KEGG   PATHWAY: ptet04010
Entry
ptet04010                   Pathway                                
Name
MAPK signaling pathway - Puntigrus tetrazona (Sumatra barb)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
ptet04010  MAPK signaling pathway
ptet04010

Other DBs
GO: 0000165
Organism
Puntigrus tetrazona (Sumatra barb) [GN:ptet]
Gene
122330866  cacna1aa; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
122354178  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b isoform X1 [KO:K04344]
122326934  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
122345458  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a isoform X1 [KO:K04849]
122342654  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
122335503  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
122353965  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
122323041  cacna1eb; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
122350454  LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
122350026  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
122350696  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
122355412  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
122338236  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
122333341  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
122341939  cacna1ia; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
122327907  cacna1sa; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, L type, alpha 1S subunit, a [KO:K04857]
122350146  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
122363109  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
122343507  cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a isoform X1 [KO:K04858]
122327305  cacna2d2b; voltage-dependent calcium channel subunit alpha-2/delta-2b isoform X1 [KO:K04859]
122346648  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
122335515  cacna2d3a; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
122353967  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
122331122  cacna2d4b; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
122342625  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
122341548  voltage-dependent L-type calcium channel subunit beta-1-like [KO:K04862]
122341678  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
122348623  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
122328628  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a isoform X1 [KO:K04864]
122329310  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
122341544  voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865]
122347603  cacnb4b; voltage-dependent L-type calcium channel subunit beta-4b isoform X1 [KO:K04865]
122352078  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a [KO:K04865]
122333409  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
122347590  cacng1a; calcium channel, voltage-dependent, gamma subunit 1a [KO:K04866]
122329447  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
122333291  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
122347048  cacng3a; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
122342171  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
122329342  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
122347444  cacng4a; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
122335298  cacng5b; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
122346622  cacng5a; calcium channel, voltage-dependent, gamma subunit 5a [KO:K04870]
122324131  cacng6a; calcium channel, voltage-dependent, gamma subunit 6a [KO:K04871]
122360163  cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
122324226  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a [KO:K04872]
122359887  cacng7b; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
122324232  cacng8a; calcium channel, voltage-dependent, gamma subunit 8a isoform X1 [KO:K04873]
122360161  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
122333172  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
122341761  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
122344253  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
122360276  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
122353933  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
122334878  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
122346932  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
122337000  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
122346931  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
122341311  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
122323091  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a isoform X1 [KO:K04347]
122346441  gng12b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
122326788  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122347976  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
122348112  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
122357460  ppp3cb; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
122345792  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
122352932  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
122335478  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
122345541  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
122322974  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
122362472  ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349]
122333831  rasgrf2a; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
122345461  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
122362898  rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K04350]
122326088  rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
122348779  RAS guanyl-releasing protein 2 [KO:K12361]
122361807  rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
122342281  rapgef2a; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
122357604  rapgef2b; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2 [KO:K08018]
122331785  nf1b; neurofibromin isoform X1 [KO:K08052]
122359004  nf1a; neurofibromin isoform X1 [KO:K08052]
122359041  neurofibromin-like [KO:K08052]
122333766  rasa1b; ras GTPase-activating protein 1 [KO:K04352]
122345178  rasa1a; ras GTPase-activating protein 1 [KO:K04352]
122362853  rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
122354231  rap1ab; ras-related protein rap1ab [KO:K04353]
122350014  rap1aa; RAP1A, member of RAS oncogene family a [KO:K04353]
122343501  rap1b; ras-related protein Rap-1b [KO:K07836]
122357370  egf; pro-epidermal growth factor [KO:K04357]
122347565  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
122326704  fgf1b; fibroblast growth factor 1b [KO:K18496]
122357455  fgf1a; putative fibroblast growth factor 1 [KO:K18496]
122333592  fgf2; fibroblast growth factor 2 [KO:K18497]
122326158  fgf10a; fibroblast growth factor 10a isoform X1 [KO:K04358]
122327822  fgf22; fibroblast growth factor 22 [KO:K04358]
122330617  fgf6a; fibroblast growth factor 6a [KO:K04358]
122332311  fgf9; fibroblast growth factor 4A isoform X1 [KO:K04358]
122333372  fgf8b; fibroblast growth factor 8b [KO:K04358]
122335628  fgf20a; fibroblast growth factor 20a [KO:K04358]
122348278  fgf3; fibroblast growth factor 3 [KO:K04358]
122348309  fgf4; fibroblast growth factor 4 [KO:K04358]
122356207  fgf8a; fibroblast growth factor 8 [KO:K04358]
122363147  fgf7; fibroblast growth factor 7 [KO:K04358]
122350079  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
122350130  fibroblast growth factor 20-like [KO:K04358]
122357314  fgf24; fibroblast growth factor 24 isoform X1 [KO:K04358]
122357445  fgf16; fibroblast growth factor 16 [KO:K04358]
122357919  fgf20b; fibroblast growth factor 20b [KO:K04358]
122343251  fgf6b; fibroblast growth factor 6b [KO:K04358]
122358285  fgf18a; fibroblast growth factor 18a isoform X1 [KO:K04358]
122344971  fgf10b; fibroblast growth factor 10b [KO:K04358]
122352577  fgf18b; fibroblast growth factor 18b isoform X1 [KO:K04358]
122345934  fgf5; fibroblast growth factor 5 [KO:K04358]
122349672  fgf19; fibroblast growth factor 19 [KO:K22603]
122332506  fgf21; fibroblast growth factor 21 [KO:K22429]
122343401  fgf23; fibroblast growth factor 23 [KO:K22428]
122328492  ngfa; neurotrophin-7 [KO:K02582]
122346605  ngfb; nerve growth factor [KO:K02582]
122347827  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
122342402  ntf3; neurotrophin-3 [KO:K04356]
122342085  insulin [KO:K04526]
122358096  insb; preproinsulin b [KO:K04526]
122344767  ins; insulin [KO:K04526]
122343405  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
122330745  igf2b; insulin-like growth factor 2b [KO:K13769]
122349497  igf2a; insulin-like growth factor 2a [KO:K13769]
122328185  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
122341462  pdgfab; platelet-derived growth factor alpha polypeptide b isoform X1 [KO:K04359]
122341906  pdgfbb; uncharacterized protein pdgfbb [KO:K04359]
122327865  myb-like protein Q isoform X1 [KO:K17386]
122358304  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
122359132  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
122354110  csf1a; macrophage colony-stimulating factor 1a [KO:K05453]
122331006  kitlga; kit ligand a [KO:K05461]
122343339  kitlgb; kit ligand b [KO:K05461]
122342650  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
122360288  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
122324419  pgfa; snake venom vascular endothelial growth factor toxin isoform X1 [KO:K16859]
122362267  pgfb; placenta growth factor [KO:K16859]
122351124  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
122354187  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
122323126  hepatocyte growth factor [KO:K05460]
122343515  hgfa; hepatocyte growth factor a isoform X1 [KO:K05460]
122323973  angpt1; angiopoietin-1 [KO:K05465]
122359938  angiopoietin-1-like [KO:K05465]
122360030  angiopoietin-1-like isoform X1 [KO:K05465]
122323416  angpt2b; LOW QUALITY PROTEIN: angiopoietin-2b [KO:K05466]
122356729  angpt2a; angiopoietin-2a [KO:K05466]
122323587  efna1a; ephrin-A1a [KO:K05462]
122323409  efna3a; ephrin-A3 [KO:K05462]
122326889  efna5a; ephrin-A5b [KO:K05462]
122356565  efna2a; ephrin-A2 isoform X1 [KO:K05462]
122351053  efna5b; ephrin-A5b isoform X1 [KO:K05462]
122353556  ephrin-A2-like [KO:K05462]
122360503  efna3b; ephrin-A3b [KO:K05462]
122360504  si:dkey-246i14.3; ephrin-A4 [KO:K05462]
122360928  efna1b; ephrin-A1b [KO:K05462]
122333875  gdnfa; glial cell line-derived neurotrophic factor [KO:K05452]
122345995  gdnfb; glial cell line-derived neurotrophic factor [KO:K05452]
122335658  neurturin [KO:K25414]
122353714  nrtn; neurturin [KO:K25414]
122357527  artemin [KO:K25415]
122346563  neurturin isoform X1 [KO:K25415]
122327087  persephin [KO:K25416]
122325042  LOW QUALITY PROTEIN: epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
122329898  epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
122360456  egfra; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
122355427  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
122328325  erbb3b; receptor tyrosine-protein kinase erbB-3b isoform X1 [KO:K05084] [EC:2.7.10.1]
122346970  erbb3a; receptor tyrosine-protein kinase erbB-3a isoform X1 [KO:K05084] [EC:2.7.10.1]
122350890  si:ch73-383l1.1; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
122351886  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
122345904  erbb4a; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
122350549  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
122353144  fgfr1b; fibroblast growth factor receptor 1b isoform X1 [KO:K04362] [EC:2.7.10.1]
122356379  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
122356737  fgfr3; LOW QUALITY PROTEIN: fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
122326566  fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
122337427  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
122355795  ngfrb; nerve growth factor receptor b isoform X1 [KO:K02583]
122359998  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
122360017  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
122360019  high affinity nerve growth factor receptor-like [KO:K03176] [EC:2.7.10.1]
122350518  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a isoform X1 [KO:K04360] [EC:2.7.10.1]
122345312  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b [KO:K04360] [EC:2.7.10.1]
122327303  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
122359571  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
122349311  igf1rb; insulin-like growth factor 1b receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
122363083  igf1ra; LOW QUALITY PROTEIN: insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
122325140  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
122325223  LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha-like [KO:K04363] [EC:2.7.10.1]
122357618  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
122326633  csf1rb; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
122357619  macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
122325240  kita; LOW QUALITY PROTEIN: mast/stem cell growth factor receptor kita [KO:K05091] [EC:2.7.10.1]
122341723  kitb; KIT proto-oncogene, receptor tyrosine kinase b isoform X1 [KO:K05091] [EC:2.7.10.1]
122330056  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
122329486  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
122357583  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
122358192  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
122342748  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
122330906  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
122344957  tek; tyrosine-protein kinase receptor Tie-2 [KO:K05121] [EC:2.7.10.1]
122328966  epha2b; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
122347446  epha2a; ephrin type-A receptor 2a [KO:K05103] [EC:2.7.10.1]
122356928  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
122347088  grb2a; growth factor receptor-bound protein 2a isoform X1 [KO:K04364]
122341812  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
122354393  son of sevenless homolog 2-like [KO:K03099]
122354677  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
122356517  sos2; son of sevenless homolog 2 [KO:K03099]
122331115  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
122349499  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
122330578  kras; GTPase KRas isoform X1 [KO:K07827]
122330765  GTPase KRas-like [KO:K07827]
122341555  zgc:55558 [KO:K07827]
122350810  nras; GTPase NRas [KO:K07828]
122348817  rras2; ras-related protein R-Ras2 [KO:K07830]
122341803  rras; ras-related protein R-Ras [KO:K07830]
122328142  mrasb; ras-related protein M-Ras [KO:K07831]
122351969  mrasa; ras-related protein M-Ras isoform X1 [KO:K07831]
122345507  araf; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
122342715  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
122328991  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
122354079  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
122323040  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
122324621  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
122327733  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
122356998  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
122338606  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122345817  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122324688  mknk2a; MAP kinase-interacting serine/threonine-protein kinase 2a isoform X1 [KO:K04372] [EC:2.7.11.1]
122349974  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
122354139  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
122329795  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
122361892  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
122357074  rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
122357385  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
122344743  rps6ka3a; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
122345427  ribosomal protein S6 kinase alpha-1-like [KO:K04373] [EC:2.7.11.1]
122333319  atf4a; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
122341910  atf4b; activating transcription factor 4b [KO:K04374]
122350582  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
122353593  elk4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
122325413  mycb; transcriptional regulator Myc-B [KO:K04377]
122329955  myca; transcriptional regulator Myc-A [KO:K04377]
122327658  srfa; serum response factor a isoform X1 [KO:K04378]
122356332  srfb; serum response factor b isoform X1 [KO:K04378]
122324473  si:ch211-153j24.3; proto-oncogene c-Fos isoform X1 [KO:K04379]
122325196  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
122361624  fosaa; proto-oncogene c-Fos isoform X1 [KO:K04379]
122355403  mapta; microtubule-associated protein tau isoform X1 [KO:K04380]
122323286  stmn1a; stathmin 1a [KO:K04381]
122360574  stmn1b; stathmin 1b [KO:K04381]
122325230  pla2g4ab; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
122361986  cytosolic phospholipase A2 delta-like [KO:K16342] [EC:3.1.1.4]
122362350  pla2g4f.1; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
122344690  LOW QUALITY PROTEIN: cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
122344691  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
122344692  LOW QUALITY PROTEIN: cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
122344695  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
122360411  pla2g4aa; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
122323306  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
122333704  il1b; interleukin-1 beta [KO:K04519]
122326853  tgfb1b; transforming growth factor beta-1 proprotein [KO:K13375]
122358909  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
122357923  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
122360659  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
122361797  tgfb3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
122360906  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
122333088  zmp:0000000936; interleukin-1 receptor type 1 [KO:K04386]
122333089  interleukin-1 receptor type 1 isoform X1 [KO:K04386]
122359171  interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
122329535  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
122359216  LOW QUALITY PROTEIN: TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
122333272  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
122351604  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
122360512  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
122324582  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
122362301  fas; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 6 [KO:K04390]
122335596  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
122355779  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
122341957  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
122333431  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
122342115  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
122328447  cell division control protein 42 homolog isoform X1 [KO:K04393]
122329267  cdc42l2; LOW QUALITY PROTEIN: cell division cycle 42 like 2 [KO:K04393]
122354652  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
122360115  cdc42l; cell division cycle 42, like [KO:K04393]
122349119  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
122347890  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
122358134  casp3b; LOW QUALITY PROTEIN: caspase-3b [KO:K02187] [EC:3.4.22.56]
122345294  traf2b; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
122345455  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
122345572  traf2a; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
122335149  LOW QUALITY PROTEIN: death domain-associated protein 6-like [KO:K02308]
122335294  LOW QUALITY PROTEIN: death domain-associated protein 6-like [KO:K02308]
122342372  death domain-associated protein 6-like [KO:K02308]
122329857  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
122350483  irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
122330912  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
122349485  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
122323081  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
122326240  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
122326646  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
122355228  gadd45bb; growth arrest and DNA-damage-inducible, beta b [KO:K04402]
122351101  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
122346440  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
122353917  growth arrest and DNA damage-inducible protein GADD45 beta-like isoform X1 [KO:K04402]
122353919  growth arrest and DNA damage-inducible protein GADD45 beta-like isoform X1 [KO:K04402]
122333337  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
122324605  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
122348336  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial-like isoform X1 [KO:K04405]
122348337  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
122362064  map4k3b; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
122354164  map4k3a; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
122357252  si:zfos-2326c3.2; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
122323179  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
122326007  pak2a; serine/threonine-protein kinase PAK 2a [KO:K04410] [EC:2.7.11.1]
122327784  pak2b; serine/threonine-protein kinase PAK 2b isoform X1 [KO:K04410] [EC:2.7.11.1]
122323703  stk3; serine/threonine-protein kinase 3 [KO:K04412]
122326690  map4k6; mitogen-activated protein kinase kinase kinase kinase 6 isoform X1 [KO:K04414] [EC:2.7.11.1]
122349403  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
122332144  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
122352837  map3k1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
122349206  mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
122346889  map3k2; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
122329800  map3k22; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
122341269  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
122356867  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
122363095  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
122356601  map3k21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
122340425  map3k12; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
122333098  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
122351453  zak; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
122346388  protein kinase Npk [KO:K04424] [EC:2.7.11.25]
122334658  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
122360136  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
122324727  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
122356415  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 4-like [KO:K04428] [EC:2.7.11.25]
122356416  map3k4; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
122326655  taok1b; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
122333366  taok2b; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
122337825  LOW QUALITY PROTEIN: serine/threonine-protein kinase TAO2-like [KO:K04429] [EC:2.7.11.1]
122358546  taok1a; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
122344830  taok3a; LOW QUALITY PROTEIN: serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
122345597  taok3b; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
122332668  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
122341614  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
122345306  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
122355522  map2k6; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
122348947  mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
122357545  C-Jun-amino-terminal kinase-interacting protein 1-like [KO:K04434]
122363016  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
122338831  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
122328540  flna; filamin-A [KO:K04437]
122326476  crkl; crk-like protein [KO:K04438]
122326541  crk; adapter molecule crk [KO:K04438]
122348598  arrb2b; arrestin, beta 2b isoform X1 [KO:K04439]
122358865  arrb1; beta-arrestin-1 [KO:K04439]
122352603  arrb2a; arrestin, beta 2a isoform X1 [KO:K04439]
122326583  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122326296  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
122333386  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122356615  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122328952  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
122362974  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
122342450  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
122350211  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
122350837  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
122343362  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
122353563  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
122345188  mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
122354673  mapkapk2a; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
122350734  mapkapk2b; MAP kinase-activated protein kinase 2b [KO:K04443] [EC:2.7.11.1]
122353599  mapkapk3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
122361480  rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
122345291  rps6ka4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
122356116  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
122323978  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
122330790  nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
122348515  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
122324581  jun; transcription factor AP-1 [KO:K04448]
122344965  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
122335618  jund; transcription factor jun-D [KO:K04449]
122351902  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
122347860  cellular tumor antigen p53-like isoform X1 [KO:K04451]
122345417  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
122334337  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
122324482  max; protein max isoform X1 [KO:K04453]
122333750  mef2ca; myocyte enhancer factor 2ca isoform X1 [KO:K04454]
122345153  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
122346040  hspb1; heat shock protein beta-1 [KO:K04455]
122325188  LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
122334475  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122355848  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
122362868  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122356955  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122342821  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122326048  ppm1nb; protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) [KO:K04457] [EC:3.1.3.16]
122356276  ppm1aa; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
122342772  ppm1ab; protein phosphatase, Mg2+/Mn2+ dependent, 1Ab [KO:K04457] [EC:3.1.3.16]
122359250  ppm1na; protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) [KO:K04457] [EC:3.1.3.16]
122342992  ptprr; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K04458] [EC:3.1.3.48]
122349695  ptpn5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
122357325  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
122326854  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122328068  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122330443  LOW QUALITY PROTEIN: dual specificity protein phosphatase 8-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122330577  dusp8a; LOW QUALITY PROTEIN: dual specificity protein phosphatase 8a [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122333185  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122350598  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122353833  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122330601  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
122325058  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
122355191  dual specificity protein phosphatase 3-like isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
122355738  dusp3a; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
122341619  dusp3b; dual specificity protein phosphatase 3b isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
122359279  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
122332175  protein phosphatase 1B-like isoform X1 [KO:K04461] [EC:3.1.3.16]
122355456  ppm1bb; protein phosphatase 1bb isoform X1 [KO:K04461] [EC:3.1.3.16]
122356806  ppm1ba; LOW QUALITY PROTEIN: protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
122341749  heat shock 70 kDa protein [KO:K03283]
122341935  heat shock 70 kDa protein-like [KO:K03283]
122350169  hspa1b; heat shock 70 kDa protein-like [KO:K03283]
122358907  heat shock cognate 71 kDa protein-like [KO:K03283]
122358948  hspa8b; LOW QUALITY PROTEIN: heat shock protein family A (Hsp70) member 8b [KO:K03283]
122352702  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
122359151  mecom; MDS1 and EVI1 complex locus protein EVI1-A isoform X1 [KO:K04462] [EC:2.1.1.367]
122348777  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
122361708  LOW QUALITY PROTEIN: mitogen-activated protein kinase 7-like [KO:K04464] [EC:2.7.11.24]
122355210  LOW QUALITY PROTEIN: mitogen-activated protein kinase 7-like [KO:K04464] [EC:2.7.11.24]
122328669  nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
122329739  uncharacterized protein LOC122329739 [KO:K04466] [EC:2.7.11.25]
122341627  map3k14a; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
122356355  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
122350917  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
122328953  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
122337270  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
122358381  serine/threonine-protein kinase NLK-like [KO:K04468] [EC:2.7.11.24]
122358437  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
122357311  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
122356137  nfkb2; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p100 subunit [KO:K04469]
122349211  rela; transcription factor p65 isoform X1 [KO:K04735]
122358357  relb; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
ptet04070  Phosphatidylinositol signaling system
ptet04110  Cell cycle
ptet04115  p53 signaling pathway
ptet04210  Apoptosis
ptet04310  Wnt signaling pathway
KO pathway
ko04010   
LinkDB

DBGET integrated database retrieval system