KEGG   PATHWAY: pyu04014
Entry
pyu04014                    Pathway                                
Name
Ras signaling pathway - Puma yagouaroundi (jaguarundi)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
pyu04014  Ras signaling pathway
pyu04014

Other DBs
GO: 0032318
Organism
Puma yagouaroundi (jaguarundi) [GN:pyu]
Gene
121009974  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
121010237  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
121010268  KSR2; kinase suppressor of Ras 2 isoform X1 [KO:K18529] [EC:2.7.11.1]
121010308  RASAL1; rasGAP-activating-like protein 1 [KO:K17632]
121010320  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
121010333  [KO:K10632] [EC:2.3.2.27]
121010516  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
121010935  RASAL3; RAS protein activator like-3 [KO:K17634]
121010979  FGF18; fibroblast growth factor 18 [KO:K04358]
121011002  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121011198  RHOA; transforming protein RhoA [KO:K04513]
121011244  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
121011444  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121011476  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
121011504  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
121011574  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
121011832  RGL1; ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [KO:K17635]
121011861  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
121011873  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
121011885  RASAL2; ras GTPase-activating protein nGAP isoform X1 [KO:K17633]
121012141  STK4; serine/threonine-protein kinase 4 [KO:K04411]
121012188  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
121012206  RALGAPB; ral GTPase-activating protein subunit beta isoform X1 [KO:K25769]
121012211  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
121012341  BCL2L1; bcl-2-like protein 1 [KO:K04570]
121012369  ANGPT4; angiopoietin-4 [KO:K05467]
121012482  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
121012549  RALGAPA2; ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768]
121012732  FGF9; fibroblast growth factor 9 [KO:K04358]
121012779  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
121012786  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
121012848  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
121013486  AFDN; afadin [KO:K05702]
121013519  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
121013551  SHC3; SHC-transforming protein 3 [KO:K17448]
121013786  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
121013826  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
121014032  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X1 [KO:K04347]
121014090  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
121014214  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
121014870  [KO:K02183]
121014873  [KO:K02183]
121014969  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121015025  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
121015111  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121015308  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
121015457  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
121015654  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
121016054  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
121016247  REL; proto-oncogene c-Rel [KO:K09254]
121016318  CALM2; calmodulin-2 [KO:K02183]
121016390  [KO:K07360] [EC:2.7.10.2]
121016402  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
121017018  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
121017046  NF1; neurofibromin [KO:K08052]
121017175  KSR1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
121017369  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
121017467  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
121017559  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
121017640  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
121017687  [KO:K17630]
121017794  [KO:K04393]
121017912  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
121018087  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
121018181  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
121018659  CALM3; calmodulin-3 isoform X1 [KO:K02183]
121018664  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
121018739  FGF21; fibroblast growth factor 21 [KO:K22429]
121018756  NTF4; neurotrophin-4 [KO:K12457]
121018775  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
121018786  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
121018827  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
121018849  [KO:K07293] [EC:3.1.3.48]
121019131  TGFA; protransforming growth factor alpha [KO:K08774]
121019302  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
121019338  CALML6; calmodulin-like protein 6 [KO:K02183]
121019369  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
121019488  [KO:K01047] [EC:3.1.1.4]
121019534  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
121019755  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
121020230  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
121020558  EXOC2; exocyst complex component 2 [KO:K17637]
121020585  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121020761  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
121021435  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
121021465  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
121021586  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
121021710  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
121021881  FGF22; fibroblast growth factor 22 [KO:K04358]
121021890  SHC2; SHC-transforming protein 2 [KO:K17447]
121021952  FGF23; fibroblast growth factor 23 [KO:K22428]
121021966  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
121021990  FGF6; fibroblast growth factor 6 [KO:K04358]
121022119  NTF3; neurotrophin-3 [KO:K04356]
121022226  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121022260  [KO:K01047] [EC:3.1.1.4]
121022283  PLA2G5; phospholipase A2 group V isoform X1 [KO:K01047] [EC:3.1.1.4]
121022316  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
121022321  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
121022331  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
121022491  LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
121022670  PLA2G3; group 3 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
121022813  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
121022826  HRAS; GTPase HRas isoform X1 [KO:K02833]
121023018  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121023145  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X1 [KO:K04541]
121023732  VEGFB; vascular endothelial growth factor B [KO:K16858]
121023744  FGF19; fibroblast growth factor 19 [KO:K22603]
121023745  FGF4; fibroblast growth factor 4 [KO:K04358]
121023888  RIN1; ras and Rab interactor 1 [KO:K17638]
121023900  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
121023947  BAD; bcl2-associated agonist of cell death [KO:K02158]
121023954  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
121023959  RELA; transcription factor p65 [KO:K04735]
121023964  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
121023965  INS; insulin [KO:K04526]
121023990  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
121024990  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
121025049  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
121025193  EFNA4; ephrin-A4 [KO:K05462]
121025237  FOXO4; forkhead box protein O4 [KO:K12358]
121025312  EFNA3; ephrin-A3 [KO:K05462]
121025344  FGF16; fibroblast growth factor 16 [KO:K04358]
121025662  VEGFD; vascular endothelial growth factor D [KO:K05449]
121025715  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
121026171  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
121027050  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
121027288  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
121027378  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
121027385  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
121027641  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
121027680  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
121027738  NRAS; GTPase NRas [KO:K07828]
121027749  NGF; beta-nerve growth factor [KO:K02582]
121028117  PDGFC; platelet-derived growth factor C [KO:K05450]
121028446  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
121028637  RAPGEF5; rap guanine nucleotide exchange factor 5 [KO:K08019]
121028731  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
121028732  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
121028796  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
121028976  [KO:K10785]
121029177  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
121029226  SYNGAP1; ras/Rap GTPase-activating protein SynGAP [KO:K17631]
121029275  RGL2; ral guanine nucleotide dissociation stimulator-like 2 [KO:K17636]
121029504  VEGFA; vascular endothelial growth factor A [KO:K05448]
121030066  FGF2; fibroblast growth factor 2 isoform X1 [KO:K18497]
121030421  RALB; ras-related protein Ral-B [KO:K07835]
121031012  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
121031448  [KO:K10784]
121031658  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X1 [KO:K25768]
121031731  ARF6; ADP-ribosylation factor 6 [KO:K07941]
121031737  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
121031761  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
121031875  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
121032059  PGF; placenta growth factor isoform X1 [KO:K16859]
121032181  CALM1; calmodulin-1 [KO:K02183]
121032358  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121033019  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121033185  RALBP1; ralA-binding protein 1 [KO:K08773]
121033616  RAB5A; ras-related protein Rab-5A [KO:K07887]
121033707  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
121033726  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
121033733  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
121033754  RASA2; ras GTPase-activating protein 2 [KO:K08053]
121033993  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
121034018  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121034022  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
121034541  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
121034834  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
121035113  ABL1; tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
121035155  RALGDS; ral guanine nucleotide dissociation stimulator [KO:K08732]
121035466  [KO:K04540]
121035518  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
121035532  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
121035565  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
121035625  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
121035937  ETS2; protein C-ets-2 [KO:K21932]
121036015  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
121036276  [KO:K13618] [EC:3.1.1.111]
121036392  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
121036778  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
121036923  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121036980  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
121037018  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
121037105  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
121037223  SHOC2; leucine-rich repeat protein SHOC-2 [KO:K19613]
121037313  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
121037542  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
121037664  RASA3; ras GTPase-activating protein 3 isoform X1 [KO:K12380]
121038809  KRAS; GTPase KRas isoform X1 [KO:K07827]
121038896  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
121039327  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
121039345  GAB2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
121039432  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
121039602  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
121039641  VEGFC; vascular endothelial growth factor C [KO:K05449]
121039893  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
121039962  FGF20; fibroblast growth factor 20 [KO:K04358]
121040328  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
121040357  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
121040395  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
121040524  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
121040655  KITLG; kit ligand [KO:K05461]
121040776  RAP1B; ras-related protein Rap-1b [KO:K07836]
121040822  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
121040953  RAB5B; ras-related protein Rab-5B [KO:K07888]
121041241  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121041478  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
121041497  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
121041554  [KO:K16342] [EC:3.1.1.4]
121041557  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
121041559  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
121041561  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
121041673  SHC4; SHC-transforming protein 4 [KO:K17449]
121041681  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
121041716  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
121041863  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
121041895  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
121042263  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
121042474  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
121042850  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
121043625  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
121044329  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
121044367  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
121044420  FGF10; fibroblast growth factor 10 [KO:K04358]
121044817  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
121044824  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
121045000  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
121045013  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
121045014  RAB5C; ras-related protein Rab-5C [KO:K07889]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
pyu04010  MAPK signaling pathway
pyu04015  Rap1 signaling pathway
pyu04020  Calcium signaling pathway
pyu04144  Endocytosis
pyu04151  PI3K-Akt signaling pathway
pyu04660  T cell receptor signaling pathway
pyu04720  Long-term potentiation
pyu04810  Regulation of actin cytoskeleton
KO pathway
ko04014   

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