KEGG   PATHWAY: clum05132
Entry
clum05132                   Pathway                                
Name
Salmonella infection - Cyclopterus lumpus (lumpfish)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
clum05132  Salmonella infection
clum05132

Organism
Cyclopterus lumpus (lumpfish) [GN:clum]
Gene
117726201  podxl; podocalyxin [KO:K06817]
117729165  ptprc; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
117738981  ras-related protein Rab-5A [KO:K07887]
117728044  ras-related protein Rab-5A [KO:K07887]
117750149  rab5b; ras-related protein Rab-5B [KO:K07888]
117748854  ras-related protein Rab-5C-like [KO:K07889]
117734820  rab5c; ras-related protein Rab-5C [KO:K07889]
117747790  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
117730775  ras-related protein rab7-like [KO:K07897]
117730316  si:dkey-13a21.4; ras-related protein rab7 isoform X1 [KO:K07897]
117730347  ras-related protein rab7 [KO:K07897]
117748505  plekhm1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
117742993  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
117743940  vps16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
117727905  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
117736722  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
117751285  vps39; vam6/Vps39-like protein isoform X1 [KO:K20183]
117749673  vps41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
117741931  rilp; RILP-like protein 1 [KO:K13883]
117751571  dync1h1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
117741134  LOW QUALITY PROTEIN: cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
117750255  dynein, cytoplasmic 1, intermediate chain 2a-like isoform X1 [KO:K10415]
117739533  LOW QUALITY PROTEIN: cytoplasmic dynein 1 intermediate chain 1 [KO:K10415]
117746151  dynein, cytoplasmic 1, intermediate chain 2a-like isoform X1 [KO:K10415]
117748089  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
117739483  dync1li1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
117744032  dync2li1; cytoplasmic dynein 2 light intermediate chain 1 isoform X1 [KO:K10417]
117736218  dynll1; dynein light chain 1, cytoplasmic [KO:K10418]
117742565  dynll2b; dynein, light chain, LC8-type 2b [KO:K10418]
117741378  dynll2a; dynein, light chain, LC8-type 2a [KO:K10418]
117730746  dynlrb1; dynein light chain roadblock-type 1 [KO:K10419]
117732226  dynein light chain roadblock-type 2-like isoform X1 [KO:K10419]
117750336  dynein light chain Tctex-type 3-like isoform X1 [KO:K10420]
117727599  dynlt1; dynein light chain Tctex-type 1 [KO:K10420]
117741327  dynein light chain Tctex-type 3-like [KO:K10420]
117725243  dctn1b; dynactin subunit 1 isoform X1 [KO:K04648]
117747638  dynactin subunit 1-like isoform X1 [KO:K04648]
117730785  dctn2; dynactin subunit 2 isoform X1 [KO:K10424]
117745160  dctn3; dynactin subunit 3 [KO:K10425]
117737509  dctn4; dynactin subunit 4 [KO:K10426]
117734963  dctn5; dynactin subunit 5 [KO:K10427]
117748186  dynactin subunit 6-like [KO:K10428]
117731691  dynactin subunit 6-like [KO:K10428]
117740717  actr1; actin related protein 1, centractin [KO:K16575]
117727722  actr10; actin-related protein 10 [KO:K16576]
117742161  tubulin alpha chain-like isoform X1 [KO:K07374]
117731092  tubulin alpha-1B chain-like [KO:K07374]
117742354  tubulin alpha-1C chain-like [KO:K07374]
117727250  tubulin alpha chain-like [KO:K07374]
117732969  tuba1c; tubulin alpha-1C chain [KO:K07374]
117733118  tubulin alpha chain-like [KO:K07374]
117733119  tubulin alpha chain-like [KO:K07374]
117733120  tubulin alpha chain-like [KO:K07374]
117733121  tubulin alpha chain-like [KO:K07374]
117733122  tubulin alpha chain-like [KO:K07374]
117733123  tubulin alpha-1C chain-like isoform X1 [KO:K07374]
117733290  tubulin alpha chain-like [KO:K07374]
117745611  si:ch211-114n24.6; tubulin alpha-1A chain [KO:K07374]
117751049  tubulin alpha chain [KO:K07374]
117751050  tubulin alpha chain-like [KO:K07374]
117751051  tubulin alpha chain-like [KO:K07374]
117733892  tuba5; LOW QUALITY PROTEIN: tubulin alpha 5 [KO:K07374]
117730752  tubb1; tubulin beta-1 chain [KO:K07375]
117736074  tubb2b; tubulin beta-2b chain [KO:K07375]
117745466  tubb5; tubulin beta-5 chain [KO:K07375]
117745956  tubulin beta chain-like isoform X1 [KO:K07375]
117751336  tubulin beta-4B chain [KO:K07375]
117734875  tubb4bl; tubulin beta chain [KO:K07375]
117730304  zgc:65894; tubulin beta-4B chain isoform X1 [KO:K07375]
117729292  fyco1a; FYVE and coiled-coil domain-containing protein 1 isoform X1 [KO:K21954]
117746465  FYVE and coiled-coil domain-containing protein 1-like [KO:K21954]
117730817  arl8bb; ADP-ribosylation factor-like 8Bb [KO:K07955]
117730850  arl8ba; ADP-ribosylation factor-like protein 8B-A [KO:K07955]
117733073  ADP-ribosylation factor-like protein 8A [KO:K07955]
117733204  plekhm2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348]
117731004  kif5ab; kinesin heavy chain isoform X1 [KO:K10396]
117749548  kinesin-1 heavy chain-like [KO:K10396]
117750309  kinesin heavy chain-like [KO:K10396]
117745001  kinesin heavy chain-like [KO:K10396]
117733480  kif5aa; kinesin family member 5Aa [KO:K10396]
117746086  kinesin-1 heavy chain [KO:K10396]
117743715  klc1b; kinesin light chain 1b isoform X1 [KO:K10407]
117751187  klc1a; kinesin light chain 1 isoform X1 [KO:K10407]
117741633  klc3; kinesin light chain 3 isoform X1 [KO:K10407]
117747803  klc2; kinesin light chain 2 [KO:K10407]
117727274  acbd3; Golgi resident protein GCP60 isoform X1 [KO:K23935]
117730678  rho-related GTP-binding protein RhoA-B [KO:K04513]
117733369  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
117733461  rho-related GTP-binding protein RhoA-D [KO:K04513]
117733462  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
117733905  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
117745481  m6pr; cation-dependent mannose-6-phosphate receptor [KO:K10089]
117742930  ras-related protein Rab-9A-like [KO:K07899]
117750065  rab9a; ras-related protein Rab-9A [KO:K07899]
117737888  rab9b; ras-related protein Rab-9B [KO:K07900]
117750134  GRIP and coiled-coil domain-containing protein 2 [KO:K20282]
117733371  syntaxin-10 [KO:K23937]
117729311  profilin-2-like isoform X1 [KO:K05759]
117746794  profilin-2-like [KO:K05759]
117747872  profilin-like [KO:K05759]
117733562  flna; filamin-A isoform X1 [KO:K04437]
117748467  exoc7; exocyst complex component 7 isoform X1 [KO:K07195]
117751375  exoc5; exocyst complex component 5 [KO:K19984]
117726013  exoc4; exocyst complex component 4 [KO:K06111]
117729152  exoc2; exocyst complex component 2 [KO:K17637]
117749646  ralaa; v-ral simian leukemia viral oncogene homolog Aa (ras related) [KO:K07834]
117739169  actb1; actin, cytoplasmic 1 [KO:K05692]
117734597  actb2; actin, cytoplasmic 2 [KO:K05692]
117745318  s100a10b; protein S100-A10b [KO:K17274]
117739540  s100a10a; protein S100-A10a isoform X1 [KO:K17274]
117732005  LOW QUALITY PROTEIN: annexin A2-like [KO:K17092]
117738567  zgc:101785; annexin A2 [KO:K17092]
117728501  annexin A2-like [KO:K17092]
117737255  ahnak; neuroblast differentiation-associated protein AHNAK [KO:K23934]
117732334  si:ch211-69b7.6; neuroblast differentiation-associated protein AHNAK [KO:K23934]
117741205  rho guanine nucleotide exchange factor 26-like isoform X1 [KO:K13744]
117742609  rhogb; ras homolog family member Gb isoform X1 [KO:K07863]
117737400  rhogd; ras homolog gene family, member Gd [KO:K07863]
117738871  elmo1; engulfment and cell motility protein 1 [KO:K12366]
117730954  elmo2; engulfment and cell motility protein 2 [KO:K18985]
117727562  rho-associated protein kinase 2-like [KO:K17388] [EC:2.7.11.1]
117751367  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
117736120  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
117736346  myosin regulatory light chain 2, atrial isoform-like [KO:K12754]
117731387  myosin regulatory light polypeptide 9 [KO:K12755]
117749655  myl12.1; myosin, light chain 12, genome duplicate 1 [KO:K12757]
117746624  myl12.2; myosin, light chain 12, genome duplicate 2 [KO:K12757]
117749039  mylpfb; myosin light chain, phosphorylatable, fast skeletal muscle b [KO:K12758]
117734734  mylpfa; myosin light chain, phosphorylatable, fast skeletal muscle a [KO:K12758]
117748770  fhod1; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938]
117732983  cell division control protein 42 homolog [KO:K04393]
117738805  cell division control protein 42 homolog [KO:K04393]
117745495  cdc42l; cell division cycle 42, like [KO:K04393]
117730294  cdc42; cell division control protein 42 homolog [KO:K04393]
117748690  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
117734495  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
117743750  nckap1; nck-associated protein 1 isoform X1 [KO:K05750]
117730324  nckap1l; nck-associated protein 1-like [KO:K05750]
117737315  cyfip2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
117730101  cyfip1; cytoplasmic FMR1-interacting protein 1 homolog [KO:K05749]
117749360  abi1a; abl interactor 1a isoform X1 [KO:K23649]
117745953  abl interactor 1-like isoform X1 [KO:K23649]
117730804  brk1; probable protein BRICK1 [KO:K05752]
117748113  zgc:109889; wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
117742934  wasf3a; wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
117749621  wasf3b; wiskott-Aldrich syndrome protein family member 3b [KO:K06083]
117743777  actin-related protein 2-A [KO:K17260]
117733013  actr2a; actin-related protein 2-A [KO:K17260]
117747655  zgc:101810; actin-related protein 2 [KO:K17260]
117750133  actin-related protein 3-like [KO:K18584]
117745730  actin-related protein 3 [KO:K18584]
117733603  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
117730446  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
117735682  zgc:86896; actin-related protein 2/3 complex subunit 1A-A [KO:K05757]
117742858  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
117740137  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
117731253  actin-related protein 2/3 complex subunit 4-like [KO:K05755]
117731390  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
117729622  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
117746953  actin-related protein 2/3 complex subunit 5-like isoform X1 [KO:K05754]
117728115  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
117742384  LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
117725423  myo6b; myosin VIb [KO:K10358]
117727206  myo6a; myosin VIa isoform X1 [KO:K10358]
117732996  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117729144  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117746514  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117741125  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117747650  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
117725922  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
117734085  si:rp71-17i16.5; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
117731766  pik3c2g; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923] [EC:2.7.1.154]
117731808  pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
117730401  pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1 [KO:K00923] [EC:2.7.1.154]
117748435  cytohesin-3 [KO:K18441]
117748647  LOW QUALITY PROTEIN: cytohesin-1-like [KO:K18441]
117730840  cyth4b; cytohesin 4b isoform X1 [KO:K18441]
117745244  si:dkey-283b15.4; cytohesin-2 isoform X1 [KO:K18441]
117734509  cyth1a; cytohesin-1a isoform X1 [KO:K18441]
117734862  cytohesin-4-like isoform X1 [KO:K18441]
117735206  cyth3b; cytohesin-3 [KO:K18441]
117725170  arf6b; ADP-ribosylation factor 6b [KO:K07941]
117727002  arf6a; ADP-ribosylation factor 6a [KO:K07941]
117749132  arf2b; ADP-ribosylation factor 2b [KO:K07937]
117746504  arf1; ADP-ribosylation factor 1 [KO:K07937]
117734848  arf2a; ADP-ribosylation factor 2a [KO:K07937]
117736254  snx18a; sorting nexin-18a [KO:K17923]
117727094  snx9b; sorting nexin-9b [KO:K17923]
117732339  snx33; sorting nexin-33 [KO:K17923]
117740863  sorting nexin-18-like [KO:K17923]
117726000  waslb; WASP like actin nucleation promoting factor b isoform X1 [KO:K23612]
117732820  wasla; WASP like actin nucleation promoting factor a isoform X1 [KO:K23612]
117726156  dynamin-2-like isoform X1 [KO:K23484] [EC:3.6.5.5]
117735108  dnm2a; dynamin-3 isoform X1 [KO:K23484] [EC:3.6.5.5]
117745125  tlr18; toll-like receptor 18 isoform X1 [KO:K10159]
117746792  toll-like receptor 2 [KO:K10159]
117747505  toll-like receptor 2 [KO:K10159]
117741390  tirap; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
117749486  myd88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
117727165  toll-like receptor 5 [KO:K10168]
117727225  toll-like receptor 5 [KO:K10168]
117733039  irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
117731873  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
117749526  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
117727180  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
117751516  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
117730776  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
117727088  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
117729460  tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
117732959  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
117748347  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
117744348  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
117736821  ikbkb; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
117727519  nfkbiaa; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a [KO:K04734]
117751264  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
117737787  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
117747396  rela; transcription factor p65 isoform X1 [KO:K04735]
117728004  nod1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
117727014  hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [KO:K04079]
117727016  hsp90aa1.1; heat shock protein HSP 90-alpha 1 [KO:K04079]
117727060  hsp90ab1; heat shock protein HSP 90-beta isoform X1 [KO:K04079]
117732103  hsp90b1; endoplasmin [KO:K09487]
117745930  receptor-interacting serine/threonine-protein kinase 2-like isoform X1 [KO:K08846] [EC:2.7.11.1]
117731021  cse1l; LOW QUALITY PROTEIN: exportin-2 [KO:K18423]
117749908  kpna1; importin subunit alpha-5 [KO:K23940]
117750244  kpna3; importin subunit alpha-4 [KO:K23583]
117741677  kpna4; importin subunit alpha-3 [KO:K23583]
117728122  rps3; 40S ribosomal protein S3 [KO:K02985]
117732119  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
117733950  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
117732847  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
117746647  map2k2b; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
117729985  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
117736137  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117735491  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
117748744  map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
117735377  dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
117731084  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
117726208  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
117726295  mapk12b; mitogen-activated protein kinase 12b isoform X1 [KO:K04441] [EC:2.7.11.24]
117732507  mapk12a; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
117733162  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
117734021  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
117734164  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
117749226  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
117735077  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
117735363  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
117748413  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117737372  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
117743832  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117740127  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117725194  fosaa; proto-oncogene c-Fos [KO:K04379]
117727586  proto-oncogene c-Fos-like [KO:K04379]
117727588  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
117740649  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
117746578  jun; transcription factor AP-1 [KO:K04448]
117736885  interleukin-1 beta-like [KO:K04519]
117739248  interleukin-6-like [KO:K05405]
117737801  cxcl8a; interleukin-8 isoform X1 [KO:K10030]
117747746  cxcl19; C-X-C motif chemokine 19 [KO:K10030]
117747747  permeability factor 2-like [KO:K10030]
117738892  catenin beta-1-like [KO:K02105]
117745083  ctnnb1; catenin beta-1 [KO:K02105]
117742499  tcf7; transcription factor 7 isoform X1 [KO:K02620]
117736417  tcf7l1b; transcription factor 7-like 1-B isoform X1 [KO:K04490]
117740101  transcription factor 7-like 1-A [KO:K04490]
117748491  tcf7l2; LOW QUALITY PROTEIN: transcription factor 7-like 2 [KO:K04491]
117733594  lef1; lymphoid enhancer-binding factor 1 [KO:K04492]
117749293  myca; transcriptional regulator Myc-A [KO:K04377]
117738971  pkn1a; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
117734731  serine/threonine-protein kinase N1-like isoform X1 [KO:K06071] [EC:2.7.11.13]
117750257  fbxo22; F-box only protein 22 [KO:K10302]
117743043  skp1; S-phase kinase-associated protein 1 [KO:K03094]
117745471  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117734050  si:ch211-112c15.8; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 25 [KO:K03158]
117735999  traf2a; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
117740351  traf2b; LOW QUALITY PROTEIN: TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
117740886  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
117750749  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
117743263  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
117746125  ripk1l; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
117738814  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
117745477  gapdh; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
117749953  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
117751134  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
117735912  hdr; hematopoietic death receptor isoform X1 [KO:K04722]
117740781  tnfrsfa; tumor necrosis factor receptor superfamily, member a [KO:K04722]
117747456  fadd; FAS-associated death domain protein [KO:K02373]
117750208  casp10; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
117746198  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
117746199  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
117732832  receptor-interacting serine/threonine-protein kinase 3-like isoform X1 [KO:K08847] [EC:2.7.11.1]
117747537  ripk3; receptor-interacting serine/threonine-protein kinase 3 isoform X1 [KO:K08847] [EC:2.7.11.1]
117725985  zgc:153993; apoptosis regulator BAX [KO:K02159]
117734463  apoptosis regulator BAX-like [KO:K02159]
117744473  cytochrome c [KO:K08738]
117750947  cytochrome c-like [KO:K08738]
117739467  cytochrome c-a-like [KO:K08738]
117746625  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
117730679  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
117737645  caspase-3-like [KO:K02187] [EC:3.4.22.56]
117748561  casp7; caspase-7 [KO:K04397] [EC:3.4.22.60]
117740104  caspase-3-like isoform X1 [KO:K04397] [EC:3.4.22.60]
117727493  rho-related GTP-binding protein RhoB-like [KO:K07856]
117739317  rhoh; rho-related GTP-binding protein RhoH [KO:K07873]
117742397  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
117743684  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117732835  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117751396  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117741120  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117732595  mixed lineage kinase domain-like protein isoform X1 [KO:K08849] [EC:2.7.11.1]
117747457  txn; thioredoxin [KO:K03671]
117735534  txn2; thioredoxin, mitochondrial [KO:K03671]
117728246  pycard; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
117728247  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
117741247  caspase-1-like isoform X1 [KO:K01370] [EC:3.4.22.36]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
clum04010  MAPK signaling pathway
clum04210  Apoptosis
clum04217  Necroptosis
clum04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

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