KEGG   PATHWAY: pcad05165
Entry
pcad05165                   Pathway                                
Name
Human papillomavirus infection - Physeter catodon (sperm whale)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
pcad05165  Human papillomavirus infection
pcad05165

Organism
Physeter catodon (sperm whale) [GN:pcad]
Gene
102983530  WNT1; proto-oncogene Wnt-1 [KO:K03209]
102984033  WNT2; protein Wnt-2 [KO:K00182]
102988919  WNT2B; protein Wnt-2b [KO:K00182]
102993662  WNT3; proto-oncogene Wnt-3 isoform X2 [KO:K00312]
102986761  WNT3A; protein Wnt-3a [KO:K00312]
102975662  WNT4; protein Wnt-4 isoform X2 [KO:K00408]
102984556  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
102993713  WNT6; protein Wnt-6 [KO:K00445]
102985991  WNT7B; protein Wnt-7b [KO:K00572]
114484267  WNT7A; protein Wnt-7a [KO:K00572]
102975016  WNT8B; protein Wnt-8b [KO:K00714]
102982375  WNT8A; protein Wnt-8a [KO:K00714]
102990829  WNT9A; protein Wnt-9a [KO:K01064]
102973614  WNT9B; protein Wnt-9b [KO:K01064]
102983815  WNT10B; protein Wnt-10b [KO:K01357]
102992887  WNT10A; protein Wnt-10a [KO:K01357]
102987189  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
102994549  WNT16; protein Wnt-16 [KO:K01558]
112066002  FZD1; frizzled-1 [KO:K02432]
102989968  FZD7; frizzled-7 [KO:K02432]
129391354  FZD2; frizzled-2 [KO:K02235]
102991087  FZD3; frizzled-3 isoform X2 [KO:K02329]
102995896  FZD4; frizzled-4 isoform X1 [KO:K02354]
112066481  FZD8; frizzled-8 [KO:K02375]
102986749  FZD5; frizzled-5 [KO:K02375]
102990598  FZD6; frizzled-6 isoform X5 [KO:K02376]
102985281  FZD9; frizzled-9 [KO:K02842]
102995752  FZD10; frizzled-10 [KO:K02842]
102989999  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X3 [KO:K02353]
102980874  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X4 [KO:K02353]
102974146  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
102978702  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
102986270  AXIN1; axin-1 isoform X1 [KO:K02157]
102990422  axin-2 [KO:K04385]
102990003  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
102973647  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
102987227  CTNNB1; catenin beta-1 [KO:K02105]
102975658  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
102982856  TERT; telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
102992878  TCF7; transcription factor 7 isoform X7 [KO:K02620]
102974053  TCF7L1; transcription factor 7-like 1 [KO:K04490]
102987858  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
102975568  UBE3A; ubiquitin-protein ligase E3A isoform X3 [KO:K10587] [EC:2.3.2.26]
102990625  LOW QUALITY PROTEIN: toll-like receptor 3 [KO:K05401]
102975837  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
102974816  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
102994478  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
102994775  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
102986279  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
102990155  IFNB1; interferon beta [KO:K05415]
114485354  CREB-binding protein [KO:K04498] [EC:2.3.1.48]
102983478  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
102991594  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
102975227  TADA3; transcriptional adapter 3 isoform X3 [KO:K11315]
102985658  TP53; cellular tumor antigen p53 [KO:K04451]
102992030  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X3 [KO:K05631]
102984551  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102990471  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
102981214  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
102994511  PARD6A; partitioning defective 6 homolog alpha [KO:K06093]
102974585  PARD6B; partitioning defective 6 homolog beta isoform X1 [KO:K06093]
102982085  PRKCI; protein kinase C iota type isoform X3 [KO:K06069] [EC:2.7.11.13]
102988631  PRKCZ; protein kinase C zeta type isoform X2 [KO:K18952] [EC:2.7.11.13]
102975958  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102976731  SCRIB; protein scribble homolog isoform X6 [KO:K16175]
102986766  DLG1; disks large homolog 1 isoform X4 [KO:K12076]
102982626  DLG2; disks large homolog 2 isoform X2 [KO:K12075]
102980305  DLG3; disks large homolog 3 isoform X3 [KO:K21098]
102983675  LLGL2; LLGL scribble cell polarity complex component 2 isoform X6 [KO:K06094]
102981425  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X6 [KO:K06094]
102994717  CRB3; protein crumbs homolog 3 [KO:K06090]
102973282  PATJ; inaD-like protein isoform X1 [KO:K06092]
102976738  PALS1; protein PALS1 isoform X1 [KO:K06091]
102980033  VWF; von Willebrand factor [KO:K03900]
102995420  THBS1; thrombospondin-1 [KO:K16857]
102977227  THBS4; thrombospondin-4 [KO:K04659]
102975576  COMP; cartilage oligomeric matrix protein [KO:K04659]
102979827  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
102986739  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
102978142  FN1; fibronectin isoform X1 [KO:K05717]
102974557  COL1A2; collagen alpha-2(I) chain [KO:K06236]
102984195  COL1A1; collagen alpha-1(I) chain [KO:K06236]
102984074  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
102992563  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
102984824  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
102975365  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
102988692  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
102978518  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
102978798  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
102984497  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
102976519  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
102978896  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
102986665  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
102987169  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
102979304  LOW QUALITY PROTEIN: collagen alpha-4(VI) chain-like [KO:K06238]
102974331  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
102975888  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
102989754  COL9A2; LOW QUALITY PROTEIN: collagen alpha-2(IX) chain [KO:K08131]
102981656  LAMA2; laminin subunit alpha-2 [KO:K05637]
102992685  LAMA1; laminin subunit alpha-1 [KO:K05637]
102982121  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
102974155  LAMA5; laminin subunit alpha-5 [KO:K06240]
102983001  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
102996119  LAMB1; laminin subunit beta-1 [KO:K05636]
102987884  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
102993220  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
102982705  LAMC1; laminin subunit gamma-1 [KO:K05635]
102982443  LAMC2; laminin subunit gamma-2 [KO:K06246]
114487451  LAMC3; laminin subunit gamma-3 [KO:K06247]
102989664  laminin subunit gamma-3 [KO:K06247]
102985243  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
102975311  SPP1; osteopontin [KO:K06250]
102986411  VTN; vitronectin [KO:K06251]
102986674  TNN; tenascin-N isoform X1 [KO:K06252]
102984868  TNXB; tenascin-X isoform X1 [KO:K06252]
102994805  TNC; tenascin isoform X1 [KO:K06252]
102987616  TNR; tenascin-R [KO:K06252]
102994673  IBSP; bone sialoprotein 2 [KO:K06253]
102976588  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
102977795  ITGA2; integrin alpha-2 [KO:K06481]
102994051  ITGA2B; integrin alpha-IIb isoform X5 [KO:K06476]
102982420  ITGA3; integrin alpha-3 isoform X2 [KO:K06482]
102977938  ITGA4; integrin alpha-4 [KO:K06483]
102983046  ITGA5; integrin alpha-5 [KO:K06484]
102993444  ITGA6; integrin alpha-6 isoform X2 [KO:K06485]
102980052  ITGA7; integrin alpha-7 isoform X6 [KO:K06583]
102990518  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
102978662  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
102983262  ITGA10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
102994576  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
102980851  ITGAV; integrin alpha-V [KO:K06487]
102984702  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
102988740  ITGB3; integrin beta-3 isoform X2 [KO:K06493]
102985278  ITGB4; integrin beta-4 isoform X3 [KO:K06525]
102995205  ITGB5; integrin beta-5 [KO:K06588]
102992382  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
102976793  ITGB7; integrin beta-7 [KO:K06590]
102982672  ITGB8; integrin beta-8 [KO:K06591]
102982229  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
102975066  PXN; paxillin isoform X2 [KO:K05760]
102983069  TNF; tumor necrosis factor [KO:K03156]
102980613  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
102986061  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
102979864  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102985097  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
102973514  FAS-associated death domain protein isoform X1 [KO:K02373]
112067437  FAS-associated death domain protein isoform X1 [KO:K02373]
102988082  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
102977692  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
102974343  NHERF1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform X2 [KO:K13365]
102974912  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
102993796  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
102992184  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X2 [KO:K03456]
102992659  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
102985759  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
102982040  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
102976080  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
102993492  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X3 [KO:K04354]
102974323  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
102985008  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
102986162  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
102983421  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
102994835  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
102984521  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
102987078  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
102996184  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
102983610  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like [KO:K11584]
102991442  TSC1; hamartin isoform X1 [KO:K07206]
102985473  TSC2; tuberin isoform X9 [KO:K07207]
102994517  RHEB; GTP-binding protein Rheb [KO:K07208]
102991493  MTOR; serine/threonine-protein kinase mTOR isoform X2 [KO:K07203] [EC:2.7.11.1]
102995068  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
102976885  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
102990399  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
102991092  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
102974655  BAD; bcl2-associated agonist of cell death [KO:K02158]
102995915  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
102986098  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102978952  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102977108  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102975555  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102991779  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102991192  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
102981524  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102976971  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
102990087  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102980680  FOXO1; forkhead box protein O1 [KO:K07201]
102981902  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
102995437  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
102996914  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102981679  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
102987349  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
102985179  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
102992532  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
102988829  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
102980091  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
102995000  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
102995201  RB1; retinoblastoma-associated protein [KO:K06618]
102991911  RBL1; retinoblastoma-like protein 1 isoform X4 [KO:K04681]
102976320  RBL2; retinoblastoma-like protein 2 [KO:K16332]
102975603  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
102993481  E2F1; transcription factor E2F1 [KO:K17454]
102986587  CCNA2; cyclin-A2 [KO:K06627]
102973638  CCNA1; cyclin-A1 [KO:K06627]
102975752  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
102979131  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
102981739  VEGFA; vascular endothelial growth factor A isoform X7 [KO:K05448]
102977668  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2 [KO:K04467] [EC:2.7.11.10]
102976706  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
114485485  NF-kappa-B essential modulator-like isoform X1 [KO:K07210]
102980964  IKBKG; NF-kappa-B essential modulator [KO:K07210]
102981135  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102974198  RELA; transcription factor p65 isoform X1 [KO:K04735]
102980125  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
102996018  NFX1; transcriptional repressor NF-X1 [KO:K12236]
102993806  HDAC2; histone deacetylase 2 isoform X3 [KO:K06067] [EC:3.5.1.98]
102991367  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
102995970  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X2 [KO:K11643] [EC:5.6.2.-]
102982890  IRF1; interferon regulatory factor 1 isoform X1 [KO:K09444]
102986226  TBPL1; TATA box-binding protein-like 1 [KO:K03120]
102986759  TBPL2; TATA box-binding protein-like 2 [KO:K03120]
102976096  TBP; LOW QUALITY PROTEIN: TATA-box-binding protein [KO:K03120]
102992455  LOW QUALITY PROTEIN: TATA-box-binding protein-like [KO:K03120]
112064291  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X2 [KO:K06751]
112064292  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
112064318  BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
102996245  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102985933  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
102983511  BCAP31; B-cell receptor-associated protein 31 [KO:K14009]
102996583  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
102977860  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
102995815  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
102992584  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
102973627  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X2 [KO:K02148]
102976248  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
102987448  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
102989820  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
102994748  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
102988333  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
102997022  V-type proton ATPase subunit G 1 [KO:K02152]
102984396  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
102973745  V-type proton ATPase subunit G 1-like [KO:K02152]
102981449  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
102976000  ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 isoform X1 [KO:K02154]
102975289  ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 [KO:K02154]
102979493  TCIRG1; V-type proton ATPase 116 kDa subunit a 3 [KO:K02154]
102986918  ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 isoform X3 [KO:K02154]
102991473  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X1 [KO:K02146]
102980876  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
102995698  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
102995354  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
102996599  V-type proton ATPase subunit e 1-like [KO:K02153]
112062206  V-type proton ATPase subunit e 1-like [KO:K02153]
112062393  V-type proton ATPase subunit e 1-like [KO:K02153]
102978613  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
102991400  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' isoform X1 [KO:K03661]
102985837  V-type proton ATPase 21 kDa proteolipid subunit c''-like [KO:K03661]
102978040  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
102977431  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102975467  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
114483947  growth factor receptor-bound protein 2 [KO:K04364]
102991639  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102981677  LOW QUALITY PROTEIN: son of sevenless homolog 2-like [KO:K03099]
102978925  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
102994715  HRAS; GTPase HRas isoform X2 [KO:K02833]
102977125  KRAS; GTPase KRas isoform X1 [KO:K07827]
102992439  LOW QUALITY PROTEIN: GTPase NRas-like [KO:K07828]
102982641  NRAS; LOW QUALITY PROTEIN: GTPase NRas [KO:K07828]
102987866  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
102992191  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102994150  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102984305  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102989074  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102982708  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
102985728  PTGER4; prostaglandin E2 receptor EP4 subtype isoform X1 [KO:K04261]
102993267  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X2 [KO:K04632]
102987258  neuroendocrine secretory protein 55-like [KO:K04632]
102988341  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
102981091  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102995361  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
102989082  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102994621  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X2 [KO:K09048]
102986078  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X3 [KO:K09048]
102987194  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
102975387  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
129391322  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
102985635  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X3 [KO:K09047]
102981170  UBR4; E3 ubiquitin-protein ligase UBR4 isoform X1 [KO:K10691] [EC:2.3.2.27]
114485054  E3 ubiquitin-protein ligase UBR4-like [KO:K10691] [EC:2.3.2.27]
102995502  tubulin gamma-2 chain isoform X1 [KO:K10389]
102974162  TUBG1; tubulin gamma-1 chain isoform X1 [KO:K10389]
114485269  tubulin gamma-2 chain-like [KO:K10389]
102983574  PKM; pyruvate kinase PKM isoform X3 [KO:K00873] [EC:2.7.1.40]
112065747  interferon alpha-1-like [KO:K05414]
102980314  interferon alpha-1-like [KO:K05414]
102991034  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
102989482  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
102988182  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
102985137  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
102977655  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
102981574  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
102992486  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
102977777  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
102979857  OASL; 2'-5'-oligoadenylate synthase-like protein isoform X1 [KO:K14608]
102982101  LOW QUALITY PROTEIN: interferon-induced GTP-binding protein Mx1 [KO:K14754]
102986939  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
102974158  JAG1; protein jagged-1 isoform X1 [KO:K06052]
102982122  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
102990689  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
102974641  NOTCH3; neurogenic locus notch homolog protein 3 isoform X2 [KO:K20995]
102974807  NOTCH4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996]
102996079  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
102990636  LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
102977711  RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
102989837  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
102987479  MAML2; mastermind-like protein 2 [KO:K06061]
102986756  MAML1; mastermind-like protein 1 [KO:K06061]
102988559  MAML3; mastermind-like protein 3 isoform X1 [KO:K06061]
102980498  recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
102989584  RBPJL; recombining binding protein suppressor of hairless-like protein isoform X1 [KO:K06053]
102996082  LOW QUALITY PROTEIN: recombining binding protein suppressor of hairless-like [KO:K06053]
102975703  HES1; transcription factor HES-1 [KO:K06054]
102989478  HES6; transcription cofactor HES-6 isoform X1 [KO:K09087]
112065282  HES2; transcription factor HES-2 [KO:K09087]
102991747  HES7; transcription factor HES-7 isoform X1 [KO:K09087]
102985217  HES3; transcription factor HES-3 [KO:K09088]
112065286  HES4; transcription factor HES-4 [KO:K09089]
112065284  HES5; transcription factor HES-5 [KO:K06055]
102980417  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
102979695  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 isoform X1 [KO:K09091]
102996380  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X2 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Human papillomavirus oncoproteins: pathways to transformation.
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Nat Rev Cancer 10:550-60 (2010)
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Rev Med Virol 25 Suppl 1:24-53 (2015)
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Rev Med Virol 19:97-113 (2009)
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Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.
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PMID:11486705
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The molecular biology of cervical cancer.
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Reference
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Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
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J Natl Cancer Inst 92:690-8 (2000)
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Reference
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Human papillomaviruses and cell signaling.
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Sci STKE 2005:pe29 (2005)
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Reference
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The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
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Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
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Viruses 7:4734-55 (2015)
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Sci Rep 5:13446 (2015)
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Pathogens 5:E8 (2016)
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The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
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Viruses 7:3530-51 (2015)
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Reference
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PDZ domains: the building blocks regulating tumorigenesis.
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Biochem J 439:195-205 (2011)
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Human tumour viruses and the deregulation of cell polarity in cancer.
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Human papillomaviruses, cervical cancer and cell polarity.
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Mol Cell Proteomics 11:M112.016998 (2012)
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Reference
PMID:9990017
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Zwerschke W, Mazurek S, Massimi P, Banks L, Eigenbrodt E, Jansen-Durr P
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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Reference
PMID:15175323
  Authors
Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y
  Title
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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J Biol Chem 279:35664-70 (2004)
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Reference
PMID:18505829
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Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Mol Cell Biol 28:4819-28 (2008)
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Reference
PMID:23536685
  Authors
Raff AB, Woodham AW, Raff LM, Skeate JG, Yan L, Da Silva DM, Schelhaas M, Kast WM
  Title
The evolving field of human papillomavirus receptor research: a review of binding and entry.
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J Virol 87:6062-72 (2013)
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Related
pathway
pcad04064  NF-kappa B signaling pathway
pcad04110  Cell cycle
pcad04115  p53 signaling pathway
pcad04150  mTOR signaling pathway
pcad04151  PI3K-Akt signaling pathway
pcad04210  Apoptosis
pcad04310  Wnt signaling pathway
pcad04330  Notch signaling pathway
pcad04510  Focal adhesion
pcad04520  Adherens junction
pcad04530  Tight junction
pcad04612  Antigen processing and presentation
pcad04620  Toll-like receptor signaling pathway
pcad04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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