KEGG   PATHWAY: aml05166
Entry
aml05166                    Pathway                                
Name
Human T-cell leukemia virus 1 infection - Ailuropoda melanoleuca (giant panda)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
aml05166  Human T-cell leukemia virus 1 infection
aml05166

Organism
Ailuropoda melanoleuca (giant panda) [GN:aml]
Gene
100476930  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
100482448  NRP1; LOW QUALITY PROTEIN: neuropilin-1 [KO:K06724]
100464396  MYC; myc proto-oncogene protein [KO:K04377]
100484031  TRRAP; transformation/transcription domain-associated protein isoform X1 [KO:K08874]
100465899  KAT5; histone acetyltransferase KAT5 isoform X3 [KO:K11304] [EC:2.3.1.48]
100471517  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100464009  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
100484264  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
100476475  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
100473836  HRAS; GTPase HRas isoform X1 [KO:K02833]
100483919  KRAS; GTPase KRas isoform X1 [KO:K07827]
100464196  NRAS; GTPase NRas [KO:K07828]
100478039  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100465700  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100470035  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100472388  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100482689  CD4; T-cell surface glycoprotein CD4 isoform X2 [KO:K06454]
100471856  TLN1; talin-1 [KO:K06271]
100469891  TLN2; talin-2 [KO:K06271]
100467456  RANBP3; ran-binding protein 3 isoform X4 [KO:K15304]
100468957  RAN; GTP-binding nuclear protein Ran [KO:K07936]
117799753  GTP-binding nuclear protein Ran [KO:K07936]
100466522  XPO1; exportin-1 isoform X1 [KO:K14290]
100479734  CALR; calreticulin [KO:K08057]
100466992  CANX; calnexin isoform X2 [KO:K08054]
100477289  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
100467653  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X5 [KO:K04348] [EC:3.1.3.16]
100474970  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X5 [KO:K04348] [EC:3.1.3.16]
100474742  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100467683  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
100470861  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
100464798  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X4 [KO:K17332]
100477832  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100471691  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
100478292  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
100468126  IL2RG; cytokine receptor common subunit gamma isoform X2 [KO:K05070]
100473460  JAK1; tyrosine-protein kinase JAK1 isoform X2 [KO:K11217] [EC:2.7.10.2]
100474005  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
100469683  signal transducer and activator of transcription 5A [KO:K11223]
100479246  signal transducer and activator of transcription 5B [KO:K11224]
100480862  IL2; interleukin-2 precursor [KO:K05429]
100483904  AIME-1906; class I histocompatibility antigen, Gogo-OKO alpha chain [KO:K06751]
100476691  AIME-152; class I histocompatibility antigen, Aime-152 precursor [KO:K06751]
100466374  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X2 [KO:K06751]
100470568  AIME-128; DLA class I histocompatibility antigen, A9/A9 alpha chain [KO:K06751]
105241843  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0102 alpha chain [KO:K06751]
100465524  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, CH28 alpha chain-like [KO:K06751]
109488766  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
100470489  B2M; beta-2-microglobulin [KO:K08055]
100474496  FDPS; farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
100463625  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100473508  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100464085  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
100469507  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
100476732  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
117799792  ADP/ATP translocase 2-like [KO:K05863]
100465507  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100470763  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
100474562  TSPO; translocator protein [KO:K05770]
100467882  TSPO2; translocator protein 2 [KO:K05770]
100482603  VAC14; protein VAC14 homolog isoform X2 [KO:K15305]
105238228  RANBP1; ran-specific GTPase-activating protein isoform X1 [KO:K15306]
105234697  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X5 [KO:K06679]
105239272  mitotic spindle assembly checkpoint protein MAD2A isoform X1 [KO:K02537]
100464546  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X3 [KO:K06637] [EC:2.7.11.1]
100469030  BUB3; mitotic checkpoint protein BUB3 isoform X2 [KO:K02180]
100474475  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
100471139  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
100476006  CDC27; cell division cycle protein 27 homolog isoform X3 [KO:K03350]
100480006  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
100466383  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
100478508  CDC16; cell division cycle protein 16 homolog isoform X3 [KO:K03353]
100477024  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
100482442  CDC23; cell division cycle protein 23 homolog [KO:K03355]
100477128  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
100479297  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
100476624  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
100465022  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
100473315  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
100466282  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
100473900  CDC20; cell division cycle protein 20 homolog [KO:K03363]
100479295  PTTG1; securin isoform X1 [KO:K06635]
100467596  ESPL1; separin [KO:K02365] [EC:3.4.22.49]
100475507  CCNB2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
100473431  cyclin-dependent kinase 4 inhibitor B [KO:K04685]
100472171  cyclin-dependent kinase inhibitor 2A isoform X3 [KO:K06621]
100481236  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100469787  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
100479467  CCND3; G1/S-specific cyclin-D3 isoform X4 [KO:K10152]
100484923  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100482271  CCNA2; cyclin-A2 [KO:K06627]
100475180  CCNA1; cyclin-A1 [KO:K06627]
100471009  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
100483627  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
100468314  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
100477714  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
117795744  E2F1; transcription factor E2F1 [KO:K17454]
100475779  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
100484544  E2F3; transcription factor E2F3 [KO:K06620]
100480638  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
100464897  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
100467858  CHEK1; serine/threonine-protein kinase Chk1 isoform X2 [KO:K02216] [EC:2.7.11.1]
100467146  CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
100468516  TP53; cellular tumor antigen p53 [KO:K04451]
100475291  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100483828  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100467916  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100463775  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100479294  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100479580  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100468763  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100480414  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100465793  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100481489  DLG1; disks large homolog 1 isoform X7 [KO:K12076]
100469483  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100471563  TNF; tumor necrosis factor [KO:K03156]
100479926  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100466442  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
100475919  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
100477951  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100482196  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100477600  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
100483834  JUN; transcription factor AP-1 [KO:K04448]
100480431  MMP7; matrilysin isoform X1 [KO:K01397] [EC:3.4.24.23]
100472991  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
100475938  IL1R2; interleukin-1 receptor type 2 isoform X2 [KO:K04387]
105234922  M1-specific T cell receptor alpha chain isoform X1 [KO:K10784]
100484718  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
100482462  CD3E; T-cell surface glycoprotein CD3 epsilon chain isoform X2 [KO:K06451]
100484468  CD3G; T-cell surface glycoprotein CD3 gamma chain isoform X2 [KO:K06452]
100475740  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
100464675  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100471679  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100470223  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100466997  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100467906  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100480158  RELA; transcription factor p65 isoform X1 [KO:K04735]
100481270  GPS2; G protein pathway suppressor 2 [KO:K15307]
100479494  LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159]
100476345  CD40; tumor necrosis factor receptor superfamily member 5 isoform X2 [KO:K03160]
100472260  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
100477158  RELB; LOW QUALITY PROTEIN: transcription factor RelB [KO:K09253]
100474781  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X2 [KO:K04469]
100464527  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
100466247  IL2RA; interleukin-2 receptor subunit alpha isoform X3 [KO:K05068]
100484790  IL15; interleukin-15 precursor [KO:K05433]
105238122  IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
100477151  IL6; interleukin-6 precursor [KO:K05405]
117803984  interleukin-6-like [KO:K05405]
100473502  uncharacterized protein LOC100473502 [KO:K05427]
109488324  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
100471816  LTA; lymphotoxin-alpha [KO:K05468]
100469922  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
100471203  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
100470703  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
100463584  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
100475861  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
100475698  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
100482939  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
100467069  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
100479304  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
100465063  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
100472777  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100473195  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100471164  ADCY3; adenylate cyclase type 3 isoform X2 [KO:K08043] [EC:4.6.1.1]
100471940  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100482519  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
100476922  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
100466965  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100474121  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
100476495  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
100468252  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
100469628  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100475307  NFYB; nuclear transcription factor Y subunit beta isoform X5 [KO:K08065]
100464393  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
100464636  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
100477284  HLA class II histocompatibility antigen, DM beta chain isoform X2 [KO:K06752]
100478290  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
100484974  HLA class II histocompatibility antigen, DQ beta 2 chain [KO:K06752]
100464780  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
100464279  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
100478546  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
100463634  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
100464025  LOW QUALITY PROTEIN: SLA class II histocompatibility antigen, DQ haplotype C alpha chain [KO:K06752]
100484237  SRF; serum response factor isoform X1 [KO:K04378]
100471598  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
100481494  ELK1; ETS domain-containing protein Elk-1 isoform X2 [KO:K04375]
100476314  SPI1; transcription factor PU.1 isoform X3 [KO:K09438]
100469300  ETS1; protein C-ets-1 isoform X3 [KO:K02678]
100477357  ETS2; protein C-ets-2 isoform X1 [KO:K21932]
100468425  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
100482953  TBP; TATA-box-binding protein [KO:K03120]
105242046  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
100474867  FOS; proto-oncogene c-Fos [KO:K04379]
100483196  EGR1; early growth response protein 1 [KO:K09203]
100484750  FOSL1; fos-related antigen 1 isoform X1 [KO:K04502]
100479556  EGR2; E3 SUMO-protein ligase EGR2 isoform X2 [KO:K12496]
100477711  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100465448  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
100472104  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100470867  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
100483482  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
100484531  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100474135  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X2 [KO:K04450]
100476284  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100474261  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
100476017  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X2 [KO:K09049]
100479645  CRTC1; LOW QUALITY PROTEIN: CREB-regulated transcription coactivator 1 [KO:K15309]
100472270  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
100479341  CRTC3; CREB-regulated transcription coactivator 3 isoform X1 [KO:K16334]
100480008  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
100468694  EP300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
100482031  KAT2B; histone acetyltransferase KAT2B isoform X1 [KO:K06062] [EC:2.3.1.48]
100468755  KAT2A; histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
100479681  TCF3; transcription factor E2-alpha isoform X3 [KO:K09063]
100471432  POLB; DNA polymerase beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
100477981  LCK; tyrosine-protein kinase Lck isoform X2 [KO:K05856] [EC:2.7.10.2]
100471095  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100470950  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
105237456  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
100464057  MSX2; homeobox protein MSX-2 [KO:K09341]
100478997  MSX1; homeobox protein MSX-1 [KO:K09341]
100471057  homeobox protein MSX-3-like [KO:K09341]
117800974  homeobox protein MSX-1-like [KO:K09341]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Sinet F.
  Title
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
  Journal
BioSciences Master Reviews, July 2013
Reference
PMID:18923409
  Authors
Sattentau Q
  Title
Avoiding the void: cell-to-cell spread of human viruses.
  Journal
Nat Rev Microbiol 6:815-26 (2008)
DOI:10.1038/nrmicro1972
Reference
PMID:15040584
  Authors
Vicente-Manzanares M, Sanchez-Madrid F
  Title
Role of the cytoskeleton during leukocyte responses.
  Journal
Nat Rev Immunol 4:110-22 (2004)
DOI:10.1038/nri1268
Reference
PMID:27334587
  Authors
Dutartre H, Claviere M, Journo C, Mahieux R
  Title
Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
  Journal
J Virol 90:7607-17 (2016)
DOI:10.1128/JVI.00407-16
Reference
PMID:15988028
  Authors
Awasthi S, Sharma A, Wong K, Zhang J, Matlock EF, Rogers L, Motloch P, Takemoto S, Taguchi H, Cole MD, Luscher B, Dittrich O, Tagami H, Nakatani Y, McGee M, Girard AM, Gaughan L, Robson CN, Monnat RJ Jr, Harrod R
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A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.
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Mol Cell Biol 25:6178-98 (2005)
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Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
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Viruses 3:861-85 (2011)
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HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
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Viruses 8:58 (2016)
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PMID:22783232
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Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.
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Front Microbiol 3:179 (2012)
DOI:10.3389/fmicb.2012.00179
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PMID:23248621
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Bai XT, Nicot C
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Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
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Front Microbiol 3:400 (2012)
DOI:10.3389/fmicb.2012.00400
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PMID:18421579
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HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
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Apoptosis 13:733-47 (2008)
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Cell Death Differ 12 Suppl 1:905-15 (2005)
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Silic-Benussi M, Biasiotto R, Andresen V, Franchini G, D'Agostino DM, Ciminale V
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HTLV-1 p13, a small protein with a busy agenda.
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Mol Aspects Med 31:350-8 (2010)
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Anti-apoptotic effect of Tax: an NF-kappaB path or a CREB way?
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Viruses 3:1001-14 (2011)
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Oncogene 24:5952-64 (2005)
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Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
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Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.
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Biochim Biophys Acta 1813:731-41 (2011)
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Pathogens 5:E8 (2016)
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Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein.
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J Biol Chem 290:26270-81 (2015)
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Mori N, Morishita M, Tsukazaki T, Giam CZ, Kumatori A, Tanaka Y, Yamamoto N
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Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
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Blood 97:2137-44 (2001)
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PMID:15310405
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Azran I, Schavinsky-Khrapunsky Y, Aboud M
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Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
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Retrovirology 1:20 (2004)
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PMID:11244044
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Yoshida M
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Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
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Annu Rev Immunol 19:475-96 (2001)
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PMID:12802280
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Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E
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Inactivation of hTERT transcription by Tax.
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Oncogene 22:3734-41 (2003)
DOI:10.1038/sj.onc.1206468
Related
pathway
aml03013  Nucleocytoplasmic transport
aml04010  MAPK signaling pathway
aml04064  NF-kappa B signaling pathway
aml04110  Cell cycle
aml04115  p53 signaling pathway
aml04151  PI3K-Akt signaling pathway
aml04210  Apoptosis
aml04350  TGF-beta signaling pathway
aml04612  Antigen processing and presentation
aml04660  T cell receptor signaling pathway
aml04668  TNF signaling pathway
KO pathway
ko05166   
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