KEGG   PATHWAY: chx05014
Entry
chx05014                    Pathway                                
Name
Amyotrophic lateral sclerosis - Capra hircus (goat)
Description
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by a progressive degeneration of motor neurons in the brain and spinal cord. In 90% of patients, ALS is sporadic, with no clear genetic linkage. On the other hand, the remaining 10% of cases show familial inheritance, with mutations in SOD1, TDP43(TARDBP), FUS, or C9orf72 genes being the most frequent causes. In spite of such difference, familial ALS and sporadic ALS have similarities in their pathological features. Proposed disease mechanisms contributing to motor neuron degeneration in ALS are: impaired proteostasis, aberrant RNA processing, mitochondrial disfunction and oxidative stress, microglia activation, and axonal dysfunction.
Class
Human Diseases; Neurodegenerative disease
Pathway map
chx05014  Amyotrophic lateral sclerosis
chx05014

Organism
Capra hircus (goat) [GN:chx]
Gene
102169621  TP53; cellular tumor antigen p53 [KO:K04451]
102176106  BID; BH3-interacting domain death agonist [KO:K04726]
100861254  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
102180684  BCL2L1; bcl-2-like protein 1 [KO:K04570]
102183607  bcl-2-like protein 1 [KO:K04570]
100846984  BAX; apoptosis regulator BAX isoform X3 [KO:K02159]
102189930  BAD; bcl2-associated agonist of cell death [KO:K02158]
102188830  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
106501717  cytochrome c 2 [KO:K08738]
102173997  cytochrome c [KO:K08738]
102174681  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
102177031  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100861196  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
1485856  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
1485857  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
1485863  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
1485865  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
1485864  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
1485866  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
1485867  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
102184322  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
102176841  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
102183643  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X2 [KO:K03944]
102177419  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
102177332  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
102172091  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
102179638  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
100861284  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
102187560  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
102171224  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
102176032  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
102168736  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
102179361  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
102181922  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
102170842  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
102181026  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
102187118  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
102189802  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
102174090  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
102168216  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
102177927  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
102189432  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
102182696  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
102171860  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
100861349  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
102188420  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
102168407  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
102188663  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
100861376  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
102190747  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
102188065  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
102170635  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
102170016  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
102181207  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform X1 [KO:K03939]
100860782  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
102185248  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
102186141  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
102182202  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
102183107  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
102183195  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
102189176  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
100860881  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
102172289  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
1485868  CYTB; cytochrome b [KO:K00412]
102169976  cytochrome c1, heme protein, mitochondrial [KO:K00413]
102188264  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
100861263  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
102176290  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
102183616  cytochrome b-c1 complex subunit 7 [KO:K00417]
102171149  cytochrome b-c1 complex subunit 8 [KO:K00418]
102187154  cytochrome b-c1 complex subunit 9 [KO:K00419]
108635646  cytochrome b-c1 complex subunit 9 [KO:K00419]
102168533  cytochrome b-c1 complex subunit 10 [KO:K00420]
1485862  COX3; cytochrome c oxidase subunit III [KO:K02262]
1485858  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
1485859  COX2; cytochrome c oxidase subunit II [KO:K02261]
102179296  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
102188434  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
102191741  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
102179291  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
102172376  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
102181181  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
102184937  cytochrome c oxidase subunit 6B2 [KO:K02267]
102179036  cytochrome c oxidase subunit 6B1 [KO:K02267]
102173770  cytochrome c oxidase subunit 6C [KO:K02268]
108635087  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
102187496  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
102188675  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
102175610  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
102186286  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
102184512  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
102170877  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
102173562  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
108633170  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
102188021  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
102184488  ATP5A1; ATP synthase subunit alpha, mitochondrial [KO:K02132]
102186463  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
102171890  ATP5C1; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
102188764  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
102188061  ATP5E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
102173355  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
1485861  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
102178499  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
102180353  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
102168606  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
102168293  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
102173603  ATP5H; ATP synthase subunit d, mitochondrial [KO:K02138]
102170632  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
102187983  ATP5J; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
1485860  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
102173290  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
102189919  TOMM40L; mitochondrial import receptor subunit TOM40B [KO:K11518]
102172257  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
102184878  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
102190832  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
102172812  PARK2; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
102172458  OPTN; optineurin isoform X1 [KO:K19946]
102172251  SQSTM1; sequestosome-1 [KO:K14381]
106502794  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
102175424  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
102185857  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
102181474  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
102185959  TANK; TRAF family member-associated NF-kappa-B activator isoform X3 [KO:K12650]
102173303  WDR41; WD repeat-containing protein 41 [KO:K23610]
102191734  SMCR8; Smith-Magenis syndrome chromosomal region candidate gene 8 protein [KO:K23611]
102168257  C8H9orf72; protein C9orf72 homolog [KO:K23609]
102180027  RAB8A; ras-related protein Rab-8A [KO:K07901]
102171959  RAB39B; ras-related protein Rab-39B [KO:K07925]
100860796  RAB1A; ras-related protein Rab-1A [KO:K07874]
100860902  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
102173325  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
102179415  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
102185716  ATG101; autophagy-related protein 101 [KO:K19730]
102169203  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
102180777  RB1CC1; RB1-inducible coiled-coil protein 1 [KO:K17589]
102184456  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
102187882  BECN2; beclin-2 [KO:K08334]
102190728  BECN1; beclin-1 [KO:K08334]
108635484  LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 4-like [KO:K08333] [EC:2.7.11.1]
102177934  phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
102173093  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
108637522  nuclear receptor-binding factor 2-like isoform X1 [KO:K21246]
102177130  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
102171561  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
102169649  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
102176171  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
102180716  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
102179237  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
102172771  ALS2; alsin isoform X2 [KO:K04575]
102184478  RAB5A; ras-related protein Rab-5A [KO:K07887]
102173438  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102187985  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
102184062  FIG4; polyphosphoinositide phosphatase isoform X1 [KO:K22913] [EC:3.1.3.-]
102191339  SPG11; spatacsin isoform X1 [KO:K19026]
102176770  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102179767  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102184033  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102177339  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
102182602  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
102185079  UBQLN2; ubiquilin-2 [KO:K04523]
102186397  UBQLN1; ubiquilin-1 isoform X1 [KO:K04523]
102175914  UBQLN4; ubiquilin-4 [KO:K04523]
102171726  ubiquilin-3 [KO:K04523]
102178357  VCP; transitional endoplasmic reticulum ATPase [KO:K13525]
102169311  DERL1; derlin-1 [KO:K11519]
100860840  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
102188113  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
102184096  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
102172642  PSMA7; proteasome subunit alpha type-7 isoform X1 [KO:K02731] [EC:3.4.25.1]
102187178  PSMA8; proteasome subunit alpha type-7-like isoform X1 [KO:K02731] [EC:3.4.25.1]
102186449  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
102190150  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
102168353  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
102176996  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
102182415  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
102175796  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
102181749  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
102175024  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
102182039  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
102178323  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
102191015  PSMC2; 26S protease regulatory subunit 7 [KO:K03061]
102190237  PSMC1; 26S protease regulatory subunit 4 [KO:K03062]
102186623  PSMC4; 26S protease regulatory subunit 6B [KO:K03063]
102180674  PSMC6; 26S protease regulatory subunit 10B [KO:K03064]
102187246  PSMC3; 26S protease regulatory subunit 6A [KO:K03065]
102176071  PSMC5; 26S protease regulatory subunit 8 [KO:K03066]
102183547  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
102187906  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
102176558  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
102169405  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
102183635  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
102187430  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
102180165  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
102174773  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
102181192  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
102173623  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
102185511  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
102176723  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
102185667  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
102190848  SHFM1; 26S proteasome complex subunit DSS1 [KO:K10881]
102183307  HDAC6; histone deacetylase 6 [KO:K11407] [EC:3.5.1.98]
102186419  TARDBP; TAR DNA-binding protein 43 isoform X1 [KO:K23600]
102171834  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
102177568  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
102187459  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741]
102189034  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
102177976  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
102172646  heterogeneous nuclear ribonucleoprotein A3 [KO:K12741]
106503022  heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741]
102172032  HNRNPA2B1; heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1 [KO:K13158]
102180146  ATXN2; ataxin-2 isoform X1 [KO:K23625]
102181918  ATXN2L; ataxin-2-like protein isoform X1 [KO:K23625]
102191234  MATR3; matrin-3 isoform X1 [KO:K13213]
106502530  angiogenin-1-like [KO:K16631] [EC:3.1.27.-]
102174398  angiogenin-1 [KO:K16631] [EC:3.1.27.-]
102185565  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
102180256  ALYREF; THO complex subunit 4 [KO:K12881]
102180637  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
102177636  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
102177698  LOW QUALITY PROTEIN: nuclear RNA export factor 3-like [KO:K14284]
102183400  nuclear RNA export factor 2 [KO:K14284]
102182285  NXF3; nuclear RNA export factor 3 [KO:K14284]
102186192  NXF1; nuclear RNA export factor 1 [KO:K14284]
102180832  NXT2; NTF2-related export protein 2 [KO:K14285]
102172640  NXT1; NTF2-related export protein 1 [KO:K14285]
102176615  GLE1; nucleoporin GLE1 isoform X2 [KO:K18723]
102176447  TPR; nucleoprotein TPR [KO:K09291]
102171314  NUP50; nuclear pore complex protein Nup50 [KO:K14295]
102171943  NUP153; nuclear pore complex protein Nup153 [KO:K14296]
102191442  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
102169026  RAE1; mRNA export factor [KO:K14298]
102184673  SEC13; protein SEC13 homolog [KO:K14004]
102180174  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
102183038  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
102174276  NUP107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
102176022  NUP37; nucleoporin Nup37 [KO:K14302]
102188880  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
102171914  NUP85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
102189126  NUP43; nucleoporin Nup43 isoform X1 [KO:K14305]
102173643  NUP62CL; nucleoporin-62 C-terminal-like protein [KO:K14306]
102187158  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
102168273  NUP58; nucleoporin p58/p45 [KO:K14307]
102188127  NUP54; nucleoporin p54 [KO:K14308]
102189510  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
102191303  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
102168360  NUP188; nucleoporin NUP188 homolog [KO:K14311]
102170363  NUP155; nuclear pore complex protein Nup155 [KO:K14312]
102189169  NUP35; nucleoporin NUP53 [KO:K14313]
102172495  NUP210; LOW QUALITY PROTEIN: nuclear pore membrane glycoprotein 210 [KO:K14314]
102182083  NUP210L; LOW QUALITY PROTEIN: nuclear pore membrane glycoprotein 210-like [KO:K14314]
102179725  NDC1; nucleoporin NDC1 [KO:K14315]
102177485  POM121L2; POM121-like protein 2 [KO:K14316]
102181259  nuclear envelope pore membrane protein POM 121C [KO:K14316]
102185190  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
102171645  NUP88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
102172632  E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
102177068  SETX; probable helicase senataxin isoform X1 [KO:K10706] [EC:5.6.2.5 5.6.2.3]
106503062  CHCHD10; coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial [KO:K22759]
102185663  HSPA5; endoplasmic reticulum chaperone BiP precursor [KO:K09490] [EC:3.6.4.10]
102176246  VAPB; vesicle-associated membrane protein-associated protein B/C [KO:K10707]
102184016  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
102175557  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
102173038  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
102184460  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
102184255  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
102172156  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
102185575  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
100861133  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
102185072  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102184768  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102185566  SIGMAR1; sigma non-opioid intracellular receptor 1 [KO:K20719]
100861232  TNF; tumor necrosis factor [KO:K03156]
102190310  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102191447  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
102188387  DAXX; death domain-associated protein 6 [KO:K02308]
108636199  LOW QUALITY PROTEIN: death domain-associated protein 6-like [KO:K02308]
102173967  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
102169516  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
102180926  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
100860996  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102189174  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102184510  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
102185490  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
102179171  CCS; copper chaperone for superoxide dismutase [KO:K04569]
102188950  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
102184023  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
102189207  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
102190911  GPX8; probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
102181442  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
102168676  GPX6; glutathione peroxidase 6 [KO:K00432] [EC:1.11.1.9]
102168954  epididymal secretory glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
100860855  CAT; catalase [KO:K03781] [EC:1.11.1.6]
102191212  PRPH; peripherin isoform X1 [KO:K07607]
102179945  NEFL; neurofilament light polypeptide [KO:K04572]
102182504  NEFM; neurofilament medium polypeptide [KO:K04573]
102190538  NEFH; neurofilament heavy polypeptide [KO:K04574]
102176115  profilin-2-like [KO:K05759]
102183109  PFN2; profilin-2 isoform X1 [KO:K05759]
102171251  PFN4; profilin-4 [KO:K05759]
102178723  PFN3; profilin-3 [KO:K05759]
102175326  PFN1; profilin-1 [KO:K05759]
102170746  profilin-2 [KO:K05759]
100860883  ACTG1; actin, cytoplasmic 2 [KO:K05692]
102179831  ACTB; actin, cytoplasmic 1 [KO:K05692]
102173262  ANXA11; annexin A11 [KO:K17095]
102183571  ANXA7; annexin A7 isoform X1 [KO:K17095]
102174633  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
102188541  KIF5C; kinesin heavy chain [KO:K10396]
102184256  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
102187797  KLC3; kinesin light chain 3 [KO:K10407]
102174462  KLC2; kinesin light chain 2 [KO:K10407]
102173138  KLC4; kinesin light chain 4 [KO:K10407]
102173837  tubulin alpha-3 chain isoform X1 [KO:K07374]
102187765  tubulin alpha-3 chain [KO:K07374]
102187059  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
102178119  tubulin alpha-1D chain [KO:K07374]
102177846  tubulin alpha-4A chain [KO:K07374]
102176404  TUBA8; tubulin alpha-8 chain [KO:K07374]
102178426  LOW QUALITY PROTEIN: tubulin alpha-1C chain [KO:K07374]
102177410  TUBA1A; tubulin alpha-1A chain [KO:K07374]
108636002  TUBA1C; tubulin alpha-1C chain [KO:K07374]
102178700  tubulin alpha-1B chain [KO:K07374]
102188330  TUBB1; tubulin beta-1 chain isoform X2 [KO:K07375]
102178062  TUBB4A; tubulin beta-4A chain [KO:K07375]
102184900  TUBB4B; tubulin beta-4B chain [KO:K07375]
102181148  tubulin beta-3 chain [KO:K07375]
102178409  TUBB6; tubulin beta-6 chain [KO:K07375]
102168953  TUBB; tubulin beta chain [KO:K07375]
108633269  TUBB2A; tubulin beta-2A chain [KO:K07375]
102172952  tubulin beta-2B chain [KO:K07375]
102175305  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
102187922  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
102172264  DCTN3; dynactin subunit 3 [KO:K10425]
102188039  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
102171396  DCTN5; dynactin subunit 5 [KO:K10427]
100861094  DCTN6; dynactin subunit 6 [KO:K10428]
102169727  ACTR1A; alpha-centractin [KO:K16575]
102179572  ACTR1B; beta-centractin isoform X1 [KO:K16575]
102191706  ACTR10; actin-related protein 10 [KO:K16576]
106503205  HAP1; LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647]
102169141  DNAH7; dynein heavy chain 7, axonemal [KO:K10408]
102177929  DNAH5; dynein heavy chain 5, axonemal [KO:K10408]
102188326  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
102175517  DNAH9; dynein heavy chain 9, axonemal [KO:K10408]
102170098  DNAH12; dynein heavy chain 12, axonemal [KO:K10408]
102185229  DNAH8; dynein heavy chain 8, axonemal [KO:K10408]
102179503  DNAH10; dynein heavy chain 10, axonemal [KO:K10408]
102178942  DNAH17; dynein heavy chain 17, axonemal [KO:K10408]
102182332  DNAH14; dynein heavy chain 14, axonemal [KO:K10408]
102170175  DNAH2; dynein heavy chain 2, axonemal [KO:K10408]
102173136  DNAH1; dynein heavy chain 1, axonemal [KO:K10408]
102188822  DNAH3; LOW QUALITY PROTEIN: dynein heavy chain 3, axonemal [KO:K10408]
106501759  DNAH11; dynein heavy chain 11, axonemal [KO:K10408]
102174801  DNALI1; LOW QUALITY PROTEIN: axonemal dynein light intermediate polypeptide 1 [KO:K10410]
102170421  DNAI1; dynein intermediate chain 1, axonemal isoform X1 [KO:K10409]
102189796  DNAI2; LOW QUALITY PROTEIN: dynein intermediate chain 2, axonemal [KO:K11143]
102185189  DNAL1; dynein light chain 1, axonemal [KO:K10411]
102184042  DNAL4; dynein light chain 4, axonemal [KO:K10412]
102172085  SLC1A2; excitatory amino acid transporter 2 isoform X3 [KO:K05613]
100860742  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
102171059  GRIA1; glutamate receptor 1 isoform X3 [KO:K05197]
102168378  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
102181789  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
102189537  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
108636054  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
102177097  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
102177187  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
102182565  NRG1; pro-neuregulin-1, membrane-bound isoform isoform X1 [KO:K05455]
102185177  NRG2; pro-neuregulin-2, membrane-bound isoform isoform X1 [KO:K05456]
102168328  NRG3; pro-neuregulin-3, membrane-bound isoform isoform X1 [KO:K05457]
102184950  NRG4; pro-neuregulin-4, membrane-bound isoform [KO:K05458]
102180167  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
Compound
C00001  H2O
C00008  ADP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00039  DNA
C00046  RNA
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C16844  Hydroxyl radical
C16845  Peroxynitrite
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Related
pathway
chx00190  Oxidative phosphorylation
chx03013  Nucleocytoplasmic transport
chx03050  Proteasome
chx04010  MAPK signaling pathway
chx04012  ErbB signaling pathway
chx04020  Calcium signaling pathway
chx04115  p53 signaling pathway
chx04137  Mitophagy - animal
chx04140  Autophagy - animal
chx04141  Protein processing in endoplasmic reticulum
chx04210  Apoptosis
chx04724  Glutamatergic synapse
chx04810  Regulation of actin cytoskeleton
KO pathway
ko05014   
LinkDB

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