KEGG   PATHWAY: ncar05166
Entry
ncar05166                   Pathway                                
Name
Human T-cell leukemia virus 1 infection - Sciurus carolinensis (gray squirrel)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
ncar05166  Human T-cell leukemia virus 1 infection
ncar05166

Organism
Sciurus carolinensis (gray squirrel) [GN:ncar]
Gene
124985724  solute carrier family 2, facilitated glucose transporter member 1 isoform X1 [KO:K07299]
124961609  neuropilin-1 isoform X1 [KO:K06724]
124965808  myc proto-oncogene protein [KO:K04377]
124969912  LOW QUALITY PROTEIN: transformation/transcription domain-associated protein-like [KO:K08874]
124959986  histone acetyltransferase KAT5 isoform X1 [KO:K11304] [EC:2.3.1.48]
124982598  G1/S-specific cyclin-D2 [KO:K10151]
124970604  integrin alpha-L-like isoform X1 [KO:K05718]
124992608  integrin beta-2 [KO:K06464]
124968554  intercellular adhesion molecule 1-like isoform X1 [KO:K06490]
124958599  GTPase HRas isoform X1 [KO:K02833]
124991017  GTPase KRas-like [KO:K07827]
124982118  GTPase KRas isoform X1 [KO:K07827]
124962389  GTPase NRas [KO:K07828]
124977990  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
124969568  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
124990635  LOW QUALITY PROTEIN: mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
124970294  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
124983047  T-cell surface glycoprotein CD4-like isoform X1 [KO:K06454]
124964375  talin-1 isoform X1 [KO:K06271]
124976148  talin-2 isoform X1 [KO:K06271]
124968386  ran-binding protein 3 isoform X1 [KO:K15304]
124991882  GTP-binding nuclear protein Ran [KO:K07936]
124963113  exportin-1 [KO:K14290]
124969172  calreticulin [KO:K08057]
124963061  calreticulin-like [KO:K08057]
124987395  calnexin isoform X1 [KO:K08054]
124992556  calnexin-like [KO:K08054]
124994051  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
124984768  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
124982403  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
124963548  calcineurin subunit B type 1 [KO:K06268]
124963939  calcineurin subunit B type 2 [KO:K06268]
124965416  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
124977074  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
124966545  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
124976754  nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
124981877  LOW QUALITY PROTEIN: interleukin-2 receptor subunit beta-like [KO:K05069]
124972015  cytokine receptor common subunit gamma-like isoform X1 [KO:K05070]
124977081  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
124968673  LOW QUALITY PROTEIN: tyrosine-protein kinase JAK3-like [KO:K11218] [EC:2.7.10.2]
124980612  signal transducer and activator of transcription 5A [KO:K11223]
124979870  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
124994815  LOW QUALITY PROTEIN: interleukin-2-like [KO:K05429]
124988087  putative HLA class I histocompatibility antigen, alpha chain H isoform X1 [KO:K06751]
124988293  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like isoform X1 [KO:K06751]
124988294  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
124988326  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
124988327  class I histocompatibility antigen, Gogo-C*0203 alpha chain-like isoform X1 [KO:K06751]
124988380  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
124989788  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
124977677  beta-2-microglobulin-like [KO:K08055]
124984753  farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
124986880  voltage-dependent anion-selective channel protein 1 [KO:K05862]
124994584  ADP/ATP translocase 4 isoform X1 [KO:K05863]
124972172  ADP/ATP translocase 3 [KO:K05863]
124972520  ADP/ATP translocase 2 [KO:K05863]
124983822  ADP/ATP translocase 1 [KO:K05863]
124984706  voltage-dependent anion-selective channel protein 2 [KO:K15040]
124983451  voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
124983005  translocator protein-like [KO:K05770]
124967291  protein VAC14 homolog isoform X1 [KO:K15305]
124990313  ran-specific GTPase-activating protein isoform X1 [KO:K15306]
124963305  LOW QUALITY PROTEIN: ran-specific GTPase-activating protein-like [KO:K15306]
124970253  mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
124994765  LOW QUALITY PROTEIN: mitotic spindle assembly checkpoint protein MAD2A-like [KO:K02537]
124994892  mitotic spindle assembly checkpoint protein MAD2A-like isoform X1 [KO:K02537]
124976879  mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
124985510  mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
124963058  anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
124964771  anaphase-promoting complex subunit 2 [KO:K03349]
124979876  cell division cycle protein 27 homolog isoform X1 [KO:K03350]
124994098  anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
124990690  anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
124984879  cell division cycle protein 16 homolog [KO:K03353]
124991612  anaphase-promoting complex subunit 7 [KO:K03354]
124994459  anaphase-promoting complex subunit 10 [KO:K03357]
124979693  anaphase-promoting complex subunit 11 [KO:K03358]
124964718  anaphase-promoting complex subunit CDC26 [KO:K03359]
124990583  anaphase-promoting complex subunit 13-like [KO:K12456]
124992568  anaphase-promoting complex subunit 13 [KO:K12456]
124958183  anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
124984352  anaphase-promoting complex subunit 16 [KO:K25229]
124983936  cell division cycle protein 20 homolog [KO:K03363]
124987197  securin-like [KO:K06635]
124989197  LOW QUALITY PROTEIN: securin-like [KO:K06635]
124983017  separin-like isoform X1 [KO:K02365] [EC:3.4.22.49]
124970575  G2/mitotic-specific cyclin-B2 [KO:K21770]
124964289  cyclin-dependent kinase 4 inhibitor B [KO:K04685]
124964288  cyclin-dependent kinase inhibitor 2A-like isoform X1 [KO:K06621]
124983907  cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
124958520  G1/S-specific cyclin-D1 [KO:K04503]
124988186  G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
124989493  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
124994687  LOW QUALITY PROTEIN: cyclin-A2-like [KO:K06627]
124985165  cyclin-A1 [KO:K06627]
124967069  G1/S-specific cyclin-E1 [KO:K06626]
124977262  G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
124982038  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
124985088  retinoblastoma-associated protein isoform X1 [KO:K06618]
124977154  transcription factor E2F1 [KO:K17454]
124990231  transcription factor E2F2 [KO:K09389]
124988927  transcription factor E2F3 isoform X1 [KO:K06620]
124958109  LOW QUALITY PROTEIN: serine-protein kinase ATM-like [KO:K04728] [EC:2.7.11.1]
124992921  serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
124958320  serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
124991831  serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
124980281  cellular tumor antigen p53 [KO:K04451]
124986648  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
124968815  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
124993166  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
124993330  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
124963509  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
124962260  LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
124976076  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124966582  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124992640  disks large homolog 1 isoform X1 [KO:K12076]
124984679  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
124988890  tumor necrosis factor [KO:K03156]
124984003  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
124986862  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1-like [KO:K04416] [EC:2.7.11.25]
124980435  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
124986765  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
124994121  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
124984745  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
124991717  transcription factor Jun [KO:K04448]
124963740  LOW QUALITY PROTEIN: transcription factor Jun-like [KO:K04448]
124958078  matrilysin-like [KO:K01397] [EC:3.4.24.23]
124962993  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
124963189  interleukin-1 receptor type 2-like isoform X1 [KO:K04387]
124958813  T-cell surface glycoprotein CD3 delta chain-like [KO:K06450]
124959811  T-cell surface glycoprotein CD3 epsilon chain-like isoform X1 [KO:K06451]
124958812  T-cell surface glycoprotein CD3 gamma chain-like [KO:K06452]
124979643  mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
124985256  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
124983354  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
124971778  NF-kappa-B essential modulator isoform X1 [KO:K07210]
124978214  NF-kappa-B inhibitor alpha [KO:K04734]
124994613  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
124960546  transcription factor p65 [KO:K04735]
124980719  G protein pathway suppressor 2 isoform X1 [KO:K15307]
124984004  tumor necrosis factor receptor superfamily member 3-like [KO:K03159]
124978300  tumor necrosis factor receptor superfamily member 5-like isoform X1 [KO:K03160]
124983044  tumor necrosis factor receptor superfamily member 13C-like [KO:K05151]
124980247  mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
124966996  transcription factor RelB isoform X1 [KO:K09253]
124985379  nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
124967606  mRNA decay activator protein ZFP36 [KO:K15308]
124961927  interleukin-2 receptor subunit alpha-like isoform X1 [KO:K05068]
124994014  interleukin-15 [KO:K05433]
124962298  interleukin-15 receptor subunit alpha-like isoform X1 [KO:K05074]
124990183  interleukin-6-like [KO:K05405]
124987664  granulocyte-macrophage colony-stimulating factor-like [KO:K05427]
124989577  lymphotoxin-alpha [KO:K05468]
124976128  bcl-2-like protein 1 isoform X1 [KO:K04570]
124972304  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
124967085  transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
124962328  transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
124977343  transforming growth factor beta-3 proprotein [KO:K13377]
124964432  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
124968435  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
124965420  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
124973148  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
124965442  mothers against decapentaplegic homolog 4 [KO:K04501]
124990345  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
124987010  adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
124962927  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
124978229  LOW QUALITY PROTEIN: adenylate cyclase type 4-like [KO:K08044] [EC:4.6.1.1]
124992559  adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
124983776  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
124966834  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
124965096  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
124970113  LOW QUALITY PROTEIN: adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
124985819  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
124969119  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
124983389  nuclear transcription factor Y subunit beta isoform X1 [KO:K08065]
124988626  HLA class II histocompatibility antigen, DRB1 beta chain-like [KO:K06752]
124988659  mamu class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
124988700  HLA class II histocompatibility antigen, DO alpha chain-like [KO:K06752]
124988738  HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
124988813  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
124988856  HLA class II histocompatibility antigen, DM beta chain-like [KO:K06752]
124988891  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
124988896  HLA class II histocompatibility antigen, DO beta chain-like [KO:K06752]
124988919  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
124988998  HLA class II histocompatibility antigen, DQ alpha 1 chain-like [KO:K06752]
124989317  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
124989318  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
124989319  HLA class II histocompatibility antigen, DRB1 beta chain-like [KO:K06752]
124989492  LOW QUALITY PROTEIN: serum response factor-like [KO:K04378]
124961726  ETS domain-containing protein Elk-4 [KO:K04376]
124971802  ETS domain-containing protein Elk-1 [KO:K04375]
124960242  transcription factor PU.1 [KO:K09438]
124958722  protein C-ets-1 isoform X1 [KO:K02678]
124992665  protein C-ets-2 [KO:K21932]
124988172  TATA-box-binding protein isoform X1 [KO:K03120]
124988286  TATA box-binding protein-like 1 [KO:K03120]
124977741  TATA box-binding protein-like 2 [KO:K03120]
124977967  protein c-Fos [KO:K04379]
124987498  early growth response protein 1 [KO:K09203]
124960610  fos-related antigen 1 [KO:K04502]
124985001  E3 SUMO-protein ligase EGR2 isoform X1 [KO:K12496]
124979032  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
124991113  cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
124958938  cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
124984689  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
124969564  cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
124964377  cyclic AMP-responsive element-binding protein 3-like isoform X1 [KO:K09048]
124979831  LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2-like [KO:K04450]
124984025  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
124991182  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
124988573  cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
124968595  CREB-regulated transcription coactivator 1 isoform X1 [KO:K15309]
124964238  CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
124976766  CREB-regulated transcription coactivator 3 isoform X1 [KO:K16334]
124969981  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
124982357  histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
124968608  LOW QUALITY PROTEIN: histone acetyltransferase KAT2B-like [KO:K06062] [EC:2.3.1.48]
124979680  histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
124968988  transcription factor E2-alpha isoform X1 [KO:K09063]
124983891  DNA polymerase beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
124986736  tyrosine-protein kinase Lck [KO:K05856] [EC:2.7.10.2]
124966672  apoptosis regulator BAX isoform X1 [KO:K02159]
124988066  cyclin-dependent kinase 4 inhibitor C [KO:K06622]
124987078  telomerase reverse transcriptase-like [KO:K11126] [EC:2.7.7.49]
124987112  homeobox protein MSX-2 [KO:K09341]
124994653  homeobox protein MSX-1 [KO:K09341]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Sinet F.
  Title
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
  Journal
BioSciences Master Reviews, July 2013
Reference
PMID:18923409
  Authors
Sattentau Q
  Title
Avoiding the void: cell-to-cell spread of human viruses.
  Journal
Nat Rev Microbiol 6:815-26 (2008)
DOI:10.1038/nrmicro1972
Reference
PMID:15040584
  Authors
Vicente-Manzanares M, Sanchez-Madrid F
  Title
Role of the cytoskeleton during leukocyte responses.
  Journal
Nat Rev Immunol 4:110-22 (2004)
DOI:10.1038/nri1268
Reference
PMID:27334587
  Authors
Dutartre H, Claviere M, Journo C, Mahieux R
  Title
Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
  Journal
J Virol 90:7607-17 (2016)
DOI:10.1128/JVI.00407-16
Reference
PMID:15988028
  Authors
Awasthi S, Sharma A, Wong K, Zhang J, Matlock EF, Rogers L, Motloch P, Takemoto S, Taguchi H, Cole MD, Luscher B, Dittrich O, Tagami H, Nakatani Y, McGee M, Girard AM, Gaughan L, Robson CN, Monnat RJ Jr, Harrod R
  Title
A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.
  Journal
Mol Cell Biol 25:6178-98 (2005)
DOI:10.1128/MCB.25.14.6178-6198.2005
Reference
PMID:21994758
  Authors
Edwards D, Fenizia C, Gold H, de Castro-Amarante MF, Buchmann C, Pise-Masison CA, Franchini G
  Title
Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
  Journal
Viruses 3:861-85 (2011)
DOI:10.3390/v3060861
Reference
PMID:26927155
  Authors
Nakano K, Watanabe T
  Title
HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
  Journal
Viruses 8:58 (2016)
DOI:10.3390/v8030058
Reference
PMID:22783232
  Authors
Shida H
  Title
Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.
  Journal
Front Microbiol 3:179 (2012)
DOI:10.3389/fmicb.2012.00179
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  Title
Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
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Front Microbiol 3:400 (2012)
DOI:10.3389/fmicb.2012.00400
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PMID:18421579
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HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
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Apoptosis 13:733-47 (2008)
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Cell Death Differ 12 Suppl 1:905-15 (2005)
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Silic-Benussi M, Biasiotto R, Andresen V, Franchini G, D'Agostino DM, Ciminale V
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HTLV-1 p13, a small protein with a busy agenda.
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Mol Aspects Med 31:350-8 (2010)
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Fuentes-Gonzalez AM, Contreras-Paredes A, Manzo-Merino J, Lizano M
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The modulation of apoptosis by oncogenic viruses.
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Virol J 10:182 (2013)
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Anti-apoptotic effect of Tax: an NF-kappaB path or a CREB way?
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Viruses 3:1001-14 (2011)
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Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
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Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.
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Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
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Blood 97:2137-44 (2001)
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Reference
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Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
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Retrovirology 1:20 (2004)
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Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
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Annu Rev Immunol 19:475-96 (2001)
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Inactivation of hTERT transcription by Tax.
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Oncogene 22:3734-41 (2003)
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Related
pathway
ncar03013  Nucleocytoplasmic transport
ncar04010  MAPK signaling pathway
ncar04064  NF-kappa B signaling pathway
ncar04110  Cell cycle
ncar04115  p53 signaling pathway
ncar04151  PI3K-Akt signaling pathway
ncar04210  Apoptosis
ncar04350  TGF-beta signaling pathway
ncar04612  Antigen processing and presentation
ncar04660  T cell receptor signaling pathway
ncar04668  TNF signaling pathway
KO pathway
ko05166   
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