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
130410783  rap1ab; ras-related protein rap1ab [KO:K04353]
130439797  rap1aa; RAP1A, member of RAS oncogene family a [KO:K04353]
130420368  rap1b; ras-related protein Rap-1b [KO:K07836]
130438198  egf; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
130425354  tgfa; protransforming growth factor alpha [KO:K08774]
130438074  fgf1a; putative fibroblast growth factor 1 [KO:K18496]
130407475  fibroblast growth factor 1-like isoform X1 [KO:K18496]
130407476  fgf1b; fibroblast growth factor 1b isoform X1 [KO:K18496]
130437687  fgf2; fibroblast growth factor 2 [KO:K18497]
130419728  fgf10b; fibroblast growth factor 10b [KO:K04358]
130436037  fgf7; fibroblast growth factor 7 [KO:K04358]
130420047  fgf5; fibroblast growth factor 5 [KO:K04358]
130412182  fgf18b; fibroblast growth factor 18b isoform X1 [KO:K04358]
130420323  fgf6b; fibroblast growth factor 6b [KO:K04358]
130429652  fgf22; fibroblast growth factor 22 [KO:K04358]
130421293  fgf3; fibroblast growth factor 3 [KO:K04358]
130421300  fgf4; fibroblast growth factor 4 [KO:K04358]
130431157  fgf8a; fibroblast growth factor 8 [KO:K04358]
130437914  fgf18a; fibroblast growth factor 18a isoform X1 [KO:K04358]
130437915  fgf24; fibroblast growth factor 24 [KO:K04358]
130413893  fgf6a; fibroblast growth factor 6a [KO:K04358]
130438199  fgf20b; fibroblast growth factor 20b [KO:K04358]
130438223  fibroblast growth factor 16 [KO:K04358]
130438232  fibroblast growth factor 16 [KO:K04358]
130438738  fgf8b; fibroblast growth factor 8b [KO:K04358]
130407996  fgf10a; fibroblast growth factor 10a [KO:K04358]
130417163  fibroblast growth factor 7-like [KO:K04358]
130440201  fgf17; fibroblast growth factor 17 [KO:K04358]
130408872  fgf20a; fibroblast growth factor 20a [KO:K04358]
130427547  fgf9; fibroblast growth factor 4B [KO:K04358]
130423207  fgf19; fibroblast growth factor 19 [KO:K22603]
130426306  fgf21; fibroblast growth factor 21 [KO:K22429]
130421182  fgf23; fibroblast growth factor 23 [KO:K22428]
130425183  ngfb; nerve growth factor [KO:K02582]
130409467  ngfa; neurotrophin-7 [KO:K02582]
130429666  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
130420313  ntf3; neurotrophin-3 [KO:K04356]
130426124  insulin [KO:K04526]
130419090  ins; insulin [KO:K04526]
130420580  igf1; LOW QUALITY PROTEIN: insulin-like growth factor I [KO:K05459]
130414291  igf2b; insulin-like growth factor 2b [KO:K13769]
130427880  igf2a; insulin-like growth factor 2a [KO:K13769]
130429407  pdgfaa; platelet-derived growth factor alpha polypeptide a isoform X1 [KO:K04359]
130425514  pdgfbb; uncharacterized protein pdgfbb [KO:K04359]
130426907  pdgfab; platelet-derived growth factor alpha polypeptide b isoform X1 [KO:K04359]
130429327  si:ch211-79m20.1; putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007 [KO:K17386]
130429169  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
130437562  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
130410434  csf1a; macrophage colony-stimulating factor 1a [KO:K05453]
130420564  kitlgb; kit ligand b [KO:K05461]
130414549  kitlga; kit ligand a [KO:K05461]
130420482  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
130433128  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
130436883  pgfb; snake venom vascular endothelial growth factor toxin ICPP [KO:K16859]
130434802  pgfa; placenta growth factor isoform X1 [KO:K16859]
130408328  vegfc; vascular endothelial growth factor C [KO:K05449]
130410585  vegfd; vascular endothelial growth factor D [KO:K05449]
130435850  hepatocyte growth factor [KO:K05460]
130420926  hgfa; hepatocyte growth factor a [KO:K05460]
130415848  angpt1; angiopoietin-1 [KO:K05465]
130432083  angpt2a; angiopoietin-2a [KO:K05466]
130407267  efna5b; ephrin-A5b isoform X1 [KO:K05462]
130415255  efna3a; ephrin-A3 isoform X1 [KO:K05462]
130432334  efna3b; ephrin-A3b [KO:K05462]
130407857  efna5a; ephrin-A5b isoform X1 [KO:K05462]
130415294  efna2a; ephrin-A2 isoform X1 [KO:K05462]
130415827  efna1a; ephrin-A1a isoform X1 [KO:K05462]
130433544  si:dkey-246i14.3; ephrin-A4 [KO:K05462]
130433553  efna1b; ephrin-A1b [KO:K05462]
130410693  ephrin-A2-like [KO:K05462]
130411841  gdnfa; glial cell line-derived neurotrophic factor [KO:K05452]
130419926  gdnfb; glial cell line-derived neurotrophic factor [KO:K05452]
130418405  neurturin [KO:K25414]
130410580  nrtn; neurturin [KO:K25414]
130424836  neurturin [KO:K25415]
130417034  glial cell line-derived neurotrophic factor [KO:K25415]
130429409  persephin [KO:K25416]
130412958  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
130417299  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
130438708  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
130424635  erbb3a; receptor tyrosine-protein kinase erbB-3a isoform X1 [KO:K05084] [EC:2.7.10.1]
130409460  erbb3b; receptor tyrosine-protein kinase erbB-3b [KO:K05084] [EC:2.7.10.1]
130406952  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
130439543  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
130427232  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
130411550  fgfr1b; fibroblast growth factor receptor 1b isoform X1 [KO:K04362] [EC:2.7.10.1]
130439863  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
130432154  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
130431290  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
130407750  fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
130425601  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
130432927  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
130439496  ngfrb; nerve growth factor receptor b isoform X1 [KO:K02583]
130432440  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
130407138  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a isoform X1 [KO:K04360] [EC:2.7.10.1]
130419056  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b [KO:K04360] [EC:2.7.10.1]
130429588  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
130417971  insra; LOW QUALITY PROTEIN: insulin receptor a [KO:K04527] [EC:2.7.10.1]
130417899  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
130435165  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
130434670  pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
130437873  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
130437874  csf1ra; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
130407452  csf1rb; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
130440036  kitb; KIT proto-oncogene, receptor tyrosine kinase b [KO:K05091] [EC:2.7.10.1]
130434613  kita; mast/stem cell growth factor receptor kita isoform X1 [KO:K05091] [EC:2.7.10.1]
130413133  flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
130413623  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
130438484  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
130438107  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
130434338  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
130414577  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
130418863  tek; tyrosine-protein kinase receptor Tie-2 isoform X1 [KO:K05121] [EC:2.7.10.1]
130425338  epha2a; ephrin type-A receptor 2a [KO:K05103] [EC:2.7.10.1]
130409226  epha2b; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
130431768  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
130426551  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
130432252  sos2; son of sevenless homolog 2 [KO:K03099]
130410242  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
130419842  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
130414027  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
130414055  kras; GTPase KRas isoform X1 [KO:K07827]
130425672  zgc:55558; GTPase KRas [KO:K07827]
130439916  nras; GTPase NRas [KO:K07828]
130426611  rras; ras-related protein R-Ras [KO:K07830]
130427220  rras2; ras-related protein R-Ras2 [KO:K07830]
130430313  mrasb; ras-related protein M-Ras [KO:K07831]
130427464  mrasa; ras-related protein M-Ras isoform X1 [KO:K07831]
130418981  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
130420618  braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
130409011  raf1a; raf-1 proto-oncogene, serine/threonine kinase a [KO:K04366] [EC:2.7.11.1]
130410117  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
130435775  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
130430266  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
130418373  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
130431134  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
130425784  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
130419097  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
130439998  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
130410656  mknk1; LOW QUALITY PROTEIN: MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
130436559  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
130412975  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
130437695  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
130431541  rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
130418817  rps6ka3a; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
130425294  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
130426359  atf4b; activating transcription factor 4b [KO:K04374]
130439827  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
130410059  elk4; ETS domain-containing protein Elk-4 [KO:K04376]
130413701  myca; transcriptional regulator Myc-A [KO:K04377]
130418541  mycb; transcriptional regulator Myc-B [KO:K04377]
130429833  srfa; serum response factor a isoform X1 [KO:K04378]
130431831  srfb; serum response factor b isoform X1 [KO:K04378]
130436958  fosaa; protein c-Fos [KO:K04379]
130434283  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
130434596  si:ch211-153j24.3; protein c-Fos isoform X1 [KO:K04379]
130425652  maptb; microtubule-associated protein tau isoform X1 [KO:K04380]
130415521  stmn1a; stathmin 1a [KO:K04381]
130433583  stmn1b; stathmin 1b [KO:K04381]
130419606  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
130436426  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
130436427  cytosolic phospholipase A2 delta-like [KO:K16342] [EC:3.1.1.4]
130436836  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
130436837  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
130436949  cytosolic phospholipase A2 delta-like [KO:K16342] [EC:3.1.1.4]
130434099  pla2g4ab; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
130418307  pla2g4aa; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
130418764  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
130419168  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
130415656  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
130411792  il1b; interleukin-1 beta [KO:K04519]
130428583  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
130408414  tgfb1b; transforming growth factor beta-1 proprotein [KO:K13375]
130437978  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
130433538  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
130436493  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
130433539  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
130427374  zmp:0000000936; interleukin-1 receptor type 1 [KO:K04386]
130428063  interleukin-1 receptor type 1 [KO:K04386]
130429068  interleukin-1 receptor accessory protein [KO:K04723]
130413167  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
130417342  tgfbr1a; TGF-beta receptor type-1a isoform X1 [KO:K04674] [EC:2.7.11.30]
130432636  tgfbr2b; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
130427877  tgfbr2l; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
130434609  faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
130437349  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
130438845  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
130425769  rac1b; ras-related C3 botulinum toxin substrate 1b [KO:K04392]
130426307  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
130438947  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
130425813  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
130432490  cdc42l; cell division cycle 42, like [KO:K04393]
130409959  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
130430385  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
130438496  casp3b; caspase-3b [KO:K02187] [EC:3.4.22.56]
130438623  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
130419591  traf2b; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
130419012  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
130419428  traf2a; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
130415803  daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
130413368  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
130407154  irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
130413857  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
130427828  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
130407863  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
130417310  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
130440234  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
130418044  gadd45bb; growth arrest and DNA-damage-inducible, beta b [KO:K04402]
130410248  gadd45ba; growth arrest and DNA-damage-inducible, beta a [KO:K04402]
130425308  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
130434055  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
130410787  map4k3a; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
130437131  map4k3b; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
130437620  si:zfos-2326c3.2; misshapen-like kinase 1 isoform X1 [KO:K04407] [EC:2.7.11.1]
130435522  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
130430296  pak2b; serine/threonine-protein kinase PAK 2b isoform X1 [KO:K04410] [EC:2.7.11.1]
130417996  pak2a; serine/threonine-protein kinase PAK 2a [KO:K04410] [EC:2.7.11.1]
130407592  map4k6; mitogen-activated protein kinase kinase kinase kinase 6 [KO:K04414] [EC:2.7.11.1]
130439348  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
130411393  map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
130418493  mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
130424759  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
130426448  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
130413365  map3k22; mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
130431405  map3k9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
130435449  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
130432234  map3k21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
130427910  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
130427684  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
130424236  protein kinase Npk [KO:K04424] [EC:2.7.11.25]
130427163  map3k20a; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
130433109  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
130434052  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
130434139  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
130431293  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
130438711  taok2b; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
130407694  taok1b; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
130426125  taok2a; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
130418802  taok3a; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
130419111  taok3b; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
130428431  taok1a; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
130439253  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
130426180  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
130426191  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
130439432  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
130438964  map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
130428878  mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
130413864  mapk8ip1a; C-Jun-amino-terminal kinase-interacting protein 1a [KO:K04434]
130435789  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
130425572  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
130408999  flna; filamin-A [KO:K04437]
130429214  crk; adapter molecule crk [KO:K04438]
130408346  crkl; crk-like protein [KO:K04438]
130411351  arrb2a; arrestin, beta 2a isoform X1 [KO:K04439]
130418904  arrb2b; arrestin, beta 2b [KO:K04439]
130428382  arrb1; beta-arrestin-1 [KO:K04439]
130431875  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
130407470  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
130407541  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
130420398  mapk12b; mitogen-activated protein kinase 12b isoform X1 [KO:K04441] [EC:2.7.11.24]
130420400  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
130440306  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
130440337  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
130409790  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
130409970  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
130435326  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
130419953  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
130407033  mapkapk2b; MAP kinase-activated protein kinase 2b [KO:K04443] [EC:2.7.11.1]
130410257  mapkapk2a; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
130410213  mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
130436849  rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
130419017  rps6ka4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
130431544  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
130415998  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
130413999  nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
130417968  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
130434107  jun; transcription factor AP-1 [KO:K04448]
130420161  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
130418274  jund; transcription factor jun-D [KO:K04449]
130427747  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
130424437  cellular tumor antigen p53-like [KO:K04451]
130419306  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
130424544  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
130434733  max; protein max isoform X1 [KO:K04453]
130411521  mef2ca; myocyte enhancer factor 2ca isoform X1 [KO:K04454]
130419694  hspb1; heat shock protein beta-1 [KO:K04455]
130435926  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
130411987  akt2l; v-akt murine thymoma viral oncogene homolog 2, like [KO:K04456] [EC:2.7.11.1]
130437305  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
130431267  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
130434336  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
130409315  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
130431569  ppm1aa; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
130407395  ppm1nb; protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) [KO:K04457] [EC:3.1.3.16]
130434621  ppm1ab; protein phosphatase, Mg2+/Mn2+ dependent, 1Ab isoform X1 [KO:K04457] [EC:3.1.3.16]
130428140  ppm1na; protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) [KO:K04457] [EC:3.1.3.16]
130421295  ptprr; tyrosine-protein phosphatase non-receptor type 7 [KO:K04458] [EC:3.1.3.48]
130427565  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
130438409  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
130420615  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
130430766  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
130414016  dusp8a; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
130407851  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
130439897  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
130410278  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
130414560  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
130434751  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
130425695  dual specificity protein phosphatase 3-like isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
130439549  dusp3a; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
130426407  dusp3b; dual specificity protein phosphatase 3b [KO:K17614] [EC:3.1.3.16 3.1.3.48]
130429254  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
130431579  ppm1ba; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
130438770  ppm1bb; protein phosphatase 1bb isoform X1 [KO:K04461] [EC:3.1.3.16]
130411634  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
130426370  heat shock 70 kDa protein-like [KO:K03283]
130426371  heat shock 70 kDa protein-like [KO:K03283]
130426372  heat shock 70 kDa protein-like [KO:K03283]
130426374  heat shock 70 kDa protein [KO:K03283]
130426375  heat shock 70 kDa protein-like [KO:K03283]
130426376  heat shock 70 kDa protein-like [KO:K03283]
130440299  hspa1b; LOW QUALITY PROTEIN: heat shock 70 kDa protein-like [KO:K03283]
130428391  hspa8b; LOW QUALITY PROTEIN: heat shock protein family A (Hsp70) member 8b [KO:K03283]
130428466  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
130428395  mecom; MDS1 and EVI1 complex locus protein EVI1-A isoform X1 [KO:K04462] [EC:2.1.1.367]
130418662  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
130438641  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
130409043  nr4a1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
130412833  uncharacterized protein LOC130412833 [KO:K04466] [EC:2.7.11.25]
130426820  mitogen-activated protein kinase kinase kinase 14-like [KO:K04466] [EC:2.7.11.25]
130426833  mitogen-activated protein kinase kinase kinase 14-like [KO:K04466] [EC:2.7.11.25]
130431939  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
130439789  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
130409812  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
130428714  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
130426708  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
130438512  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
130431590  LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p100 subunit-like [KO:K04469]
130417861  rela; transcription factor p65 [KO:K04735]
130428398  relb; transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
tdw04070  Phosphatidylinositol signaling system
tdw04110  Cell cycle
tdw04115  p53 signaling pathway
tdw04210  Apoptosis
tdw04310  Wnt signaling pathway
KO pathway
ko04010   
LinkDB

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