KEGG   PATHWAY: els04010
Entry
els04010                    Pathway                                
Name
MAPK signaling pathway - Esox lucius (northern pike)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
els04010  MAPK signaling pathway
els04010

Other DBs
GO: 0000165
Organism
Esox lucius (northern pike) [GN:els]
Gene
105012190  cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
105024166  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
105014924  voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
105014228  voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
105023097  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
105006991  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
105007355  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
105020186  voltage-dependent R-type calcium channel subunit alpha-1E isoform X6 [KO:K04852]
105029164  cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
105022404  voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
105008776  voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
105023045  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X9 [KO:K04854]
105008290  cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
105024153  voltage-dependent T-type calcium channel subunit alpha-1I isoform X2 [KO:K04856]
105030898  voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
105013561  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1 [KO:K04857]
105016828  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1 [KO:K04857]
105020378  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
105018430  voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
105025419  cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
105028112  voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
105006995  voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
105014015  voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
105023094  cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
105031141  voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
105013307  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
105031374  cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X2 [KO:K04863]
105026314  voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
105023164  voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
105016118  cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
105013015  voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
105021571  cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
105031192  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
105008357  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
105010309  voltage-dependent calcium channel gamma-3 subunit-like isoform X1 [KO:K04868]
105030719  cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
105013014  voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
105021570  cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
105026134  voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
105021569  cacng5; voltage-dependent calcium channel gamma-5 subunit isoform X2 [KO:K04870]
105019022  voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
105025870  voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
105019085  voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
105025872  voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
105019021  voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
105025871  voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
105013090  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105008738  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105029732  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
105019307  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105021568  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105026133  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105009402  protein kinase C beta type-like isoform X4 [KO:K19662] [EC:2.7.11.13]
105030718  prkcb; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
105019084  protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
105006302  gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
105011763  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
105012885  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1 [KO:K04347]
105024071  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
105010896  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
105006198  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105014753  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105029501  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105026748  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
106024317  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
105021516  calcineurin subunit B type 1 [KO:K06268]
105025695  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
105016644  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
105014758  rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
105015690  rasgrp1; RAS guanyl-releasing protein 1 [KO:K04350]
105027019  RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
105010908  RAS guanyl-releasing protein 2 [KO:K12361]
105020724  rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
105023235  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
105027765  rapgef2; rap guanine nucleotide exchange factor 2 isoform X3 [KO:K08018]
105013024  neurofibromin isoform X1 [KO:K08052]
105028667  nf1; neurofibromin isoform X1 [KO:K08052]
105014649  rasa1; ras GTPase-activating protein 1 isoform X2 [KO:K04352]
105012570  rasa2; ras GTPase-activating protein 2 [KO:K08053]
105023688  rap1a; RAP1A, member of RAS oncogene family [KO:K04353]
105022336  rap1b; RAP1B, member of RAS oncogene family [KO:K04353]
105017798  rap1b; ras-related protein Rap-1b [KO:K07836]
105027559  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
105016898  protransforming growth factor alpha isoform X2 [KO:K08774]
105008249  proepiregulin isoform X2 [KO:K09784]
105011240  putative fibroblast growth factor 1 [KO:K18496]
105025969  putative fibroblast growth factor 1 [KO:K18496]
105028130  fgf2; fibroblast growth factor 2 [KO:K18497]
105011535  fgf22; fibroblast growth factor 22 [KO:K04358]
105012239  fibroblast growth factor 8b isoform X1 [KO:K04358]
105007510  fibroblast growth factor 8 isoform X1 [KO:K04358]
109616700  fibroblast growth factor 4A-like isoform X1 [KO:K04358]
105017565  fgf3; fibroblast growth factor 3 [KO:K04358]
105026179  fibroblast growth factor 18 isoform X1 [KO:K04358]
105014730  fibroblast growth factor 10 [KO:K04358]
105022659  fgf7; fibroblast growth factor 7 [KO:K04358]
105018229  fgf6; fibroblast growth factor 6 [KO:K04358]
105018277  fibroblast growth factor 3-like [KO:K04358]
105018278  fibroblast growth factor 4B [KO:K04358]
105006764  fgf5; fibroblast growth factor 5 [KO:K04358]
105029255  fibroblast growth factor 18 [KO:K04358]
105014412  fgf10; fibroblast growth factor 10 [KO:K04358]
105020244  fibroblast growth factor 4B-like [KO:K04358]
105014140  fgf17; fibroblast growth factor 17 [KO:K04358]
105021023  fibroblast growth factor 20 [KO:K04358]
105030037  fgf16; fibroblast growth factor 16 isoform X1 [KO:K04358]
105017296  fgf4; fibroblast growth factor 4 [KO:K04358]
105026497  fibroblast growth factor 20 [KO:K04358]
105028255  fibroblast growth factor 18 isoform X1 [KO:K04358]
105017556  fgf19; fibroblast growth factor 19 [KO:K22603]
109615792  fgf21; fibroblast growth factor 21 [KO:K22429]
105020243  fibroblast growth factor 23 [KO:K22428]
105007566  nerve growth factor [KO:K02582]
105028952  nerve growth factor [KO:K02582]
105022251  bdnf; brain-derived neurotrophic factor isoform X3 [KO:K04355]
109614653  ntf3; neurotrophin-3 isoform X3 [KO:K04356]
105025960  insulin [KO:K04526]
105021727  insulin [KO:K04526]
105030158  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
105005983  insulin-like growth factor II [KO:K13769]
105012099  platelet-derived growth factor subunit A [KO:K04359]
105021652  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
105012081  transcription activator MSS11 isoform X1 [KO:K17386]
105027646  pdgfc; platelet-derived growth factor C [KO:K05450]
105024074  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
105016804  macrophage colony-stimulating factor 1 [KO:K05453]
105020288  uncharacterized protein LOC105020288 isoform X2 [KO:K05461]
105018304  kitlg; kit ligand [KO:K05461]
105026727  vegfb; vascular endothelial growth factor B [KO:K05448]
105006584  vascular endothelial growth factor A-A isoform X1 [KO:K05448]
105017629  vascular endothelial growth factor A-A isoform X5 [KO:K05448]
105017540  snake venom vascular endothelial growth factor toxin ICPP [KO:K16859]
105026447  pgf; placenta growth factor isoform X1 [KO:K16859]
105024500  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
105019936  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
105030013  vascular endothelial growth factor C [KO:K05449]
105020379  hepatocyte growth factor isoform X2 [KO:K05460]
105018431  hepatocyte growth factor isoform X1 [KO:K05460]
105012765  angpt1; angiopoietin-1 [KO:K05465]
105018891  angiopoietin-1 [KO:K05465]
105008642  angiopoietin-2 [KO:K05466]
105021347  angpt2; angiopoietin-2 [KO:K05466]
105011408  ephrin-A2 isoform X1 [KO:K05462]
105024467  ephrin-A4 [KO:K05462]
105024466  efna3; ephrin-A3 [KO:K05462]
105019815  ephrin-A2-like isoform X1 [KO:K05462]
105027147  ephrin-A1 [KO:K05462]
105027148  ephrin-A3 [KO:K05462]
105015058  ephrin-A5 isoform X2 [KO:K05462]
105023350  efna5; ephrin-A5 isoform X2 [KO:K05462]
105024464  ephrin-A1 [KO:K05462]
105025178  gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
105014584  glial cell line-derived neurotrophic factor-like [KO:K05452]
105023692  neurturin [KO:K25414]
109616022  neurturin [KO:K25414]
105011891  artn; artemin isoform X1 [KO:K25415]
109615175  glial cell line-derived neurotrophic factor-like [KO:K25415]
109616089  persephin-like [KO:K25416]
105027310  melanoma receptor tyrosine-protein kinase [KO:K04361] [EC:2.7.10.1]
105019998  epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
105030222  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105008046  receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
105017227  receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
105023139  receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
105016195  receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
105015194  fibroblast growth factor receptor 1-A [KO:K04362] [EC:2.7.10.1]
105014025  fibroblast growth factor receptor 1-A-like isoform X4 [KO:K04362] [EC:2.7.10.1]
105010630  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
105015916  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105011125  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
105006338  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
105012986  tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
105018750  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
105019278  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
105027931  BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
105014455  ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
105005877  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
105022623  insulin receptor [KO:K04527] [EC:2.7.10.1]
105016672  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105023472  igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105011836  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105025839  platelet-derived growth factor receptor beta-like isoform X1 [KO:K05089] [EC:2.7.10.1]
105030015  platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
105025838  macrophage colony-stimulating factor 1 receptor 1 isoform X1 [KO:K05090] [EC:2.7.10.1]
105030014  macrophage colony-stimulating factor 1 receptor 1 [KO:K05090] [EC:2.7.10.1]
105011837  kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
105020866  mast/stem cell growth factor receptor kita [KO:K05091] [EC:2.7.10.1]
105021947  flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
105029482  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
105021948  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
105026780  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
105011839  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
105029522  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
105020503  tek; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
105013703  ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
105025429  ephrin type-A receptor 2-like isoform X1 [KO:K05103] [EC:2.7.10.1]
105028647  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X3 [KO:K05126] [EC:2.7.10.1]
105012273  growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
105013161  growth factor receptor-bound protein 2 [KO:K04364]
105025539  sos2; son of sevenless homolog 2 [KO:K03099]
105026828  son of sevenless homolog 1 isoform X3 [KO:K03099]
105018344  hras; GTPase HRas [KO:K02833]
105022136  kras; GTPase KRas isoform X1 [KO:K07827]
105029053  GTPase HRas-like [KO:K07827]
105022267  rras2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
105029096  rras; ras-related protein R-Ras [KO:K07830]
105019972  ras-related protein M-Ras [KO:K07831]
105026246  ras-related protein M-Ras isoform X1 [KO:K07831]
105014388  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
105006078  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105013076  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
105029139  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
105006978  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105011557  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105020581  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
105023295  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
105012809  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105006515  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105006075  MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
105028139  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
105011671  mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
105006544  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
105030211  rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
105027683  ribosomal protein S6 kinase alpha-3 isoform X2 [KO:K04373] [EC:2.7.11.1]
105021344  ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
105021995  ribosomal protein S6 kinase alpha-3 isoform X2 [KO:K04373] [EC:2.7.11.1]
105008440  atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105029665  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105006467  elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
105025447  ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
105019386  transcriptional regulator Myc [KO:K04377]
105029935  transcriptional regulator Myc-2 [KO:K04377]
105023685  myc; myc proto-oncogene protein [KO:K04377]
105010673  serum response factor isoform X1 [KO:K04378]
105030761  serum response factor isoform X1 [KO:K04378]
105005940  proto-oncogene c-Fos-like [KO:K04379]
105005941  proto-oncogene c-Fos [KO:K04379]
105026425  proto-oncogene c-Fos-like isoform X1 [KO:K04379]
105006079  mapt; microtubule-associated protein tau isoform X1 [KO:K04380]
105023364  microtubule-associated protein tau [KO:K04380]
105012645  uncharacterized protein LOC105012645 [KO:K04381]
105008413  uncharacterized protein LOC105008413 [KO:K04381]
105029083  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
105028802  cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
105031348  tumor necrosis factor-like [KO:K03156]
105007339  interleukin-1 beta [KO:K04519]
105009489  interleukin-1 beta isoform X1 [KO:K04519]
105010856  transforming growth factor beta-1 proprotein [KO:K13375]
105027026  transforming growth factor beta-1 proprotein [KO:K13375]
105007294  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
105026733  transforming growth factor beta-2 proprotein [KO:K13376]
105015709  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
105029941  transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
105013803  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105019071  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105016335  interleukin-1 receptor type 1 [KO:K04386]
105016334  interleukin-1 receptor type 1 [KO:K04386]
105016333  interleukin-1 receptor type 1-like [KO:K04386]
105006651  interleukin-1 receptor accessory protein [KO:K04723]
105019479  TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
105024259  TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
105012782  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
105023521  tgfbr2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
105030836  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
105011736  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105014159  tumor necrosis factor [KO:K04389]
105022722  tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
105026138  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105031492  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105022954  rac2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
105031187  rac2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
105005703  rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
105031329  ras-related C3 botulinum toxin substrate 3 [KO:K07861]
105013744  cdc42; uncharacterized protein LOC105013744 [KO:K04393]
105029961  cell division control protein 42 homolog [KO:K04393]
105025850  cell division control protein 42 homolog [KO:K04393]
105025458  cell division control protein 42 homolog isoform X1 [KO:K04393]
105016269  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105029385  casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105006735  casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105015142  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
105014393  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
105015035  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
105028589  daxx; death domain-associated protein 6 [KO:K02308]
105007691  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
105028326  irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
105026619  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
105025313  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
105030709  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
105011357  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
105011762  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
105015060  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
105024086  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
105031193  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
105017897  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
105020716  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
105006890  mitogen-activated protein kinase kinase kinase kinase 3 isoform X9 [KO:K04406] [EC:2.7.11.1]
105026822  mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
105016331  map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X12 [KO:K04407] [EC:2.7.11.1]
105027314  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
105010576  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
105011658  pak2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
105019806  serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
105010087  serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
105027710  serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
105020711  mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
105024640  mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
105019416  map3k8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
105021721  map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
105020697  map3k11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
105019952  map3k2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
105012974  map3k3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
105007693  mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
105015920  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
105011943  map3k10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
105021218  map3k21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
105030567  mitogen-activated protein kinase kinase kinase 12 isoform X2 [KO:K04423] [EC:2.7.11.25]
105026325  mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
105006267  map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
105007215  mitogen-activated protein kinase kinase kinase 20-like [KO:K04424] [EC:2.7.11.25]
105016206  map3k20; mitogen-activated protein kinase kinase kinase 20 isoform X2 [KO:K04424] [EC:2.7.11.25]
105019305  mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
105017906  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
105017873  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
105015746  mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
105008100  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X3 [KO:K04428] [EC:2.7.11.25]
105005890  taok3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
105023190  serine/threonine-protein kinase TAO1 isoform X2 [KO:K04429] [EC:2.7.11.1]
105024368  serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
105028334  taok2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
105031161  serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
105014913  serine/threonine-protein kinase TAO3-like [KO:K04429] [EC:2.7.11.1]
105023011  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
105022938  dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
105021508  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
105027407  dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
105031287  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
105018289  mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
105022191  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X5 [KO:K04435]
105012833  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
105013504  filamin-A isoform X2 [KO:K04437]
105005921  adapter molecule crk [KO:K04438]
105015072  crkl; crk-like protein [KO:K04438]
105024111  adapter molecule crk [KO:K04438]
105027656  arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
105027032  beta-arrestin-1 [KO:K04439]
105023937  arrestin red cell isoform X1 [KO:K04439]
105006595  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105031053  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105024911  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
105025816  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105027233  mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
105007426  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
105023895  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
105018147  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
105020225  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
105020226  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
105013860  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105023872  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
105014602  mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
105013205  MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
105017185  MAP kinase-activated protein kinase 2 [KO:K04444] [EC:2.7.11.1]
105017320  MAP kinase-activated protein kinase 2 [KO:K04444] [EC:2.7.11.1]
105026862  ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
105010921  ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
105015857  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
105028214  nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
105031624  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
105018090  nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
105022674  nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
105011734  transcription factor AP-1 [KO:K04448]
105022094  jun; transcription factor AP-1 [KO:K04448]
105020506  transcription factor AP-1 [KO:K04448]
105026205  jund; transcription factor jun-D [KO:K04449]
105016218  atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
105008589  cellular tumor antigen p53-like isoform X1 [KO:K04451]
105020676  cellular tumor antigen p53 [KO:K04451]
105028306  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
105024334  max; protein max [KO:K04453]
105015679  protein max isoform X5 [KO:K04453]
105014655  mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
105015210  myocyte-specific enhancer factor 2C [KO:K04454]
105014911  heat shock protein beta-1 [KO:K04455]
105027776  hspb1; heat shock protein beta-1 [KO:K04455]
105023568  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105017614  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105015651  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105024916  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105021234  akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105021541  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105012088  protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
105017648  protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
105026983  protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
105015567  protein phosphatase 1A isoform X2 [KO:K04457] [EC:3.1.3.16]
105023110  ptprr; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
105007395  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
105027769  ptpn7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
105026777  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
105012120  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105007393  dusp8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105013553  dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105014742  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105029097  uncharacterized protein LOC105029097 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105029132  dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105026527  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105018300  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
105015321  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
105007528  dusp3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
105028432  dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
105027029  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
105006041  protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
105021243  ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
105029202  heat shock 70 kDa protein [KO:K03283]
105019107  heat shock cognate 71 kDa protein [KO:K03283]
106024497  heat shock 70 kDa protein-like [KO:K03283]
105012826  heat shock 70 kDa protein [KO:K03283]
105023216  heat shock cognate 70 kDa protein [KO:K03283]
105006577  heat shock cognate 70 kDa protein-like [KO:K03283]
114840508  heat shock 70 kDa protein-like [KO:K03283]
114828708  heat shock 70 kDa protein-like [KO:K03283]
105028966  heat shock cognate 70 kDa protein [KO:K03283]
105024028  mecom; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
105013604  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
105007802  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
105022309  probable nuclear hormone receptor HR38 isoform X4 [KO:K04465]
105017087  nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
105013210  mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
105007974  mitogen-activated protein kinase kinase kinase 14 isoform X2 [KO:K04466] [EC:2.7.11.25]
105006906  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105010696  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105014298  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105030753  ikbkg; NF-kappa-B essential modulator [KO:K07210]
105008258  serine/threonine-protein kinase NLK2 [KO:K04468] [EC:2.7.11.24]
105014125  nlk; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
105029910  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105010701  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
105020694  putative transcription factor p65 homolog [KO:K04735]
105012012  relb; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
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Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
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Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Reference
PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Reference
PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Reference
PMID:22296764
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Reference
PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
els04070  Phosphatidylinositol signaling system
els04110  Cell cycle
els04115  p53 signaling pathway
els04210  Apoptosis
els04310  Wnt signaling pathway
KO pathway
ko04010   
LinkDB

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