KEGG   PATHWAY: mpuf05022
Entry
mpuf05022                   Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Mustela putorius furo (domestic ferret)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
mpuf05022  Pathways of neurodegeneration - multiple diseases
mpuf05022

Organism
Mustela putorius furo (domestic ferret) [GN:mpuf]
Gene
101686001  APP; amyloid beta A4 protein [KO:K04520]
101679947  MAPT; microtubule-associated protein tau isoform X2 [KO:K04380]
101689417  SNCA; alpha-synuclein [KO:K04528]
101671013  LOW QUALITY PROTEIN: TAR DNA-binding protein 43-like [KO:K23600]
101677431  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
101673938  FUS; RNA-binding protein FUS isoform X3 [KO:K13098]
101670031  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
101691584  ATXN2; ataxin-2 [KO:K23625]
101680666  ATXN2L; ataxin-2-like protein [KO:K23625]
101687209  HTT; huntingtin [KO:K04533]
101675346  ATXN1; ataxin-1 [KO:K23616]
101671672  ATXN1L; ataxin-1-like [KO:K23616]
101684939  ATXN3; ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
101677643  PRNP; major prion protein [KO:K05634]
101681312  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101670723  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
101679448  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
101687155  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
101686929  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
101683208  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
101674115  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
101689578  PARK2; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
101679345  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101673753  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
101687768  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
101678347  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
101685356  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101679339  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101680372  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101671536  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101675176  TRPC3; short transient receptor potential channel 3 isoform X1 [KO:K04966]
101683740  SIGMAR1; sigma non-opioid intracellular receptor 1 [KO:K20719]
101677799  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
101684131  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101688102  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
101672983  RYR1; ryanodine receptor 1 [KO:K04961]
101677570  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
101679745  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
101676977  PDYN; proenkephalin-B [KO:K15840]
101677223  DLG4; disks large homolog 4 isoform X1 [KO:K11828]
101683487  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
101672107  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
101683074  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101674678  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
101691917  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
101691708  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
101694457  GRIA2; glutamate receptor 2 isoform X5 [KO:K05198]
101674543  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
101684476  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
101673094  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X2 [KO:K04849]
101679746  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X10 [KO:K04850]
101669870  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101689134  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
101688476  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
101682413  STX1A; syntaxin-1A [KO:K04560]
101681443  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
101674156  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
101688541  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
101690442  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
101692341  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
101693386  PSEN2; presenilin-2 isoform X7 [KO:K04522] [EC:3.4.23.-]
101673904  DERL1; derlin-1 [KO:K11519]
101692211  VCP; transitional endoplasmic reticulum ATPase isoform X1 [KO:K13525]
101673211  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
101686900  ubiquitin-like [KO:K02927]
101674222  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
101673526  polyubiquitin-like [KO:K04551]
101680590  polyubiquitin-B isoform X3 [KO:K04551]
101687891  UBC; polyubiquitin-C [KO:K04551]
101694465  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
101682226  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
101688003  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
101685934  PSMA8; proteasome subunit alpha type-7-like [KO:K02731] [EC:3.4.25.1]
101678084  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
101688820  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
101691417  LOW QUALITY PROTEIN: proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
101693287  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
101681087  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
101689827  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
101673192  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
101682336  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
101681952  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
101684806  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
101677063  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
101692243  PSMB4; proteasome subunit beta type-4 isoform X3 [KO:K02736] [EC:3.4.25.1]
101689387  26S protease regulatory subunit 7-like [KO:K03061]
101691078  PSMC2; 26S protease regulatory subunit 7 [KO:K03061]
101691713  PSMC1; 26S protease regulatory subunit 4 [KO:K03062]
101689211  PSMC4; 26S protease regulatory subunit 6B [KO:K03063]
101689832  PSMC6; 26S protease regulatory subunit 10B isoform X1 [KO:K03064]
101688313  PSMC3; 26S protease regulatory subunit 6A [KO:K03065]
106004683  ATP-dependent zinc metalloprotease YME1L1-like [KO:K03066]
101671803  PSMC5; 26S protease regulatory subunit 8 isoform X1 [KO:K03066]
101679423  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
101677647  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
101689542  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
101681801  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
101682559  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
101682352  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
101670551  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
101690051  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
101674526  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X2 [KO:K03039]
101672325  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
101670572  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
101687128  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
101687725  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
101683996  SHFM1; 26S proteasome complex subunit DSS1 [KO:K10881]
101671160  UCHL1; ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
101680877  UBA1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
101671149  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
101674853  UBE2L3; ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
101687700  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1 [KO:K04553] [EC:2.3.2.23]
101693314  UBE2J2; ubiquitin-conjugating enzyme E2 J2 isoform X1 [KO:K04554] [EC:2.3.2.23]
101688713  UBE2J1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
101689646  UBE2G2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
101690012  UBE2G1; ubiquitin-conjugating enzyme E2 G1 isoform X1 [KO:K10575] [EC:2.3.2.23]
101682826  GPR37; prosaposin receptor GPR37 [KO:K04243]
101690500  SEPT5; septin-5 isoform X1 [KO:K04557]
101673611  SNCAIP; synphilin-1 isoform X1 [KO:K04558]
101693461  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
101691521  VAPB; vesicle-associated membrane protein-associated protein B/C isoform X1 [KO:K10707]
101689116  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
101684783  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101682738  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
101689378  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
101691230  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
101686402  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101690814  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
101672072  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101681349  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101676423  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101670985  caspase-12-like [KO:K04741] [EC:3.4.22.-]
101688180  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
101689747  EIF2AK3; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
101692556  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101680524  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101694124  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
101689277  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
101682150  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
101677220  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
101694351  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
101679801  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
101683103  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
101681305  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
101671885  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
101678258  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
101678946  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
101671166  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
101688416  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
101673253  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
101686920  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
101675000  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
101680168  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
101693615  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
101679477  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
101682163  acyl carrier protein, mitochondrial [KO:K03955]
101684673  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
101674482  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
101679389  NDUFA13; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
101694062  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
101674641  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial isoform X2 [KO:K03958]
101683892  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
101691663  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
101687434  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
101688606  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
101675882  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
101675804  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
101682240  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
101681324  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
101682983  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
101693700  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
101688652  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
101686313  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
101674933  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
101684469  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
101692362  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial-like [KO:K03939]
101688718  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
101674706  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
101679983  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
101691647  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
101678403  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
101678731  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
101692858  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
101685355  LOW QUALITY PROTEIN: succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
101680264  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
101694292  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
101674608  cytochrome c1, heme protein, mitochondrial [KO:K00413]
101694055  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
101672152  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
101685926  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit 2, mitochondrial-like [KO:K00415]
101681748  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
101680018  cytochrome b-c1 complex subunit 7 [KO:K00417]
101683221  cytochrome b-c1 complex subunit 8 [KO:K00418]
101677535  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
101690736  cytochrome b-c1 complex subunit 10 [KO:K00420]
101680163  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
101676075  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
101679783  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
101684324  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
101679257  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
106003852  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
101689659  cytochrome c oxidase subunit 6B1 [KO:K02267]
101670731  cytochrome c oxidase subunit 6B2 [KO:K02267]
101693169  cytochrome c oxidase subunit 6C [KO:K02268]
101672219  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
101693652  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
101682432  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
101672021  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
101691909  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
101673376  ATP5A1; ATP synthase subunit alpha, mitochondrial [KO:K02132]
101670112  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
101689814  ATP5C1; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
101677101  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
101683533  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
101672934  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
101673943  ATP5G2; LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
106005210  LOW QUALITY PROTEIN: uncharacterized protein LOC106005210 [KO:K02128]
106006495  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
101690076  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
101693434  ATP5H; ATP synthase subunit d, mitochondrial [KO:K02138]
101677485  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
101678985  ATP5J; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
101681308  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101679422  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101678959  TOMM40L; mitochondrial import receptor subunit TOM40B [KO:K11518]
101680015  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
101679131  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
101674862  CALM3; calmodulin [KO:K02183]
101674924  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
101681170  calmodulin-like [KO:K02183]
101681446  calmodulin-like protein 3 [KO:K02183]
101688912  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
101683659  CALM2; calmodulin [KO:K02183]
101691254  CALM1; calmodulin [KO:K02183]
101675854  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101675984  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101682554  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101675380  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101688800  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101686427  BAD; bcl2-associated agonist of cell death [KO:K02158]
101687517  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101677976  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
101671860  FADD; FAS-associated death domain protein [KO:K02373]
101678102  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
101686636  BID; BH3-interacting domain death agonist [KO:K04726]
101681070  BH3-interacting domain death agonist-like [KO:K04726]
101686802  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
101688916  BAK1; bcl-2 homologous antagonist/killer isoform X3 [KO:K14021]
101684592  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 [KO:K08844] [EC:2.7.11.1]
101681959  HTRA2; serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
101682570  TRAP1; heat shock protein 75 kDa, mitochondrial [KO:K09488]
101674296  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
101687790  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
101694615  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
101688977  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
101689099  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
101683729  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
101676150  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
106003371  cytochrome c, testis-specific [KO:K08738]
101690488  cytochrome c [KO:K08738]
101691091  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
101681290  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101690858  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
101677512  HIP1; huntingtin-interacting protein 1 isoform X1 [KO:K04559]
101681973  IFT57; intraflagellar transport protein 57 homolog isoform X1 [KO:K04638]
101693030  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
101683942  PPID; peptidyl-prolyl cis-trans isomerase D isoform X1 [KO:K05864] [EC:5.2.1.8]
101683731  PARK7; protein deglycase DJ-1 isoform X1 [KO:K05687] [EC:3.5.1.124]
101674297  BCL2L1; bcl-2-like protein 1 [KO:K04570]
101685303  MFN1; mitofusin-1 isoform X1 [KO:K21356] [EC:3.6.5.-]
101691353  MFN2; mitofusin-2 isoform X1 [KO:K06030] [EC:3.6.5.-]
101684024  OPTN; optineurin [KO:K19946]
101680892  SQSTM1; sequestosome-1 [KO:K14381]
101675711  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
101675872  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
101676992  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101694085  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
101687944  WDR41; WD repeat-containing protein 41 [KO:K23610]
101670526  SMCR8; Smith-Magenis syndrome chromosomal region candidate gene 8 protein [KO:K23611]
101687732  protein C9orf72 homolog [KO:K23609]
101687916  RAB8A; ras-related protein Rab-8A isoform X1 [KO:K07901]
101682696  RAB39B; ras-related protein Rab-39B [KO:K07925]
101682931  RAB1A; ras-related protein Rab-1A [KO:K07874]
101676245  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101670633  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
101682377  ULK2; LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
101682698  serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
101675999  ATG101; autophagy-related protein 101 [KO:K19730]
101679604  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
101692151  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
101680997  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
101680757  BECN1; beclin-1 isoform X2 [KO:K08334]
101684048  BECN2; beclin-2 [KO:K08334]
101684646  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
101681569  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
101679553  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
101691773  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
101674575  ATG2A; autophagy-related protein 2 homolog A isoform X2 [KO:K17906]
101688271  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
101676578  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
101691222  ZFYVE1; zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603]
101679702  ALS2; alsin isoform X1 [KO:K04575]
101684536  RAB5A; ras-related protein Rab-5A [KO:K07887]
101693834  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
101671627  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
101692520  FIG4; polyphosphoinositide phosphatase isoform X1 [KO:K22913] [EC:3.1.3.-]
101673468  SPG11; spatacsin [KO:K19026]
101687148  TNF; tumor necrosis factor isoform X1 [KO:K03156]
101676562  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101689344  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
101684105  DAXX; death domain-associated protein 6 isoform X3 [KO:K02308]
101679855  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
101670597  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
101684873  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
101692143  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101686271  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101684009  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101692439  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
101679788  CCS; copper chaperone for superoxide dismutase isoform X1 [KO:K04569]
101671982  GPX8; probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
101680193  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
101686834  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
101688198  GPX5; epididymal secretory glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
101675537  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
101682223  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
101689040  GPX6; glutathione peroxidase 6 [KO:K00432] [EC:1.11.1.9]
101682593  CAT; catalase [KO:K03781] [EC:1.11.1.6]
101693665  PRPH; peripherin [KO:K07607]
101689653  NEFL; neurofilament light polypeptide [KO:K04572]
101689943  NEFM; neurofilament medium polypeptide [KO:K04573]
101681011  NEFH; neurofilament heavy polypeptide isoform X1 [KO:K04574]
101672332  KIF5B; kinesin-1 heavy chain [KO:K10396]
101689294  KIF5A; kinesin heavy chain isoform 5A [KO:K10396]
101684053  KIF5C; kinesin heavy chain isoform 5C [KO:K10396]
101685097  KLC1; kinesin light chain 1 isoform X7 [KO:K10407]
101693620  KLC3; kinesin light chain 3 [KO:K10407]
101687767  KLC2; kinesin light chain 2 [KO:K10407]
101676637  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
101678877  tubulin alpha-8 chain [KO:K07374]
101692890  tubulin alpha-1A chain-like [KO:K07374]
101679966  tubulin alpha-1C chain [KO:K07374]
101680178  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
101680276  tubulin alpha-1B chain [KO:K07374]
101675663  TUBA3E; tubulin alpha-3E chain isoform X1 [KO:K07374]
101689201  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
101677236  TUBA4A; tubulin alpha-4A chain [KO:K07374]
101685931  TUBB6; tubulin beta-6 chain [KO:K07375]
101686650  tubulin beta-2B chain [KO:K07375]
101680362  TUBB3; tubulin beta-3 chain [KO:K07375]
101693433  TUBB4A; tubulin beta-4A chain [KO:K07375]
101674529  TUBB; tubulin beta chain [KO:K07375]
101670624  tubulin beta chain [KO:K07375]
101671254  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
101691057  TUBB4B; tubulin beta-4B chain isoform X1 [KO:K07375]
101692999  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101684867  CSNK2A1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
101673634  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
101680702  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
101687038  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
101672848  DCTN1; dynactin subunit 1 isoform X7 [KO:K04648]
101688644  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
101682549  DCTN3; dynactin subunit 3 isoform X2 [KO:K10425]
101677994  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
101680068  DCTN5; dynactin subunit 5 [KO:K10427]
101686473  DCTN6; dynactin subunit 6 [KO:K10428]
101678441  ACTR1A; alpha-centractin [KO:K16575]
101684030  ACTR1B; beta-centractin isoform X1 [KO:K16575]
101686683  ACTR10; actin-related protein 10 [KO:K16576]
101687210  LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647]
101691572  DNAH7; dynein heavy chain 7, axonemal [KO:K10408]
101679291  DNAH12; dynein heavy chain 12, axonemal isoform X1 [KO:K10408]
101673236  DNAH11; dynein heavy chain 11, axonemal isoform X1 [KO:K10408]
101673976  DNAH1; dynein heavy chain 1, axonemal isoform X1 [KO:K10408]
101674259  DNAH9; dynein heavy chain 9, axonemal isoform X4 [KO:K10408]
101693416  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
101674625  DNAH5; dynein heavy chain 5, axonemal [KO:K10408]
101680905  DNAH14; dynein heavy chain 14, axonemal isoform X5 [KO:K10408]
101674881  DNAH17; dynein heavy chain 17, axonemal isoform X5 [KO:K10408]
101682048  DNAH8; dynein heavy chain 8, axonemal isoform X1 [KO:K10408]
101682372  DNAH10; dynein heavy chain 10, axonemal isoform X1 [KO:K10408]
101677023  DNAH2; dynein heavy chain 2, axonemal isoform X1 [KO:K10408]
101671134  DNAH3; dynein heavy chain 3, axonemal isoform X1 [KO:K10408]
101692651  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
101679241  DNAI1; dynein intermediate chain 1, axonemal isoform X2 [KO:K10409]
101682859  DNAI2; dynein intermediate chain 2, axonemal [KO:K11143]
101679103  DNAL1; dynein light chain 1, axonemal isoform X2 [KO:K10411]
101672760  DNAL4; dynein light chain 4, axonemal [KO:K10412]
101681123  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
101682911  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101670702  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
101684734  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2 [KO:K04515] [EC:2.7.11.17]
101689283  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
101675244  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
101682656  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
101677047  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
101683818  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
101694003  DKK2; dickkopf-related protein 2 [KO:K02165]
101686225  DKK1; dickkopf-related protein 1 [KO:K02165]
101687505  DKK4; dickkopf-related protein 4 [KO:K02165]
101672619  WNT1; proto-oncogene Wnt-1 [KO:K03209]
101673430  WNT2; protein Wnt-2 [KO:K00182]
101688821  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
101683083  WNT3A; protein Wnt-3a isoform X1 [KO:K00312]
101683842  WNT3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
101687072  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
101675756  WNT5A; protein Wnt-5a [KO:K00444]
106004732  atherin-like [KO:K00444]
101676588  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
101692089  WNT6; protein Wnt-6 [KO:K00445]
101672097  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
101678897  WNT7A; protein Wnt-7a [KO:K00572]
101680834  WNT8A; LOW QUALITY PROTEIN: protein Wnt-8a [KO:K00714]
101677277  WNT8B; protein Wnt-8b [KO:K00714]
101682603  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
101684306  WNT9B; protein Wnt-9b [KO:K01064]
101672902  WNT10B; protein Wnt-10b [KO:K01357]
101692379  WNT10A; protein Wnt-10a [KO:K01357]
101680529  WNT11; protein Wnt-11 [KO:K01384]
101692294  WNT16; protein Wnt-16 [KO:K01558]
101680312  FZD7; frizzled-7 [KO:K02432]
101676104  FZD1; frizzled-1 [KO:K02432]
101685770  FZD2; frizzled-2 [KO:K02235]
101674595  FZD3; frizzled-3 isoform X1 [KO:K02329]
101680102  FZD4; frizzled-4 [KO:K02354]
101688794  FZD5; frizzled-5 [KO:K02375]
101680838  FZD6; frizzled-6 [KO:K02376]
101681159  FZD9; frizzled-9 [KO:K02842]
106003358  frizzled-9 [KO:K02842]
101691048  FZD10; frizzled-10 [KO:K02842]
101692817  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
101674621  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
101690214  casein kinase I isoform epsilon isoform X2 [KO:K08960] [EC:2.7.11.1]
101672500  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
101676333  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
101677876  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
101672972  GSK-3-binding protein FRAT2 [KO:K03096]
101671201  AXIN1; axin-1 isoform X1 [KO:K02157]
101677849  AXIN2; axin-2 isoform X1 [KO:K04385]
101673283  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
101687635  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
101689502  CTNNB1; catenin beta-1 [KO:K02105]
101689637  CSNK1A1; casein kinase I isoform alpha isoform X1 [KO:K08957] [EC:2.7.11.1]
101682399  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
101681355  HRAS; GTPase HRas isoform X1 [KO:K02833]
101681333  KRAS; GTPase KRas isoform X3 [KO:K07827]
101683038  NRAS; GTPase NRas [KO:K07828]
101687799  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
101671970  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
101690482  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101680975  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101678743  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101679748  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101671073  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101689704  NOX1; NADPH oxidase 1 [KO:K08008]
101677761  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
101683815  NOX4; NADPH oxidase 4 isoform X2 [KO:K21423] [EC:1.6.3.-]
101680239  RELA; transcription factor p65 [KO:K04735]
101680542  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101694448  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
101688096  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
101671465  IL6; interleukin-6 [KO:K05405]
101691850  IL1A; interleukin-1 alpha [KO:K04383]
101688006  IL1B; interleukin-1 beta [KO:K04519]
101686911  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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PMID:30258237
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Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
  Journal
Nat Neurosci 21:1300-1309 (2018)
DOI:10.1038/s41593-018-0237-7
Reference
PMID:28062563
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Dugger BN, Dickson DW
  Title
Pathology of Neurodegenerative Diseases.
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Cold Spring Harb Perspect Biol 9:a028035 (2017)
DOI:10.1101/cshperspect.a028035
Reference
PMID:20070435
  Authors
Jellinger KA
  Title
Basic mechanisms of neurodegeneration: a critical update.
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J Cell Mol Med 14:457-87 (2010)
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Reference
PMID:19707851
  Authors
Jellinger KA
  Title
Recent advances in our understanding of neurodegeneration.
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J Neural Transm (Vienna) 116:1111-62 (2009)
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Reference
PMID:30743990
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Van Bulck M, Sierra-Magro A, Alarcon-Gil J, Perez-Castillo A, Morales-Garcia JA
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Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease.
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Int J Mol Sci 20:E719 (2019)
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Reference
PMID:15272267
  Authors
Ross CA, Poirier MA
  Title
Protein aggregation and neurodegenerative disease.
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Nat Med 10 Suppl:S10-7 (2004)
DOI:10.1038/nm1066
Reference
PMID:30250260
  Authors
Soto C, Pritzkow S
  Title
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.
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Nat Neurosci 21:1332-1340 (2018)
DOI:10.1038/s41593-018-0235-9
Reference
PMID:25132814
  Authors
Dantuma NP, Bott LC
  Title
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution.
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Front Mol Neurosci 7:70 (2014)
DOI:10.3389/fnmol.2014.00070
Reference
PMID:25413678
  Authors
Zheng C, Geetha T, Babu JR
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Failure of ubiquitin proteasome system: risk for neurodegenerative diseases.
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Neurodegener Dis 14:161-75 (2014)
DOI:10.1159/000367694
Reference
PMID:32397599
  Authors
Park H, Kang JH, Lee S
  Title
Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates.
  Journal
Int J Mol Sci 21:E3369 (2020)
DOI:10.3390/ijms21093369
Reference
PMID:31783880
  Authors
Malik BR, Maddison DC, Smith GA, Peters OM
  Title
Autophagic and endo-lysosomal dysfunction in neurodegenerative disease.
  Journal
Mol Brain 12:100 (2019)
DOI:10.1186/s13041-019-0504-x
Reference
PMID:29734735
  Authors
Metaxakis A, Ploumi C, Tavernarakis N
  Title
Autophagy in Age-Associated Neurodegeneration.
  Journal
Cells 7:E37 (2018)
DOI:10.3390/cells7050037
Reference
PMID:25270767
  Authors
Vidal RL, Matus S, Bargsted L, Hetz C
  Title
Targeting autophagy in neurodegenerative diseases.
  Journal
Trends Pharmacol Sci 35:583-91 (2014)
DOI:10.1016/j.tips.2014.09.002
Reference
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Related
pathway
mpuf00190  Oxidative phosphorylation
mpuf03050  Proteasome
mpuf04020  Calcium signaling pathway
mpuf04120  Ubiquitin mediated proteolysis
mpuf04137  Mitophagy - animal
mpuf04140  Autophagy - animal
mpuf04141  Protein processing in endoplasmic reticulum
mpuf04142  Lysosome
mpuf04210  Apoptosis
mpuf04310  Wnt signaling pathway
mpuf04724  Glutamatergic synapse
mpuf04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   
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