KEGG   PATHWAY: dle05163
Entry
dle05163                    Pathway                                
Name
Human cytomegalovirus infection - Delphinapterus leucas (beluga whale)
Description
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
Class
Human Diseases; Infectious disease: viral
Pathway map
dle05163  Human cytomegalovirus infection
dle05163

Disease
H00368  Cytomegalovirus infection
Organism
Delphinapterus leucas (beluga whale) [GN:dle]
Gene
111162913  CRKL; crk-like protein [KO:K04438]
111163022  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
111163101  [KO:K05414]
111163130  [KO:K05414]
111163175  [KO:K06621]
111163373  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
111163675  CCL5; C-C motif chemokine 5 [KO:K12499]
111163731  [KO:K05408]
111163732  [KO:K12964]
111163733  [KO:K05408]
111163760  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
111163875  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
111163963  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
111164202  NFATC4; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
111164225  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
111164391  MYC; myc proto-oncogene protein [KO:K04377]
111164400  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
111164467  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
111164599  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
111164991  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
111165046  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
111165310  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
111165354  CX3CL1; fractalkine [KO:K05508]
111165564  ELK1; LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1 [KO:K04375]
111165617  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
111165653  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
111165994  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
111166066  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
111166195  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
111166309  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
111166491  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
111166599  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
111166652  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111166674  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
111166685  CALR; calreticulin [KO:K08057]
111166690  [KO:K06751]
111166783  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
111166949  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
111167075  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
111167114  ARHGEF11; rho guanine nucleotide exchange factor 11 isoform X1 [KO:K12331]
111167181  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
111167284  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
111167479  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
111168040  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111168973  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111169035  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111169326  AKAP13; A-kinase anchor protein 13 isoform X12 [KO:K16529]
111169388  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X2 [KO:K04346]
111169438  CTNNB1; catenin beta-1 [KO:K02105]
111169692  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
111170127  [KO:K02183]
111170265  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
111170340  HRAS; GTPase HRas isoform X1 [KO:K02833]
111170644  [KO:K06751]
111170657  TNF; tumor necrosis factor [KO:K03156]
111170918  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
111170946  ATF6B; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
111170969  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
111171121  [KO:K05414]
111171122  [KO:K05414]
111171351  [KO:K08055]
111171394  [KO:K06751]
111171639  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
111171650  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
111171726  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
111171769  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
111171816  CXCR2; C-X-C chemokine receptor type 2 isoform X1 [KO:K05050]
111172396  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
111172519  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
111172563  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
111172717  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
111172890  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
111172911  [KO:K08738]
111173156  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
111173161  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
111173177  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
111173225  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
111173401  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
111173509  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
111173552  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
111173763  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
111173795  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
111173824  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
111173828  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
111173839  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111173942  SP1; transcription factor Sp1 [KO:K04684]
111174031  [KO:K08738]
111174035  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
111174169  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
111174197  [KO:K08738]
111174368  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
111174398  RHOA; transforming protein RhoA [KO:K04513]
111174478  [KO:K04178]
111174479  [KO:K04176]
111174480  [KO:K04180]
111174560  IFNB1; interferon beta [KO:K05415]
111174571  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
111174575  [KO:K08738]
111174794  CALM2; calmodulin-2 [KO:K02183]
111174855  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
111175000  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
111175081  RB1; retinoblastoma-associated protein [KO:K06618]
111175474  [KO:K08057]
111175760  [KO:K02649]
111175930  [KO:K08738]
111176008  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111176162  CALM1; calmodulin-1 [KO:K02183]
111176587  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
111176656  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
111176675  RHEB; GTP-binding protein Rheb [KO:K07208]
111176690  [KO:K07825]
111176694  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
111176851  KRAS; GTPase KRas [KO:K07827]
111176861  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
111177009  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
111177090  TSC1; hamartin [KO:K07206]
111177332  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
111177559  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111177624  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
111177745  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111177758  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
111177962  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
111178375  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
111178380  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
111178422  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
111178437  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
111178461  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
111178556  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
111178659  TAP2; antigen peptide transporter 2 isoform X1 [KO:K05654] [EC:7.4.2.14]
111178660  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
111178682  TAPBP; tapasin isoform X1 [KO:K08058]
111178690  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
111178692  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
111178736  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
111178738  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
111178743  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
111178866  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
111179107  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111179110  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111179235  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111179506  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
111179609  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
111179654  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
111179996  NRAS; GTPase NRas [KO:K07828]
111180070  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
111180225  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
111180543  [KO:K08738]
111180609  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
111180640  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
111180709  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
111180711  CALM3; calmodulin-3 [KO:K02183]
111180799  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
111180855  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111180943  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
111180981  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
111181049  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
111181305  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
111181407  E2F3; transcription factor E2F3 isoform X2 [KO:K06620]
111181452  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
111181647  [KO:K08055]
111181648  [KO:K08055]
111181668  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
111181753  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
111181886  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
111181977  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
111181978  IL6; interleukin-6 [KO:K05405]
111182181  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
111182232  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
111182516  STING1; stimulator of interferon genes protein [KO:K12654]
111182589  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
111182681  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X2 [KO:K07861]
111182833  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
111182897  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
111182908  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
111182917  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111183022  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
111183240  CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
111183521  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111183629  FADD; FAS-associated death domain protein [KO:K02373]
111183632  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
111183673  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
111183745  RELA; transcription factor p65 isoform X1 [KO:K04735]
111183812  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
111183856  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
111183987  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
111184199  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
111184273  E2F1; transcription factor E2F1 isoform X1 [KO:K17454]
111184277  [KO:K08055]
111184534  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
111184548  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
111184673  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
111184706  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
111185128  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
111185176  TSC2; tuberin isoform X1 [KO:K07207]
111185250  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
111185408  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
111185687  CRK; adapter molecule crk isoform X1 [KO:K04438]
111185731  [KO:K14624]
111185755  TP53; cellular tumor antigen p53 [KO:K04451]
111185984  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111186212  ATF4; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
111186216  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
111186361  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
111186364  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
111186607  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
111186741  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
111186746  [KO:K04632]
111186778  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
111187055  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
111187099  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
111187200  CALML6; calmodulin-like protein 6 [KO:K02183]
111187219  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
111187262  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
111187265  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
111187389  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
111187492  IL1B; interleukin-1 beta [KO:K04519]
111187634  CXCL8; interleukin-8 isoform X1 [KO:K10030]
111188007  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
111188120  PPP3R2; LOW QUALITY PROTEIN: calcineurin subunit B type 2 [KO:K06268]
111188135  PXN; paxillin isoform X5 [KO:K05760]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00584  Prostaglandin E2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:19107226
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Michaelis M, Doerr HW, Cinatl J
  Title
The story of human cytomegalovirus and cancer: increasing evidence and open questions.
  Journal
Neoplasia 11:1-9 (2009)
DOI:10.1593/neo.81178
Reference
PMID:24839861
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Roy S, Arav-Boger R
  Title
New cell-signaling pathways for controlling cytomegalovirus replication.
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Am J Transplant 14:1249-58 (2014)
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Reference
PMID:14720582
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Cinatl J, Scholz M, Kotchetkov R, Vogel JU, Doerr HW
  Title
Molecular mechanisms of the modulatory effects of HCMV infection in tumor cell biology.
  Journal
Trends Mol Med 10:19-23 (2004)
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Reference
PMID:15380778
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Evers DL, Wang X, Huang ES
  Title
Cellular stress and signal transduction responses to human cytomegalovirus infection.
  Journal
Microbes Infect 6:1084-93 (2004)
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Reference
PMID:29547547
  Authors
Murray MJ, Peters NE, Reeves MB
  Title
Navigating the Host Cell Response during Entry into Sites of Latent Cytomegalovirus Infection.
  Journal
Pathogens 7:E30 (2018)
DOI:10.3390/pathogens7010030
Reference
PMID:27501260
  Authors
Campadelli-Fiume G, Collins-McMillen D, Gianni T, Yurochko AD
  Title
Integrins as Herpesvirus Receptors and Mediators of the Host Signalosome.
  Journal
Annu Rev Virol 3:215-236 (2016)
DOI:10.1146/annurev-virology-110615-035618
Reference
PMID:28132838
  Authors
Fu YZ, Su S, Gao YQ, Wang PP, Huang ZF, Hu MM, Luo WW, Li S, Luo MH, Wang YY, Shu HB
  Title
Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity.
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Cell Host Microbe 21:231-243 (2017)
DOI:10.1016/j.chom.2017.01.001
Reference
PMID:29082387
  Authors
Hancock MH, Nelson JA
  Title
Modulation of the NFkappab Signalling Pathway by Human Cytomegalovirus.
  Journal
Virology (Hyderabad) 1:104 (2017)
Reference
PMID:21383764
  Authors
Rahman MM, McFadden G
  Title
Modulation of NF-kappaB signalling by microbial pathogens.
  Journal
Nat Rev Microbiol 9:291-306 (2011)
DOI:10.1038/nrmicro2539
Reference
PMID:27060663
  Authors
Zhang J, Feng H, Xu S, Feng P
  Title
Hijacking GPCRs by viral pathogens and tumor.
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Biochem Pharmacol 114:69-81 (2016)
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Related
pathway
dle00590  Arachidonic acid metabolism
dle03050  Proteasome
dle04010  MAPK signaling pathway
dle04064  NF-kappa B signaling pathway
dle04110  Cell cycle
dle04150  mTOR signaling pathway
dle04151  PI3K-Akt signaling pathway
dle04210  Apoptosis
dle04612  Antigen processing and presentation
dle04623  Cytosolic DNA-sensing pathway
dle04630  JAK-STAT signaling pathway
dle04668  TNF signaling pathway
dle04810  Regulation of actin cytoskeleton
KO pathway
ko05163   

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