Entry
Name
MAPK signaling pathway - Esox lucius (northern pike)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Esox lucius (northern pike) [GN:
els ]
Gene
105012190 cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344 ]
105024166 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344 ]
105014924 voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849 ]
105014228 voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849 ]
105023097 cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850 ]
105006991 voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851 ]
105007355 cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851 ]
105020186 voltage-dependent R-type calcium channel subunit alpha-1E isoform X6 [KO:K04852 ]
105029164 cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852 ]
105022404 voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853 ]
105008776 voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853 ]
105023045 cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X9 [KO:K04854 ]
105008290 cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855 ]
105024153 voltage-dependent T-type calcium channel subunit alpha-1I isoform X2 [KO:K04856 ]
105030898 voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856 ]
105013561 dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1 [KO:K04857 ]
105016828 dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1 [KO:K04857 ]
105020378 voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858 ]
105018430 voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858 ]
105025419 cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859 ]
105028112 voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859 ]
105006995 voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860 ]
105014015 voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860 ]
105023094 cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861 ]
105031141 voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861 ]
105013307 cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862 ]
105031374 cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X2 [KO:K04863 ]
105026314 voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864 ]
105023164 voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865 ]
105016118 cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865 ]
105021571 cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866 ]
105010309 voltage-dependent calcium channel gamma-3 subunit-like isoform X1 [KO:K04868 ]
105030719 cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868 ]
105021570 cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869 ]
105021569 cacng5; voltage-dependent calcium channel gamma-5 subunit isoform X2 [KO:K04870 ]
105025870 voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871 ]
105006302 gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346 ]
105011763 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
105012885 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1 [KO:K04347 ]
105024071 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
105010896 serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105006198 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105014753 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105029501 ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105026748 serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105025695 rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349 ]
105014758 rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326 ]
105027765 rapgef2; rap guanine nucleotide exchange factor 2 isoform X3 [KO:K08018 ]
105017540 snake venom vascular endothelial growth factor toxin ICPP [KO:K16859 ]
105024500 vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449 ]
105019936 vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449 ]
105012986 tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583 ]
105008440 atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374 ]
105029941 transforming growth factor beta-3 proprotein isoform X1 [KO:K13377 ]
105011736 faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
105022722 tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
105026138 ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
105022954 rac2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860 ]
105031187 rac2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860 ]
105005703 rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
105016269 tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
105007691 myd88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
105030709 gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402 ]
105011357 gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
105011762 growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402 ]
105015060 growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402 ]
105024086 gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402 ]
105031193 tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403 ]
105017897 tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404 ]
105020716 ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405 ]
105018289 mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434 ]
105022191 mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X5 [KO:K04435 ]
105012833 mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436 ]
105031624 nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
105018090 nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
105016218 atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450 ]
105014655 mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454 ]
105017087 nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465 ]
105029910 nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
105010701 nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference
Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
Title
MAP kinases.
Journal
Reference
Authors
Tanoue T, Nishida E.
Title
Docking interactions in the mitogen-activated protein kinase cascades.
Journal
Reference
Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
Title
MAPK pathways in radiation responses.
Journal
Reference
Authors
Huang EJ, Reichardt LF.
Title
Trk receptors: roles in neuronal signal transduction.
Journal
Reference
Authors
Harper SJ, LoGrasso P.
Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
Journal
Reference
Authors
Takeda K, Ichijo H
Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
Journal
Reference
Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
Title
Transcriptional regulation by the MAP kinase signaling cascades.
Journal
Reference
Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
Journal
Reference
Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
Journal
Reference
Authors
Lemmon MA, Schlessinger J
Title
Cell signaling by receptor tyrosine kinases.
Journal
Reference
Authors
Skaper SD
Title
The neurotrophin family of neurotrophic factors: an overview.
Journal
Reference
Authors
Chu WM
Title
Tumor necrosis factor.
Journal
Reference
Authors
Newton K, Dixit VM
Title
Signaling in innate immunity and inflammation.
Journal
Reference
Authors
Gaestel M, Kotlyarov A, Kracht M
Title
Targeting innate immunity protein kinase signalling in inflammation.
Journal
Reference
Authors
Ajibade AA, Wang HY, Wang RF
Title
Cell type-specific function of TAK1 in innate immune signaling.
Journal
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Related pathway
els04070 Phosphatidylinositol signaling system
KO pathway
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